Abstract:
STUDY OBJECTIVE:Our objective was to compare the efficacy of ultrahigh frequency ventilation (UHFV) (frequencies > 3 Hz) with respect to oxygenation, airway pressures, and hemodynamic parameters in patients with adult respiratory distress syndrome (ARDS) who were not responding to conventional ventilation. DESIGN:We used a prospective, multicenter, nonrandomized study design in which each patient served as his own control. SETTING:Three university-affiliated, tertiary-care medical centers participated. PATIENTS:Persons aged 16 to 79 years old with ARDS and unresponsive to conventional ventilation, as defined by a Food and Drug Administration (FDA) approved protocol, were included. INTERVENTIONS:Ninety patients who were not responding to conventional ventilation were changed to UHFV using a microcomputer-controlled device. MEASUREMENTS AND RESULTS:The patient's blood gas, hemodynamic, and airway pressure variables were measured just before, and at 1 and 24 h after the switch to UHFV. We demonstrated clinically significant improvements in arterial oxygen tension (PaO2) and reductions in peak and mean inspiratory pressures. CONCLUSIONS:In a multicenter study, UHFV improved respiratory gas exchange and reduced airway pressure variables at both 1 h and 24 h after the onset of UHFV when compared with conventional ventilation just prior to the change and without hemodynamic deterioration, in patients with severe ARDS.
journal_name
Chestjournal_title
Chestauthors
Gluck E,Heard S,Patel C,Mohr J,Calkins J,Fink MP,Landow Ldoi
10.1378/chest.103.5.1413subject
Has Abstractpub_date
1993-05-01 00:00:00pages
1413-20issue
5eissn
0012-3692issn
1931-3543pii
S0012-3692(15)41957-9journal_volume
103pub_type
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