Health-related quality of life trajectories among adults with tuberculosis: differences between latent and active infection.


BACKGROUND:Tuberculosis (TB) remains a public health threat with significant annual impacts on morbidity and mortality. However, few studies have examined the impact of active and latent TB infection (LTBI) on health-related quality of life (HRQL). METHODS:Patients with recently diagnosed active TB or LTBI patients were administered the Short Form-36 (SF-36) and the Beck depression inventory (DI) at baseline, 3 months, and 6 months. Mixed-effect linear regression was used to compare the trajectory of HRQL over time in the two patient groups after adjusting for potential confounders. Ordinal logistic regression was used to determine the relationship between changes in HRQL of at least the minimal important difference. RESULTS:One hundred four active TB and 102 LTBI patients participated. At baseline, participants with active TB had significantly lower SF-36 mean domain and component scores (4 to 12 points lower, p < 0.03) and higher mean Beck DI scores (4 points higher, p < 0.0001) when compared to LBTI participants. In the responder analysis, those with active TB were associated with reporting improved scores at 6 months of at least the minimal important difference in vitality (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.3 to 5.6), role physical (OR, 3.1; 95% CI, 1.4 to 6.5), mental component score (OR, 3.2; 95% CI, 1.5 to 6.9), social functioning (OR, 11.1; 95% CI, 3.8 to 33), and role emotional (OR, 2.7; 95% CI, 1.2 to 6.0). CONCLUSIONS:Active TB patients had large improvements in most HRQL domains by 6 months. However, when compared to LTBI participants and US norms, HRQL was still low at completion of therapy.






Marra CA,Marra F,Colley L,Moadebi S,Elwood RK,Fitzgerald JM




Has Abstract


2008-02-01 00:00:00
















  • Health-related quality of life of persons with sarcoidosis.

    abstract:STUDY OBJECTIVES:To describe the health-related quality of life (HRQL) and mental health of persons with sarcoidosis, as well as to assess physician-patient agreement about the presence of sarcoidosis symptoms. DESIGN AND SETTING:Cross-sectional study at three university medical center outpatient pulmonary clinics. P...


    pub_type: 杂志文章


    authors: Cox CE,Donohue JF,Brown CD,Kataria YP,Judson MA

    更新日期:2004-03-01 00:00:00

  • Impact of a bronchiolitis guideline: a multisite demonstration project.

    abstract:STUDY OBJECTIVES:The purpose of this study was to determine the impact of a multisite implementation of an evidence-based clinical practice guideline for bronchiolitis. DESIGN:Before and after study. SETTING:Eleven Child Health Accountability Initiative (CHAI) study hospitals. PATIENTS:Children < 12 months of age wi...


    pub_type: 杂志文章,多中心研究


    authors: Kotagal UR,Robbins JM,Kini NM,Schoettker PJ,Atherton HD,Kirschbaum MS

    更新日期:2002-06-01 00:00:00

  • Pulmonary rehabilitation: a classic tune with a new beat, but is anyone listening?

    abstract::Comprehensive pulmonary rehabilitation and respiratory therapy services benefit patients with chronic lung disease and other diseases of the lung by reducing symptoms and restoring independent function. Although the science of these therapies is not new, commercial payers and Medicare have generally been slow to suppo...


    pub_type: 杂志文章,评审


    authors: Birnbaum S

    更新日期:2011-06-01 00:00:00

  • Late carmustine lung fibrosis. Age at treatment may influence severity and survival.

    abstract::Previously, we have reported in 1990 that 35% of carmustine treated patients (6 of 17) who survived childhood brain tumors died of pulmonary fibrosis between 2 and 13 years after treatment. In addition, 8 patients studied in 1989 (13 to 17 years post treatment), had physiologic and biopsy or radiologic evidence of pul...


    pub_type: 杂志文章


    authors: O'Driscoll BR,Kalra S,Gattamaneni HR,Woodcock AA

    更新日期:1995-05-01 00:00:00

  • Right chest electrocardiographic patterns in normal subjects.

    abstract::Right-sided chest lead ECGs (V3R to V6R) were recorded in 110 normal male subjects who were between the ages of 17 and 22 years old (mean, 17.9 years). The prevalence of the rS pattern decreased from V3R (89 percent) to V6R (37 percent). However, the opposite was the case for the rSr pattern (10 percent in V3R and 36 ...


    pub_type: 杂志文章


    authors: Tan CC,Hiew TM,Chia BL

    更新日期:1990-03-01 00:00:00

  • Cardiopulmonary exercise testing in children: an individualized protocol for workload increase.

