Noninvasive evaluation of instantaneous total mechanical activity of the respiratory muscles during pressure support ventilation.

Abstract:

OBJECTIVE:The measurement of esophageal pressure (Pes) is the conventional method for the evaluation of the forces applied to the respiratory system by the respiratory muscles. As an alternative to Pes measurement, we propose the calculation of the instantaneous net pressure applied by the respiratory muscles [Pmusc(t)]. DESIGN:Prospective, randomized study. SETTING:A general ICU of a university hospital. PATIENTS:Eight intubated patients submitted to pressure support ventilation for acute respiratory failure. INTERVENTIONS:Four different levels of pressure support were used to unload progressively the respiratory muscles. Pmusc(t) was calculated at all levels of pressure support and compared with Pes corrected for chest wall load as a reference. Pmusc(t) was further used to calculate inspiratory work of breathing, which in turn was compared with data obtained with the conventional method. MEASUREMENTS AND RESULTS:Airway pressure, airflow, and Pes were measured. Both for amplitude and for timing, Pmusc(t) showed good agreement with reference measurements. Work of breathing as calculated from Pmusc(t) agreed well with the measurement obtained with the conventional method (mean difference, 0.057 +/- 0.157 J). CONCLUSIONS:Noninvasive evaluation of Pmusc(t) allows extended monitoring of mechanical ventilation, which is particularly interesting for pressure preset ventilation modes.

journal_name

Chest

journal_title

Chest

authors

Iotti GA,Braschi A,Brunner JX,Palo A,Olivei MC

doi

10.1378/chest.108.1.208

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

208-15

issue

1

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)38618-4

journal_volume

108

pub_type

临床试验,杂志文章,随机对照试验

相关文献

CHEST文献大全
  • In vivo right heart thrombus. Precursor of life-threatening pulmonary embolism.

    abstract::This report describes three cases of massive mobile right heart thrombus and reviews the available literature to better define the pathophysiology, natural history and most appropriate therapy of the syndrome. The clinical presentation of most patients has been severe cardiopulmonary dysfunction and the diagnosis has ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.94.6.1236

    authors: Crowell RH,Adams GS,Koilpillai CJ,McNutt EJ,Montague TJ

    更新日期:1988-12-01 00:00:00

  • Effects of long-term treatment with corticosteroids in COPD.

    abstract:STUDY OBJECTIVE:To determine the effectiveness of treatment with corticosteroids in patients with COPD. METHODS:In this study, we investigated the effect of a 2-year treatment with corticosteroids on clinical symptoms and the decline of lung function in 58 nonallergic patients with COPD. Subjects were treated in a dou...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.109.5.1156

    authors: Renkema TE,Schouten JP,Koëter GH,Postma DS

    更新日期:1996-05-01 00:00:00

  • Bilateral functioning Vineberg grafts. A 25-year follow-up.

    abstract::This report describes a 25-year follow-up of angiographically proven bilateral functioning Vineberg grafts. This represents the longest angiographic follow-up found in the literature. The relevance of these grafts in present-day revascularization procedures is discussed. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.111.3.824

    authors: Hughes MM

    更新日期:1997-03-01 00:00:00

  • Respiratory Disease and Lower Pulmonary Function as Risk Factors for Dementia: A Systematic Review With Meta-analysis.

    abstract:BACKGROUND:In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). In this meta-analysis of existing longitudinal studies, the hypothesis that lower pulmonary function and respiratory illness...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.12.012

    authors: Russ TC,Kivimäki M,Batty GD

    更新日期:2020-06-01 00:00:00

  • Current status of the implantable cardioverter-defibrillator.

    abstract::Clinical trials have established the superiority of the implantable cardioverter-defibrillator (ICD) over antiarrhythmic drug therapy in survivors of sudden cardiac death and in high-risk patients with coronary artery disease. The ICD has evolved to overcome the limitation of earlier devices that required thoracotomy ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.119.4.1210

    authors: Gollob MH,Seger JJ

    更新日期:2001-04-01 00:00:00

  • Ventilatory and metabolic effects of glucose infusions.

    abstract::It has been demonstrated that total parenteral nutrition (TPN) results in increased O2 consumption (VO2), CO2 production (VCO2) and minute ventilation (VE). TPN consists of a mixture of glucose and amino acids. The individual role of each of these nutrients in mediating these changes has not been well established. To ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.88.4.512

    authors: Rodriguez JL,Askanazi J,Weissman C,Hensle TW,Rosenbaum SH,Kinney JM

    更新日期:1985-10-01 00:00:00

  • Effect of routine intensive care interactions on metabolic rate.

