Abstract:
:Advances in critical care practice have led to a substantial decline in the incidence of ARDS over the past several years. Low tidal volume ventilation, timely resuscitation and antimicrobial administration, restrictive transfusion practices, and primary prevention of aspiration and nosocomial pneumonia have likely contributed to this reduction. Despite decades of research, there is no proven pharmacologic treatment of ARDS, and mortality from ARDS remains high. Consequently, recent initiatives have broadened the scope of lung injury research to include targeted prevention of ARDS. Prediction scores have been developed to identify patients at risk for ARDS, and clinical trials testing aspirin and inhaled budesonide/formoterol for ARDS prevention are ongoing. Future trials aimed at preventing ARDS face several key challenges. ARDS has not been validated as an end point for pivotal clinical trials, and caution is needed when testing toxic therapies that may prevent ARDS yet potentially increase mortality.
journal_name
Chestjournal_title
Chestauthors
Beitler JR,Schoenfeld DA,Thompson BTdoi
10.1378/chest.14-0555subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1102-1113issue
4eissn
0012-3692issn
1931-3543pii
S0012-3692(15)50078-0journal_volume
146pub_type
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