Preventing ARDS: progress, promise, and pitfalls.

Abstract:

:Advances in critical care practice have led to a substantial decline in the incidence of ARDS over the past several years. Low tidal volume ventilation, timely resuscitation and antimicrobial administration, restrictive transfusion practices, and primary prevention of aspiration and nosocomial pneumonia have likely contributed to this reduction. Despite decades of research, there is no proven pharmacologic treatment of ARDS, and mortality from ARDS remains high. Consequently, recent initiatives have broadened the scope of lung injury research to include targeted prevention of ARDS. Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing. Future trials aimed at preventing ARDS face several key challenges. ARDS has not been validated as an end point for pivotal clinical trials, and caution is needed when testing toxic therapies that may prevent ARDS yet potentially increase mortality.

journal_name

Chest

journal_title

Chest

authors

Beitler JR,Schoenfeld DA,Thompson BT

doi

10.1378/chest.14-0555

subject

Has Abstract

pub_date

2014-10-01 00:00:00

pages

1102-1113

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)50078-0

journal_volume

146

pub_type

杂志文章

相关文献

CHEST文献大全
  • Pulmonary venous infarction secondary to squamous cell carcinoma.

    abstract::This type of pulmonary venous infarction has not been previously reported, namely: pulmonary vein obstruction from squamous cell carcinoma. Furthermore, this case is unique in that the characteristic pathologic vascular changes observed with pulmonary venous infarction were contrasted with a noninfarcted upper lobe th...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.3.950

    authors: Williamson WA,Tronic BS,Levitan N,Webb-Johnson DC,Shahian DM,Ellis FH Jr

    更新日期:1992-09-01 00:00:00

  • Mucosa-associated lymphoid tissue lymphoma of the lung with cold-reacting autoantibody-mediated hemolytic anemia.

    abstract::Mucosa-associated lymphoid tissue lymphoma (MALT-oma) of the lung is a rare low-grade B cell lymphoma arising from bronchus-associated lymphoid tissue. This report concerns a 39-year-old woman with bilateral diffuse alveolar consolidations and cold-reacting autoantibody-mediated hemolytic anemia. Open-lung biopsy show...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.1.288

    authors: Liaw YS,Yang PC,Su IJ,Kuo SH,Wang CH,Luh KT

    更新日期:1994-01-01 00:00:00

  • Spontaneous middle lobe torsion secondary to pleural effusion.

    abstract::Pulmonary torsion is very rare, and usually occurs following lung resection. We report a case of spontaneous middle lobe torsion in a patient presenting with a right pleural effusion. The condition was treated by lobectomy through a totally thoracoscopic approach. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.08-2373

    authors: Raynaud C,Lenoir S,Caliandro R,Raffenne L,Validire P,Gossot D

    更新日期:2009-07-01 00:00:00

  • Surgical treatment of malignant pleural mesothelioma: a review.

    abstract::Despite many years of clinical research, there is still no effective therapy for malignant pleural mesothelioma (MPM). Untreated, the prognosis is poor, with a median survival of < 1 year. Single-agent or combination chemotherapy as well as radiotherapy have not shown persistent improvements in response or survival. I...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.123.2.551

    authors: van Ruth S,Baas P,Zoetmulder FA

    更新日期:2003-02-01 00:00:00

  • Relevance of latent TB infection in areas of high TB prevalence.

    abstract::About one-third of the world population has latent TB infection (LTBI), the majority of which is distributed in 22 high-burden countries. Early diagnosis and treatment of active TB remains the top priority in resource-poor countries with high TB prevalence. Notwithstanding, because LTBI contributes significantly to th...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-0142

    authors: Sharma SK,Mohanan S,Sharma A

    更新日期:2012-09-01 00:00:00

  • Tetralogy of Fallot with discrete fibrous subaortic stenosis.

    abstract::This is the first reported case of discrete fibrous subaortic stenosis in tetralogy of Fallot. Transaortic excision of the subaortic membrane was readily accomplished. To detect this and other forms of left ventricular outflow-tract obstruction in tetralogy of Fallot before surgery, routine selective left ventriculogr...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.69.4.543

    authors: Sanders JH,Van Praagh R,Sade RM

    更新日期:1976-04-01 00:00:00

  • The Neurokinin-1 Receptor Antagonist Orvepitant Is a Novel Antitussive Therapy for Chronic Refractory Cough: Results From a Phase 2 Pilot Study (VOLCANO-1).

