Abstract:
:The value of home spirometry in detecting acute lung rejection and opportunistic infections was studied in 15 heart-lung transplant recipients over a six-month period. The patients measured their FEV1 and FVC twice daily at home using a portable turbine spirometer. The records were then reviewed in relation to the results of transbronchial lung biopsy carried out during occurrences of respiratory symptoms and during routine posttransplant assessment. FEV1 and FVC fell by a mean (+/- SD) of 10.4 +/- 6.9 percent and 9.3 +/- 7.9 percent, respectively, during 20 episodes of lung rejection. The corresponding figures during opportunistic infections were 12.8 +/- 10.1 percent and 12.5 +/- 14.3 percent. No such change was observed during routine normal biopsies. Regular home spirometry offered early detection of these complications allowing early transbronchial lung biopsy as well as assessing efficacy of their therapy. Above all, measurements can be made daily, which is unique in the assessment of solid organ transplants.
journal_name
Chestjournal_title
Chestauthors
Otulana BA,Higenbottam T,Ferrari L,Scott J,Igboaka G,Wallwork Jdoi
10.1378/chest.97.2.353subject
Has Abstractpub_date
1990-02-01 00:00:00pages
353-7issue
2eissn
0012-3692issn
1931-3543pii
S0012-3692(15)40669-5journal_volume
97pub_type
杂志文章相关文献
CHEST文献大全abstract:STUDY OBJECTIVES:There are large reported differences for the carboxyhemoglobin (COHb) half-life (COHb t(1/2)) in humans breathing 100% atmospheric O(2) following CO inhalation in tightly controlled experiments compared to the COHb t(1/2) observed in clinical CO poisoning (range, 36 to 131 min, respectively). Other rep...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.117.3.801
更新日期:2000-03-01 00:00:00
abstract::In previous research, we have demonstrated the value of using necropsy "surprise" lung cancer cases, in those in whom lung cancer was not suspected during life, to estimate the size and composition of the "reservoir" of undetected lung cancer in the general population. The current research was done to determine the ch...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.291
更新日期:1989-08-01 00:00:00
abstract:OBJECTIVE:To highlight the incidence of subglottic stenosis (SGS) as a complication of surgery for congenital heart disease and the role of single-stage laryngotracheoplasty in treating this complication. DESIGN:Retrospective case series. SETTING:University-based referral center specializing in surgery for congenital...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.111.6.1769
更新日期:1997-06-01 00:00:00
abstract:OBJECTIVE:The epigenetic basis for human asthma is not well studied, particularly among older adults. This study investigated the methylation profiles in sputum DNA among older adults with asthma, using a population of smokers. METHODS:This was a cross-sectional study using the Lovelace Smokers Cohort, a population of...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.11-2519
更新日期:2012-08-01 00:00:00
abstract::Seventy-two consecutive adult asthmatic patients seen in the Pulmonary Clinic at Rhode Island Hospital were tested for atopy by prick test with 14 standard aeroallergens and by in vitro total and specific IgE determinations (FAST). A total of 58.3 percent of patients were found to be atopic by these tests. There was a...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.6.1336
更新日期:1989-12-01 00:00:00
abstract:BACKGROUND:Peak exercise oxygen consumption (peak VO2), which is considered an indicator of prognosis in advanced heart failure, is currently being used as a major criterion in many centers for the selection of candidates for heart transplantation. Available studies suggest that patients with peak VO2 < 14 mL/min/kg ha...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.115.2.410
更新日期:1999-02-01 00:00:00
abstract::The etiology of the SAS is unknown. To test whether endogenous opioids could be pathologically active in SAS, markers of opioid systems were measured in the CSF of 15 patients with SAS and in control subjects. Measured by receptor assay, the concentration of so-called fraction 1 opioid was higher in patients with SAS ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.2.250
更新日期:1989-08-01 00:00:00
abstract::We studied retrospectively 69 cases of chagasic megaesophagus (group 1) and 207 cases of chronic chagasic myocardiopathy (CCM) without megaesophagus (group 2) by autopsy in the Pathology Department of the Federal University of Bahia, Brazil, from 1953 to 1975. It was shown that pulmonary tuberculosis was significantly...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.83.1.87
更新日期:1983-01-01 00:00:00
abstract:OBJECTIVES:A fixed combination of long-acting beta(2)-agonists (LABA) plus inhaled corticosteroids (ICS) has never been proven to reduce asthma exacerbations vs ICS alone in children. This 12-month, double-blind, randomized study in 341 children (age range, 4 to 11 years) with asthma uncontrolled on ICS investigated wh...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.130.6.1733
更新日期:2006-12-01 00:00:00
abstract::Interstitial pneumonitis in children is a rare and poorly understood disease. Controversy exists as to whether the varoius histologic changes encountered represent different disease or a spectrum of the same disease. Fourteen biopsy-confirmed cases of desquamative interstitial pneumonitis in children were seen at the ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.2.165
更新日期:1980-02-01 00:00:00
abstract::Preoperative evaluation of patients being considered for pulmonary resection is a common practice for both pulmonologists and internists. Traditionally, preoperative evaluation of this population has entailed identifying patients in whom pulmonary resection carries an unacceptably high risk of morbidity and mortality....
