Airway hyperreactivity in cystic fibrosis. Clinical correlates and possible effects on the course of the disease.

Abstract:

:To evaluate whether increased airway reactivity affected the course of patients with cystic fibrosis (CF), we categorized 40 CF patients as to methacholine sensitivity and then evaluated their disease activity and natural history. Twenty methacholine reactors had more severe lung disease (lower S-K clinical scores and more impairment of pulmonary function) than did 16 nonreactive patients, and acute bronchodilator response was greater in the methacholine reactors. Thirty-four patients were followed prospectively over a 17- to 24-month period. Among 19 methacholine reactors, there were more pulmonary exacerbations and a more rapid decline in FEV1. In general, increased obstruction was associated with increased reactivity. Although the data are subject to differing interpretations, they are consistent with the hypothesis that in patients with CF, airway hyperreactivity occurs secondary to bronchial damage, age, is associated with more rapid pulmonary deterioration, and is an unfavorable prognostic finding.

journal_name

Chest

journal_title

Chest

authors

Eggleston PA,Rosenstein BJ,Stackhouse CM,Alexander MF

doi

10.1378/chest.94.2.360

subject

Has Abstract

pub_date

1988-08-01 00:00:00

pages

360-5

issue

2

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)33459-6

journal_volume

94

pub_type

杂志文章

相关文献

CHEST文献大全
  • Does chest physical therapy work?

    abstract::Postural drainage has usually been shown to be an effective component of chest physical therapy; there is currently no data showing a beneficial effect of percussion or vibration; directed coughing may be as efficacious as postural drainage (Table 3); the forced expiration technique may increase sputum clearance with ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.88.3.436

    authors: Kirilloff LH,Owens GR,Rogers RM,Mazzocco MC

    更新日期:1985-09-01 00:00:00

  • Massive pulmonary emboli in children: does fiber-optic-guided embolectomy have a role? Review of the literature and report of two cases.

    abstract::Massive pulmonary emboli is a rare disease in children, with only 39 reported cases in the last 50 years. Almost 50% of the patients died suddenly without receiving medical treatment. Most of the patients who were managed medically (70% of the treated patients) underwent surgical pulmonary embolectomy with 80% surviva...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-2759

    authors: Eini ZM,Houri S,Cohen I,Sion R,Tamir A,Sasson L,Mandelberg A

    更新日期:2013-02-01 00:00:00

  • Detection and evaluation of asymptomatic myocarditis in schoolchildren: report of four cases.

    abstract:STUDY OBJECTIVE:Data on the prevalence of myocarditis in children are limited. Autopsy studies have shown that myocarditis is often undiagnosed. We attempted to investigate the clinical features of asymptomatic myocarditis in four schoolchildren detected during a mass ECG screening in schoolchildren. DESIGN AND SETTIN...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.2.340

    authors: Nakagawa M,Sato A,Okagawa H,Kondo M,Okuno M,Takamatsu T

    更新日期:1999-08-01 00:00:00

  • Natriuretic peptides, respiratory disease, and the right heart.

    abstract::It is well-recognized that atrial natriuretic peptide (ANP) and B-type natriuretic peptide (BNP) are raised in conditions with ventricular volume and pressure overload. In addition to this established role in left ventricular congestive cardiac failure, there is good evidence that BNP has a diagnostic role in right ve...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.126.4.1330

    authors: Yap LB,Mukerjee D,Timms PM,Ashrafian H,Coghlan JG

    更新日期:2004-10-01 00:00:00

  • Lymphoid interstitial pneumonia: a narrative review.

    abstract::Lymphoid interstitial pneumonia (LIP) is regarded as both a disease and a nonneoplastic, inflammatory pulmonary reaction to various external stimuli or systemic diseases. It is an uncommon condition with incidence and prevalence rates that are largely unknown. Liebow and Carrington originally classified LIP as an idio...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.6.2150

    authors: Swigris JJ,Berry GJ,Raffin TA,Kuschner WG

    更新日期:2002-12-01 00:00:00

  • Color Doppler features of left ventricular pseudoaneurysm.