    abstract:OBJECTIVES:To investigate the feasibility of individualized workload increments, as used in adults, for exercise testing in children; and to investigate whether this individualized protocol makes it possible to satisfy the usual criteria for maximal exercise (clinical exhaustion, predicted maximum heart rate [HRmax], o...


    pub_type: 杂志文章


    authors: Karila C,de Blic J,Waernessyckle S,Benoist MR,Scheinmann P

    更新日期:2001-07-01 00:00:00

  • Emphysema presence, severity, and distribution has little impact on the clinical presentation of a cohort of patients with mild to moderate COPD.

    abstract:BACKGROUND:Phenotypic characterization of patients with COPD may have potential prognostic and therapeutic implications. Available information on the relationship between emphysema and the clinical presentation in patients with COPD is limited to advanced stages of the disease. The objective of this study was to descri...


    pub_type: 杂志文章


    authors: de Torres JP,Bastarrika G,Zagaceta J,Sáiz-Mendiguren R,Alcaide AB,Seijo LM,Montes U,Campo A,Zulueta JJ

    更新日期:2011-01-01 00:00:00

  • Expression of alveolar macrophage adhesion molecules in pulmonary sarcoidosis.

    abstract::Beta-2-integrins belong to a family of leukocyte surface glycoproteins that are essential for immune functions of bronchoalveolar cells. The expression of three alpha chains designed as CD11a, CD11b, CD11c, a common beta chain CD18, and of a ligand for several integrins CD54 (ICAM-1) was studied on alveolar macrophage...


    pub_type: 杂志文章


    authors: Striz I,Wang YM,Kalaycioglu O,Costabel U

    更新日期:1992-09-01 00:00:00

  • Thoracic outlet syndrome mimicking angina pectoris with elevated creatine phosphokinase values.

    abstract::Four patients with elevated creatine phosphokinase (CPK) values and recurrent chest pain were found to have thoracic outlet syndrome. This association of abnormal CPK levels and chest pain due to thoracic outlet syndrome has not been previously reported. Symptoms and CPK values improved with anti-inflammatory medicati...


    pub_type: 杂志文章


    authors: Godfrey NF,Halter DG,Minna DA,Weiss M,Lorber A

    更新日期:1983-03-01 00:00:00

  • Nocturnal noninvasive ventilation.

    abstract::Nocturnal noninvasive ventilation (NNV), the provision of ventilatory assistance via a noninvasive interface mainly during sleep, has assumed an important role in the management of chronic hypoventilatory syndromes. This review focuses on recent developments related to the use of NNV to treat various forms of chronic ...


    pub_type: 杂志文章,评审


    authors: Ozsancak A,D'Ambrosio C,Hill NS

    更新日期:2008-05-01 00:00:00

  • Ultrafiltration in moderate heart failure. Exercise oxygen uptake as a predictor of the clinical benefits.

    abstract:OBJECTIVE:Ultrafiltration (UF) can improve the exercise performance of patients with moderate congestive heart failure (CHF). Our aim was to define the starting levels of performance below which UF is beneficial. PATIENTS AND METHOD:We studied 26 patients in 2 to 3 NYHA class, whose clinical condition was stable, left...


    pub_type: 杂志文章


    authors: Marenzi GC,Lauri G,Guazzi M,Perego GB,Agostoni PG

    更新日期:1995-07-01 00:00:00

  • Relationship between pulmonary function and sleep-induced respiratory abnormalities.

    abstract::The relationships between pulmonary function and sleep-induced respiratory events were studied in 34 consecutive male patients with suspected sleep apnea syndrome. In view of the effects of obstructive airway disease on pulmonary volume and airway resistance (Raw), patients were divided into two groups, those with and...


    pub_type: 杂志文章


    authors: Onal E,Leech JA,Lopata M

    更新日期:1985-04-01 00:00:00

  • Treatment of sarcoidosis-associated pulmonary hypertension. A two-center experience.

    abstract:BACKGROUND:Pulmonary hypertension (PH) is a common complication of sarcoidosis that is associated with increased mortality. The pathogenesis of PH in sarcoidosis is uncertain, and the role of pulmonary arterial hypertension (PAH)-specific therapies remains to be determined. METHODS:We conducted a retrospective study o...


    pub_type: 杂志文章,多中心研究


    authors: Barnett CF,Bonura EJ,Nathan SD,Ahmad S,Shlobin OA,Osei K,Zaiman AL,Hassoun PM,Moller DR,Barnett SD,Girgis RE

