Paclitaxel and docetaxel combinations in non-small cell lung cancer.

Abstract:

:Paclitaxel, the first of the taxanes, has exhibited unique and encouraging single-agent activity in the treatment of non-small cell lung cancer (NSCLC). Yet, with single-agent response rates approaching 25%, it was logical to examine the impact of paclitaxel in combination chemotherapy regimens. In trials evaluating the activity of paclitaxel in combination with one of the platinum compounds, cisplatin or carboplatin, response rates have ranged from 35 to > 50% and were significantly better than response rates observed with etoposide/cisplatin, the previous standard regimen for treatment of NSCLC. Docetaxel is a newer taxane that also has exhibited notable single-agent activity and response rates ranging from 20 to 50% when combined with cisplatin. Future research will look to refine the use of taxane combinations in NSCLC and to examine the potential of these unique and promising drugs when combined with newer agents that are active against this disease.

journal_name

Chest

journal_title

Chest

authors

Belani CP

doi

10.1378/chest.117.4_suppl_1.144s

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

144S-151S

issue

4 Suppl 1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)38866-8

journal_volume

117

pub_type

杂志文章,评审

相关文献

CHEST文献大全
  • High-intensity physical training in adults with asthma. A 10-week rehabilitation program.

    abstract::Twenty-six adults (23 to 58 years) with mild to moderate asthma underwent a 10-week supervised rehabilitation program, with emphasis on physical training. In the first 2 weeks, they exercised daily in an indoor swimming pool (33 degrees C) and received education about asthma, medication, and principles of physical tra...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.109.2.323

    authors: Emtner M,Herala M,Stålenheim G

    更新日期:1996-02-01 00:00:00

  • Mycobacterium avium complex pulmonary disease presenting as an isolated lingular or middle lobe pattern. The Lady Windermere syndrome.

    abstract:BACKGROUND:Pulmonary disease due to Mycobacterium avium complex (MAC-PD) radiographically resembles that due to tuberculosis; it preferentially affects elderly white men with predisposing pulmonary disorders (PDPD). METHODS:Twenty-nine patients with MAC-PD were identified from a community-based population, and the med...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.6.1605

    authors: Reich JM,Johnson RE

    更新日期:1992-06-01 00:00:00

  • The effect of glucagon on the pulmonary transvascular fluid filtration rate.

    abstract::Administration of glucagon has been shown to decrease pulmonary vascular resistance, but its primary site of action is undetermined. Whether this is on the arterial or venous side of the capillary would be reflected in the microvascular hydrostatic pressure. We used the pulmonary flow of lymph, a sensitive index of th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.74.2.196

    authors: Demling RH,Manohar M,Will J

    更新日期:1978-08-01 00:00:00

  • Comparison of acetazolamide and medroxyprogesterone as respiratory stimulants in hypercapnic patients with COPD.

    abstract:BACKGROUND:Acetazolamide and medroxyprogesterone acetate (MPA) are two respiratory stimulants that can be used in patients with stable hypercapnic COPD. DESIGN AND METHODS:The effects of acetazolamide, 250 mg bid, and MPA, 30 mg bid, on daytime and nighttime blood gas values and the influences on the hypercapnic and h...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.123.5.1450

    authors: Wagenaar M,Vos P,Heijdra Y,Teppema L,Folgering H

    更新日期:2003-05-01 00:00:00

  • Coronary artery fistula diagnosed by transesophageal echocardiography.

    abstract::Coronary artery fistulas have been traditionally diagnosed by angiography. This report describes a congenital and a traumatic coronary artery fistula diagnosed by transesophageal echocardiography. Transesophageal echocardiography was superior to transthoracic echocardiography in both cases and to angiography in one ca...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.3.959

    authors: Prewitt KC,Smolin MR,Coster TS,Vernalis MN,Bunda M,Wortham DC

    更新日期:1994-03-01 00:00:00

  • Interpretability of Change Scores in Measures of Balance in People With COPD.

    abstract:BACKGROUND:Balance deficits and an increased fall risk are well documented in individuals with COPD. Despite evidence that balance training programs can improve performance on clinical balance tests, their minimal clinically important difference (MCID) is unknown. The aim of this study was to determine the MCID of the ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.15-0717

    authors: Beauchamp MK,Harrison SL,Goldstein RS,Brooks D

    更新日期:2016-03-01 00:00:00

  • Post-ICU weaning from mechanical ventilation: the role of long-term facilities.

