Abstract:
:Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Epithelial damage and functional abnormalities have been described in bronchial asthma, along with changes in mucus-secreting cells and the chemical and rheological properties of airway fluid. Although the mechanisms of MCC impairment in asthma are not clearly understood, data in the recent literature suggest that airway inflammation plays a major role. In this article, we review studies on MCC alterations in light of up-to-date findings on pathogenetic mechanisms in asthma.
journal_name
Chestjournal_title
Chestauthors
Del Donno M,Bittesnich D,Chetta A,Olivieri D,Lopez-Vidriero MTdoi
10.1378/chest.118.4.1142subject
Has Abstractpub_date
2000-10-01 00:00:00pages
1142-9issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)37720-5journal_volume
118pub_type
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