    更新日期:2009-06-01 00:00:00

  • Understanding cardiopulmonary resuscitation decision making: perspectives of seriously ill hospitalized patients and family members.

    abstract:BACKGROUND:To improve communication and decision making related to cardiopulmonary resuscitation (CPR), a greater understanding of the perspectives of hospitalized patients with advanced diseases and their family members are needed. METHODS:In five Canadian hospitals, we administered a face-to-face questionnaire to ol...


    pub_type: 杂志文章,多中心研究


    authors: Heyland DK,Frank C,Groll D,Pichora D,Dodek P,Rocker G,Gafni A

    更新日期:2006-08-01 00:00:00

  • Establishing pulmonary and critical care medicine as a subspecialty in China: joint statement of the Chinese thoracic society and the American college of chest physicians.

    abstract::This commentary heralds the recognition in China of a new subspecialty, Pulmonary and Critical Care Medicine, and the first national fellowship training pathway in any medical specialty. Because of striking environmental health-care similarities that existed in the United States, the Chinese medical community decided ...


    pub_type: 杂志文章


    authors: Qiao R,Rosen MJ,Chen R,Wu S,Marciniuk D,Wang C,CTS-ACCP Pulmonary and Critical Care Medicine Workgroup.

    更新日期:2014-01-01 00:00:00

  • Patient Engagement Using New Technology to Improve Adherence to Positive Airway Pressure Therapy: A Retrospective Analysis.

    abstract:BACKGROUND:Sleep apnea has major neurocognitive and cardiovascular and metabolic risks. Treatment of sleep apnea is suboptimal because of variable adherence to existing therapies. METHODS:This trial compared positive airway pressure adherence among patients who were provided active patient engagement (APE) technology ...


    pub_type: 临床试验,杂志文章,多中心研究


    authors: Malhotra A,Crocker ME,Willes L,Kelly C,Lynch S,Benjafield AV

    更新日期:2018-04-01 00:00:00

  • Intensive Monitoring of Urine Output Is Associated With Increased Detection of Acute Kidney Injury and Improved Outcomes.

    abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...


    pub_type: 杂志文章


    authors: Jin K,Murugan R,Sileanu FE,Foldes E,Priyanka P,Clermont G,Kellum JA

    更新日期:2017-11-01 00:00:00

  • Sex differences in response to tadalafil in pulmonary arterial hypertension.

    abstract:BACKGROUND:Pulmonary arterial hypertension (PAH) is a progressive disease with high rates of morbidity and mortality. Current therapies improve symptoms, functional capacity, and, in select cases, survival. Little is known about patient factors that may predict the likelihood of patient-important, clinically relevant r...


    pub_type: 杂志文章,随机对照试验


    authors: Mathai SC,Hassoun PM,Puhan MA,Zhou Y,Wise RA

    更新日期:2015-01-01 00:00:00

  • Disseminated histoplasmosis followed by disseminated coccidioidomycosis.

    abstract::A case of disseminated histoplasmosis followed later by disseminated coccidioidomycosis is described. The clinical illness and immunologic studies suggest subtle defects that may have existed antecedent to infection and, thus, provided an opportunity for widespread dissemination by these normally nonopportunistic orga...


    pub_type: 杂志文章


    authors: Kaplan P,Graybill JR,Thor D

    更新日期:1977-08-01 00:00:00

  • Limitations of the fast green assay for chemosensitivity testing in human lung cancer.

    abstract::Selection of patients with lung cancer who are most likely to benefit from chemotherapeutic treatment would be a substantial step forward. Therefore, a prospective study in predictive chemosensitivity testing in vitro using the fast green assay (FGA) as developed by Weisenthal et al was carried out. Sixty-six pretreat...


    pub_type: 杂志文章


    authors: Smit EF,de Vries EG,Meijer C,Mulder NH,Postmus PE

    更新日期:1991-11-01 00:00:00

  • Sequential atrioventricular pacing as a stress test. Evaluation of left ventricular function in second-degree AV heart block developing during atrial pacing.

    abstract::Advanced or second-degree atrioventricular (AV) heart block pre-existing or developing during atrial pacing (AP) at low heart rates of smaller than 130 per minute, limits the value of AP to stress the left ventricle. When Wenkebach type AV block is present, the heart rate can be increased by administration of atropine...


    pub_type: 杂志文章


    authors: Kimbiris D,Linhart JW

    更新日期:1975-05-01 00:00:00

  • Emergency room intubations--complications and survival.

