The effect of inflammation on mucociliary clearance in asthma: an overview.

Abstract:

:Mucociliary clearance (MCC) is one of the most important nonspecific defense mechanisms of the respiratory tract, and its impairment is a well-documented feature of chronic respiratory diseases, including asthma. In vitro and in vivo data suggest that several inflammatory mediators influence the mucociliary apparatus. Epithelial damage and functional abnormalities have been described in bronchial asthma, along with changes in mucus-secreting cells and the chemical and rheological properties of airway fluid. Although the mechanisms of MCC impairment in asthma are not clearly understood, data in the recent literature suggest that airway inflammation plays a major role. In this article, we review studies on MCC alterations in light of up-to-date findings on pathogenetic mechanisms in asthma.

journal_name

Chest

journal_title

Chest

authors

Del Donno M,Bittesnich D,Chetta A,Olivieri D,Lopez-Vidriero MT

doi

10.1378/chest.118.4.1142

subject

Has Abstract

pub_date

2000-10-01 00:00:00

pages

1142-9

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)37720-5

journal_volume

118

pub_type

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