Abstract:
BACKGROUND:Recent study of the inflammatory reactions occurring during and after cardiopulmonary bypass (CPB) has improved our understanding of the involvement of the inflammatory cascade in perioperative injury. However, the exact mechanisms of this complex response remain to be fully determined. METHODS:Literature on the inflammatory response to CPB was reviewed to define current knowledge on the possible pathways and mediators involved, and to discuss recent developments of therapeutic interventions aimed at attenuating the inflammatory response to CPB. RESULTS:CPB has been shown to induce complement activation, endotoxin release, leukocyte activation, the expression of adhesion molecules, and the release of many inflammatory mediators including oxygen-free radicals, arachidonic acid metabolites, cytokines, platelet-activating factor, nitric oxide, and endothelins. Therapies aimed at interfering with the inflammatory response include the administration of pharmacologic agents such as corticosteroids, aprotinin, and antioxidants, as well as modification of techniques and equipment by the use of heparin-coated CPB circuits, intraoperative leukocyte depletion, and ultrafiltration. CONCLUSIONS:Improved understanding of the inflammatory reactions to CPB can lead to improved patient outcome by enabling the development of novel therapies aimed at limiting this response.
journal_name
Chestjournal_title
Chestauthors
Wan S,LeClerc JL,Vincent JLdoi
10.1378/chest.112.3.676subject
Has Abstractpub_date
1997-09-01 00:00:00pages
676-92issue
3eissn
0012-3692issn
1931-3543pii
S0012-3692(16)31735-4journal_volume
112pub_type
杂志文章,评审相关文献
CHEST文献大全abstract::Aortopulmonary window is a rare congenital cardiac anomaly. When it coexists with a ventricular septal defect, the accurate diagnosis of aortopulmonary window on the basis of clinical examination is difficult. We report the case of an infant who had an aortopulmonary window together with a ventricular septal defect. A...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.1.280
更新日期:1992-01-01 00:00:00
abstract:BACKGROUND:The aim of this prospective, multicenter study was to define the accuracy of lung ultrasound (LUS) in the diagnosis of community-acquired pneumonia (CAP). METHODS:Three hundred sixty-two patients with suspected CAP were enrolled in 14 European centers. At baseline, history, clinical examination, laboratory ...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.12-0364
更新日期:2012-10-01 00:00:00
abstract:OBJECTIVE:To determine the usefulness of performing routine postprocedure chest radiographs (CXRs) following percutaneous dilatational tracheostomy (PDT) under bronchoscopic visualization. DESIGN:Retrospective, chart review. SETTING:Medical-surgical ICU of a teaching hospital. METHODS:Sixty patients who underwent PD...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.123.5.1603
更新日期:2003-05-01 00:00:00
abstract::Fifty-nine patients were studied who had severe tricuspid regurgitation which was confirmed by right ventriculography and during surgery in order to determine the incidence of clinical, radiologic, and hemodynamic clues of severe tricuspid regurgitation. Eighty-eight percent of patients had Carvallo sign alone or in c...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.82.6.726
更新日期:1982-12-01 00:00:00
abstract:BACKGROUND:Patients with usual interstitial pneumonia (UIP) associated with collagen vascular disease (CVD) have been reported to have a better prognosis than those with idiopathic pulmonary fibrosis with a UIP pattern (IPF/UIP) seen on histology. The aim of this study was to evaluate the pathologic and radiologic diff...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-2572
更新日期:2009-07-01 00:00:00
abstract:STUDY OBJECTIVES:Patients with COPD have an increased sympathetic modulation and reduced baroreflex sensitivity (BRS). Therefore, we studied the effects of breathing 31% supplemental oxygen (SuppO(2)) on autonomic modulation in a group of COPD patients. DESIGN:We measured autonomic modulation before and during the adm...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.118.3.691
更新日期:2000-09-01 00:00:00
abstract:STUDY OBJECTIVE:This prospective study was performed in an attempt to evaluate (1) the rate of magnetic resonance imaging (MRI) demonstrating bone marrow (BM) abnormalities, (2) the correlation of these abnormalities with a pathologic malignant BM involvement, and (3) the possible modification of patients' usual diseas...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.4.1030
更新日期:1994-10-01 00:00:00
