Abstract:
:We have observed five patients for whom the presence of fibers of elastin in potassium hydroxide (KOH) preparations of sputum represented the first evidence of necrotizing pulmonary disease. In four cases, the discovery of elastin fibers in sputum provided additional evidence supporting initiation or modification of antibiotic therapy. Necrotizing disease was confirmed in all cases by autopsy or by the development of cavitation on chest x-ray film. Cytochemical staining, electron microscopy, and elastase digestion all suggest that the refractile fibers seen on KOH wet mount of sputum are elastin. The test, first described in 1846, is simple to perform, requires little experience to read, and may be a valuable adjunct to the chest roentgenogram in the diagnosis of pulmonary parenchymal destruction.
journal_name
Chestjournal_title
Chestauthors
Shlaes DM,Lederman M,Chmielewski R,Tweardy D,Wolinsky Edoi
10.1378/chest.83.6.885subject
Has Abstractpub_date
1983-06-01 00:00:00pages
885-9issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(15)33929-5journal_volume
83pub_type
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