    abstract::A review of the largest observational studies on post-ICU weaning from prolonged mechanical ventilation yields evidence that more than half of such patients can be successfully liberated from mechanical ventilation. Success is likely to fall within a 3-month window, with late successes and partial ventilator independe...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.120.6_suppl.482s

    authors: Scheinhorn DJ,Chao DC,Hassenpflug MS,Gracey DR

    更新日期:2001-12-01 00:00:00

  • Airway hyperreactivity in cystic fibrosis. Clinical correlates and possible effects on the course of the disease.

    abstract::To evaluate whether increased airway reactivity affected the course of patients with cystic fibrosis (CF), we categorized 40 CF patients as to methacholine sensitivity and then evaluated their disease activity and natural history. Twenty methacholine reactors had more severe lung disease (lower S-K clinical scores and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.2.360

    authors: Eggleston PA,Rosenstein BJ,Stackhouse CM,Alexander MF

    更新日期:1988-08-01 00:00:00

  • Immunohistochemistry: applications to the evaluation of lung and pleural neoplasms: part 1.

    abstract::Immunohistochemistry has come to occupy a key position among the armamentarium of tools pathologists apply to the evaluation of lung and pleural neoplasms. This technique uses antibodies that bind to specific antigens, usually proteins, enabling microscopic detection of the antigens. Over the last several decades, an ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-3327

    authors: Mani H,Zander DS

    更新日期:2012-11-01 00:00:00

  • Discontinuing mechanical ventilatory support.

    abstract::The ventilator discontinuation process is a critical component of ICU care. Ongoing ventilator dependency is caused by both disease factors (eg, respiratory, cardiac, metabolic, and neuromuscular) and clinician management factors (eg, failing to recognize discontinuation potential and inappropriate ventilator settings...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.06-2862

    authors: MacIntyre N

    更新日期:2007-09-01 00:00:00

  • Needle aspiration biopsy of malignant lung masses with necrotic centers. Improved sensitivity with ultrasonic guidance.

    abstract::False-negative results from transthoracic needle aspiration biopsy of malignant lung masses may occur if a central necrotic area is present and is the source of the biopsy material. The purpose of this study is to determine if the use of ultrasonic guidance can improve the sensitivity of lung needle biopsies in this c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.5.1452

    authors: Pan JF,Yang PC,Chang DB,Lee YC,Kuo SH,Luh KT

    更新日期:1993-05-01 00:00:00

  • Effects of nutritional status on exercise performance in advanced cystic fibrosis.

    abstract::Initial evaluation of 22 patients with cystic fibrosis (CF) on entry into a trial of home oxygen therapy was used to elucidate the possible effects of poor nutritional status on exercise performance in CF. The patients had advanced lung disease (mean FEV1, 36 percent predicted) and all had a stable resting PaO2 less t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.3.375

    authors: Marcotte JE,Canny GJ,Grisdale R,Desmond K,Corey M,Zinman R,Levison H,Coates AL

    更新日期:1986-09-01 00:00:00

  • Assessment and diagnosis of renal dysfunction in the ICU.

    abstract::Identifying patients with impaired renal function is crucial in the setting of critical illness. Serum creatinine serves as the gold standard for assessing steady-state renal function, helping to define those with chronic kidney disease (CKD). Although these baseline creatinine values are often not available in the se...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-1513

    authors: Koyner JL

    更新日期:2012-06-01 00:00:00

  • Pulmonary function and high-resolution CT findings in patients with an inherited form of pulmonary fibrosis, Hermansky-Pudlak syndrome, due to mutations in HPS-1.

    abstract:OBJECTIVE:To describe and correlate pulmonary function and high-resolution CT (HRCT) scan scores in individuals with a high risk for development of pulmonary fibrosis, ie, Hermansky-Pudlak syndrome (HPS) patients with mutations in the HPS-1 gene. DESIGN:Cross-sectional analysis of consecutive, eligible patients. PATI...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.1.129

    authors: Brantly M,Avila NA,Shotelersuk V,Lucero C,Huizing M,Gahl WA

    更新日期:2000-01-01 00:00:00

  • A prospective study of community-acquired pneumonia in Hong Kong.

