International trends in asthma mortality rates in the 5- to 34-year age group: a call for closer surveillance.


BACKGROUND:International time trends in asthma mortality have played an important sentinel role in the identification of two epidemics of asthma mortality in some countries in the 1960s and the 1970s and 1980s. Since then, little attention has been paid to the ongoing international time trends. METHODS:Country-specific data on asthma mortality rates since 1960 in the 5- to 34-year-old age group were collated. To be included in the analysis, countries were required to have data available prior to 1980. A scatter plot smoothing technique was used to model the change in asthma mortality rates with time. RESULTS:Asthma mortality rates from 20 countries were included in the analysis. An increase in asthma mortality rates was found in the 1960s, with a mean increase of 53% from 0.55 per 100,000 in 1960 and 1961 to a peak of 0.84 in 1966 and 1967. This trend was followed by a progressive decline to a nadir of 0.45 per 100,000 in 1974 and 1975. A gradual increase was then found in asthma mortality rates to a peak of 0.62 per 100,000 in 1985 and 1986, with a mean increase of 38% during this period. Since the late 1980s, there has been a widespread and progressive reduction in mortality rates to a level of 0.23 per 100,000 in 2004 and 2005, with a mean reduction of 63% during this period. CONCLUSIONS:The widespread increase in asthma mortality in the 1980s and the subsequent, even greater reduction has largely gone unrecognized. We propose that awareness of such trends and their causes is important and that they are investigated contemporaneously.






Wijesinghe M,Weatherall M,Perrin K,Crane J,Beasley R




Has Abstract


2009-04-01 00:00:00
















  • Systolic time intervals in chronic hypertension: Alterations and response to treatment.

    abstract::Systolic time interval studies were performed to evaluate left ventricular performance in 28 patients with untreated systemic hypertension but without clinical heart failure. The pre-ejection period (PEP) was significantly prolonged (p smaller than 0.001) and left ventricular ejectime time (LVET) was shortened (p smal...


    pub_type: 杂志文章


    authors: Dodek A,Burg JR,Kloster FR

    更新日期:1975-07-01 00:00:00

  • Methodologic standards for diagnostic test research in pulmonary medicine.

    abstract:STUDY OBJECTIVES:To determine conformance with methodologic standards in the evaluation of diagnostic tests. DATA SOURCES:MEDLINE database search (1992 to 1997) of nine prominent general medicine and six subspecialty journals for articles that report discriminative properties of diagnostic tests in pulmonary medicine....


    pub_type: 杂志文章


    authors: Heffner JE,Feinstein D,Barbieri C

    更新日期:1998-09-01 00:00:00

  • High-frequency modulation of heart rate variability during exercise in patients with COPD.

    abstract:STUDY OBJECTIVES:To evaluate cardiac autonomic modulation in patients with COPD during peak exercise. METHODS:Fifty-three patients with COPD (mean FEV(1), 35% predicted [SD, 11% predicted]; mean PaO(2), 68 mm Hg [SD, 11 mm Hg]; mean PaCO(2), 40 mm Hg [SD, 7 mm Hg]; mean age, 61 years [SD, 10 years]; 26 women and 27 me...


    pub_type: 杂志文章


    authors: Bartels MN,Jelic S,Ngai P,Basner RC,DeMeersman RE

    更新日期:2003-09-01 00:00:00

  • Ultrastructural and functional studies of cilia from patients with asthma, aspirin intolerance, and nasal polyps.

    abstract::"Triad" asthmatics often have sinus disease, nasal polyps, and obstructive airways disease. This presentation is reminiscent of the symptoms of persons afflicted with various forms of ciliary dyskinesia. Therefore, we examined tissues from seven "triad" asthmatic patients for ciliary structural or functional abnormali...


    pub_type: 杂志文章


    authors: Lewis FH,Beals TF,Carey TE,Baker SR,Mathews KP

    更新日期:1983-03-01 00:00:00

  • Immune Checkpoint Immunotherapy for Non-Small Cell Lung Cancer: Benefits and Pulmonary Toxicities.

    abstract::Immune checkpoint inhibitors (ICIs) are newer, immunotherapy-based drugs that have been shown to improve survival in advanced non-small cell lung cancer (NSCLC). Unlike traditional chemotherapeutic agents, ICIs work by boosting the body's natural tumor killing response. However, this unique mechanism of action has als...


    pub_type: 杂志文章,评审


    authors: Suresh K,Naidoo J,Lin CT,Danoff S

    更新日期:2018-12-01 00:00:00

  • Sleepiness and hypertension in obstructive sleep apnea.

