Abstract:
:Beta 2-adrenoceptor agonists act against bronchoconstriction by stimulating beta 2-adrenoceptors in bronchial smooth muscle. However, tachyphylaxis has been argued to occur because of beta 2-adrenoceptor down-regulation following therapy with beta 2-adrenergic agents. To investigate receptor alterations, human peripheral mononuclear leukocytes are frequently used, since human lung tissue is not easily available. In order to study whether beta 2-adrenoceptors in MNL reliably reflect the conditions in the human lung tissue, we compared MNL and human lung tissue of 18 patients who had to undergo lung resection. Ten patients were untreated, and eight had bronchodilator therapy prior to therapy with terbutaline because of bronchoconstriction. Both in human lung and MNL, the beta 2-adrenoceptor subpopulation was characterized by competition experiments with the beta 1-selective antagonist CGP 207.12 A and the beta 2-selective antagonist ICI 118.551. In MNL, a significant decrease in the density of beta 2-adrenoceptors was found in treated but not in untreated patients, while the antagonist affinity of the beta 2-adrenoceptors remained unchanged. However, in lung parenchyma, which was obtained at the very same time from the same patients, no down-regulation of the total amount of beta 2-adrenoceptors could be measured. It is concluded that MNLs are a reliable model for studying properties of beta 2-adrenoceptor regulation. However, the hereby obtained results show that MNLs do not reflect the conditions of beta 2-adrenoceptors in human lung tissue. Human lung tissue is found to be less susceptible than human MNL for beta 2-adrenoceptor down-regulation by terbutaline treatment at therapeutic doses.(ABSTRACT TRUNCATED AT 250 WORDS)
journal_name
Chestjournal_title
Chestauthors
Hauck RW,Böhm M,Gengenbach S,Sunder-Plassmann L,Fruhmann G,Erdmann Edoi
10.1378/chest.98.2.376subject
Has Abstractpub_date
1990-08-01 00:00:00pages
376-81issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(16)31656-7journal_volume
98pub_type
杂志文章相关文献
CHEST文献大全abstract:BACKGROUND AND STUDY OBJECTIVES:Noninvasive positive airway pressure may play a significant role in treating patients with congestive heart failure (CHF). We tested our hypothesis that noninvasive bilevel positive airway pressure improves left ventricular performance in patients with chronic CHF secondary to severe sys...
journal_title:Chest
pub_type: 临床试验,杂志文章
doi:10.1378/chest.118.4.1004
更新日期:2000-10-01 00:00:00
abstract::Patient-focused or patient-centered care is not a new concept, but its value has been overlooked in preference to the technology-based, disease-centered model that has prevailed in medicine for the last 50 years. Patient-focused care includes four broad areas of intervention: communication with patients, partnerships,...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.130.1_suppl.73S
更新日期:2006-07-01 00:00:00
abstract:STUDY OBJECTIVE:The benefit of smoking cessation just prior to surgery in preventing postoperative pulmonary complications has not been proven. Some studies actually show a paradoxical increase in complications in those quitting smoking only a few weeks or days prior to surgery. We studied the effect of smoking and the...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.127.6.1977
更新日期:2005-06-01 00:00:00
abstract::Systemic lupus erythematosus (SLE) frequently involves the pleura with resultant pleural effusion. Previous studies have reported that detection of antinuclear antibodies (ANA) in pleural fluid using animal tissue as substrate was a sensitive and specific method for distinguishing SLE pleural effusions from other etio...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.3.866
更新日期:1994-09-01 00:00:00
abstract:INTRODUCTION:The specific causes and mechanism(s) for asthma occurring among occupants of non-residential buildings with poor indoor air quality are not known, but allergic and nonallergic processes are possible explanations METHODS:Repeated indoor air quality measurements were made while employees were working in a b...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1720
更新日期:2005-09-01 00:00:00
abstract::A noninvasive radionuclide study of the paradoxical pulse in pericardial effusion is described. The study shows complementary changes of the right and left ventricular ejection fractions in a patient with paradoxical pulse, supporting the theory that the inspiratory reduction of the left ventricular stroke volume is a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.74.6.687
更新日期:1978-12-01 00:00:00
abstract::A smoker presented with pleuritic chest pain and was found to have reticulonodular interstitial opacities on chest x-ray film. Open lung biopsy revealed changes consistent with histiocytosis X, a disease seen almost exclusively in smokers. Smoking cessation was recommended, and the patient complied. A chest x-ray film...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.3.765
