Abstract:
STUDY OBJECTIVES:To characterize the prevalence of undiagnosed pulmonary hypertension in patients with limited and diffuse scleroderma. DESIGN:Prospective cross-sectional study. SETTING:University-based outpatient clinic. PATIENTS:Thirty-four consecutive patients with limited (n = 29) or diffuse (n = 5) scleroderma but without the clinical diagnosis of pulmonary hypertension. MEASUREMENTS AND RESULTS:All patients had 12-lead ECGs and two-dimensional and Doppler echocardiograms. The pulmonary artery systolic pressure (PAs) was calculated as the sum of the Doppler transtricuspid pressure gradient and the right atrial pressure as estimated by the caval respiratory index. Thirty-three patients (97%) had adequate spectral signals of tricuspid regurgitation. The velocity of tricuspid regurgitation ranged from 1.6 to 4.5 m/s. The calculated PAs ranged from 15 to 95 (mean +/- SD = 30 +/- 14 mm Hg). Twelve patients (35% of the total cohort) had pulmonary hypertension defined as PAs of 30 mm Hg or greater. CONCLUSIONS:Undiagnosed elevation of PAs is common in patients with scleroderma. Noninvasive assessment of PAs can be performed accurately in most patients independent of clinical signs of pulmonary hypertension. If successful treatment strategies are identified, it may be possible to identify patients early in the development of pulmonary hypertension and intervene before significant end-organ damage occurs.
journal_name
Chestjournal_title
Chestauthors
Battle RW,Davitt MA,Cooper SM,Buckley LM,Leib ES,Beglin PA,Tischler MDdoi
10.1378/chest.110.6.1515subject
Has Abstractpub_date
1996-12-01 00:00:00pages
1515-9issue
6eissn
0012-3692issn
1931-3543pii
S0012-3692(15)46596-1journal_volume
110pub_type
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