    abstract::The alterations in metabolic (oxygen consumption [VO2] and carbon dioxide production [VCO2]) and hemodynamic (heart rate and blood pressure) parameters caused by various common intensive care activities were examined in a group of 23 mechanically-ventilated critically-ill patients. The observed variations in metabolic...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.86.6.815

    authors: Weissman C,Kemper M,Damask MC,Askanazi J,Hyman AI,Kinney JM

    更新日期:1984-12-01 00:00:00

  • Nearly fatal idiopathic anaphylactic reaction resulting in cardiovascular collapse and myocardial infarction.

    abstract::We report a case of nearly fatal cardiovascular collapse attributable to an idiopathic anaphylactic reaction in a 76-year-old man. The event began with gastrointestinal symptoms of abdominal cramps, diarrhea, nausea, and vomiting as manifestations of IA. The patient subsequently progressed to develop urticaria, flushi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.98.2.501

    authors: Wong S,Greenberger PA,Patterson R

    更新日期:1990-08-01 00:00:00

  • Pleurectomy/decortication and adjuvant therapy for malignant mesothelioma.

    abstract::Malignant mesothelioma is an uncommon and usually fatal cancer, for which there is no standard treatment. However, surgical resection remains the mainstay of treatment because of the inability to treat the entire hemithorax effectively with radiation and the lack of effective chemotherapy drugs. Extrapleural pneumonec...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.4_supplement.382s

    authors: Rusch VW

    更新日期:1993-04-01 00:00:00

  • Pulmonary Artery Invasion Caused by Mycobacterium tuberculosis.

    abstract::Extrapulmonary tuberculosis refers to Mycobacterium tuberculosis involving organs other than the lungs (eg, pleura, lymph nodes, genitourinary tract, abdomen, skin, joints and bones, or meninges). In non-HIV-endemic areas, where reactivation is the predominant mechanism of tuberculosis, pleural involvement occurs in 4...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2016.02.655

    authors: Gleason JB,Tashtoush B,Mehta J,Savage E,Martinez F,Mehta AC

    更新日期:2016-10-01 00:00:00

  • Candida endocarditis. A treatable form of pacemaker infection.

    abstract::Fungal endocarditis is a rare complication of permanent pacemaker implantation. In all reports we have identified, this infection has been fatal, diagnosed postmortem. We present a patient in whom early echocardiographic diagnosis resulted in curative surgical and antimicrobial therapy. Fungal endocarditis is an unusu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.1.283

    authors: Wilson HA Jr,Downes TR,Julian JS,White WL,Haponik EF

    更新日期:1993-01-01 00:00:00

  • Predictors of short-term rehospitalization following discharge of patients hospitalized with community-acquired pneumonia.

    abstract:BACKGROUND:Among patients hospitalized for community-acquired pneumonia (CAP), the risk factors for short-term hospital readmission after discharge are unknown. METHODS:We conducted a prospective observational study of 1,117 patients who had been discharged alive after hospitalization for CAP. We collected variables a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2950

    authors: Capelastegui A,España Yandiola PP,Quintana JM,Bilbao A,Diez R,Pascual S,Pulido E,Egurrola M

    更新日期:2009-10-01 00:00:00

  • Comparison of 24 versus 12 hours of ambulatory ECG monitoring.

    abstract::In order to assess the additional information obtained from 24 hours compared to 12 hours of ambulatory ECG (electrocardiogram) recording, we analyzed 72 ambulatory ECG monitoring tapes in which arrhythmias were present. In all cases the second 12 hours included the entire period of sleep. Only 38 of 233 (16 percent) ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.67.3.269

    authors: Lopes MG,Runge P,Harrison DC,Schroeder JS

    更新日期:1975-03-01 00:00:00

  • Methodological approach: American College of Chest Physicians guidelines for the prevention and management of postoperative atrial fibrillation after cardiac surgery.

    abstract::Atrial fibrillation remains a common and challenging problem following cardiac surgery. The American College of Chest Physicians, through the Health and Science Policy Committee, established a panel to develop a set of clinical practice guidelines for the management or prophylaxis of atrial fibrillation or flutter in ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.2_suppl.17s

    authors: Fleisher LA,Bass EB,McKeown P,American College of Chest Physicians.

