Abstract:
STUDY OBJECTIVES:To investigate whether oxidative stress occurs following lobectomy and pneumonectomy and to evaluate whether markers of oxidative stress might be of value in the assessment of the diagnosis, course, and prognosis of postoperative complications. DESIGN:A prospective study. SETTING:A specialized thoracic surgical unit in a large referral hospital. PATIENTS:Twenty-eight patients with lung carcinoma undergoing thoracotomy. MEASUREMENTS:Exhaled H(2)O(2) concentrations in breath condensate were measured by spectrophotometry, while malondialdehyde (MDA) levels in urine samples collected every 24 h were measured by reversed-phase, ion-pair high-performance liquid chromatography using ultraviolet detection. RESULTS:Our results show increased H(2)O(2) and MDA levels in lobectomy patients compared with pneumonectomy patients. A strong correlation was found between the levels of H(2)O(2) and MDA. CONCLUSION:The present data support the hypothesis that oxidative stress may occur following pulmonary resection.
journal_name
Chestjournal_title
Chestauthors
Lases EC,Duurkens VA,Gerritsen WB,Haas FJdoi
10.1378/chest.117.4.999subject
Has Abstractpub_date
2000-04-01 00:00:00pages
999-1003issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)32796-3journal_volume
117pub_type
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