    abstract::In order to assess the complications of sleep apnea, we have reviewed a data base of 619 consecutive admissions to a university sleep disorders center. Although patients with obstructive sleep apnea (OSA) described more subjective sleepiness than patients with central sleep apnea (CSA) or primary snoring (PS), the mul...


    pub_type: 杂志文章


    authors: Mendelson WB

    更新日期:1992-04-01 00:00:00

  • High frequency of atopic asthma in a pulmonary clinic population.

    abstract::Seventy-two consecutive adult asthmatic patients seen in the Pulmonary Clinic at Rhode Island Hospital were tested for atopy by prick test with 14 standard aeroallergens and by in vitro total and specific IgE determinations (FAST). A total of 58.3 percent of patients were found to be atopic by these tests. There was a...


    pub_type: 杂志文章


    authors: Kalliel JN,Goldstein BM,Braman SS,Settipane GA

    更新日期:1989-12-01 00:00:00

  • Orbital herniation associated with noninvasive positive pressure ventilation.

    abstract::A diagnosis of severe obstructive sleep apnea was made after a 52-year-old hypertensive man developed a large intracranial hemorrhage. Therapeutic noninvasive positive pressure ventilation (NPPV) for obstructive sleep apnea and hypoventilation was complicated by transient unilateral orbital herniation. As best as can ...


    pub_type: 杂志文章


    authors: Lazowick D,Meyer TJ,Pressman M,Peterson D

    更新日期:1998-03-01 00:00:00

  • Safety and Efficacy of Remimazolam Compared With Placebo and Midazolam for Moderate Sedation During Bronchoscopy.

    abstract:BACKGROUND:While the complexity of flexible bronchoscopy has increased, standard options for moderate sedation medications have not changed in three decades. There is a need to improve moderate sedation while maintaining safety. Remimazolam was developed to address shortcomings of current sedation strategies. METHODS:...


    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Pastis NJ,Yarmus LB,Schippers F,Ostroff R,Chen A,Akulian J,Wahidi M,Shojaee S,Tanner NT,Callahan SP,Feldman G,Lorch DG Jr,Ndukwu I,Pritchett MA,Silvestri GA,PAION Investigators.

    更新日期:2019-01-01 00:00:00

  • Long-term outcome of noninvasive positive pressure ventilation for obesity hypoventilation syndrome.

    abstract:BACKGROUND:Few data are available on the long-term outcome of noninvasive positive pressure ventilation (NPPV) for obesity hypoventilation syndrome (OHS). This study was designed to determine long-term survival, treatment adherence, and prognostic factors in patients with OHS in whom NPPV was initiated in an acute sett...


    pub_type: 杂志文章


    authors: Priou P,Hamel JF,Person C,Meslier N,Racineux JL,Urban T,Gagnadoux F

    更新日期:2010-07-01 00:00:00

  • Sleep-disordered breathing in Down syndrome.

    abstract::OSA is associated with significant adverse outcomes with far-reaching health-care implications. OSA is much more common and severe in patients with Down syndrome (DS) than in the general population, yet there is a striking lack of literature in this area. In this review article, we have summarized the current state of...


    pub_type: 杂志文章,评审


    authors: Lal C,White DR,Joseph JE,van Bakergem K,LaRosa A

    更新日期:2015-02-01 00:00:00

  • Loculated interlobar air-fluid collection in congestive heart failure.

    abstract::Two patients are described who had congestive heart failure with loculated interlobar air-fluid collections. Although pseudotumor (interlobar effusion) is a well-known finding in congestive heart failure, the additional presence of air is unique. Both are somewhat related to the underlying failure. ...


    pub_type: 杂志文章


    authors: Rabinowitz JG,Kongtawng T

    更新日期:1978-12-01 00:00:00

  • Acceptance of CPAP therapy for sleep apnea.

    abstract::Although NCPAP is the most efficient nonsurgical treatment for patients with OSA, many patients do not accept sleeping with a nose mask. To determine the factors influencing acceptance, treatment with NCPAP was offered to 95 patients with an AHI greater than 15. After the first night on NCPAP, 47 of 65 patients decide...


    pub_type: 杂志文章


    authors: Rauscher H,Popp W,Wanke T,Zwick H

    更新日期:1991-10-01 00:00:00

  • Sensitivity, specificity, positive predictive value, and negative predictive value of the dipyridamole sestamibi stress test comparing arterial to vein conduits.

    abstract:STUDY OBJECTIVES:To determine the sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of the dipyridamole stress test (DSST) in predicting > or = 50% obstruction of an internal mammary artery or new native coronary artery disease (CAD) compared with saphenous vein graft obstru...