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.112.4_supplement.206s
更新日期:1997-10-01 00:00:00
abstract::It has been suggested that spirometry should be incorporated into the routine examination of every patient, analogous to obtaining vital signs. To determine the impact of spirometry on the management of outpatients with respiratory disease, spirometry was performed on 150 consecutive patients (123 men and 27 women, me...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.99.3.730
更新日期:1991-03-01 00:00:00
abstract:STUDY OBJECTIVE:To establish the prevalence of pulmonary embolism (PE) in autopsy material at a tertiary cardiac referral center and its importance as a cause of death in patients with heart disease (HD). DESIGN:Case series. SETTING:National Heart Institute, Mexico City. PATIENTS:One thousand thirty-two patients who...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.129.5.1282
更新日期:2006-05-01 00:00:00
abstract::A retrospective study was conducted in 23 subjects with previous occupational exposure to asbestos and exhibiting rounded atelectasis (RA) on high-resolution computed tomography scan (HRCT scan) to evaluate the retention of asbestos bodies (ABs) using light microscopy in the bronchoalveolar lavage (BAL) fluid or lung ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.2.477
更新日期:1995-02-01 00:00:00
abstract::Chronic thromboembolic pulmonary hypertension (CT-E PH) is a rare and aberrant outcome of acute pulmonary embolism. Because it has become a potentially curable form of pulmonary hypertension, the frequency of recognized cases has increased. We report a case series of 72 patients with CT-E PH evaluated in our instituti...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.107.1_supplement.52s
更新日期:1995-01-01 00:00:00
abstract:STUDY OBJECTIVE:To ascertain the incidence, types, morbidity, and mortality of infectious episodes in isolated lung transplant recipients. DESIGN:Retrospective chart review of patients who have undergone transplants over a six-year period in one institution. PATIENTS:Twenty-three single and 17 double lung transplants...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.101.4.1056
更新日期:1992-04-01 00:00:00
abstract:OBJECTIVES:The purpose of the study was to evaluate a novel, combined sensor for transcutaneous monitoring of arterial oxygen saturation and carbon dioxide tension. DESIGN:The new monitoring technique was compared to established reference methods. SETTING:ICU and sleep laboratory of a university hospital. PATIENTS:E...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.128.3.1291
更新日期:2005-09-01 00:00:00
abstract::We describe three cases of acute uncomplicated bacterial pneumonia due to viridans streptococci in previously healthy adults, which were indistinguishable from those caused by other well-known respiratory pathogens. On arrival, all of these patients were treated with IV aqueous penicillin based on Gram stain of sputum...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.96.4.831
更新日期:1989-10-01 00:00:00
abstract:BACKGROUND:Pulmonary edema may alter alveolar bacterial clearance and infectivity. Manipulation of fluid balance aimed at reducing fluid overload may, therefore, influence ventilator-associated pneumonia (VAP) occurrence in intubated patients. The objective of the present study was to assess the impact of a depletive f...
