Myocardial oxygen supply and demand.

Abstract:

:The supply of oxygen to the myocardium is determined by coronary blood flow and oxygen carrying capacity. Coronary blood flow is a dynamic process modulated via multiple parameters. Cardiac metabolism is also affected by several factors. Under normal physiologic conditions, the demand is easily met by the supply of oxygen. In fact, there is a significant reserve on the supply side. Under certain pathologic states such as coronary artery disease, the supply of oxygen may be exhausted and an imbalance between supply and demand occurs which is translated into ischemia. The area of myocardium most susceptible to ischemia is the subendocardium due to mechanical and metabolic forces. In therapy of coronary artery disease, attention should be directed to directional changes in factors influencing supply and demand to improve blood flow to the most susceptible area.

journal_name

Chest

journal_title

Chest

authors

Ardehali A,Ports TA

doi

10.1378/chest.98.3.699

subject

Has Abstract

pub_date

1990-09-01 00:00:00

pages

699-705

issue

3

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)32105-5

journal_volume

98

pub_type

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