Phospholipid biosynthesis: the activity of phosphatidic acid phosphohydrolase in the developing lung and amnionic fluid.

Abstract:

:The presented data suggest that PAPase may, indeed, be important in the biosynthesis of lung phospholipids. The observed increase in the specific activity of rabbit lung precedes the "surge" of phosphatidylcholine concentration and surfactant biosynthesis by at least 24 hours. In human amnionic fluid, PAPase specific activity was markedly increased in pregnancies of 35 weeks of gestation or more. The increase in the specific activity of PAPase preceded the "surge" of acetone precipitated phosphatidylcholine. The reported studies may provide an additional procedure to examine the problems associated with surfactant biosynthesis.

journal_name

Chest

journal_title

Chest

authors

Johnston JM,Schultz M,Jimenez JM,MacDonald PC

doi

10.1378/chest.67.2.18s

subject

Has Abstract

pub_date

1975-02-01 00:00:00

pages

18S-21S

issue

2 Suppl

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)53070-5

journal_volume

67

pub_type

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