The induction of ventricular arrhythmias in acute myocardial ischemia by atrial pacing with long-short cycle sequences.

Abstract:

:Recent studies emphasize the importance of heart rate in the genesis of ventricular arrhythmias during myocardial ischemia. The role of alterations in rhythm has not previously been systematically investigated. In 20 dogs subjected to acute myocardial ischemia and crushing of the sinus node, standard electrocardiographic leads were recorded, as well as His bundle and epicardial electrograms from the normal and ischemic areas. Abrupt pauses in regular atrial pacing did not cause arrhythmias prior to the onset of ischemia; however, during ischemia, atrial pacing with intermittent abrupt pauses resulted in the induction of ventricular arrhythmias beginning after the second conducted beat following each pause (ventricular premature beats, 20/20; ventricular tachycardia, 19/20; and ventricular fibrillation, 8/20). Onset of the arrhythmia was associated with increased delay in activation of ischemic epicardium and fractionation of the electrogram potential of the second conducted impulse. Typical Gouaux-Ashman phenomenon was an incidental observation. Unlike the Gouaux-Ashman phenomenon, which is restricted to the His-Purkinje system, the phenomenon we observed orginated within ischemic myocardium. In vitro studies indicate that the underlying mechanism may be related to postrepolarization refractoriness induced by ischemia.

journal_name

Chest

journal_title

Chest

authors

Hope RR,Lazzara R,Scherlag BJ

doi

10.1378/chest.71.5.651

subject

Has Abstract

pub_date

1977-05-01 00:00:00

pages

651-8

issue

5

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(16)40560-X

journal_volume

71

pub_type

杂志文章

相关文献

CHEST文献大全
  • How should we measure arm exercise capacity in patients with COPD? A systematic review.

    abstract:BACKGROUND:There are no recommendations on how to measure arm exercise capacity in individuals with COPD. The objectives of this study were (1) to synthesize the literature on measures of arm exercise capacity in individuals with COPD, (2) to describe the psychometric properties and the target construct of each measure...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.11-0475

    authors: Janaudis-Ferreira T,Beauchamp MK,Goldstein RS,Brooks D

    更新日期:2012-01-01 00:00:00

  • Vasoconstrictor effects of angiotensin II on the pulmonary vascular bed.

    abstract::The systemic pressor effects of angiotensin II (ANGII) are well described, whereas relatively little is known regarding its effects on the pulmonary circulation in humans. Doppler echocardiographic measurements were performed in eight normal volunteers after a 30-min control infusion (baseline), after sequential 30 mi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.5.1360

    authors: Lipworth BJ,Dagg KD

    更新日期:1994-05-01 00:00:00

  • Current approach to the diagnosis of acute nonmassive pulmonary embolism.

    abstract::Pulmonary embolism is a common and potentially lethal disease. Given the variable presentation and associated morbidity of this condition, an accurate and efficient diagnostic algorithm is required. Clinical pretest probability serves as the root of any diagnostic approach. We, thus, review several clinical decision r...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.10-2468

    authors: Moores LK,King CS,Holley AB

    更新日期:2011-08-01 00:00:00

  • The undervaluation of evaluation and management professional services: the lasting impact of current procedural terminology code deficiencies on physician payment.

    abstract::The Resource-Based Relative Value Scale (RBRVS) is fundamentally undermined by the following foundational errors: (1) The full range of office-based evaluation and management (E/M) activities are not captured by the Current Procedural Terminology (CPT) code choices, (2) it places relatively high values on procedural s...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.13-0381

    authors: Kumetz EA,Goodson JD

    更新日期:2013-09-01 00:00:00

  • Myocardial thickening in children with acute myocarditis.

    abstract::Two-dimensional echocardiography showed myocardial thickening in 3 of 16 acute myocarditis patients in childhood. In all 3 cases, this myocardial thickening was transient and diminished within 3 weeks. This myocardial thickening was most marked at a few days after the onset; the interventricular septal thickness for e...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.6.1676

    authors: Nakagawa M,Hamaoka K

    更新日期:1993-12-01 00:00:00

  • Effect of mechanical ventilation on hepatic drug pharmacokinetics.

