Plasma and BAL fluid concentrations of antimicrobial peptides in patients with Mycobacterium avium-intracellulare infection.

Abstract:

STUDY OBJECTIVES:To investigate the roles of human alpha-defensin (HAD), human beta-defensin (HBD)-1, and HBD-2, novel antimicrobial peptides, in patients with Mycobacterium avium-intracellulare infection (MAI). PATIENTS:The study included 25 patients (10 men) with MAI who visited our hospital between June 1998 and August 1999. MEASUREMENTS AND RESULTS:In patients with pulmonary MAI, we measured HAD and HBD-1, and HBD-2 levels in plasma and in BAL fluid (BALF) by radioimmunoassay. Plasma concentrations of HAD and HBD-2 in those patients were higher than those in control subjects, whereas HBD-1 levels were similar to those in the control subjects. High levels of HAD and HBD-2, but not HBD-1, also were observed in the BALF of MAI patients. There was a positive correlation between HAD and interleukin (IL)-8 concentrations in the BALF of patients with MAI. BALF HBD-2 concentrations also correlated positively with those of plasma HBD-2 and BALF IL-1 beta in MAI patients. Patients with cavity formation on the chest roentgenogram had higher HAD and HBD-2 levels in their BALF than those of patients without cavity formation. Treatment with clarithromycin combined with two or three other antibiotics, including ethambutol, rifampicin, ofloxacin, or ciprofloxacin, for at least 6 months resulted in a significant fall in plasma HBD-2 concentrations in responders, but not in nonresponders. CONCLUSION:Our findings suggest that HAD and HBD-2 may participate in host defense and local remodeling of the respiratory tract in patients with MAI and that plasma HBD-2 levels may be a useful marker of disease activity in patients with pulmonary MAI.

journal_name

Chest

journal_title

Chest

authors

Ashitani J,Mukae H,Hiratsuka T,Nakazato M,Kumamoto K,Matsukura S

doi

10.1378/chest.119.4.1131

subject

Has Abstract

pub_date

2001-04-01 00:00:00

pages

1131-7

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)52071-0

journal_volume

119

pub_type

杂志文章

相关文献

CHEST文献大全
  • PREPARED: Preparation for Angiography in Renal Dysfunction: a randomized trial of inpatient vs outpatient hydration protocols for cardiac catheterization in mild-to-moderate renal dysfunction.

    abstract:BACKGROUND:IV hydration before and after cardiac catheterization is effective in preventing contrast-associated renal dysfunction for patients with mild-to-moderate renal insufficiency, but necessitates overnight hospital admission. We tested an outpatient oral precatheterization hydration strategy in comparison with o...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.114.6.1570

    authors: Taylor AJ,Hotchkiss D,Morse RW,McCabe J

    更新日期:1998-12-01 00:00:00

  • Nocturnal nasal continuous positive airway pressure in patients with chronic obstructive pulmonary disease. Influence on waking respiratory muscle function.

    abstract::Patients with COPD often have reduced inspiratory muscle strength and endurance as well as poor exercise tolerance. Increased inspiratory work during sleep (probably due to increased upper airway resistance) may further strain these compromised respiratory muscles in COPD patients. We hypothesized that nasal continuou...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.106.4.1100

    authors: Mezzanotte WS,Tangel DJ,Fox AM,Ballard RD,White DP

    更新日期:1994-10-01 00:00:00

  • What is hypopnea, anyway?

    abstract::Quantitation of apneas and hypopneas is routinely included in studies of epidemiology, diagnosis, and treatment of sleep-disordered breathing (SDB). The definition of apnea appears clear-cut in the sleep literature. In contrast, the literature contains remarkable variety in both recording techniques and definitions of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.2.426

    authors: Moser NJ,Phillips BA,Berry DT,Harbison L

    更新日期:1994-02-01 00:00:00

  • Long-term outcome of pulmonary rehabilitation in patients with COPD.

    abstract:BACKGROUND:This study investigates the long-term benefits of pulmonary rehabilitation in terms of health-related quality of life (HRQL). Such information is of particular importance in developing strategies for aftercare at home which aim to maintain the initial improvements seen after rehabilitation. METHODS:Criteria...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.112.2.363

    authors: Ketelaars CA,Abu-Saad HH,Schlösser MA,Mostert R,Wouters EF

    更新日期:1997-08-01 00:00:00

  • Predictors of survival in patients with chronic obstructive pulmonary disease treated with long-term oxygen therapy.