更新日期:1990-09-01 00:00:00
abstract::Although NCPAP is the most efficient nonsurgical treatment for patients with OSA, many patients do not accept sleeping with a nose mask. To determine the factors influencing acceptance, treatment with NCPAP was offered to 95 patients with an AHI greater than 15. After the first night on NCPAP, 47 of 65 patients decide...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.100.4.1019
更新日期:1991-10-01 00:00:00
abstract::Primary neurogenic tumors of the lung are rare. Often, their histologic behavior presents a treatment dilemma. We present a case of benign endobronchial neurilemmoma managed by means of YAG laser resection together with a brief discussion of the management options available for these tumors. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.95.2.461
更新日期:1989-02-01 00:00:00
abstract:BACKGROUND:Average volume-assured pressure support (AVAPS) has been introduced as a new additional mode for a bilevel pressure ventilation (BPV) device (BiPAP; Respironics; Murrysville, PA), but studies on the physiologic and clinical effects have not yet been performed. There is a particular need to better define the ...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.130.3.815
更新日期:2006-09-01 00:00:00
abstract::The management of intractable hemoptysis, short of surgery, is poorly defined. A technique is described utilizing a bronchofiberscope and a Fogarty catheter that not only provides visualization of the source of bleeding, but also furnishes a means of controlling the bleeding. This technique can also be used through a ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.4.482
更新日期:1975-04-01 00:00:00
abstract::We retrospectively studied the acute toxicity of corticosteroid therapy in 23 episodes of PCP occurring in the setting of AIDS and determined the incidence of HIV-related complications following these and 16 other contemporaneous episodes of AIDS-related PCP treated with antimicrobials alone. The mean duration of cort...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.98.1.38
更新日期:1990-07-01 00:00:00
abstract::An unusual case of essential thrombocythemia in a young man presenting with progressive angina pectoris is presented. Angiography revealed proximal left anterior descending artery stenosis. Successful percutaneous transluminal angioplasty along with antiplatelet therapy and a calcium channel blocking drug have rendere...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.86.6.933
更新日期:1984-12-01 00:00:00
abstract::The toxic-oil syndrome (TOS) is a multisystem disorder whose etiology and pathogenesis are as yet unknown. Lung alterations persist in a significant number of TOS patients due to the underlying vascular lesion. Computer-assisted 67Ga scanning and bronchoalveolar lavage (BAL) studies were performed in 14 TOS patients w...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.88.3.398
更新日期:1985-09-01 00:00:00
abstract:OBJECTIVE:To compare the efficacy of noninvasive positive pressure ventilation (NPPV) by helmet and face mask in immunocompromised patients with hypoxemic acute respiratory failure (ARF). DESIGN:Case-control study. SETTING:The general ICU of a university hospital. PATIENTS:Nineteen immunocompromised patients (hemato...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.5.1508
更新日期:2004-11-01 00:00:00
abstract::The role of thoracic radiation therapy in the management of limited-stage small cell lung cancer (SCLC) is reviewed. Although chest irradiation has been used to treat SCLC for over four decades, its standard role in the management of limited-stage disease was established only during the last decade. Multiple prospecti...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.112.4_supplement.259s
更新日期:1997-10-01 00:00:00
abstract:BACKGROUND:IV hydration before and after cardiac catheterization is effective in preventing contrast-associated renal dysfunction for patients with mild-to-moderate renal insufficiency, but necessitates overnight hospital admission. We tested an outpatient oral precatheterization hydration strategy in comparison with o...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.114.6.1570
更新日期:1998-12-01 00:00:00
abstract::Endobronchial ultrasonography (EBUS) has become an invaluable tool in the diagnosis of patients with a variety of thoracic abnormalities. The majority of EBUS procedures are used to diagnose and stage mediastinal and hilar abnormalities, as well as peripheral pulmonary targets, with a probe-based technology. Nearly 1,...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1016/j.chest.2016.05.009
更新日期:2016-12-01 00:00:00
