Abstract:
:Paclitaxel, the first of the taxanes, has exhibited unique and encouraging single-agent activity in the treatment of non-small cell lung cancer (NSCLC). Yet, with single-agent response rates approaching 25%, it was logical to examine the impact of paclitaxel in combination chemotherapy regimens. In trials evaluating the activity of paclitaxel in combination with one of the platinum compounds, cisplatin or carboplatin, response rates have ranged from 35 to > 50% and were significantly better than response rates observed with etoposide/cisplatin, the previous standard regimen for treatment of NSCLC. Docetaxel is a newer taxane that also has exhibited notable single-agent activity and response rates ranging from 20 to 50% when combined with cisplatin. Future research will look to refine the use of taxane combinations in NSCLC and to examine the potential of these unique and promising drugs when combined with newer agents that are active against this disease.
journal_name
Chestjournal_title
Chestauthors
Belani CPdoi
10.1378/chest.117.4_suppl_1.144ssubject
Has Abstractpub_date
2000-04-01 00:00:00pages
144S-151Sissue
4 Suppl 1eissn
0012-3692issn
1931-3543pii
S0012-3692(15)38866-8journal_volume
117pub_type
杂志文章,评审相关文献
CHEST文献大全abstract::Twenty-six adults (23 to 58 years) with mild to moderate asthma underwent a 10-week supervised rehabilitation program, with emphasis on physical training. In the first 2 weeks, they exercised daily in an indoor swimming pool (33 degrees C) and received education about asthma, medication, and principles of physical tra...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.109.2.323
更新日期:1996-02-01 00:00:00
abstract:BACKGROUND:Pulmonary disease due to Mycobacterium avium complex (MAC-PD) radiographically resembles that due to tuberculosis; it preferentially affects elderly white men with predisposing pulmonary disorders (PDPD). METHODS:Twenty-nine patients with MAC-PD were identified from a community-based population, and the med...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.6.1605
更新日期:1992-06-01 00:00:00
abstract::Administration of glucagon has been shown to decrease pulmonary vascular resistance, but its primary site of action is undetermined. Whether this is on the arterial or venous side of the capillary would be reflected in the microvascular hydrostatic pressure. We used the pulmonary flow of lymph, a sensitive index of th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.2.196
更新日期:1978-08-01 00:00:00
abstract:BACKGROUND:Acetazolamide and medroxyprogesterone acetate (MPA) are two respiratory stimulants that can be used in patients with stable hypercapnic COPD. DESIGN AND METHODS:The effects of acetazolamide, 250 mg bid, and MPA, 30 mg bid, on daytime and nighttime blood gas values and the influences on the hypercapnic and h...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.123.5.1450
更新日期:2003-05-01 00:00:00
abstract::Coronary artery fistulas have been traditionally diagnosed by angiography. This report describes a congenital and a traumatic coronary artery fistula diagnosed by transesophageal echocardiography. Transesophageal echocardiography was superior to transthoracic echocardiography in both cases and to angiography in one ca...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.3.959
更新日期:1994-03-01 00:00:00
abstract:BACKGROUND:Balance deficits and an increased fall risk are well documented in individuals with COPD. Despite evidence that balance training programs can improve performance on clinical balance tests, their minimal clinically important difference (MCID) is unknown. The aim of this study was to determine the MCID of the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.15-0717
更新日期:2016-03-01 00:00:00
abstract::A review of the largest observational studies on post-ICU weaning from prolonged mechanical ventilation yields evidence that more than half of such patients can be successfully liberated from mechanical ventilation. Success is likely to fall within a 3-month window, with late successes and partial ventilator independe...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.120.6_suppl.482s
更新日期:2001-12-01 00:00:00
abstract::To evaluate whether increased airway reactivity affected the course of patients with cystic fibrosis (CF), we categorized 40 CF patients as to methacholine sensitivity and then evaluated their disease activity and natural history. Twenty methacholine reactors had more severe lung disease (lower S-K clinical scores and...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.94.2.360
更新日期:1988-08-01 00:00:00
abstract::Immunohistochemistry has come to occupy a key position among the armamentarium of tools pathologists apply to the evaluation of lung and pleural neoplasms. This technique uses antibodies that bind to specific antigens, usually proteins, enabling microscopic detection of the antigens. Over the last several decades, an ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-3327
更新日期:2012-11-01 00:00:00
abstract::The ventilator discontinuation process is a critical component of ICU care. Ongoing ventilator dependency is caused by both disease factors (eg, respiratory, cardiac, metabolic, and neuromuscular) and clinician management factors (eg, failing to recognize discontinuation potential and inappropriate ventilator settings...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.06-2862
更新日期:2007-09-01 00:00:00
abstract::False-negative results from transthoracic needle aspiration biopsy of malignant lung masses may occur if a central necrotic area is present and is the source of the biopsy material. The purpose of this study is to determine if the use of ultrasonic guidance can improve the sensitivity of lung needle biopsies in this c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.5.1452
更新日期:1993-05-01 00:00:00
abstract::Initial evaluation of 22 patients with cystic fibrosis (CF) on entry into a trial of home oxygen therapy was used to elucidate the possible effects of poor nutritional status on exercise performance in CF. The patients had advanced lung disease (mean FEV1, 36 percent predicted) and all had a stable resting PaO2 less t...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.3.375
更新日期:1986-09-01 00:00:00
abstract::Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.11-1513