    abstract::Long-term oxygen is the only therapy that has been shown to improve survival in patients with chronic obstructive pulmonary disease. The aim of this study was to assess the predictors of survival in such patients treated with long-term oxygen therapy. We studied 179 patients who were assessed for long-term oxygen ther...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.6.1522

    authors: Skwarski K,MacNee W,Wraith PK,Sliwinski P,Zielinski J

    更新日期:1991-12-01 00:00:00

  • Patient with bilateral pleural effusion: are the findings the same in each fluid?

    abstract:STUDY OBJECTIVES:To determine whether, in patients with bilateral pleural effusions, the main cellular and biochemical features of the pleural fluid on the right side differ from or correlate with those on the left side. We examined lactate dehydrogenase (LDH), glucose, and total protein (TP) levels, RBC count, nucleat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.1.167

    authors: Kalomenidis I,Rodriguez M,Barnette R,Gupta R,Hawthorne M,Parkes KB,Light RW

    更新日期:2003-07-01 00:00:00

  • Macrolides: a treatment alternative for bronchiolitis obliterans organizing pneumonia?

    abstract::Some macrolides have been found to exert anti-inflammatory effects. Lung diseases such as asthma, panbronchiolitis, cystic fibrosis, and bronchiectasis are thought to respond to the immunomodulatory properties of macrolides. We report three cases of idiopathic bronchiolitis obliterans organizing pneumonia, now called ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.5.3611

    authors: Stover DE,Mangino D

    更新日期:2005-11-01 00:00:00

  • Diagnostic value of hemosiderin-containing macrophages in bronchoalveolar lavage.

    abstract:STUDY OBJECTIVE:Our objective was to determine if the hemosiderin content of BAL macrophages allows us to draw any differential diagnostic conclusions in a variety of lung diseases. PATIENTS AND STUDY DESIGN:One hundred one patients who underwent BAL for different diagnostic reasons were studied prospectively. MAIN R...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.6.1794

    authors: Grebski E,Hess T,Hold G,Speich R,Russi E

    更新日期:1992-12-01 00:00:00

  • Posaconazole therapy for chronic refractory coccidioidomycosis.

    abstract:BACKGROUND:Coccidioides infections often result in chronic relapsing disease that presents a challenge to the currently available therapy. Posaconazole, an oral extended-spectrum triazole agent, has been shown in vitro and in vivo to have potent activity against this fungus. METHODS:An open-label multinational study o...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.07-0114

    authors: Stevens DA,Rendon A,Gaona-Flores V,Catanzaro A,Anstead GM,Pedicone L,Graybill JR

    更新日期:2007-09-01 00:00:00

  • Inspiratory work and airway pressure with continuous positive airway pressure delivery systems.

    abstract::To determine work-of breathing with continuous positive airway pressure (CPAP) delivery systems, we used a lung model to simulate spontaneous breathing. "Additional work" during tidal breathing was derived by comparing change in airway pressure with change in tidal volume. Seven demand-flow CPAP delivery systems were ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.4.519

    authors: Katz JA,Kraemer RW,Gjerde GE

    更新日期:1985-10-01 00:00:00

  • Successful correction of all mechanical complications of ischemic heart disease in the same patient.

    abstract::Extensive surgery for all of the mechanical complications of ischemic heart disease is feasible with early diagnosis, catheterization, and aggressive medical and surgical therapy. A patient is report who, after recovering from cardiogenic shock, required a coronary bypass, closure of ventricular septal defects, mitral...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.1.85

    authors: Lemole GM,Perez J,Strong MD,McDonough MT

    更新日期:1977-01-01 00:00:00

  • Gastroesophageal reflux-induced bronchoconstriction. Is microaspiration a factor?

    abstract:STUDY OBJECTIVE:To evaluate the role of microaspiration in gastroesophageal reflux-induced bronchoconstriction. DESIGN:Prospective study blinded to the subject. SETTING:Outpatient laboratory of a 908-bed university hospital. PARTICIPANTS:Thirty nonsmoking adults divided into two groups: asthmatics with reflux (AR), ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.108.5.1220

    authors: Harding SM,Schan CA,Guzzo MR,Alexander RW,Bradley LA,Richter JE

    更新日期:1995-11-01 00:00:00

  • Angioimmunoblastic lymphadenopathy presenting as superior vena caval obstruction.

    abstract::A 60-year-old man presented with features of superior vena cava (SVC) obstruction. On evaluation, he was diagnosed as having angioimmunoblastic lymphadenopathy with dysproteinemia (AILD). SVC obstruction due to AILD, to our knowledge, has not been described. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.6.1721

    authors: Sanghvi S,Kothari AS,Hathi BC,Sharma RG

    更新日期:1991-12-01 00:00:00

  • Endocarditis-associated paravalvular abscesses. Do clinical parameters predict the presence of abscess?