    pub_type: 杂志文章


    authors: Deluca AJ,Cusack E,Aronow WS,Monsen CE

    更新日期:2004-10-01 00:00:00

  • Hospital survival rates of patients with acute respiratory failure in modern respiratory intensive care units. An international, multicenter, prospective survey.

    abstract::An international, multicenter, prospective survey has been conducted to determine the hospital survival rates of patients with potentially reversible acute respiratory failure (ARF) who are managed in sophisticated intensive care units by leading critical care specialists, using current (1991 to 1992) support and trea...


    pub_type: 杂志文章,多中心研究


    authors: Vasilyev S,Schaap RN,Mortensen JD

    更新日期:1995-04-01 00:00:00

  • The measurement of thoraco-abdominal asynchrony in infants with severe laryngotracheobronchitis.

    abstract::Retractions of the lower ribcage (chest wall distortion [CWD]) during inspiration are frequently observed with moderate to severe respiratory disease in the infant. Laryngotracheobronchitis (LTB) results in a reversible partial airway obstruction with severe CWD. We wished to measure the motion of the chest wall durin...


    pub_type: 杂志文章


    authors: Davis GM,Cooper DM,Mitchell I

    更新日期:1993-06-01 00:00:00

  • Noninvasive evaluation of instantaneous total mechanical activity of the respiratory muscles during pressure support ventilation.

    abstract:OBJECTIVE:The measurement of esophageal pressure (Pes) is the conventional method for the evaluation of the forces applied to the respiratory system by the respiratory muscles. As an alternative to Pes measurement, we propose the calculation of the instantaneous net pressure applied by the respiratory muscles [Pmusc(t)...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iotti GA,Braschi A,Brunner JX,Palo A,Olivei MC

    更新日期:1995-07-01 00:00:00

  • Prostacyclin but not phentolamine increases oxygen consumption and skin microvascular blood flow in patients with sepsis and respiratory failure.

    abstract::Inadequate tissue oxygenation may occur in critically ill patients with sepsis despite an apparently adequate O2 transport (QO2), and this may contribute to the development of an O2 debt and also to multiple organ failure. It has been shown that increasing QO2 by infusing a vasodilator may reveal this O2 debt in septi...


    pub_type: 杂志文章


    authors: Pittet JF,Lacroix JS,Gunning K,Laverriere MC,Morel DR,Suter PM

    更新日期:1990-12-01 00:00:00

  • Bone marrow-derived cells contribute to pulmonary vascular remodeling in hypoxia-induced pulmonary hypertension.

    abstract:STUDY OBJECTIVE:In these days, it was reported that bone marrow (BM) cells might take part in the remodeling of some systemic vascular diseases; however, it remains unknown whether the BM cells were involved in the vascular remodeling of pulmonary arteries and the progression of pulmonary hypertension (PH). The purpose...


    pub_type: 杂志文章


    authors: Hayashida K,Fujita J,Miyake Y,Kawada H,Ando K,Ogawa S,Fukuda K

    更新日期:2005-05-01 00:00:00

  • Iron lung vs mask ventilation in the treatment of acute on chronic respiratory failure in COPD patients: a multicenter study.

    abstract:STUDY OBJECTIVES:Evaluation of the effectiveness of negative-pressure ventilation (NPV) with the use of the iron lung vs noninvasive positive-pressure ventilation (NIPPV) in the treatment of COPD patients with acute on chronic respiratory failure. DESIGN:A retrospective case-control study. SETTING:Four Italian respir...


    pub_type: 杂志文章,多中心研究


    authors: Corrado A,Confalonieri M,Marchese S,Mollica C,Villella G,Gorini M,Della Porta R

    更新日期:2002-01-01 00:00:00

  • Clinical characteristics and outcome of severe melioidosis requiring intensive care.

    abstract:STUDY OBJECTIVE:To describe the clinical characteristics and outcome of patients with severe melioidosis requiring intensive care. DESIGN:Retrospective chart review. SETTING:Two ICUs from a tertiary-care teaching hospital. PATIENTS:Twenty-seven adult ICU patients with microbiologically documented melioidosis. INTER...


    pub_type: 杂志文章


    authors: Chan KP,Low JG,Raghuram J,Fook-Chong SM,Kurup A

    更新日期:2005-11-01 00:00:00

  • Intrapleural talc for the prevention of recurrent pneumothorax.

    abstract::The ipsilateral recurrence rate after the first spontaneous pneumothorax treated with tube thoracostomy is reported to be between 23 percent and 52 percent. The incidence of recurrence after the first recurrence is substantially higher. Chemical pleurodesis has been attempted to decrease the recurrence rate. Tetracycl...