    abstract:BACKGROUND:Substance P and the neurokinin-1 (NK-1) receptor are implicated in chronic refractory cough pathophysiology. We assessed the efficacy and safety of orvepitant, a brain-penetrant NK-1 antagonist, in an open-label study in CRC patients with chronic refractory cough. METHODS:Thirteen patients with daytime coug...

    journal_title:Chest

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.chest.2019.08.001

    authors: Smith J,Allman D,Badri H,Miller R,Morris J,Satia I,Wood A,K Trower M

    更新日期:2020-01-01 00:00:00

  • Transmitral flow changes during dipyridamole-induced ischemia. A Doppler-echocardiographic study.

    abstract::Myocardial ischemia results in altered left ventricular (LV) diastolic compliance, reflected by an abnormal mitral inflow pattern on Doppler echocardiography. To investigate the relationship of Doppler echocardiography and regional myocardial systolic function during dipyridamole infusion, we evaluated transmitral flo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.95.5.1037

    authors: Lattanzi F,Picano E,Masini M,De Prisco F,Distante A,L'Abbate A

    更新日期:1989-05-01 00:00:00

  • Late outcome from percutaneous tracheostomy using the Portex kit.

    abstract:OBJECTIVE:To assess late outcome following percutaneous tracheostomy using the Portex kit (Hythe, Kent, UK). DESIGN:Prospective observational cohort study. SETTING:Teaching hospital. PATIENTS:Forty-nine consecutive patients who underwent percutaneous tracheostomy in the ICU using the Portex kit and who survived 6 mo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.4.1070

    authors: Leonard RC,Lewis RH,Singh B,van Heerden PV

    更新日期:1999-04-01 00:00:00

  • Pulmonary involvement in the eosinophilia-myalgia syndrome.

    abstract::We describe the cases of three women with pulmonary involvement in the eosinophilia-myalgia syndrome. The illness was characterized by elevated peripheral blood eosinophil counts, myalgias, fatigue, and dyspnea. Two of three patients had bilateral infiltrates on chest roentgenograms. All three had markedly decreased c...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.2.327

    authors: Catton CK,Elmer JC,Whitehouse AC,Clode JB,Hustrulid RI

    更新日期:1991-02-01 00:00:00

  • Catheter-induced tricuspid regurgitation. Incidence and clinical significance.

    abstract::The incidence and severity of catheter-induced tricuspid regurgitation has not been studied extensively. Given the frequency with which right heart catheters are employed to measure cardiac output, it is important to know whether the severity of catheter-induced tricuspid regurgitation is sufficient to invalidate the ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.99.3.651

    authors: Stewart D,Leman RB,Kaiser J,Mann DL

    更新日期:1991-03-01 00:00:00

  • Osteoprotegerin in sputum is a potential biomarker in COPD.

    abstract:BACKGROUND:COPD is characterized by chronic airflow limitation and inflammation of the respiratory tract. Several inflammatory biomarkers have been evaluated in COPD but are poorly related to disease severity and progression. Osteoprotegerin (OPG) is a glycoprotein mediator that is expressed in the lung and macrophages...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-1608

    authors: To M,Ito K,Ausin PM,Kharitonov SA,Barnes PJ

    更新日期:2011-07-01 00:00:00

  • Disagreement among common measures of asthma control in children.

    abstract:BACKGROUND:Asthma is a worldwide problem. It cannot be prevented or cured, but it is possible, at least in principle, to control asthma with modern management. Control usually is assessed by history of symptoms, physical examination, and measurement of lung function. A practical problem is that these measures of contro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.12-1070

    authors: Green RJ,Klein M,Becker P,Halkas A,Lewis H,Kitchin O,Moodley T,Masekela R

    更新日期:2013-01-01 00:00:00

  • Effects of theophylline on breathlessness and exercise tolerance in patients with chronic airflow obstruction.

    abstract::Theophylline is commonly prescribed for patients with nonasthmatic chronic airflow obstruction (CAO) even though clinical efficacy is not well established. We studied objective and subjective responses to theophylline in 14 men with CAO. Subjects randomly received week-long treatments of placebo or theophylline at two...