    abstract:STUDY OBJECTIVE:To determine whether standard clinical and transthoracic echocardiographic criteria considered to be suggestive of the presence of endocarditis-associated paravalvular abscess are predictive of which patients would benefit from reliable but invasive transesophageal echocardiographic investigations for a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.4.898

    authors: Blumberg EA,Karalis DA,Chandrasekaran K,Wahl JM,Vilaro J,Covalesky VA,Mintz GS

    更新日期:1995-04-01 00:00:00

  • Sulfasalazine-induced pulmonary disease.

    abstract::We report the findings in two patients with sulfasalazine-induced pulmonary disease. The first patient developed pulmonary interstitial fibrosis after more than 4 yr of treatment for Crohn's disease. Pulmonary symptoms and chest roentgenographic and pulmonary function abnormalities gradually reversed after stopping th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.4.1033

    authors: Hamadeh MA,Atkinson J,Smith LJ

    更新日期:1992-04-01 00:00:00

  • Pneumothorax in cystic fibrosis.

    abstract:BACKGROUND:Spontaneous pneumothorax is a complication that is commonly reported in patients with cystic fibrosis (CF). An understanding of the pathophysiology of this complication and its consequences is important for the management of patients with CF. OBJECTIVE:To identify risk factors associated with pneumothorax a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.2.720

    authors: Flume PA,Strange C,Ye X,Ebeling M,Hulsey T,Clark LL

    更新日期:2005-08-01 00:00:00

  • Emphysema presence, severity, and distribution has little impact on the clinical presentation of a cohort of patients with mild to moderate COPD.

    abstract:BACKGROUND:Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited to advanced stages of the disease. The objective of this study was to descri...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-0984

    authors: de Torres JP,Bastarrika G,Zagaceta J,Sáiz-Mendiguren R,Alcaide AB,Seijo LM,Montes U,Campo A,Zulueta JJ

    更新日期:2011-01-01 00:00:00

  • Tracheal bronchus: a cause of prolonged atelectasis in intubated children.

    abstract::Tracheal bronchus is a common anomaly that occurs in approximately 2% of people. Two children with multiple medical problems which led to endotracheal intubation are described. The hospital course for each child was complicated by persistent right upper lobe atelectasis. The presence of a tracheal bronchus was not rec...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.113.2.537

    authors: O'Sullivan BP,Frassica JJ,Rayder SM

    更新日期:1998-02-01 00:00:00

  • Complete resolution of roentgenographic changes in a patient with pulmonary histiocytosis X.

    abstract::A smoker presented with pleuritic chest pain and was found to have reticulonodular interstitial opacities on chest x-ray film. Open lung biopsy revealed changes consistent with histiocytosis X, a disease seen almost exclusively in smokers. Smoking cessation was recommended, and the patient complied. A chest x-ray film...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.3.765

    authors: Von Essen S,West W,Sitorius M,Rennard SI

    更新日期:1990-09-01 00:00:00

  • Oral Low-dose Theophylline on Top of Inhaled Fluticasone-Salmeterol Does Not Reduce Exacerbations in Patients With Severe COPD: A Pilot Clinical Trial.

    abstract:BACKGROUND:COPD is characterized by chronic inflammation. In vitro and ex vivo observations suggest that this inflammatory response is partially resistant to the effect of corticosteroids and that low-dose theophylline can restore this response via enhancement of histone deacetylase (HDAC) activity. Whether this occurs...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.chest.2016.04.011

    authors: Cosío BG,Shafiek H,Iglesias A,Yanez A,Córdova R,Palou A,Rodriguez-Roisin R,Peces-Barba G,Pascual S,Gea J,Sibila O,Barnes PJ,Agusti A

    更新日期:2016-07-01 00:00:00

  • The clinical use of lung MRI in cystic fibrosis: what, now, how?

    abstract::To assess airway and lung parenchymal damage non-invasively in cystic fibrosis (CF), chest MRI has been historically out of the scope of routine clinical imaging due to technical difficulties such as the low proton density and respiratory and cardiac motion. However, technological breakthroughs have recently emerged t...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2020.12.008

    authors: Dournes G,Walkup LL,Benlala I,Willmering MM,Macey J,Bui S,Laurent F,Woods JC

    更新日期:2020-12-17 00:00:00

  • Alpha 1-antitrypsin deficiency deaths in the United States from 1979-1991. An analysis using multiple-cause mortality data.