    abstract::A prospective study of community-acquired pneumonia in Hong Kong was carried out between January and December, 1988. Ninety adults (57 male) with a mean age of 57.3 years were admitted to the Prince of Wales Hospital with community-acquired pneumonia. The etiologic diagnosis of pneumonia was made in 37 cases (41 perce...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.2.442

    authors: Chan CH,Cohen M,Pang J

    更新日期:1992-02-01 00:00:00

  • Cytomegalovirus infection with idiopathic pulmonary fibrosis. Diagnosis suggested by bronchoalveolar lavage.

    abstract::Bronchoalveolar lavage was used to provide important diagnostic information for a patient found to have idiopathic pulmonary fibrosis and concomitant cytomegalovirus infection. The use of this procedure may not only provide useful information regarding the underlying disease, but may also suggest alternative diagnosti...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.84.4.500

    authors: Martin WJ 2nd,McDougall JC

    更新日期:1983-10-01 00:00:00

  • Effect of menthol cigarettes on biochemical markers of smoke exposure among black and white smokers.

    abstract:STUDY OBJECTIVES:Black smokers have been reported to have higher serum cotinine levels than do white smokers, and have higher rates of most smoking-related diseases, despite smoking fewer cigarettes per day. Another striking racial difference is the preference for mentholated cigarettes among black smokers. The contrib...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.110.5.1194

    authors: Clark PI,Gautam S,Gerson LW

    更新日期:1996-11-01 00:00:00

  • Worsening of vasovagal syncope after beta-blocker therapy.

    abstract::Head-up tilt test was done in a 27-year-old man with recurrent syncope of unexplained cause. Severe sinus bradycardia and hypotension accompanied by light-headedness, cold sweating, and nausea occurred at 80 degrees head-up position during 4 micrograms/min isoproterenol infusion. Oral propranolol, 160 mg/d, in four di...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.106.3.963

    authors: Wang CC,Yeh SJ,Wen MS,Lin FC,Wu D

    更新日期:1994-09-01 00:00:00

  • Proteomics in pulmonary medicine.

    abstract::Proteomics is the study of the entire protein complement of the genome (the proteome) in a biological system. Proteomic studies require a multidisciplinary approach and have only been practical with the convergence of technical and methodologic improvements including the following: advances in mass spectrometry and ge...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.130.2.567

    authors: Bowler RP,Ellison MC,Reisdorph N

    更新日期:2006-08-01 00:00:00

  • Bitolterol mesylate (WIN 32784) aerosol. A new long-acting bronchodilator with reduced chronotropic effects.

    abstract::Bitolterol mesylate (WIN 37284) is alpha-[tert-butylaminomethyl]-3,4-dihydroxybenzyl alcohol 3,4-di(p-toluate) methanesulfonate, a diester sympathomimetic amine bronchodilator. Bitolterol mesylate represents a new concept in sympathomimetic amine therapy. It is "prodrug" which is inactive until altered in the body. Th...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.78.2.283

    authors: Kass I,Mingo TS

    更新日期:1980-08-01 00:00:00

  • Acute Kidney Injury During Hospitalization Increases the Risk of VTE.

    abstract:BACKGROUND:Kidney disease has been linked to risk for hospitalization-related (HR) VTE, but the effect size and differences across types of kidney disease are described poorly. RESEARCH QUESTION:Can the risk for HR VTE among patients with acute kidney injury (AKI) and chronic kidney disease be quantified, and if so, h...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.09.257

    authors: McMahon MMJ,Collen LPJF,Chung CKK,Stewart LIJ,Haydar L,Moores CRLK,Holley CAB

    更新日期:2020-10-05 00:00:00

  • The use of 201thallium for myocardial perfusion imaging in sarcoid heart disease.

    abstract::Cardiac dysfunction due to systemic sarcoidosis is most of ten due to severe restrictive pulmonary diseases. Although the diagnosis is frequently missed during life, direct granulomatous infiltration of the myocardium may occur with systemic sarcoidosis and, when present in the heart, is a major cause of death. To exp...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.72.1.27

    authors: Bulkley BH,Rouleau JR,Whitaker JQ,Strauss HW,Pitt B

    更新日期:1977-07-01 00:00:00

  • Pulmonary complications of hormone treatment in prostate carcinoma.