    abstract::A patient had left ventricular pseudoaneurysm after mitral valve replacement surgery. The diagnosis was made by color flow Doppler demonstration of systolic flow between the left ventricular chamber and an echo-free space posterior to the heart which was initially interpreted as localized pleural effusion. Color Doppl...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.1.231

    authors: Alam M,Rosman HS,Lewis JW,Brymer JF

    更新日期:1989-01-01 00:00:00

  • Myopathy following mechanical ventilation for acute severe asthma: the role of muscle relaxants and corticosteroids.

    abstract:BACKGROUND:Acute myopathy following mechanical ventilation for near-fatal asthma (NFA) has been described recently, and some researchers have suggested that this complication is related to the use of neuromuscular blocking agents (NMBAs) and corticosteroids (CSs). OBJECTIVES:To determine the incidence of acute myopath...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1378/chest.115.6.1627

    authors: Behbehani NA,Al-Mane F,D'yachkova Y,Paré P,FitzGerald JM

    更新日期:1999-06-01 00:00:00

  • Calcified plaque in the superior portion of the major fissure. An unusual manifestation of asbestos exposure.

    abstract::Parietal pleural plaque is a well-recognized sign of exposure to asbestos. Visceral pleural involvement is an uncommon manifestation, and calcified visceral pleural plaques are rare. Those reported have been in the minor fissure and inferior major fissure. We describe a unique calcified plaque in the superior major fi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.96.6.1436

    authors: Rupp SB,Jolles H

    更新日期:1989-12-01 00:00:00

  • Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. An international, multicenter, prospective survey.

    abstract::An international, multicenter, prospective survey has been conducted to determine the hospital survival rates of patients with potentially reversible acute respiratory failure (ARF) who are managed in sophisticated intensive care units by leading critical care specialists, using current (1991 to 1992) support and trea...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.107.4.1083

    authors: Vasilyev S,Schaap RN,Mortensen JD

    更新日期:1995-04-01 00:00:00

  • Thrombocytopenia in cardiovascular patients: diagnosis and management.

    abstract::Thrombocytopenia is a common problem in cardiovascular patients, but the etiology and management of this condition may be different than those in other populations. Around the time that percutaneous coronary interventions are performed, the drugs most commonly associated with thrombocytopenia are the glycoprotein (GP)...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.127.2_suppl.46S

    authors: Matthai WH Jr

    更新日期:2005-02-01 00:00:00

  • Lung function abnormalities after bone marrow transplantation in children: has the trend recently changed?

    abstract:STUDY OBJECTIVES:To evaluate early and late lung function abnormalities and their predictors in a large sample of children who underwent bone marrow transplantation (BMT) for leukemias in the 1990s, highlighting changes with respect to the 1980s. DESIGNS:Prospective cohort. SETTING:A university department of pediatri...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.6.1900

    authors: Cerveri I,Fulgoni P,Giorgiani G,Zoia MC,Beccaria M,Tinelli C,Locatelli F

    更新日期:2001-12-01 00:00:00

  • Patterns of Use of Adjunctive Therapies in Patients With Early Moderate to Severe ARDS: Insights From the LUNG SAFE Study.

    abstract:BACKGROUND:Adjunctive strategies are an important part of the management of ARDS. However, their application in clinical practice remains inconsistent. RESEARCH QUESTION:We wished to determine the frequency and patterns of use of adjunctive strategies in patients with moderate to severe ARDS (Pao2/Fio2 [P/F ratio] < 1...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.01.041

    authors: Duggal A,Rezoagli E,Pham T,McNicholas BA,Fan E,Bellani G,Rubenfeld G,Pesenti AM,Laffey JG,LUNG SAFE Investigators and the ESICM Trials Group.

    更新日期:2020-06-01 00:00:00

  • Trazodone-related exercise-induced nonsustained ventricular tachycardia.

    abstract::A 79-year-old woman in the course of a syncope evaluation is shown to have a trazodone-related cardiac arrhythmia confirmed by drug rechallenge. This nontricyclic antidepressant should be considered as potentially arrhythmogenic despite its generally favorable cardiovascular profile. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.1.247

    authors: Vitullo RN,Wharton JM,Allen NB,Pritchett EL

    更新日期:1990-07-01 00:00:00

  • Treatment failure in community-acquired pneumonia.

