Health-related quality of life trajectories among adults with tuberculosis: differences between latent and active infection.


BACKGROUND:Tuberculosis (TB) remains a public health threat with significant annual impacts on morbidity and mortality. However, few studies have examined the impact of active and latent TB infection (LTBI) on health-related quality of life (HRQL). METHODS:Patients with recently diagnosed active TB or LTBI patients were administered the Short Form-36 (SF-36) and the Beck depression inventory (DI) at baseline, 3 months, and 6 months. Mixed-effect linear regression was used to compare the trajectory of HRQL over time in the two patient groups after adjusting for potential confounders. Ordinal logistic regression was used to determine the relationship between changes in HRQL of at least the minimal important difference. RESULTS:One hundred four active TB and 102 LTBI patients participated. At baseline, participants with active TB had significantly lower SF-36 mean domain and component scores (4 to 12 points lower, p < 0.03) and higher mean Beck DI scores (4 points higher, p < 0.0001) when compared to LBTI participants. In the responder analysis, those with active TB were associated with reporting improved scores at 6 months of at least the minimal important difference in vitality (odds ratio [OR], 2.7; 95% confidence interval [CI], 1.3 to 5.6), role physical (OR, 3.1; 95% CI, 1.4 to 6.5), mental component score (OR, 3.2; 95% CI, 1.5 to 6.9), social functioning (OR, 11.1; 95% CI, 3.8 to 33), and role emotional (OR, 2.7; 95% CI, 1.2 to 6.0). CONCLUSIONS:Active TB patients had large improvements in most HRQL domains by 6 months. However, when compared to LTBI participants and US norms, HRQL was still low at completion of therapy.






Marra CA,Marra F,Colley L,Moadebi S,Elwood RK,Fitzgerald JM




Has Abstract


2008-02-01 00:00:00
















  • Patient with bilateral pleural effusion: are the findings the same in each fluid?

    abstract:STUDY OBJECTIVES:To determine whether, in patients with bilateral pleural effusions, the main cellular and biochemical features of the pleural fluid on the right side differ from or correlate with those on the left side. We examined lactate dehydrogenase (LDH), glucose, and total protein (TP) levels, RBC count, nucleat...


    pub_type: 杂志文章


    authors: Kalomenidis I,Rodriguez M,Barnette R,Gupta R,Hawthorne M,Parkes KB,Light RW

    更新日期:2003-07-01 00:00:00

  • Successful treatment of primary pulmonary angiosarcoma.

    abstract::Angiosarcoma in the lung is an uncommon disorder and is usually attributable to metastasis from a primary site. Primary pulmonary angiosarcoma is extremely rare, and the prognosis of affected individuals is dismal, with most patients dying within months of presentation. Indeed, there have been no reported instances of...


    pub_type: 杂志文章


    authors: Kojima K,Okamoto I,Ushijima S,Yoshinaga T,Kitaoka M,Suga M,Sasaki Y

    更新日期:2003-12-01 00:00:00

  • Circulating Endometrial Cells in Women With Spontaneous Pneumothorax.

    abstract:BACKGROUND:The occurrence of catamenial pneumothorax (CP) is rare, and the awareness of this diagnosis among physicians is insufficient. CP is highly correlated with pelvic endometriosis and remains the most common form of thoracic endometriosis syndrome. Circulating endometrial cells (CECs) have been previously detect...


    pub_type: 杂志文章


    authors: Kiss I,Pospisilova E,Kolostova K,Maly V,Stanek I,Lischke R,Schutzner J,Pawlak I,Bobek V

    更新日期:2020-02-01 00:00:00

  • Clinical staging of patients with non-small cell lung cancer.

    abstract::This article is the first in a planned series from the Section on Lung Cancer of the ACCP addressing the important and clinically relevant aspects of what is now the most common malignancy in the world, lung cancer. This initial report addresses the problem of staging of lung cancer. Staging, or identifying the anatom...


    pub_type: 杂志文章


    authors: Little AG,Stitik FP

    更新日期:1990-06-01 00:00:00

  • Endobronchial Ultrasound: Clinical Uses and Professional Reimbursements.

    abstract::Endobronchial ultrasonography (EBUS) has become an invaluable tool in the diagnosis of patients with a variety of thoracic abnormalities. The majority of EBUS procedures are used to diagnose and stage mediastinal and hilar abnormalities, as well as peripheral pulmonary targets, with a probe-based technology. Nearly 1,...