journal_title:Chest
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1378/chest.13-2564
更新日期:2014-07-01 00:00:00
abstract:STUDY OBJECTIVE:We conducted the first randomized controlled study to assess the effects of short-term 28% and 100% oxygen on PaCO(2) and peak expiratory flow rate (PEFR) in patients with acute severe asthma. PATIENTS AND INTERVENTIONS:Seventy-four patients (mean age, 37.9 +/- 9.7 years [+/- SD]; PEFR, 41.0 +/- 12.1% ...
journal_title:Chest
pub_type: 临床试验,杂志文章,随机对照试验
doi:10.1378/chest.124.4.1312
更新日期:2003-10-01 00:00:00
abstract::The risk and benefits of three treatment strategies were examined in 64 consecutive patients with acute myocardial infarction and cardiogenic shock. Thirteen patients received thrombolytic therapy (group 1), 29 patients received intra-aortic balloon pump counterpulsation support (group 2), and 22 patients were treated...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.105.4.997
更新日期:1994-04-01 00:00:00
abstract::We present an unusual case of a patient with chronic hepatitis C who experienced dyspnea, fever, and cough after 2 1/2 months' treatment with interferon. His radiograph demonstrated diffuse pulmonary infiltrates and bronchoalveolar lavage fluid showed an increase in lymphocytes, especially CD8-positive cells. The lung...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.106.2.612
更新日期:1994-08-01 00:00:00
abstract:BACKGROUND:Increased expression of the human epididymis protein 4 (HE4) was previously described in lung biopsy samples from patients with cystic fibrosis (CF). It remains unknown, however, whether serum HE4 concentrations are elevated in CF. METHODS:Seventy-seven children with CF from six Hungarian CF centers and 57 ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.04.006
更新日期:2016-09-01 00:00:00
abstract:BACKGROUND:Asbestos bodies (AB) in BAL cells are specific markers of asbestos exposure. METHODS:We retrospectively reviewed BAL cytocentrifuge slides of 30 utility workers with a history of asbestos exposure and 30 normal volunteers. BAL cytocentrifuge slides were blinded and scanned under 40 x light microscope. RESU...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.126.3.966
更新日期:2004-09-01 00:00:00
abstract:BACKGROUND:Obesity is known to be an important risk factor for OSA; however, OSA can also be seen in nonobese patients with a small maxilla and/or mandible as well as in all obese patients with such features. Thus, we hypothesized that regional factors, oropharyngeal crowding associated with fat deposition, and maxillo...
journal_title:Chest
pub_type: 杂志文章
doi:10.1016/j.chest.2016.03.005
更新日期:2016-08-01 00:00:00
abstract::A case of idiopathic pulmonary hypertension is associated with portal venous thrombosis. The patient's chest roentgenogram revealed numerous nodular densities which at necropsy were found to have been caused by an exuberant fibroblastic reaction around small pulmonary arterioles. This is an example of the unusual asso...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.78.1.111
更新日期:1980-07-01 00:00:00
abstract::Primary pulmonary hypertension (PPH) is a serious pulmonary vascular disease occurring mostly in adult women. Although its occurrence in families was reported within a few years after the original clinical report, PPH was formerly believed rarely to have a genetic basis. Recent progress has not only clarified a basic ...
journal_title:Chest
pub_type: 杂志文章,评审
doi:10.1378/chest.122.6_suppl.284s
更新日期:2002-12-01 00:00:00
abstract::Systemic embolization is a common complication of left atrial myxoma; however, coronary embolism leading to acute myocardial infarction is rare. The use of echocardiography has increased the detection of intracardiac tumors when signs and symptoms are not evident. Echocardiography is the diagnostic procedure of choice...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.109.4.1106
更新日期:1996-04-01 00:00:00
abstract::A 72-year-old physician with myeloid metaplasia developed marked thrombocytosis, pulmonary hypertension, and right heart failure following splenectomy. No cause for the pulmonary hypertension could be found. The pulmonary hypertension and right heart failure returned to normal when hydroxyurea therapy corrected the th...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.103.2.642
更新日期:1993-02-01 00:00:00
abstract::A ventricular inhibited unipolar pacing system in a case of so-called pacemaker syndrome was successfully converted into an atrioventricular sequential system without replacing the ventricular lead. ...
journal_title:Chest
pub_type: 杂志文章
doi:10.1378/chest.77.3.436
更新日期:1980-03-01 00:00:00