Deficiency of alveolar fluid glutathione in patients with sepsis and the adult respiratory distress syndrome.

Abstract:

:The adult respiratory distress syndrome (ARDS) is a devastating clinical illness characterized by refractory hypoxemia and high-permeability pulmonary edema. Reactive oxygen species such as hydrogen peroxide and hypochlorous acid may play a key role in the pathogenesis of the acute lung injury. Glutathione (GSH) is a tripeptide that is able to react with and effectively neutralize oxidants such as hydrogen peroxide and hypochlorous acid. The present study found that the alveolar epithelial lining fluid of patients with ARDS was deficient in total GSH compared to normal subjects (21.7 mumols +/- 7.8 mumols vs 91.8 mumols +/- 14.5 mumols; p = 0.002). In addition, if GSH was measured in unconcentrated bronchoalveolar lavage (BAL) fluid and indexed to total BAL protein, there was also a deficiency in patients with ARDS compared to normal subjects (0.004 +/- 0.003 nmol of GSH per microgram of total protein vs 0.026 +/- 0.005 nmol of GSH per microgram of total protein; p = 0.002). Since patients with ARDS are subjected to an increased burden of oxidants in the alveolar fluid, principally released by recruited neutrophils, this deficiency of GSH may predispose these patients to enhanced lung cell injury.

journal_name

Chest

journal_title

Chest

authors

Pacht ER,Timerman AP,Lykens MG,Merola AJ

doi

10.1378/chest.100.5.1397

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

1397-403

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)33697-2

journal_volume

100

pub_type

杂志文章

相关文献

CHEST文献大全
  • The role of open lung biopsy in patients with the acquired immunodeficiency syndrome.

    abstract::To assess the role of open lung biopsy in patients with the acquired immunodeficiency syndrome (AIDS), we retrospectively reviewed the cases of 42 patients with AIDS who underwent this procedure for the diagnosis of pulmonary infiltrates. Four patients had no preceding bronchoscopy because the severity of the respirat...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.91.5.659

    authors: Fitzgerald W,Bevelaqua FA,Garay SM,Aranda CP

    更新日期:1987-05-01 00:00:00

  • Prevention of cytomegalovirus infection and disease after lung transplantation: results using a unique regimen employing delayed ganciclovir.

    abstract:BACKGROUND:Many lung transplant programs employ lengthy regimens of IV ganciclovir therapy to prevent disease due to cytomegalovirus (CMV). In 1994, we introduced a regimen of delayed ganciclovir prophylaxis for CMV infection. This consisted of 2 weeks of IV ganciclovir therapy, initiated 3 to 4 weeks after transplanta...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.2.407

    authors: Brumble LM,Milstone AP,Loyd JE,Ely EW,Pierson RN 3rd,Gautam S,Dummer JS

    更新日期:2002-02-01 00:00:00

  • Maximal sniff mouth pressure compared with maximal inspiratory pressure in acute respiratory failure.

    abstract::Inspiratory muscle strength most often is better reflected by sniff Pes than PImax against occlusion. Furthermore, sniff Pes can be estimated noninvasively by the measurement of sniff Pmo in normal subjects and in patients with respiratory muscle weakness. The aim of this study was to compare sniff Pmo and P.PImax to ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.100.1.175

    authors: Héritier F,Perret C,Fitting JW

    更新日期:1991-07-01 00:00:00

  • Video-assisted thoracoscopic surgery is a promising treatment for solitary fibrous tumor of the pleura.

    abstract:STUDY OBJECTIVES:Solitary fibrous tumors of the pleura (SFTPs) are slow-growing neoplasms. Approximately 800 cases have been reported in the literature to date. The aim of this study was to address our experience with the management of SFTPs and to evaluate the advantage of video-assisted thoracoscopic surgery (VATS) i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.3.1144

    authors: Takahama M,Kushibe K,Kawaguchi T,Kimura M,Taniguchi S

    更新日期:2004-03-01 00:00:00

  • Development of a giant bulla after lung volume reduction surgery.

    abstract::Lung volume reduction surgery (LVRS) is being evaluated in the treatment of emphysema. The proposed mechanisms of improvement are increased elastic recoil of the lung and improved mechanical efficiency of the muscles of respiration. We report a unique patient with emphysema who developed a giant bulla 3 years subseque...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.6.1809

    authors: Iqbal M,Rossoff L,McKeon K,Graver M,Scharf SM

    更新日期:1999-12-01 00:00:00

  • Mask proportional assist vs pressure support ventilation in patients in clinically stable condition with chronic ventilatory failure.