    pub_type: 杂志文章,评审


    authors: Gildea TR,Nicolacakis K

    更新日期:2016-12-01 00:00:00

  • The relationship of sleepiness and blood pressure to respiratory variables in obstructive sleep apnea.

    abstract::As a follow-up to a previous assessment of complications of sleep-disturbed breathing in 265 patients, we have reevaluated measures of sleepiness and hypertension in patients with obstructive sleep apnea (OSA) (n = 518), central sleep apnea (n = 50), and subclinical sleep-disordered breathing (SDB) (n = 107). Both sub...


    pub_type: 杂志文章


    authors: Mendelson WB

    更新日期:1995-10-01 00:00:00

  • Catamenial hemoptysis. New methods of diagnosis and therapy.

    abstract::Bronchopulmonary endometriosis is a rare cause of hemoptysis. We describe a woman with catamenial hemoptysis which was localized with chest CAT scanning and treated successfully with danazol. The proposed pathogenesis and manifestations of thoracic endometriosis are reviewed, and the use of new diagnostic and therapeu...


    pub_type: 杂志文章


    authors: Elliot DL,Barker AF,Dixon LM

    更新日期:1985-05-01 00:00:00

  • Critical care rationing: international comparisons.

    abstract::Every country has finite resources that are expended to provide citizens with social "goods," including education, protection, infrastructure, and health care. Rationing-of any resource-refers to distribution of an allotted amount and may involve withholding some goods that would benefit some citizens. Health-care rat...


    pub_type: 杂志文章,评审


    authors: Evans TW,Nava S,Mata GV,Guidet B,Estenssoro E,Fowler R,Scheunemann LP,White D,Manthous CA

    更新日期:2011-12-01 00:00:00

  • Role for interleukin-6 in COPD-related pulmonary hypertension.

    abstract:BACKGROUND:Pulmonary artery remodeling triggered by alveolar hypoxia is considered the main mechanism of pulmonary hypertension (PH) in COPD patients. We hypothesized that the risk for PH in COPD is increased by an elevation in the proinflammatory cytokines interleukin (IL)-6, monocyte chemoattractant protein-1 (MCP-1)...


    pub_type: 杂志文章


    authors: Chaouat A,Savale L,Chouaid C,Tu L,Sztrymf B,Canuet M,Maitre B,Housset B,Brandt C,Le Corvoisier P,Weitzenblum E,Eddahibi S,Adnot S

    更新日期:2009-09-01 00:00:00

  • Admission hyperglycemia and other risk factors as predictors of hospital mortality in a medical ICU population.

    abstract:BACKGROUND:Tight glycemic control is recommended for patients in the ICU, as hyperglycemia is associated with increased morbidity and mortality. DESIGN:Observational cohort of patients admitted to a 12-bed, inner-city, medical ICU (MICU). SUBJECTS:A total of 1,185 of 1,506 patients from July 1, 1999, to December 31, ...


    pub_type: 杂志文章


    authors: Freire AX,Bridges L,Umpierrez GE,Kuhl D,Kitabchi AE

    更新日期:2005-11-01 00:00:00

  • Pulmonary hypertension and right heart failure in patients with beta-thalassemia intermedia.

    abstract::We analyzed seven patients with beta-thalassemia intermedia presenting with congestive heart failure secondary to pulmonary hypertension. This condition has been recognized only recently as part of the clinical spectrum of beta-thalassemia. Our group of patients included two men and five women with the clinical pictur...


    pub_type: 杂志文章


    authors: Aessopos A,Stamatelos G,Skoumas V,Vassilopoulos G,Mantzourani M,Loukopoulos D

    更新日期:1995-01-01 00:00:00

  • Closure of a tracheoesophageal fistula by bronchoscopic application of fibrin glue and decontamination of the oral cavity.

    abstract::A tracheoesophageal fistula was successfully closed with a fibrin adhesive applied by means of a fiberoptic bronchoscope, instead of by esophagoscopy. To facilitate closure of the fistula, the technique was combined with decontamination of the oral cavity, to avoid bacterial contamination. The procedure is proposed as...


    pub_type: 杂志文章


    authors: Antonelli M,Cicconetti F,Vivino G,Gasparetto A

    更新日期:1991-08-01 00:00:00

  • Silicone thorax due to a ruptured breast implant.