abstract:BACKGROUND:Low-density gas mixtures and oxygen (O₂) supplementation are known to improve physical performance and ventilatory adaptation during incremental maximal exercise in COPD. We investigated whether their combined use during intense physical training is also effective in ameliorating exercise tolerance in patien...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.10-0120
更新日期:2010-11-01 00:00:00
abstract::To further delineate indications for noninvasive pressure support ventilation (NIPSV), we proposed this noninvasive technique as an alternative to endotracheal intubation in 17 consecutive patients with acute respiratory failure from various causes. Eight patients (47 percent) were successfully ventilated with NIPSV, ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.3.907
更新日期:1993-03-01 00:00:00
abstract::We have assessed right and left ventricular function by multigated radionuclide ventriculography in 12 consecutive patients with acquired immunodeficiency syndrome (AIDS) grouped according to the CDC classification system for HIV infection. Results were correlated with clinical, electrocardiographic and echocardiograp...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.93.3.592
更新日期:1988-03-01 00:00:00
abstract::Respiratory manifestations of systemic lupus erythematosus (SLE) are frequent. They include respiratory muscle abnormalities, which have been implicated in the pathogenesis of the "shrinking lung syndrome" (SLS). We report the case of a patient with this syndrome, in whom diaphragmatic paralysis due to demyelinating p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.119.4.1274
更新日期:2001-04-01 00:00:00
abstract:BACKGROUND:The presence of aerobic Gram-negative bacilli (AGNB) in the oropharynx can be either temporary or persistent. Prolonged colonization (ie, carriage) is distinguished from transient presence (ie, acquisition), which often occurs in healthy individuals but less frequently in those with underlying disease. Preva...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.6.1570
更新日期:1999-06-01 00:00:00
abstract::Bilateral tuberculous pneumonia with the syndrome of inappropriate secretion of antidiuretic hormone was the cause of the adult respiratory distress syndrome in an elderly patient. Early recognition and prompt therapy enabled the patient to make a complete recovery without the necessity for mechanical ventilation. Wit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.72.5.678
更新日期:1977-11-01 00:00:00
abstract:OBJECTIVE:To assess the incidence of pseudomonal infection, colonization, and inflammation in the allograft of lung transplant recipients with cystic fibrosis (CF) as compared with recipients with other end-stage lung disease. DESIGN:Retrospective review. SETTING:University medical center transplant service. PATIENT...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.5.1235
更新日期:1998-05-01 00:00:00
abstract:STUDY OBJECTIVES:Surgical resection remains the treatment of choice for anatomically resectable non-small cell lung cancer. However, the presence of associated comorbid conditions increases the risk of death and surgical complications. Several studies have evaluated the usefulness of preoperative exercise testing for p...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.4.1159
更新日期:2005-04-01 00:00:00
abstract::We describe the first case, to our knowledge, of usual interstitial pneumonia (UIP) as the pulmonary manifestation in primary Sjögren's syndrome (SjS). A 45-year-old woman was admitted to our hospital because of a dry cough and an interstitial shadow on a chest roentgenogram. Labial biopsy and sialogram confirmed a di...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.108.6.1756
更新日期:1995-12-01 00:00:00
abstract:PURPOSE:The aim of this study was to assess the usefulness of a specific inspiratory muscle training in Duchenne muscular dystrophy (DMD). PATIENTS AND METHODS:Fifteen patients with DMD started 6 months of training the inspiratory muscles and 15 patients served as a control group. Pulmonary and inspiratory muscle func...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.105.2.475
更新日期:1994-02-01 00:00:00
abstract::A 39-year-old woman presented with recurrent acute illness, characterized by high-grade fever, pleuritic chest pain, and unilateral nodular infiltrate on chest radiograph. During the follow-up period, there were six similar episodes, each starting 2 to 3 days prior to her menstrual period and resolving within 5 to 10 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.118.1.253
更新日期:2000-07-01 00:00:00
abstract:STUDY OBJECTIVES:Levofloxacin is a fluoroquinolone antimicrobial agent for which pharmacodynamic relationships between the maximum serum antibiotic concentration (Cmax)/minimum inhibitory concentration (MIC) ratio and/or the area under the serum concentration-time curve during a 24-h dosing period (AUC(0-24))/MIC ratio...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.128.4.2093