    abstract::Mechanical ventilation was able to induce a decrease in cardiac output and regional blood flow, especially hepatic flow. Thus, hepatic elimination of drugs with a high hepatic-extraction ratio, which was linked to alteration in hepatic blood flow, could be reduced during mechanical ventilation. The aim of this work wa...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.90.6.837

    authors: Richard C,Berdeaux A,Delion F,Riou B,Rimailho A,Giudicelli JF,Auzépy P

    更新日期:1986-12-01 00:00:00

  • Cholesterol in pleural effusions. A diagnostic aid.

    abstract::In this prospective study of 70 patients with pleural effusion, the underlying disease could be identified in 62 cases. By predefined criteria, 31 of these effusions were classified as transudates and 31 as exudates. Pleural fluid protein content, LDH activity and cholesterol level were measured to investigate their u...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.2.296

    authors: Hamm H,Brohan U,Bohmer R,Missmahl HP

    更新日期:1987-08-01 00:00:00

  • Hypoxic activation of adventitial fibroblasts: role in vascular remodeling.

    abstract::Substantial experimental evidence supports the idea that the fibroblast may play a significant role in the vascular response to injury, especially under hypoxic conditions. Fibroblasts have the ability to rapidly respond to hypoxic stress and to modulate their function to adapt rapidly to local vascular needs. Fibrobl...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.122.6_suppl.326s

    authors: Stenmark KR,Gerasimovskaya E,Nemenoff RA,Das M

    更新日期:2002-12-01 00:00:00

  • Differential diagnostic value of plasma cells in bronchoalveolar lavage fluid.

    abstract::The aim of this study was to investigate whether the demonstration of plasma cells (PC), which are normally absent in bronchoalveolar lavage (BAL) fluid, facilitates differentiation among pulmonary disorders. Initial BAL fluid samples of 1,260 patients were analyzed. In 83 of these, PC were found. Of these 83, 47 were...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.103.6.1720

    authors: Drent M,van Velzen-Blad H,Diamant M,Wagenaar SS,Donckerwolck-Bogaert M,van den Bosch JM

    更新日期:1993-06-01 00:00:00

  • Idiopathic hypereosinophilic syndrome-related pulmonary involvement diagnosed by bronchoalveolar lavage.

    abstract::Patients with HES and pulmonary infiltrates may pose certain diagnostic problems as the infiltrates may be attributed to infection, infarction, congestive heart failure, or HES itself. We report an 87-year-old woman with idiopathic HES presenting with bibasal alveolar infiltrates. Differential cell count in BAL fluid ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.101.4.1178

    authors: Slabbynck H,Impens N,Naegels S,Dewaele M,Schandevyl W

    更新日期:1992-04-01 00:00:00

  • The impact of new-onset atrial fibrillation on in-hospital mortality following cardiac surgery.

    abstract:BACKGROUND:The impact of new-onset postoperative atrial fibrillation (NAF) on in-hospital mortality (IHM) following cardiac surgery is unknown. METHODS:All patients without preoperative atrial fibrillation undergoing isolated coronary artery bypass graft surgery (CABG) and concomitant CABG and valve surgery were ident...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-0735

    authors: Kalavrouziotis D,Buth KJ,Ali IS

    更新日期:2007-03-01 00:00:00

  • Development and Validation of an Improved, COPD-Specific Version of the St. George Respiratory Questionnaire.

    abstract:OBJECTIVE:To produce an improved, COPD-specific version of the St. George respiratory questionnaire (SGRQ-C). METHODS:Five different steps were required: (1) Rasch analysis of the responses of 893 COPD patients to the St. George respiratory questionnaire (SGRQ) identified weaker items to be removed; (2) a scoring algo...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.06-0702

    authors: Meguro M,Barley EA,Spencer S,Jones PW

    更新日期:2007-08-01 00:00:00

  • Lipid mediator dysregulation in primary pulmonary hypertension.