    pub_type: 杂志文章


    authors: Milanez JR,Vargas FS,Filomeno LT,Fernandez A,Jatene A,Light RW

    更新日期:1994-10-01 00:00:00

  • Quadriceps fatigue after cycle exercise in patients with COPD compared with healthy control subjects.

    abstract:STUDY OBJECTIVES:Quadriceps fatigue can occur in patients with COPD after exhaustive cycle exercise. The purpose of this study was to determine whether the degree of fatigue elicited by cycle exercise was greater in patients with COPD compared with matched control subjects. SUBJECTS:Nine male patients with COPD with a...


    pub_type: 临床试验,杂志文章


    authors: Mador MJ,Bozkanat E,Kufel TJ

    更新日期:2003-04-01 00:00:00

  • Distinct characteristics of pleuroparenchymal fibroelastosis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). METHOD...


    pub_type: 杂志文章


    authors: Oda T,Ogura T,Kitamura H,Hagiwara E,Baba T,Enomoto Y,Iwasawa T,Okudela K,Takemura T,Sakai F,Hasegawa Y

    更新日期:2014-11-01 00:00:00

  • Interpreting periodic lung function tests in individuals: the relationship between 1- to 5-year and long-term FEV1 changes.

    abstract:STUDY OBJECTIVE:Spirometry is performed to monitor lung health, but variability between tests can hinder recognition of excessive FEV(1) declines. We sought to describe the relationship between FEV(1) changes over 1 to 5 years and FEV(1) declines over longer terms, using 21,821 test results from 1,884 workers who parti...


    pub_type: 杂志文章


    authors: Wang ML,Avashia BH,Petsonk EL

    更新日期:2006-08-01 00:00:00

  • Severe gastroesophageal reflux is associated with reduced carbon monoxide diffusing capacity.

    abstract:OBJECTIVE:To assess whether severe gastroesophageal reflux (GER) is associated with abnormalities in lung function including measures of lung volume and gas diffusion. METHODS:Data from 147 patients with obesity (body mass index [BMI] range, 31.7 to 70 kg/m(2)) who presented for obesity surgery was analyzed retrospect...


    pub_type: 杂志文章


    authors: Schachter LM,Dixon J,Pierce RJ,O'Brien P

    更新日期:2003-06-01 00:00:00

  • Analysis of neural mechanisms accompanying different intensities of dynamic exercise.

    abstract::The neural mechanisms accompanying dynamic exercise of different intensities were analyzed in dogs and human subjects by means of autoregressive spectral analysis of heart period and arterial pressure variabilities. In the animal experiments, 8 conscious dogs were examined after implanting a solid state pressure gauge...


    pub_type: 杂志文章


    authors: Rimoldi O,Furlan R,Pagani MR,Piazza S,Guazzi M,Pagani M,Malliani A

    更新日期:1992-05-01 00:00:00

  • Learning experience of linear endobronchial ultrasound among pulmonary trainees.

    abstract:BACKGROUND:Linear endobronchial ultrasound (EBUS) allows real-time guidance of transbronchial needle aspiration of thoracic structures and has become an increasingly important diagnostic tool for chest physicians. Little has been published about the learning experience of operators with this technology. The purpose of ...


    pub_type: 杂志文章,多中心研究


    authors: Wahidi MM,Hulett C,Pastis N,Shepherd RW,Shofer SL,Mahmood K,Lee H,Malhotra R,Moser B,Silvestri GA

    更新日期:2014-03-01 00:00:00

  • Grade of pulmonary right-to-left shunt on contrast echocardiography and cerebral complications: a striking association.

    abstract:BACKGROUND:A pulmonary right-to-left shunt (RLS) carries the risk of cerebral paradoxical embolization and severe neurologic complications. Recognizing patients at risk is important to facilitate appropriate management strategies, but a direct relation between pulmonary shunt size and risk of complications remains cont...


    pub_type: 杂志文章,多中心研究


    authors: Velthuis S,Buscarini E,van Gent MWF,Gazzaniga P,Manfredi G,Danesino C,Schonewille WJ,Westermann CJJ,Snijder RJ,Mager JJ,Post MC

    更新日期:2013-08-01 00:00:00

  • Inhaled diuretics attenuate acid-induced cough in children with asthma.

    abstract::To evaluate the effect of inhaled diuretics, furosemide and amiloride, on cough induced by acid inhalation challenge in asthmatic children, a double-blind, randomized, placebo-controlled study was conducted. On separate days, 12 asthmatic children (10.3 +/- 0.7 [SEM] years) underwent acetic acid (AD) inhalation challe...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Mochizuki H,Shimizu T,Morikawa A,Kuroume T

    更新日期:1995-02-01 00:00:00