    更新日期:2005-08-01 00:00:00

  • Treatment of bronchospasm by metered-dose inhaler albuterol in mechanically ventilated patients.

    abstract::beta 2-agonist bronchodilators delivered by metered-dose inhalers (MDI) are commonly used in the treatment of bronchospasm in both intubated and nonintubated patients. Substantial data support the effectiveness of MDI delivery systems in nonintubated patients. However, few studies have examined the effectiveness of MD...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.107.1.210

    authors: Manthous CA,Chatila W,Schmidt GA,Hall JB

    更新日期:1995-01-01 00:00:00

  • Nerve growth factor in serum and lymphocyte culture in pigeon fanciers' acute hypersensitivity pneumonitis.

    abstract:BACKGROUND:Nerve growth factor (NGF) is a neurotrophic cytokine with immunomodulatory activity. NGF contributes to neurogenic inflammation and has been described in asthma and idiopathic pulmonary fibrosis. OBJECTIVES:To identify and quantify NGF in serum and peripheral blood lymphocyte cultures from pigeon fanciers, ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.1.37

    authors: McSharry CP,Fraser I,Chaudhuri R,Anderson K,Bourke SJ,Thomson NC,Boyd G

    更新日期:2006-07-01 00:00:00

  • Cough in Ambulatory Immunocompromised Adults: CHEST Expert Panel Report.

    abstract:BACKGROUND:Cough is a common symptom prompting patients to seek medical care. Like patients in the general population, patients with compromised immune systems also seek care for cough. However, it is unclear whether the causes of cough in immunocompromised patients who are deemed unlikely to have a life-threating cond...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1016/j.chest.2017.07.039

    authors: Rosen MJ,Ireland B,Narasimhan M,French C,Irwin RS,CHEST Expert Cough Panel.

    更新日期:2017-11-01 00:00:00

  • N-terminal pro-brain natriuretic peptide and renal insufficiency as predictors of mortality in pulmonary hypertension.

    abstract:BACKGROUND:N-terminal pro-brain natriuretic peptide (NT-proBNP) is a byproduct of the brain natriuretic peptide (BNP) that was shown to be of prognostic value in pulmonary hypertension (PH). The role of NT-proBNP in PH has to be determined, especially under the influence of renal impairment that might lead to an accumu...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-1758

    authors: Leuchte HH,El Nounou M,Tuerpe JC,Hartmann B,Baumgartner RA,Vogeser M,Muehling O,Behr J

    更新日期:2007-02-01 00:00:00

  • Simplified technique for permanent atrioventricular pacing via a single venipuncture.

    abstract::The use of physiologic pacing utilizing transvenous atrial and ventricular electrodes has recently taken on increased importance. A simple, safe, technique for electrode implantation has been used in 14 patients and enabled the implanting physicians to establish permanent atrioventricular (A-V) sequential pacing with ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.6.745

    authors: Fox S,Toonder FG

    更新日期:1981-12-01 00:00:00

  • Hypoxic pulmonary vasoconstriction and gas exchange during exercise in chronic obstructive pulmonary disease.

    abstract::In patients with chronic obstructive pulmonary disease (COPD) studied at rest, nifedipine releases hypoxic pulmonary vasoconstriction (HPV) and worsens gas exchange. During exercise, this drug lowers pulmonary hypertension, but the effects of this lower pulmonary vascular tone on ventilation-perfusion (VA/Q) relations...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.97.2.268

    authors: Agustí AG,Barberá JA,Roca J,Wagner PD,Guitart R,Rodriguez-Roisín R

    更新日期:1990-02-01 00:00:00

  • Perforin down-regulation and adhesion molecules activation in pulmonary sarcoidosis: an induced sputum and BAL study.

    abstract:BACKGROUND:Sarcoidosis is thought to be a T-helper type 1 cytokine-mediated disorder. Sputum induction has been proposed as a useful noninvasive method mainly for the assessment of airway diseases. However, it is unknown whether the balance of T-cytotoxic (Tc1) type 1 and Tc2 cells is altered in sarcoidosis. STUDY OBJ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.129.6.1592

    authors: Antoniou KM,Tsiligianni I,Kyriakou D,Tzanakis N,Tzouvelekis A,Siafakas NM,Bouros D

    更新日期:2006-06-01 00:00:00

  • Combined pulmonary fibrosis and emphysema syndrome: a review.

    abstract::There is increasing clinical, radiologic, and pathologic recognition of the coexistence of emphysema and pulmonary fibrosis in the same patient, resulting in a clinical syndrome known as combined pulmonary fibrosis and emphysema (CPFE) that is characterized by dyspnea, upper-lobe emphysema, lower-lobe fibrosis, and ab...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-1062

    authors: Jankowich MD,Rounds SIS

    更新日期:2012-01-01 00:00:00

  • The role of open lung biopsy in patients with the acquired immunodeficiency syndrome.