    journal_title:Chest

    pub_type: 临床试验,杂志文章,随机对照试验

    doi:10.1378/chest.82.5.538

    authors: Eaton ML,MacDonald FM,Church TR,Niewoehner DE

    更新日期:1982-11-01 00:00:00

  • Greater risk of hospitalization in children with Down syndrome and OSA at higher elevation.

    abstract:BACKGROUND:Children with Down syndrome (DS) are at high risk for OSA. Increasing elevation is known to exacerbate underlying respiratory disorders and worsen sleep quality in people without DS, but whether altitude modulates the severity of OSA in DS is uncertain. In this study, we evaluate the impact of elevation (≤ 1...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.14-1883

    authors: Jensen KM,Sevick CJ,Seewald LAS,Halbower AC,Davis MM,McCabe ERB,Kempe A,Abman SH

    更新日期:2015-05-01 00:00:00

  • Cardiopulmonary exercise testing in children: an individualized protocol for workload increase.

    abstract:OBJECTIVES:To investigate the feasibility of individualized workload increments, as used in adults, for exercise testing in children; and to investigate whether this individualized protocol makes it possible to satisfy the usual criteria for maximal exercise (clinical exhaustion, predicted maximum heart rate [HRmax], o...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.120.1.81

    authors: Karila C,de Blic J,Waernessyckle S,Benoist MR,Scheinmann P

    更新日期:2001-07-01 00:00:00

  • Respiratory Disease and Lower Pulmonary Function as Risk Factors for Dementia: A Systematic Review With Meta-analysis.

    abstract:BACKGROUND:In addition to affecting the oxygen supply to the brain, pulmonary function is a marker of multiple insults throughout life (including smoking, illness, and socioeconomic deprivation). In this meta-analysis of existing longitudinal studies, the hypothesis that lower pulmonary function and respiratory illness...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2019.12.012

    authors: Russ TC,Kivimäki M,Batty GD

    更新日期:2020-06-01 00:00:00

  • Management of pulmonary arterial hypertension during pregnancy: a retrospective, multicenter experience.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a rare disease with a predilection for young women that is associated with right ventricular failure and premature death. PAH can complicate pregnancy with hemodynamic instability or sudden death during parturition and postpartum. Our aim was to examine the impact of ...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1378/chest.12-0528

    authors: Duarte AG,Thomas S,Safdar Z,Torres F,Pacheco LD,Feldman J,deBoisblanc B

    更新日期:2013-05-01 00:00:00

  • Distinct characteristics of pleuroparenchymal fibroelastosis with usual interstitial pneumonia compared with idiopathic pulmonary fibrosis.

    abstract:BACKGROUND:Pleuroparenchymal fibroelastosis (PPFE) is a rare form of interstitial pneumonia and sometimes coexists with a histologic usual interstitial pneumonia (UIP) pattern. This study aimed to describe the distinct clinical features of PPFE with UIP pattern compared with idiopathic pulmonary fibrosis (IPF). METHOD...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.13-2866

    authors: Oda T,Ogura T,Kitamura H,Hagiwara E,Baba T,Enomoto Y,Iwasawa T,Okudela K,Takemura T,Sakai F,Hasegawa Y

    更新日期:2014-11-01 00:00:00

  • Benefits of nocturnal nasal CPAP in patients with cystic fibrosis.

    abstract::Patients with cystic fibrosis (CF) often hypoventilate during sleep with marked falls in oxygen saturation (SaO2%). This occurs most commonly during REM sleep, when there is a reduction in rib cage excursion and a fall in end-expiratory lung volume (EELV). The aim of this study was to examine the effect of nocturnal n...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.106.6.1717

    authors: Regnis JA,Piper AJ,Henke KG,Parker S,Bye PT,Sullivan CE

    更新日期:1994-12-01 00:00:00

  • Changing the work environment in ICUs to achieve patient-focused care: the time has come.

    abstract::The American Association of Critical-Care Nurses (AACN) Standards for Establishing and Sustaining Healthy Work Environments and the American College of Chest Physicians (ACCP) Patient-Focused Care Project are complementary initiatives that provide a road map for creating practice environments where interdisciplinary, ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.130.5.1571

    authors: McCauley K,Irwin RS

    更新日期:2006-11-01 00:00:00

  • Lung volumes: measurement, clinical use, and coding.