    abstract:OBJECTIVE:To compare the short-term physiologic effects of mask pressure support ventilation (PSV) and proportional assist ventilation (PAV) in patients in clinically stable condition with chronic ventilatory failure (CVF). DESIGN:Randomized, controlled physiologic study. SETTING:Lung function units of two pulmonary ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

    doi:10.1378/chest.122.2.479

    authors: Porta R,Appendini L,Vitacca M,Bianchi L,Donner CF,Poggi R,Ambrosino N

    更新日期:2002-08-01 00:00:00

  • Neural network prediction of obstructive sleep apnea from clinical criteria.

    abstract:STUDY OBJECTIVES:Clinical prediction models for the diagnosis of obstructive sleep apnea (OSA) have lacked the accuracy necessary to confidently replace polysomnography (PSG). Artificial neural networks are computer programs that can be trained to predict outcomes based on experience. This study was conducted to test t...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.116.2.409

    authors: Kirby SD,Eng P,Danter W,George CF,Francovic T,Ruby RR,Ferguson KA

    更新日期:1999-08-01 00:00:00

  • Defensive role of pleural mesothelial cell sialomucins in tumor metastasis.

    abstract:STUDY OBJECTIVES:Sialomucin complex (SMC) is a heterodimeric glycoprotein, and is found on the surfaces of the mesothelia of the pleura, pericardium, and peritoneum. Sialomucins play a significant role in adhesion as well as in defense. In this study, we hypothesized that pleural mesothelial cells (PMCs) express SMC an...

    journal_title:Chest

    pub_type: 杂志文章

    doi:

    authors: Sharma RK,Mohammed KA,Nasreen N,Hardwick J,Van Horn RD,Ramirez-Icaza C,Antony VB

    更新日期:2003-08-01 00:00:00

  • Transbronchial lung biopsy via the fiberoptic bronchoscope. Experience with 107 consecutive cases and comparison with bronchial brushing.

    abstract::Transbronchial lung biopsy (TBB) was performed during fiberoptic bronchoscopy under fluoroscopic guidance in 107 patients. TBB was diagnostic in 17 of 21 (81 percent) cases with localized malignant lesions greater than 4 cm in diameter and bronchial brushing was positive in 12 (57 percent). TBB was diagnostic in 14 of...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.68.4.524

    authors: Ellis JH Jr

    更新日期:1975-10-01 00:00:00

  • Pain location, distribution, and intensity after cardiac surgery.

    abstract:STUDY OBJECTIVES:To study the location, distribution, and intensity of pain in a sample of adult cardiac surgery patients during their postoperative hospital stay. DESIGN:In a prospective study, pain location, distribution (number of pain areas per patient), and intensity (0 to 10 numerical rating scale) were document...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.118.2.391

    authors: Mueller XM,Tinguely F,Tevaearai HT,Revelly JP,Chioléro R,von Segesser LK

    更新日期:2000-08-01 00:00:00

  • Safety of long-term treatment with HFA albuterol.

    abstract:BACKGROUND:Chlorofluorocarbons (CFCs) used as propellants in metered-dose inhalers deplete stratospheric ozone, which results in serious public health concerns. Albuterol has been reformulated in the non-ozone-depleting propellant, hydrofluoroalkane-134a (HFA albuterol). OBJECTIVES:The primary objective was to compare...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.115.4.945

    authors: Ramsdell JW,Klinger NM,Ekholm BP,Colice GL

    更新日期:1999-04-01 00:00:00

  • Quantification of traumatic hemomediastinum using transesophageal echocardiography: impact on patient management.

    abstract:STUDY OBJECTIVES:To determine whether the quantitative evaluation of hemomediastinum using transesophageal echocardiography (TEE) is predictive of the presence of a traumatic disruption of the thoracic aorta (TDA) or its branches in patients who have sustained severe blunt chest trauma. DESIGN:Retrospective study. SE...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.113.6.1475

    authors: Vignon P,Rambaud G,François B,Preux PM,Lang RM,Gastinne H

    更新日期:1998-06-01 00:00:00

  • Elastin fibers in the sputum of patients with necrotizing pneumonia.

    abstract::We have observed five patients for whom the presence of fibers of elastin in potassium hydroxide (KOH) preparations of sputum represented the first evidence of necrotizing pulmonary disease. In four cases, the discovery of elastin fibers in sputum provided additional evidence supporting initiation or modification of a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.83.6.885

    authors: Shlaes DM,Lederman M,Chmielewski R,Tweardy D,Wolinsky E

    更新日期:1983-06-01 00:00:00

  • Prediction of postoperative performance status in patients with giant bulla.