    abstract:OBJECTIVE:To describe trends of reported alpha 1-antitrypsin deficiency mortality in the United States from 1979-1991. METHODS:We analyzed death certificate reports in the multiple-cause mortality files compiled by the National Center for Health Statistics. RESULTS:Of the 26,866,600 deaths that occurred during the 13...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.1.78

    authors: Browne RJ,Mannino DM,Khoury MJ

    更新日期:1996-07-01 00:00:00

  • Cough and wheezing from beclomethasone aerosol.

    abstract::Cough and wheezing are frequent side effects of inhaling beclomethasone dipropionate aerosol (BA) in patients with asthma. Twenty percent of our outpatient asthmatic subjects are unable to take BA due to these side effects. Twelve patients with history of severe cough and wheezing after inhaling BA were tested. Three ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.91.2.207

    authors: Shim C,Williams MH Jr

    更新日期:1987-02-01 00:00:00

  • Indwelling pleural catheters reduce inpatient days over pleurodesis for malignant pleural effusion.

    abstract:BACKGROUND:Patients with malignant pleural effusion (MPE) have limited prognoses. They require long-lasting symptom relief with minimal hospitalization. Indwelling pleural catheters (IPCs) and talc pleurodesis are approved treatments for MPE. Establishing the implications of IPC and talc pleurodesis on subsequent hospi...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.11-2657

    authors: Fysh ETH,Waterer GW,Kendall PA,Bremner PR,Dina S,Geelhoed E,McCarney K,Morey S,Millward M,Musk AWB,Lee YCG

    更新日期:2012-08-01 00:00:00

  • Some epidemiologic aspects of acute myocardial infarction in Israel.

    abstract::A nationwide study of acute myocardial infarction in Israel was carried out during a one-year period. There were 2,504 new and 968 repeated attacks. Annual incidence rate of first attacks was 0.9 per 1,000 (1.3 in men and 0.5 in women). Incidence was highest among the European born in both sexes. But, while the patter...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.68.2.214

    authors: Shani M,Schor S,Modan B

    更新日期:1975-08-01 00:00:00

  • Effects of inhalation of beta 2-sympathicomimetic and anticholinergic agents on the impedance of the respiratory system in normal subjects.

    abstract::Impedance measurement of the respiratory system by forced oscillations is a sensitive and accurate method to detect mechanical parameters, especially in normal subjects. The effects of inhalation of 0.2 mg of fenoterol and 0.02 mg of ipratropium bromide on the impedance of the respiratory system was studied in 20 heal...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.5.1137

    authors: Wesseling G,Vonk HM,Wouters EF

    更新日期:1990-05-01 00:00:00

  • Self-injection with olive oil. A cause of lipoid pneumonia.

    abstract::A 48-year-old man with unipolar depression and a psychosexual problem concerning his body image was injecting his scrotum repeatedly with olive oil to increase the size of his genitals. He developed respiratory failure following accidental intravenous injection of olive oil and was found to have lipogranulomatous lesi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.3.875

    authors: Bhagat R,Holmes IH,Kulaga A,Murphy F,Cockcroft DW

    更新日期:1995-03-01 00:00:00

  • Crackles (rales) in the interstitial pulmonary diseases.

    abstract::There is renewed interest in the classification and methods of recording adventitious pulmonary sounds. This is a study of the importance of fine crackles (rales) in the diagnosis and estimation of the severity of diffuse infiltrative pulmonary disease. Among 272 cases documented by lung biopsy, bilateral fine crackle...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.73.3.333

    authors: Epler GR,Carrington CB,Gaensler EA

    更新日期:1978-03-01 00:00:00

  • Endobronchial tuberculosis simulating lung cancer.

    abstract::Endobronchial tuberculosis, while relatively common before the advent of effective antituberculosis chemotherapy, is seldom recognized now. Four patients with what appeared to be primary tuberculosis complicated by endobronchial spread were recently seen by us. Three of the four patients presented with anterior segmen...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.86.4.642

    authors: Matthews JI,Matarese SL,Carpenter JL

    更新日期:1984-10-01 00:00:00

  • Lung elastic recoil does not correlate with pulmonary hemodynamics in severe emphysema.

    abstract:BACKGROUND:It has been postulated that right ventricular (RV) function may improve after lung volume reduction surgery (LVRS) for severe emphysema due to improvement in lung elastic recoil. Improved lung elastic recoil after LVRS is hypothesized to "tether" open extraalveolar vessels, thereby leading to a decrease in p...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.07-0041

    authors: Falk JA,Martin UJ,Scharf S,Criner GJ

    更新日期:2007-11-01 00:00:00