    abstract::Treatment failure (TF) is defined as a clinical condition with inadequate response to antimicrobial therapy. Clinical response should be evaluated within the first 72 h of treatment, whereas infiltrate images may take up to 6 weeks to resolve. Early failure is considered when ventilatory support and/or septic shock ap...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.06-1995

    authors: Menendez R,Torres A

    更新日期:2007-10-01 00:00:00

  • Left atrial size, chemosensitivity, and central sleep apnea in heart failure.

    abstract:BACKGROUND:Central sleep apnea (CSA) is common among patients with heart failure (HF) and is promoted by elevated CO2 chemosensitivity. Left atrial size is a marker of the hemodynamic severity of HF. The aim of this study was to determine if left atrial size predicts chemosensitivity to CO2 and CSA in patients with HF....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-0309

    authors: Calvin AD,Somers VK,Johnson BD,Scott CG,Olson LJ

    更新日期:2014-07-01 00:00:00

  • Effects of a beta adrenergic drug and a secretolytic agent on regional mucociliary clearance in patients with COLD.

    abstract::The effect of clenbuterol, a beta adrenergic drug, and ambroxol, a secretolytic agent, on regional mucociliary clearance and pulmonary radioaerosol distribution was investigated in two groups of 15 patients with COLD in a double-blind cross-over trial with placebo. Clearance rates of inhaled 99mTc-labelled human serum...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.80.6.881

    authors: Weiss T,Dorow P,Felix R

    更新日期:1981-12-01 00:00:00

  • Pulmonary Hypertension in Parenchymal Lung Diseases: Any Future for New Therapies?

    abstract::Pulmonary hypertension (PH) due to chronic lung disease is associated with a poor prognosis, regardless of the underlying respiratory condition. Updated PH guidelines recommend optimal treatment of the underlying lung disease, including long-term oxygen therapy, in patients with chronic hypoxemia despite the lack of r...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.06.008

    authors: Harari S,Elia D,Humbert M

    更新日期:2018-01-01 00:00:00

  • Myocardial oxygen supply and demand.

    abstract::The supply of oxygen to the myocardium is determined by coronary blood flow and oxygen carrying capacity. Coronary blood flow is a dynamic process modulated via multiple parameters. Cardiac metabolism is also affected by several factors. Under normal physiologic conditions, the demand is easily met by the supply of ox...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.98.3.699

    authors: Ardehali A,Ports TA

    更新日期:1990-09-01 00:00:00

  • Sarcoidosis presenting as a central nervous system mass lesion.

    abstract::Neurosarcoidosis occurs in approximately 5% of patients with systemic sarcoidosis. A review of medical literature shows that intracranial mass-like lesions secondary to sarcoidosis are quite rare. CT and MRI scanning would suggest that this manifestation of neurosarcoidosis may be more common than previously realized....

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.2.518

    authors: Veres L,Utz JP,Houser OW

    更新日期:1997-02-01 00:00:00

  • Impact of intensive care management on the prognosis of tetanus. Analysis of 641 cases.

    abstract::These studies show the results of intensive care management of 306 consecutive patients with tetanus compared with 335 patients treated conservatively in the same hospital before the institution of the ICU. The impact of the ICU treatment was manifested in a decrease in mortality, from 43.58 percent to 15 percent. In ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.1.63

    authors: Trujillo MH,Castillo A,España J,Manzo A,Zerpa R

    更新日期:1987-07-01 00:00:00

  • Further observations on the electrophysiologic effects of oral amiodarone therapy.

    abstract::A case is presented of a reversible intra-Hisian block occurring under amiodarone treatment for atrial tachycardia in a patient without clear intraventricular conduction abnormalities. His bundle recordings showed an atrial tachycardia with intermittent exit block and greatly prolonged BH and HV intervals (40 and 100 ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.82.1.117

    authors: Santinelli V,Chiariello M,Ambrosio G,Stanislao M,Condorelli M

    更新日期:1982-07-01 00:00:00

  • Asthma treatment preference study: a conjoint analysis of preferred drug treatments.

    abstract:OBJECTIVE:Assessment of patient preferences for attributes of asthma treatments. METHODS:Two hundred ninety-eight patients (age range, 18 to 60 years) from 15 centers in Sweden completed a questionnaire concerning their asthma, and ranked 18 alternative treatments using conjoint analysis. Patients were receiving treat...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.125.3.916

    authors: Johansson G,Ställberg B,Tornling G,Andersson S,Karlsson GS,Fält K,Berggren F