    abstract::The characteristic arteriopathy of primary pulmonary hypertension (PPH) with attendant endothelial dysfunction provides an opportunity for enhanced cellular activation in the lung. Data from many laboratories support the concept of altered eicosanoid metabolism in PPH. Rigorously quantitative measurements of the excre...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.114.3_supplement.205s

    authors: Christman BW

    更新日期:1998-09-01 00:00:00

  • Continuous Fick cardiac output measurement during exercise by monitoring of mixed venous oxygen saturation and oxygen uptake.

    abstract::To determine whether continuous Fick cardiac output measurement is applicable to exercise testing, cardiac output data obtained by the continuous Fick method (Qcf) during exercise were compared with data obtained by the thermodilution method (Qth). Seventeen patients with old myocardial infarction underwent a 1-min or...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.2.419

    authors: Nakanishi N,Yoshioka T,Okano Y,Nishimura T

    更新日期:1993-08-01 00:00:00

  • Bilateral proximal pulmonary artery aneurysms simulating hilar adenopathy.

    abstract::Proximal pulmonary artery aneurysms (PAAs) are rare. Most are associated with secondary pulmonary hypertension or a variety of rare systemic disorders. An asymptomatic adult patient presented with bilateral hilar enlargement on a routine chest roentgenogram. Computed tomography of the chest revealed 5 cm bilateral pro...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.1.311

    authors: Girgis R,Kavuru MS,Miller M,Spizarny D

    更新日期:1992-07-01 00:00:00

  • Idiopathic Pulmonary Fibrosis: Prospective, Case-Controlled Study of Natural History and Circulating Biomarkers.

    abstract:BACKGROUND:Idiopathic pulmonary fibrosis (IPF) is a fatal lung disease with 3 to 5 years' survival. Although FVC is used to assess disease progression and treatment response, identifying predictive circulating blood biomarkers could help identify specific biologic pathways for treatment. An international, prospective, ...

    journal_title:Chest

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.chest.2018.08.1083

    authors: Raghu G,Richeldi L,Jagerschmidt A,Martin V,Subramaniam A,Ozoux ML,Esperet CA,Soubrane C

    更新日期:2018-12-01 00:00:00

  • Health-related quality of life of persons with sarcoidosis.

    abstract:STUDY OBJECTIVES:To describe the health-related quality of life (HRQL) and mental health of persons with sarcoidosis, as well as to assess physician-patient agreement about the presence of sarcoidosis symptoms. DESIGN AND SETTING:Cross-sectional study at three university medical center outpatient pulmonary clinics. P...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.125.3.997

    authors: Cox CE,Donohue JF,Brown CD,Kataria YP,Judson MA

    更新日期:2004-03-01 00:00:00

  • A 62-Year-Old Woman With Diffuse Myalgias, Fatigue, and Shortness of Breath.

    abstract:CASE PRESENTATION:A 62-year-old woman with a history of partially treated Graves disease and hypertension presented with approximately 3 weeks of worsening fatigue, lower extremity myalgias, and shortness of breath. Her medical history included a thyroid radiofrequency ablation several years earlier. Following the abla...

    journal_title:Chest

    pub_type:

    doi:10.1016/j.chest.2019.09.041

    authors: Park BD,Lyn-Kew K,Granchelli A,Mehta A

    更新日期:2020-03-01 00:00:00

  • Candida colonization of the respiratory tract and subsequent pseudomonas ventilator-associated pneumonia.

    abstract:BACKGROUND:Recovery of Candida from the respiratory tract of a critically ill patient receiving mechanical ventilation (MV) usually indicates colonization rather than infection of the respiratory tract. However, interactions between Candida and bacteria, particularly Pseudomonas, have been reported. Thus, Candida colon...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.129.1.110

    authors: Azoulay E,Timsit JF,Tafflet M,de Lassence A,Darmon M,Zahar JR,Adrie C,Garrouste-Orgeas M,Cohen Y,Mourvillier B,Schlemmer B,Outcomerea Study Group.