abstract::In order to assess the additional information obtained from 24 hours compared to 12 hours of ambulatory ECG (electrocardiogram) recording, we analyzed 72 ambulatory ECG monitoring tapes in which arrhythmias were present. In all cases the second 12 hours included the entire period of sleep. Only 38 of 233 (16 percent) ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.67.3.269
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:Studies have demonstrated that high-flow nasal cannula (HFNC) prevents intubation in acute hypoxic respiratory failure when compared with conventional oxygen therapy (COT). However, the data examining routine HFNC use in the immediate postoperative period are less clear. RESEARCH QUESTION:Is routine HFNC us...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2020.06.038
更新日期:2020-11-01 00:00:00
abstract::Morbid obesity is often associated with severe respiratory insufficiency, commonly known as the pickwickian syndrome. This can be divided into the following two primary breathing disorders which can affect patients alone or in combination: the obstructive sleep apnea syndrome (SAS); and the obesity-hypoventilation syn...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.1.81
更新日期:1986-07-01 00:00:00
abstract::This article describes the methodology for the Seventh American College of Chest Physicians (ACCP) Conference on Antithrombotic and Thrombolytic Therapy: Evidence-Based Guidelines. Guideline authors began by specifying the population, the intervention and alternative, and the outcomes for each clinical question, and d...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.3_suppl.174S
更新日期:2004-09-01 00:00:00
abstract:STUDY OBJECTIVES:The purpose of this 12-week study was to evaluate the efficacy and safety of adjunct modafinil to treat excessive sleepiness in patients with obstructive sleep apnea (OSA) who experience residual sleepiness despite regular nasal continuous positive airway pressure (nCPAP) use. DESIGN:Twelve-week, open...
journal_title:Chest
pub_type: 临床试验,杂志文章,多中心研究
doi:10.1378/chest.124.6.2192
更新日期:2003-12-01 00:00:00
abstract::Pill aspiration represents a unique type of foreign body aspiration requiring a distinct diagnostic and therapeutic approach. In many cases, the "foreign body" itself may no longer be present, whereas the airway manifestations may persist for months to years. Limited data exist to guide management decisions. We report...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.12-1571
更新日期:2013-06-01 00:00:00
abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a frequent cause of morbidity and mortality in patients with systemic sclerosis (SSc). PAH is generally considered to be a late complication of limited cutaneous SSc. This study identified and investigated a subset of SSc patients with early-onset PAH. METHODS:Clinic...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.08-3042
更新日期:2009-11-01 00:00:00
abstract::The efficacy of a new tissue-culture technique for the diagnosis of malignant pleural effusions was contrasted with conventional cytologic methods. The new technique is based on the ability of the tissue-culture medium to transform mesothelial cells into fibroblasts while not sustaining lymphoreticular cells. Against ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.69.5.626
更新日期:1976-05-01 00:00:00
abstract:BACKGROUND:It has been postulated that differences in provocative concentration of methacholine causing a 20% fall in FEV1 (PC20) values between the dosimeter method and tidal breathing method might be due to differences in the dose of agonist delivered to the mouth. The aim of the present study was to determine the in...
journal_title:Chest
pub_type: 杂志文章,随机对照试验
doi:10.1378/chest.08-0093
更新日期:2008-10-01 00:00:00
abstract::Until recently, a definitive diagnosis of lipoma in the thorax could only be established by thoracotomy. We undertook this study to determine if chest CT could provide such an answer. Among 4,000 chest CT scans, six patients were found to have lipoma according to the following selected criteria: CT features of a pleur...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.90.2.265
更新日期:1986-08-01 00:00:00
abstract:STUDY OBJECTIVES:Poor dental hygiene has been linked to respiratory pathogen colonization in residents of long-term care facilities. We sought to investigate the association between dental plaque (DP) colonization and lower respiratory tract infection in hospitalized institutionalized elders using molecular genotyping....
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.5.1575
更新日期:2004-11-01 00:00:00
abstract::Following an outline that details the pathogens causing community-acquired pneumonia (CAP) identified in studies from Europe, this article reviews the guidelines for the management of CAP in four European countries--France, Italy, Spain, and the United Kingdom. The method behind the development of each document is des...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.113.3_supplement.183s
更新日期:1998-03-01 00:00:00