    abstract::Fever, dyspnea, dry cough and interstitial fibrosis occurred in a man with prostate carcinoma treated with nilutamide and buserelin for two and one-half months. The diagnosis of drug-induced fibrosis was established on the basis of chronologic and semiologic events. This is the first such case reported. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.93.5.1106

    authors: Seigneur J,Trechot PF,Hubert J,Lamy P

    更新日期:1988-05-01 00:00:00

  • "High-Risk" Clinical and Inflammatory Clusters in COPD of Chinese Descent.

    abstract:BACKGROUND:COPD is a heterogeneous disease demonstrating inter-individual variation. A high COPD prevalence in Chinese populations is described, but little is known about disease clusters and prognostic outcomes in the Chinese population across Southeast Asia. We aim to determine if clusters of Chinese patients with CO...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.01.043

    authors: Tiew PY,Ko FWS,Narayana JK,Poh ME,Xu H,Neo HY,Loh LC,Ong CK,Mac Aogáin M,Tan JHY,Kamaruddin NH,Sim GJH,Lapperre TS,Koh MS,Hui DSC,Abisheganaden JA,Tee A,Tsaneva-Atanasova K,Chotirmall SH

    更新日期:2020-07-01 00:00:00

  • Relationship between ICU design and mortality.

    abstract:BACKGROUND:Architectural design of health-care facilities can influence patient safety; however, it is unknown whether patient outcomes are significantly affected by ICU design. METHODS:Six hundred sixty-four patients admitted to the medical ICU (MICU) of Columbia University Medical Center during 2008 were included in...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.09-1458

    authors: Leaf DE,Homel P,Factor PH

    更新日期:2010-05-01 00:00:00

  • Palliative Care in Advanced Lung Disease: The Challenge of Integrating Palliation Into Everyday Care.

    abstract::The tendency toward "either/or" thinking (either cure or comfort) in traditional biomedical care paradigms does little to optimize care in advancing chronic illness. Calls for improved palliation in chronic lung disease mandate a review of related care gaps and current clinical practices. Although specialist palliativ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-2593

    authors: Rocker GM,Simpson AC,Horton R

    更新日期:2015-09-01 00:00:00

  • Clinical Approach to the Therapy of Asthma-COPD Overlap.

    abstract::Over the last few years, there has been a renewed interest in patients with characteristics of both asthma and COPD. Although the precise definition of asthma-COPD overlap (ACO) is still controversial, patients with overlapping features are frequently encountered in clinical practice, and may indeed have worse clinica...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2018.07.028

    authors: Maselli DJ,Hardin M,Christenson SA,Hanania NA,Hersh CP,Adams SG,Anzueto A,Peters JI,Han MK,Martinez FJ

    更新日期:2019-01-01 00:00:00

  • Lymphoid interstitial pneumonia: a narrative review.

    abstract::Lymphoid interstitial pneumonia (LIP) is regarded as both a disease and a nonneoplastic, inflammatory pulmonary reaction to various external stimuli or systemic diseases. It is an uncommon condition with incidence and prevalence rates that are largely unknown. Liebow and Carrington originally classified LIP as an idio...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.6.2150

    authors: Swigris JJ,Berry GJ,Raffin TA,Kuschner WG

    更新日期:2002-12-01 00:00:00

  • Safety and efficacy of two courses of OM-85 BV in the prevention of respiratory tract infections in children during 12 months.

    abstract:BACKGROUND:Acute respiratory tract infections (ARTIs) are among the main causes of morbidity and mortality in children. The bacterial extract OM-85 BV (bronchovaxom) has shown protective effect for ARTIs on children. We report a double-blind, placebo-controlled, parallel, prospective clinical trial to assess the safety...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.119.6.1742

    authors: Gutiérrez-Tarango MD,Berber A

    更新日期:2001-06-01 00:00:00

  • Evaluation of changes in forgoing life-sustaining treatment in Israeli ICU patients.

    abstract:INTRODUCTION:Over the last several years, there have been legal decisions and changes in medical directives concerning end-of-life decisions in Israel. METHODS:The data were compared to evaluate the changes in the frequency and types of forgoing of life-sustaining treatment (FLST) in patients who were admitted to the ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.126.6.1969

    authors: Jakobson DJ,Eidelman LA,Worner TM,Oppenheim AE,Pizov R,Sprung CL

    更新日期:2004-12-01 00:00:00