更新日期:2005-10-01 00:00:00
abstract:BACKGROUND:Although alveolar epithelial injury is a major determinant of outcome in patients with acute lung injury, there is no reliable biological marker of alveolar epithelial injury. The primary objective was to determine whether elevated levels of the receptor for advanced glycation end products (RAGE), a marker o...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-0919
更新日期:2009-02-01 00:00:00
abstract::Volatile organic compounds (VOCs) are produced by virtually all metabolic processes of the body. As such, they have potential to serve as noninvasive metabolic biomarkers. Since exhaled VOCs are either derived from the respiratory tract itself or have passed the lungs from the circulation, they are candidate biomarker...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-0781
更新日期:2015-01-01 00:00:00
abstract:BACKGROUND:The clinical manifestations of bronchial remodeling in asthma and the potential impact of this process on lung function remain unclear. We aimed to determine whether the presence of pathologic features of airway remodeling in patients with asthma was associated with steroid responsiveness in the short term. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-0232
更新日期:2012-06-01 00:00:00
abstract:BACKGROUND:The impact of new-onset postoperative atrial fibrillation (NAF) on in-hospital mortality (IHM) following cardiac surgery is unknown. METHODS:All patients without preoperative atrial fibrillation undergoing isolated coronary artery bypass graft surgery (CABG) and concomitant CABG and valve surgery were ident...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.06-0735
更新日期:2007-03-01 00:00:00
abstract:BACKGROUND:Although tuberculosis (TB) and other lung infections are common throughout the developing world, they are not among the most common causes of chronic cough. METHODS:Articles were selected from a MEDLINE search from 1966 through 2003 (using medical subject heading words "cough," "tuberculosis," and "lung inf...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.129.1_suppl.197S
更新日期:2006-01-01 00:00:00
abstract::Bronchoscopy specimens from 183 known/suspected acquired immunodeficiency syndrome patients were evaluated for pathogens. In each case, transbronchial biopsies were evaluated and bronchoalveolar lavage material was cultured for viruses, fungi and mycobacteria and examined cytologically. A specimen was considered posit...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.24
更新日期:1990-07-01 00:00:00
abstract:BACKGROUND:It would be valuable to have a noninvasive method of measuring impaired pulmonary gas exchange in patients with lung disease and thus reduce the need for repeated arterial punctures. This study reports the results of using a new test in a group of outpatients attending a pulmonary clinic. METHODS:Inspired a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2018.02.001
更新日期:2018-08-01 00:00:00
abstract:OBJECTIVES:To compare the systemic bioavailability (assessed by cortisol suppression) of high-dose budesonide when given by four inhaler devices and orally. Also studied are the relative systemic potencies of three inhaled steroids (budesonide, fluticasone propionate, and beclomethasone dipropionate) when given by mete...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.115.5.1278
更新日期:1999-05-01 00:00:00
abstract::Bronchopulmonary C-fibers and a subset of mechanically sensitive, acid-sensitive myelinated sensory nerves play essential roles in regulating cough. These vagal sensory nerves terminate primarily in the larynx, trachea, carina, and large intrapulmonary bronchi. Other bronchopulmonary sensory nerves, sensory nerves inn...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.14-1481
更新日期:2014-12-01 00:00:00
abstract::We wanted to determine the long-term effects of a continuous infusion of PGE1 on DO2 and VO2 in patients with ARDS. Data were obtained from a randomized double-blind multicenter trial, which evaluated the effects of PGE1 on survival in patients with ARDS. Patients were stratified according to treatment and outcome: pl...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.98.2.405
更新日期:1990-08-01 00:00:00
abstract:STUDY OBJECTIVES:To evaluate the safety and efficacy of sitaxsentan, an endothelin-A receptor antagonist, in a 12-week, open-label trial of patients with pulmonary arterial hypertension (PAH). PATIENTS:Six children and 14 adults with New York Heart Association (NYHA) functional class II, III, or IV primary pulmonary h...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.121.6.1860
更新日期:2002-06-01 00:00:00