    abstract::Measurement of lung volumes is an integral part of complete pulmonary function testing. Some lung volumes can be measured during spirometry; however, measurement of the residual volume (RV), functional residual capacity (FRC), and total lung capacity (TLC) requires special techniques. FRC is typically measured by one ...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-2964

    authors: Flesch JD,Dine CJ

    更新日期:2012-08-01 00:00:00

  • Video-assisted thoracoscopic surgery for small indeterminate pulmonary nodules: indications for preoperative marking.

    abstract:STUDY OBJECTIVE:To determine the indications for preoperative localization of a small indeterminate pulmonary nodule. DESIGN:In this retrospective study, univariate and multivariate analyses were performed by the logistic regression procedure. SETTING:A single National Cancer Center Hospital in Japan. PATIENTS:A ser...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.115.2.563

    authors: Suzuki K,Nagai K,Yoshida J,Ohmatsu H,Takahashi K,Nishimura M,Nishiwaki Y

    更新日期:1999-02-01 00:00:00

  • Effect of filtration and concentration on the composition of bronchoalveolar lavage fluid.

    abstract::The effects of filtration and concentration on the cellular and protein composition of bronchoalveolar lavage fluids were examined in ten normal subjects and 11 patients with asthma. Filtration of lavage fluid preferentially removed bronchial epithelial cells, resulting in a relative increase in the proportion of alve...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.87.6.740

    authors: Lam S,LeRiche JC,Kijek K

    更新日期:1985-06-01 00:00:00

  • The irregularly irregular pattern of respiratory dyskinesia.

    abstract::The respiratory pattern during wakefulness and sleep was characterized in a 70-year-old woman with respiratory dyskinesia. During wakefulness, both respiratory frequency and tidal volume exhibited an irregularly irregular pattern. In addition, wide fluctuations occurred in the position of the rib cage and abdomen at e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.5.779

    authors: Kuna ST,Awan R

    更新日期:1986-11-01 00:00:00

  • Sleep medicine pharmacotherapeutics overview: today, tomorrow, and the future (Part 1: insomnia and circadian rhythm disorders).

    abstract::Over the past 10 years, significant strides have been made in the understanding, development, and availability of sleep disorder therapeutics. In this review series, we discuss the current evidence surrounding the mechanisms of actions, indications, efficacy, and adverse side effects associated with the available arma...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.12-0465

    authors: Gulyani S,Salas RE,Gamaldo CE

    更新日期:2012-12-01 00:00:00

  • Hydrochlorothiazide-induced noncardiogenic pulmonary edema: BAL fluid analysis.

    abstract::Hydrochlorothiazide (HCTZ)-induced pulmonary disease has been described as either an allergic interstitial pneumonitis or a cause of noncardiogenic pulmonary edema. The mechanism of this rare life-threatening side effect is largely unknown. Many patients show peripheral leukopenia and extensive immunologic studies rev...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-0944

    authors: Darwish OS,Criley J

    更新日期:2011-01-01 00:00:00

  • Recombinant interferon alpha-2b in the management of malignant pleural effusions.

    abstract::Twenty-one patients with malignant pleural effusion (MPE) were prospectively entered into a nonrandomized, single-armed study to evaluate the efficacy and safety of recombinant interferon (IFN) alpha-2b (INTRON A; Schering-Plough; Kenilworth, NJ) as an intrapleural palliative agent. From March 1989 through February 19...

    journal_title:Chest

    pub_type: 临床试验,杂志文章

    doi:10.1378/chest.111.6.1597

    authors: Wilkins HE 3rd,Connolly MM,Grays P,Marquez G,Nelson D

    更新日期:1997-06-01 00:00:00

  • The Vital Capacity Is Vital: Epidemiology and Clinical Significance of the Restrictive Spirometry Pattern.

    abstract::Epidemiologic research has revealed a substantial portion of the general population with abnormal spirometry results that are characterized by decreased FEV1 and FVC but a preserved FEV1/FVC ratio. This restrictive spirometry pattern (RSP) is inconsistently defined in the literature and not well addressed by current g...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.15-1045

    authors: Godfrey MS,Jankowich MD

    更新日期:2016-01-01 00:00:00

  • Management of adult acute epiglottitis by tracheal intubation.

    abstract::We present a case of adult acute epiglottitis that was successfully managed by endotracheal intubation without the need for subsequent tracheostomy. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.71.1.93

    authors: Ward CF,Benumof JL,Shapiro HM

    更新日期:1977-01-01 00:00:00