    abstract::A woman with a history of bilateral mastectomy and silicone implants for fibrocystic disease and a history of atrial septal defect repair presented with pleural nodules on a chest radiograph. A thorascopic biopsy performed for possible mesothelioma demonstrated chronic inflammation and focal pleural fibrosis due to a ...


    pub_type: 杂志文章


    authors: Levine RL,Allen TC,Cartwright J Jr,Cagle PT

    更新日期:2005-05-01 00:00:00

  • Impact of a bronchiolitis guideline: a multisite demonstration project.

    abstract:STUDY OBJECTIVES:The purpose of this study was to determine the impact of a multisite implementation of an evidence-based clinical practice guideline for bronchiolitis. DESIGN:Before and after study. SETTING:Eleven Child Health Accountability Initiative (CHAI) study hospitals. PATIENTS:Children < 12 months of age wi...


    pub_type: 杂志文章,多中心研究


    authors: Kotagal UR,Robbins JM,Kini NM,Schoettker PJ,Atherton HD,Kirschbaum MS

    更新日期:2002-06-01 00:00:00

  • Intensive Monitoring of Urine Output Is Associated With Increased Detection of Acute Kidney Injury and Improved Outcomes.

    abstract:BACKGROUND:Urine output (UO) is a vital sign for critically ill patients, but standards for monitoring and reporting vary widely between ICUs. Careful monitoring of UO could lead to earlier recognition of acute kidney injury (AKI) and better fluid management. We sought to determine if the intensity of UO monitoring is ...


    pub_type: 杂志文章


    authors: Jin K,Murugan R,Sileanu FE,Foldes E,Priyanka P,Clermont G,Kellum JA

    更新日期:2017-11-01 00:00:00

  • Limitations of the fast green assay for chemosensitivity testing in human lung cancer.

    abstract::Selection of patients with lung cancer who are most likely to benefit from chemotherapeutic treatment would be a substantial step forward. Therefore, a prospective study in predictive chemosensitivity testing in vitro using the fast green assay (FGA) as developed by Weisenthal et al was carried out. Sixty-six pretreat...


    pub_type: 杂志文章


    authors: Smit EF,de Vries EG,Meijer C,Mulder NH,Postmus PE

    更新日期:1991-11-01 00:00:00

  • Rapidly progressive coronary artery bypass graft atherosclerosis. Report of a case documented by serial coronary arteriograms and pathologic examination.

    abstract::Atherosclerosis occurred in a coronary artery saphenous vein bypass graft. Serial angiograms are presented documenting subtotal occlusion of this graft which occurred over a nine-month period. Pathologic examination of graft material obtained at surgery demonstrated ulcerating atherosclerotic plaque. The occurrence of...


    pub_type: 杂志文章


    authors: Hanlon JT,Massie B,Riches W,Wilson J,Ellis RJ,Gertz EW

    更新日期:1981-01-01 00:00:00

  • Pulmonary impairment after tuberculosis.

    abstract:BACKGROUND:Pulmonary impairment subsequent to a cure of pulmonary tuberculosis has been described only in selected populations. METHODS:We compared pulmonary function in a case-control study of 107 prospectively identified patients with pulmonary tuberculosis who had completed at least 20 weeks of therapy and 210 pati...


    pub_type: 杂志文章


    authors: Pasipanodya JG,Miller TL,Vecino M,Munguia G,Garmon R,Bae S,Drewyer G,Weis SE

    更新日期:2007-06-01 00:00:00

  • Echocardiographic findings after tricuspid valvectomy.

    abstract::Resection of the tricuspid valve without prosthetic replacement has successfully been performed in patients with tricuspid valvular endocarditis. Using M-mode, two-dimensional, and Doppler echocardiograms, we studied four patients who underwent tricuspid valvectomy. All patients had previous history of intravenous dru...


    pub_type: 杂志文章


    authors: Friedman G,Kronzon I,Nobile J,Cohen ML,Winer HE

    更新日期:1985-05-01 00:00:00

  • Persistence of lung function abnormalities despite sustained success of percutaneous mitral valvotomy: the need for an early indication.

    abstract:AIMS:We assessed early and long-term pulmonary function changes after percutaneous balloon mitral valvotomy (PBMV). METHODS AND RESULTS:Mitral area, lung function, and exercise capacity were evaluated before, immediately after, and 3 months, 6 months, and 12 months after successful PBMV in 24 patients. PBMV resulted i...