    abstract::To assess the role of open lung biopsy in patients with the acquired immunodeficiency syndrome (AIDS), we retrospectively reviewed the cases of 42 patients with AIDS who underwent this procedure for the diagnosis of pulmonary infiltrates. Four patients had no preceding bronchoscopy because the severity of the respirat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.5.659

    authors: Fitzgerald W,Bevelaqua FA,Garay SM,Aranda CP

    更新日期:1987-05-01 00:00:00

  • The utility of 99mTc depreotide compared with F-18 fluorodeoxyglucose positron emission tomography and surgical staging in patients with suspected non-small cell lung cancer.

    abstract:STUDY OBJECTIVES:The findings from conventional imaging modalities, such as chest CT, are frequently unreliable in patients with lung cancer. This study was designed to compare the relative diagnostic accuracies and utility of the two most widely used functional imaging examinations, F-18-2-fluoro-2-deoxyglucose (FDG) ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.2.494

    authors: Kahn D,Menda Y,Kernstine K,Bushnell D,McLaughlin K,Miller S,Berbaum K

    更新日期:2004-02-01 00:00:00

  • Inspiratory capacity and decrease in lung hyperinflation with albuterol in COPD.

    abstract:STUDY OBJECTIVES:Inspiratory capacity (IC) has been proposed as a simple method to assess acute changes in functional residual capacity (FRC) with bronchodilation, assuming that total lung capacity (TLC) is unchanged. This assumption is based on studies using body plethysmography, which may not accurately measure TLC i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.122.6.2009

    authors: Duranti R,Filippelli M,Bianchi R,Romagnoli I,Pellegrino R,Brusasco V,Scano G

    更新日期:2002-12-01 00:00:00

  • Left ventricular laceration due to stented prosthesis.

    abstract::Complications following open chest massage in patients with porcine xenografts in the mitral location have not been previously described. The authors report a case of cardiac resuscitation following mitral valve replacement with a stented porcine valve. The patient died following brief closed chest, and then, prolonge...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.77.2.216

    authors: Wild LM,Lajos TZ,Lee AB Jr,Wright J

    更新日期:1980-02-01 00:00:00

  • The effect of exercise on ischemic mitral regurgitation.

    abstract::This study investigated the effect of dynamic exercise on mitral regurgitation (MR) as assessed by color flow Doppler imaging and tested the hypothesis that MR increases in patients with left ventricular (LV) function worsening during exercise. We studied 513 patients (390 men, 123 women:mean age [+/-1 SD] 58+/-11 yea...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.114.4.1075

    authors: Peteiro J,Freire E,Montserrat L,Castro-Beiras A

    更新日期:1998-10-01 00:00:00

  • Nocturnal oxygen desaturation correlates with the severity of coronary atherosclerosis in coronary artery disease.

    abstract:STUDY OBJECTIVES:It has been suggested that sleep-disordered breathing (SDB) is a risk factor for ischemic heart disease, and may be associated with increased morbidity and mortality due to cardiovascular disease. The aim of this study was to examine the relation between nocturnal oxygen desaturation (NOD) due to SDB a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.124.3.936

    authors: Hayashi M,Fujimoto K,Urushibata K,Uchikawa S,Imamura H,Kubo K

    更新日期:2003-09-01 00:00:00

  • Evolution of the postoperative pericardial effusion after day 15: the problem of the late tamponade.

    abstract:STUDY OBJECTIVES:To evaluate, through clinical and transthoracic echocardiography (TTE) follow-up, the natural history of persistent pericardial effusion (PE) after postoperative day 15 in patients who were given and were not given anticoagulant therapy. DESIGN AND PATIENTS:We retrospectively studied a cohort of 1,277...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.6.2182

    authors: Meurin P,Weber H,Renaud N,Larrazet F,Tabet JY,Demolis P,Ben Driss A

    更新日期:2004-06-01 00:00:00

  • Transition from exercise to rest. Ventilatory and arterial blood gas responses.

    abstract::The mechanisms leading to rapid changes in arterial blood gas values soon after exercise ends have not been well established. To further study these phenomena, we exercised seven normal male volunteers to exhaustion on a cycle ergometer with a 25-W/min ramped protocol measuring arterial blood gas values, and breath-by...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.5.1145

    authors: O'Neill AV,Johnson DC

    更新日期:1991-05-01 00:00:00