    abstract::To predict the postoperative improvement in performance status after bullectomy, preoperative pulmonary function and dyspneic grade were evaluated in 20 patients with giant bulla. The patients were divided into two groups, based on postoperative performance status: group 1 consisted of 15 patients with improved status...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.3.668

    authors: Ohta M,Nakahara K,Yasumitsu T,Ohsugi T,Maeda M,Kawashima Y

    更新日期:1992-03-01 00:00:00

  • A 75-Year-Old Man With Organizing Pneumonia Presenting With Worsening Dyspnea.

    abstract:CASE PRESENTATION:A 75-year-old man was referred to our institution for worsening dyspnea, decreased activity tolerance, myalgias, and an increase in oxygen requirement. Nine months before the initial referral, the patient presented to an outside hospital for acute hypoxemic respiratory failure requiring a right-sided ...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2019.11.012

    authors: Tseng S,Olson K,Shamsid-Deen N,Savajiyani S,Sista R,Hodges T,Saggar R

    更新日期:2020-05-01 00:00:00

  • A comparison of albuterol administered by metered-dose inhaler and spacer with albuterol by nebulizer in adults presenting to an urban emergency department with acute asthma.

    abstract:STUDY OBJECTIVES:To determine the efficacy of albuterol by metered-dose inhaler (MDI) and spacer compared to a nebulizer. DESIGN:A prospective, open-label study. SETTING:Large urban emergency department (ED). PATIENTS:All consecutive adult asthma patients over a 2.5-year period. INTERVENTIONS:ED personnel used a st...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.121.4.1036

    authors: Newman KB,Milne S,Hamilton C,Hall K

    更新日期:2002-04-01 00:00:00

  • Upper airway dysfunction in olivopontocerebellar atrophy.

    abstract::We report the findings in a patient known to have olivopontocerebellar atrophy who developed respiratory distress, inspiratory stridor, and maximum inspiratory and expiratory flow volume loops. Treatment with carbidopa-levodopa gave symptomatic relief. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.4.1291

    authors: Schiffman PL,Golbe LI

    更新日期:1992-10-01 00:00:00

  • Video-assisted contralateral treatment for bronchial stump diastasis after left pneumonectomy.

    abstract::Postoperative bronchial stump failure is a life-threatening complication, and several surgical approaches and procedures have been developed to close the stump. In this report, we describe a case of left mainstem bronchial stump diastasis after pneumonectomy for lung cancer, in which the bronchial stump was re-closed ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.117.3.884

    authors: Tsunezuka Y,Sato H,Kodama T

    更新日期:2000-03-01 00:00:00

  • Bronchopulmonary bacillary angiomatosis.

    abstract::A man with prior AIDS developed acute febrile interstitial pneumonitis, hilar and paratracheal adenopathy, and bronchial polyps. The polyps were histologically typical for bacillary angiomatosis and complete symptomatic and radiographic response to oral clarithromycin was seen. The clinical presentation of bacillary a...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.3.973

    authors: Foltzer MA,Guiney WB Jr,Wager GC,Alpern HD

    更新日期:1993-09-01 00:00:00

  • Radiation effect on implanted pacemakers.

    abstract::It was previously thought that diagnostic or therapeutic ionizing radiation did not have an adverse effect on the function of cardiac pacemakers. Recently, however, some authors have reported damaging effect of the therapeutic radiation on cardiac pulse generators. An analysis of a recently-extracted pacemaker documen...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.84.4.499

    authors: Pourhamidi AH

    更新日期:1983-10-01 00:00:00

  • The effect of high-dose inhaled beclomethasone dipropionate in patients with stable COPD.

    abstract:BACKGROUND:The benefits of inhaled corticosteroids in the management of COPD are less apparent than they are in asthma therapy, and the potential for adverse systemic effects of high-dose inhaled corticosteroids has been recognized recently. It is therefore essential to know the maximal obtainable benefits in order to ...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.115.1.31

    authors: Nishimura K,Koyama H,Ikeda A,Tsukino M,Hajiro T,Mishima M,Izumi T

    更新日期:1999-01-01 00:00:00

  • Potential future therapies for the management of cough: ACCP evidence-based clinical practice guidelines.