    pub_type: 杂志文章


    authors: Gómez-Hospital JA,Cequier A,Romero PV,Cañete C,Ugartemendia C,Iràculis E,Esplugas E

    更新日期:2005-01-01 00:00:00

  • Physical development of surgically treated patients with primary spontaneous pneumothorax.

    abstract:STUDY OBJECTIVES:There have been many studies on the physical characteristics at the time of contraction of a primary spontaneous pneumothorax (PSP), but it has not been shown when and how such physical characteristics develop. These issues were investigated. PATIENTS AND DESIGN:Physical development of 27 male patient...


    pub_type: 杂志文章


    authors: Fujino S,Inoue S,Tezuka N,Hanaoka J,Sawai S,Ichinose M,Kontani K

    更新日期:1999-10-01 00:00:00

  • Race Correction and Spirometry: Why History Matters.

    abstract::In recent months, medical institutions across the United States redoubled their efforts to examine the history of race and racism in medicine, in classrooms, in research, and in clinical practice. In this essay, I explore the history of racialization of the spirometer, a widely used instrument in pulmonary medicine to...


    pub_type: 杂志文章,评审


    authors: Braun L

    更新日期:2020-10-24 00:00:00

  • Aberrant systemic arterial supply to the left lung with congestive heart failure.

    abstract::A six-month-old girl with an aberrant systemic arterial supply from the descending thoracic aorta to the left lower lobe had congestive heart failure. Although the pulmonary parenchyma was normal, there was an absence of normal pulmonary arterial supply to the left lower lobe. Main pulmonary arterial and aortic cinean...


    pub_type: 杂志文章


    authors: Yabek SM,Burstein J,Berman W Jr,Dillon T

    更新日期:1981-11-01 00:00:00

  • Tuberculosis in Korea. The relationship between prior therapy and drug resistance.

    abstract::A review of 121 culture-positive cases of pulmonary tuberculosis from 1979 to 1984, including both Korean and American patients, at the major US military hospital in Korea indicated that most antituberculosis drug resistance occurred in patients with a history of previous antituberculosis therapy. The 98 patients with...


    pub_type: 杂志文章


    authors: Etzkorn ET,Lillis PK,McAllister CK

    更新日期:1986-08-01 00:00:00

  • The changing status of ejection fraction as a predictor of early mortality following surgery for acquired heart disease.

    abstract::Several reports in the literature and our experience prior to 1974 support the thesis that operative risk in patients with acquired heart disease and poor ventricular function (as assessed by a biplane ejection fraction [EF] less than or equal to 0.40) was very significantly increased over the risk in patients with no...


    pub_type: 杂志文章


    authors: Tyers GF,Williams DR,Babb JD,Levenson L,Zelis RF,Waldhausen JA

    更新日期:1977-03-01 00:00:00

  • Pulmonary embolism as a cause of death in patients with heart disease: an autopsy study.

    abstract:STUDY OBJECTIVE:To establish the prevalence of pulmonary embolism (PE) in autopsy material at a tertiary cardiac referral center and its importance as a cause of death in patients with heart disease (HD). DESIGN:Case series. SETTING:National Heart Institute, Mexico City. PATIENTS:One thousand thirty-two patients who...


    pub_type: 杂志文章


    authors: Pulido T,Aranda A,Zevallos MA,Bautista E,Martínez-Guerra ML,Santos LE,Sandoval J

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  • Prediction of successful ventilator weaning using airway occlusion pressure and hypercapnic challenge.

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    pub_type: 杂志文章


    authors: Montgomery AB,Holle RH,Neagley SR,Pierson DJ,Schoene RB

    更新日期:1987-04-01 00:00:00

  • Serologic diagnosis of tuberculosis using a simple commercial multiantigen assay.

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    pub_type: 杂志文章


    authors: Perkins MD,Conde MB,Martins M,Kritski AL

    更新日期:2003-01-01 00:00:00

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    pub_type: 杂志文章,评审


    authors: Freedman N

    更新日期:2019-10-01 00:00:00

  • Flow-proportional administration of nitric oxide with a new delivery system: inspiratory nitric oxide concentration fluctuation during different flow conditions.

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    pub_type: 杂志文章


    authors: Sydow M,Bristow F,Zinserling J,Allen SJ

    更新日期:1997-08-01 00:00:00