    更新日期:2004-03-01 00:00:00

  • Percutaneous multiple-site parietal pleural biopsy: description and evaluation of a new and safe technique.

    abstract:STUDY OBJECTIVES:(1) To describe a new percutaneous pleural biopsy technique to obtain multiple-site parietal pleural biopsy specimens in patients with pleural effusion (PE), and (2) to evaluate its effectiveness and safety compared to current techniques. DESIGN:Prospective interventional study. SETTING:University te...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.125.5.1776

    authors: Uthaman B,Behbehani N,Abal A,Madda J,Khan S

    更新日期:2004-05-01 00:00:00

  • Unusual complications after embolization of a pulmonary arteriovenous malformation.

    abstract::A pulmonary arteriovenous malformation was embolized in a patient with hereditary hemorrhagic telangiectasia. Several unusual complications, including early deflation of a detachable balloon, migration of a coil, and development of severe pulmonary hypertension, occurred. Pulmonary hypertension was attributed to a coe...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.109.5.1401

    authors: Haitjema T,ten Berg JM,Overtoom TT,Ernst JM,Westermann CJ

    更新日期:1996-05-01 00:00:00

  • Coronary artery bypass surgery in patients less than 40 years of age.

    abstract::Coronary bypass patients less than 40 years of age were identified and compared with a control group previously studied at our hospital. In patients less than 40 years, the average age was 35 years. Men comprised 90.1 percent of group 1, and 83.4 percent of group 2. Operative mortality was 2.89 percent for group 1 and...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.94.6.1138

    authors: Kelly ME,DeLaria GA,Najafi H

    更新日期:1988-12-01 00:00:00

  • Lung elastic recoil does not correlate with pulmonary hemodynamics in severe emphysema.

    abstract:BACKGROUND:It has been postulated that right ventricular (RV) function may improve after lung volume reduction surgery (LVRS) for severe emphysema due to improvement in lung elastic recoil. Improved lung elastic recoil after LVRS is hypothesized to "tether" open extraalveolar vessels, thereby leading to a decrease in p...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.07-0041

    authors: Falk JA,Martin UJ,Scharf S,Criner GJ

    更新日期:2007-11-01 00:00:00

  • Analysis of neural mechanisms accompanying different intensities of dynamic exercise.

    abstract::The neural mechanisms accompanying dynamic exercise of different intensities were analyzed in dogs and human subjects by means of autoregressive spectral analysis of heart period and arterial pressure variabilities. In the animal experiments, 8 conscious dogs were examined after implanting a solid state pressure gauge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.5_supplement.226s

    authors: Rimoldi O,Furlan R,Pagani MR,Piazza S,Guazzi M,Pagani M,Malliani A

    更新日期:1992-05-01 00:00:00

  • High rhinovirus burden in lower airways of children with cystic fibrosis.

    abstract:BACKGROUND:Rhinovirus (RV)-induced pulmonary exacerbations are common in cystic fibrosis (CF) and have been associated with impaired virus clearance by the CF airway epithelium in vitro. Here, we assess in vivo the association of RV prevalence and load with antiviral defense mechanisms, airway inflammation, and lung fu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-0954

    authors: Kieninger E,Singer F,Tapparel C,Alves MP,Latzin P,Tan HL,Bossley C,Casaulta C,Bush A,Davies JC,Kaiser L,Regamey N

    更新日期:2013-03-01 00:00:00

  • Antibiotic utilization: is there an effect on antimicrobial resistance?

    abstract::The antimicrobial resistance problem in hospitals continues to worsen. In particular, extended-spectrum beta-lactamase-producing Klebsiella pneumoniae (ESBL-KP) and vancomycin-resistant enterococci (VRE) are significant causes of morbidity and mortality among critically ill patients. Treating infections caused by thes...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.119.2_suppl.426s

    authors: Patterson JE

    更新日期:2001-02-01 00:00:00

  • Oxidative stress after lung resection therapy: A pilot study.

    abstract:STUDY OBJECTIVES:To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications. DESIGN:A prospective study. SETTING:A specialized thorac...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.4.999

    authors: Lases EC,Duurkens VA,Gerritsen WB,Haas FJ

    更新日期:2000-04-01 00:00:00