AIDS and malignant mesothelioma--is there a connection?

Abstract:

:A 35-year-old male homosexual, a former intravenous drug abuser, was found to be human immunodeficiency virus (HIV) positive in 1984. He developed AIDS in 1987 and began treatment with zidovudine in 1989. One year later he developed left apical pleural blebs, a pneumothorax and an exudative pleural effusion. A malignant mesothelioma developed at the pleural blebs in the left apex. He was treated with adriamycin but rapid progression of the malignancy occurred and he died three months later. At autopsy, a malignant mesothelioma, causing respiratory failure and death, was found. The patient had no exposure to asbestos and asbestosis was not present at autopsy. We postulate that the development of malignant mesothelioma was probably related to HIV immune suppression or HIV and/or cytomegalovirus or zidovudine and is a complication of AIDS similar to the development of other malignant neoplasms in patients with AIDS.

journal_name

Chest

journal_title

Chest

authors

Behling CA,Wolf PL,Haghighi P

doi

10.1378/chest.103.4.1268

subject

Has Abstract

pub_date

1993-04-01 00:00:00

pages

1268-9

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)41835-5

journal_volume

103

pub_type

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