    abstract::Forty-three consecutive patients requiring endotracheal intubation in an emergency room were studied prospectively to define the complications associated with intubation and the survival of these patients, and to evaluate emergency room policies. The indications for intubation were acute respiratory failure (ARF) in 2...


    pub_type: 杂志文章


    authors: Taryle DA,Chandler JE,Good JT Jr,Potts DE,Sahn SA

    更新日期:1979-05-01 00:00:00

  • Right mammary-coronary anastomosis in a patient with situs inversus.

    abstract::We report a patient with situs inversus and ischemic heart disease who had myocardial revascularization with anastomosis of the right mammary artery to the anterior descending coronary artery. ...


    pub_type: 杂志文章


    authors: Abensur H,Ramires JA,Dallan LA,Jatene A

    更新日期:1988-10-01 00:00:00

  • Transient superior vena cava syndrome due to propylthiouracil therapy in intrathoracic goiter.

    abstract::Intrathoracic goiter is a rare cause of superior vena cava syndrome. We present the findings in a patient in whom the syndrome was precipitated by therapy with propylthiouracil and remitted on withdrawal of the medication. The superior vena cava syndrome did not recur on medical management, suggesting that surgery is ...


    pub_type: 杂志文章


    authors: Hershey CO,McVeigh RC,Miller RP

    更新日期:1981-03-01 00:00:00

  • Long-Term Disabilities of Survivors of Out-of-Hospital Cardiac Arrest: The Hanox Study.

    abstract:BACKGROUND:Long-term outcomes of awakened survivors of out-of-hospital cardiac arrest (OHCA) are poorly known. RESEARCH QUESTION:What are the month (M) 18 outcomes of survivors of out-of-hospital cardiac arrest (OHCA) who awakened during the first 2 weeks' post-OHCA and their poor-outcome risk factors? STUDY DESIGN A...


    pub_type: 杂志文章


    authors: Peskine A,Cariou A,Hajage D,Deye N,Guérot E,Dres M,Sonneville R,Lafourcade A,Navarro V,Robert H,Azouvi P,Sharshar T,Bayen E,Luyt CE,Hanox Study Group.

    更新日期:2020-07-20 00:00:00

  • Primary coronary artery dissection.

    abstract::Three patients had angiographic appearance of chronic primary coronary artery dissection with features that differed from other patients with this entity studied at autopsy; they were men, greater than or equal to 40 years of age, had angina pectoris and severe coronary artery disease. The right coronary artery, which...


    pub_type: 杂志文章


    authors: Iskandrian AS,Bemis CE,Kimbiris D,Mintz GS,Hakki AH

    更新日期:1985-02-01 00:00:00

  • Randomized, controlled trials of interventions to improve communication in intensive care: a systematic review.

    abstract:BACKGROUND:Communication between families and providers in the ICU affects patient and family outcomes and use of health-care resources. Recent research studies have tested interventions designed to improve communication quality and outcomes between providers and families of patients in the ICU. We conducted a systemat...


    pub_type: 杂志文章,评审


    authors: Scheunemann LP,McDevitt M,Carson SS,Hanson LC

    更新日期:2011-03-01 00:00:00

  • Pneumopericardium following laparoscopy.

    abstract::There have been no published reports of pneumopericardium complicating laparoscopy. Following an apparently uncomplicated laparoscopy, a 35-year-old woman developed pneumopericardium associated with subcutaneous emphysema of the neck. This resolved without specific therapy and without sequelae. ...


    pub_type: 杂志文章


    authors: Nicholson RD,Berman ND

    更新日期:1979-11-01 00:00:00

  • Association of Psychological Disorders With 30-Day Readmission Rates in Patients With COPD.

    abstract:BACKGROUND:There is a growing understanding of the prevalence and impact of psychological disorders on COPD. However, the role of these disorders in early readmission is unclear. METHODS:We analyzed data from 5% fee-for-service Medicare beneficiaries diagnosed with COPD (International Classification of Diseases, Ninth...


    pub_type: 杂志文章


    authors: Singh G,Zhang W,Kuo YF,Sharma G

    更新日期:2016-04-01 00:00:00

  • Pulmonary artery thrombus detection by magnetic resonance imaging.

    abstract::We report a patient in whom cardiac magnetic resonance imaging detected a clinically unsuspected pulmonary artery thromboembolus. Follow-up MRI after surgical removal of the thromboembolus showed normal pulmonary arteries. This case illustrates the potential utility of MRI in the detection and follow-up of central pul...


    pub_type: 杂志文章


    authors: Szucs RA,Rehr RB,Tatum JL

    更新日期:1989-01-01 00:00:00