Value of in situ elemental microanalysis in the histologic diagnosis of silicosis.

Abstract:

:Pulmonary specimens obtained from ten normal subjects and 53 patients with various pulmonary diseases were studied with energy-dispersive x-ray analysis. The amount of silicon in the pulmonary tissue was determined and expressed as a silicon/sulfur (Si/S) ratio. This Si/S ratio was below 0.2 in the ten normal subjects and in 14 patients who had various interstitial pulmonary diseases but had no previous history of exposure to silica or other dusts known to cause pulmonary fibrosis. The Si/S ratio was greater than 0.3 in 19 of 22 patients who had a history of exposure to silica dust and had clear-cut histologic evidence of silicosis. The Si/S ratio was less than 0.2 in 12 and between 0.2 and 0.3 in two of the 14 patients who had a history of exposure to silica dusts but no clinical or histologic evidence of silicosis. We conclude that the determination of the silicon content of tissue by energy-dispersive x-ray analysis is useful in separating the fibrosis due to silicosis from the other causes of pulmonary fibrosis.

journal_name

Chest

journal_title

Chest

authors

Funahashi A,Schlueter DP,Pintar K,Siegesmund KA

doi

10.1378/chest.85.4.506

subject

Has Abstract

pub_date

1984-04-01 00:00:00

pages

506-9

issue

4

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)37848-5

journal_volume

85

pub_type

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