    abstract:BACKGROUND:When the etiology of a patient's chronic cough is established, specific antitussive therapy that is aimed at a particular cause of cough is highly effective. Nevertheless, in certain situations, therapy with cough suppressants, which previously were classified as nonspecific antitussive therapy, and which ai...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.129.1_suppl.284S

    authors: Dicpinigaitis PV

    更新日期:2006-01-01 00:00:00

  • Effect of air filtration systems on asthma: a systematic review of randomized trials.

    abstract:STUDY OBJECTIVES:To systematically review the evidence of randomized trials evaluating the effects of residential air filtration systems on patients with asthma. DATA SOURCES:We searched for published and unpublished studies using MEDLINE, the Cumulative Index to Nursing and Allied Health Literature, and the Cochrane ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.5.1535

    authors: McDonald E,Cook D,Newman T,Griffith L,Cox G,Guyatt G

    更新日期:2002-11-01 00:00:00

  • Sleep apnea and asymptomatic carotid stenosis: a complex interaction.

    abstract:BACKGROUND:Carotid arteriosclerosis and sleep apnea are considered as independent risk factors for stroke. Whether sleep apnea mediates severity of carotid stenosis remains unclear. Sleep apnea comprises two pathophysiologic conditions: OSA and central sleep apnea (CSA). Although OSA results from upper airway occlusion...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-1655

    authors: Ehrhardt J,Schwab M,Finn S,Guenther A,Schultze T,Witte OW,Rupprecht S

    更新日期:2015-04-01 00:00:00

  • Coronary artery bypass graft and/or valvular operations following prior pneumonectomy: report of four new patients and review of the literature.

    abstract:BACKGROUND:The reported experience is sparse for patients with prior pneumonectomy who are undergoing surgery for ischemic or valvular heart disease. Such surgery poses special technical challenges. To expand the experience with this challenging clinical intervention, we reviewed the reported patients with prior pneumo...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.06-2545

    authors: Stoller JK,Blackstone E,Pettersson G,Mihaljevic T

    更新日期:2007-07-01 00:00:00

  • Genetics and pulmonary hypertension.

    abstract::Primary pulmonary hypertension (PPH) is a serious pulmonary vascular disease occurring mostly in adult women. Although its occurrence in families was reported within a few years after the original clinical report, PPH was formerly believed rarely to have a genetic basis. Recent progress has not only clarified a basic ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.6_suppl.284s

    authors: Loyd JE

    更新日期:2002-12-01 00:00:00

  • Aberrant systemic arterial supply to the left lung with congestive heart failure.

    abstract::A six-month-old girl with an aberrant systemic arterial supply from the descending thoracic aorta to the left lower lobe had congestive heart failure. Although the pulmonary parenchyma was normal, there was an absence of normal pulmonary arterial supply to the left lower lobe. Main pulmonary arterial and aortic cinean...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.80.5.636

    authors: Yabek SM,Burstein J,Berman W Jr,Dillon T

    更新日期:1981-11-01 00:00:00

  • Follow-up and surveillance of the lung cancer patient following curative intent therapy: ACCP evidence-based clinical practice guideline (2nd edition).

    abstract:BACKGROUND:To develop an evidence-based approach to follow-up of patients after curative intent therapy for lung cancer. METHODS:Guidelines on lung cancer diagnosis and management published between 2002 and December 2005 were identified by a systematic review of the literature, and supplemental material appropriate to...

    journal_title:Chest

    pub_type: 杂志文章,实务指引

    doi:10.1378/chest.07-1390

    authors: Rubins J,Unger M,Colice GL,American College of Chest Physicians.

    更新日期:2007-09-01 00:00:00

  • Interpretation of cough provoked by airway challenges.

    abstract:STUDY OBJECTIVE:To analyze the cough response to three airway challenges in order to clarify whether the recording of the provoked coughs would be beneficial in the management of asthma. DESIGN:A prospective study. SETTING:University hospital. PARTICIPANTS:Fifteen healthy subjects, 16 steroid-naïve subjects with ast...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1378/chest.128.5.3329

    authors: Koskela HO,Kontra KM,Purokivi MK,Randell JT

    更新日期:2005-11-01 00:00:00

  • Symptomatic high grade heart block in Lyme disease.

    abstract::We describe an unusual and remediable form of heart block which developed in the course of Lyme disease. The diagnosis of Lyme disease requires a careful clinical history pertaining to epidemiologic geography or a history of erythema chronicum migrans. In this case, a highly selective cardiac abnormality responded pro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.79.2.236

    authors: Bedell SE,Pastor BM,Cohen SI

    更新日期:1981-02-01 00:00:00