Oxidative stress after lung resection therapy: A pilot study.

Abstract:

STUDY OBJECTIVES:To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications. DESIGN:A prospective study. SETTING:A specialized thoracic surgical unit in a large referral hospital. PATIENTS:Twenty-eight patients with lung carcinoma undergoing thoracotomy. MEASUREMENTS:Exhaled H(2)O(2) concentrations in breath condensate were measured by spectrophotometry, while malondialdehyde (MDA) levels in urine samples collected every 24 h were measured by reversed-phase, ion-pair high-performance liquid chromatography using ultraviolet detection. RESULTS:Our results show increased H(2)O(2) and MDA levels in lobectomy patients compared with pneumonectomy patients. A strong correlation was found between the levels of H(2)O(2) and MDA. CONCLUSION:The present data support the hypothesis that oxidative stress may occur following pulmonary resection.

journal_name

Chest

journal_title

Chest

authors

Lases EC,Duurkens VA,Gerritsen WB,Haas FJ

doi

10.1378/chest.117.4.999

subject

Has Abstract

pub_date

2000-04-01 00:00:00

pages

999-1003

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)32796-3

journal_volume

117

pub_type

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