更新日期:2012-06-01 00:00:00
abstract:OBJECTIVE:To describe and correlate pulmonary function and high-resolution CT (HRCT) scan scores in individuals with a high risk for development of pulmonary fibrosis, ie, Hermansky-Pudlak syndrome (HPS) patients with mutations in the HPS-1 gene. DESIGN:Cross-sectional analysis of consecutive, eligible patients. PATI...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.117.1.129
更新日期:2000-01-01 00:00:00
abstract::A prospective study of community-acquired pneumonia in Hong Kong was carried out between January and December, 1988. Ninety adults (57 male) with a mean age of 57.3 years were admitted to the Prince of Wales Hospital with community-acquired pneumonia. The etiologic diagnosis of pneumonia was made in 37 cases (41 perce...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.2.442
更新日期:1992-02-01 00:00:00
abstract::Bronchoalveolar lavage was used to provide important diagnostic information for a patient found to have idiopathic pulmonary fibrosis and concomitant cytomegalovirus infection. The use of this procedure may not only provide useful information regarding the underlying disease, but may also suggest alternative diagnosti...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.84.4.500
更新日期:1983-10-01 00:00:00
abstract:STUDY OBJECTIVES:Black smokers have been reported to have higher serum cotinine levels than do white smokers, and have higher rates of most smoking-related diseases, despite smoking fewer cigarettes per day. Another striking racial difference is the preference for mentholated cigarettes among black smokers. The contrib...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.110.5.1194
更新日期:1996-11-01 00:00:00
abstract::Head-up tilt test was done in a 27-year-old man with recurrent syncope of unexplained cause. Severe sinus bradycardia and hypotension accompanied by light-headedness, cold sweating, and nausea occurred at 80 degrees head-up position during 4 micrograms/min isoproterenol infusion. Oral propranolol, 160 mg/d, in four di...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.106.3.963
更新日期:1994-09-01 00:00:00
abstract::Proteomics is the study of the entire protein complement of the genome (the proteome) in a biological system. Proteomic studies require a multidisciplinary approach and have only been practical with the convergence of technical and methodologic improvements including the following: advances in mass spectrometry and ge...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.130.2.567
更新日期:2006-08-01 00:00:00
abstract::Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. Th...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.78.2.283
更新日期:1980-08-01 00:00:00
abstract:BACKGROUND:Kidney disease has been linked to risk for hospitalization-related (HR) VTE, but the effect size and differences across types of kidney disease are described poorly. RESEARCH QUESTION:Can the risk for HR VTE among patients with acute kidney injury (AKI) and chronic kidney disease be quantified, and if so, h...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.09.257
更新日期:2020-10-05 00:00:00
abstract::Cardiac dysfunction due to systemic sarcoidosis is most of ten due to severe restrictive pulmonary diseases. Although the diagnosis is frequently missed during life, direct granulomatous infiltration of the myocardium may occur with systemic sarcoidosis and, when present in the heart, is a major cause of death. To exp...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.1.27
更新日期:1977-07-01 00:00:00
abstract::Fever, dyspnea, dry cough and interstitial fibrosis occurred in a man with prostate carcinoma treated with nilutamide and buserelin for two and one-half months. The diagnosis of drug-induced fibrosis was established on the basis of chronologic and semiologic events. This is the first such case reported. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.5.1106
更新日期:1988-05-01 00:00:00
abstract:BACKGROUND:COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with CO...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.01.043
更新日期:2020-07-01 00:00:00
abstract:BACKGROUND:Architectural design of health-care facilities can influence patient safety; however, it is unknown whether patient outcomes are significantly affected by ICU design. METHODS:Six hundred sixty-four patients admitted to the medical ICU (MICU) of Columbia University Medical Center during 2008 were included in...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.09-1458
更新日期:2010-05-01 00:00:00
abstract::The tendency toward "either/or" thinking (either cure or comfort) in traditional biomedical care paradigms does little to optimize care in advancing chronic illness. Calls for improved palliation in chronic lung disease mandate a review of related care gaps and current clinical practices. Although specialist palliativ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.14-2593
更新日期:2015-09-01 00:00:00
abstract::Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinica...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2018.07.028
更新日期:2019-01-01 00:00:00
abstract::Lymphoid interstitial pneumonia (LIP) is regarded as both a disease and a nonneoplastic, inflammatory pulmonary reaction to various external stimuli or systemic diseases. It is an uncommon condition with incidence and prevalence rates that are largely unknown. Liebow and Carrington originally classified LIP as an idio...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.122.6.2150
更新日期:2002-12-01 00:00:00
abstract:BACKGROUND:Acute respiratory tract infections (ARTIs) are among the main causes of morbidity and mortality in children. The bacterial extract OM-85 BV (bronchovaxom) has shown protective effect for ARTIs on children. We report a double-blind, placebo-controlled, parallel, prospective clinical trial to assess the safety...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.119.6.1742
更新日期:2001-06-01 00:00:00
abstract:INTRODUCTION:Over the last several years, there have been legal decisions and changes in medical directives concerning end-of-life decisions in Israel. METHODS:The data were compared to evaluate the changes in the frequency and types of forgoing of life-sustaining treatment (FLST) in patients who were admitted to the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.6.1969
更新日期:2004-12-01 00:00:00