    更新日期:2006-01-01 00:00:00

  • Patient-focused care: using the right tools.

    abstract::Patient-focused or patient-centered care is not a new concept, but its value has been overlooked in preference to the technology-based, disease-centered model that has prevailed in medicine for the last 50 years. Patient-focused care includes four broad areas of intervention: communication with patients, partnerships,...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.130.1_suppl.73S

    authors: Irwin RS,Richardson ND

    更新日期:2006-07-01 00:00:00

  • Takayasu's arteritis associated with interstitial lung disease and glomerulonephritis.

    abstract::Takayasu's arteritis is a vasculitis characterized by inflammation and obliteration of large- and medium-sized arteries and has not been previously associated with interstitial pulmonary fibrosis. A patient with Takayasu's arteritis was shown to have interstitial pulmonary fibrosis and mesangial glomerulonephritis, su...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.89.4.605

    authors: Greene NB,Baughman RP,Kim CK

    更新日期:1986-04-01 00:00:00

  • Pitfalls in diagnosis and clinical, echocardiographic, and hemodynamic findings in endomyocardial fibrosis: a 25-year experience.

    abstract::Endomyocardial fibrosis (EMF) is a fascinating disease entity of unknown etiology. It is prevalent in the tropical zone. Its essential features are the formation of fibrous tissue on the endocardium and to a lesser extent in the myocardium of the inflow tract and apex of one or both ventricles. It results in endocardi...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.128.6.3985

    authors: Hassan WM,Fawzy ME,Al Helaly S,Hegazy H,Malik S

    更新日期:2005-12-01 00:00:00

  • Clinical efficacy of doxycycline for pleurodesis.

    abstract::To determine the efficacy of doxycycline as a pleural sclerosing agent, we examined the outcomes in 31 patients (aged 31 to 87 years) receiving doxycycline (500 to 1,000 mg) through a chest tube for malignant pleural effusions or persistent bronchopleural fistulae. Of the 27 patients with malignant pleural effusions, ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.105.6.1743

    authors: Heffner JE,Standerfer RJ,Torstveit J,Unruh L

    更新日期:1994-06-01 00:00:00

  • The therapeutic potential of nitric oxide in lung transplantation.

    abstract::Endogenously produced oxides of nitrogen appear to play important roles in tissue and organ homeostasis. Endogenous production of nitric oxide, which can be altered in response to various stimuli, can modulate vascular tone, oxyradical cascades, cell adhesion, and other aspects of inflammation. Because exogenously adm...

    journal_title:Chest

    pub_type: 杂志文章,评审

    doi:10.1378/chest.113.5.1360

    authors: Meyer KC,Love RB,Zimmerman JJ

    更新日期:1998-05-01 00:00:00

  • Pitolisant for Residual Excessive Daytime Sleepiness in OSA Patients Adhering to CPAP: A Randomized Trial.

    abstract:BACKGROUND:Excessive daytime sleepiness (EDS) in individuals with OSA syndrome persisting despite good adherence to CPAP is a disabling condition. Pitolisant is a selective histamine H3-receptor antagonist with wake-promoting effects. RESEARCH QUESTION:Is pitolisant effective and safe for reducing daytime sleepiness i...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1016/j.chest.2020.09.281

    authors: Pépin JL,Georgiev O,Tiholov R,Attali V,Verbraecken J,Buyse B,Partinen M,Fietze I,Belev G,Dokic D,Tamisier R,Lévy P,Lecomte I,Lecomte JM,Schwartz JC,Dauvilliers Y,HAROSA I Study Group.

    更新日期:2020-10-26 00:00:00

  • Work disability among adults with asthma.

    abstract:OBJECTIVE:To estimate the incidence of work disability among adults with asthma and to evaluate a clinically based illness severity score as a predictor of such disability. DESIGN:Baseline and follow-up telephone interviews and medical record review. SETTING:University-based outpatient pulmonary specialty practice. ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.5.1371

    authors: Blanc PD,Jones M,Besson C,Katz P,Yelin E

    更新日期:1993-11-01 00:00:00

  • Prolonged myocardial ischemia after intravenous dipyridamole thallium imaging.

    abstract::Intravenous dipyridamole thallium imaging is reported to be a safe test with minimal side effects. It has been proposed by some that the test simply dilates the coronary vessels without actually producing myocardial ischemia. In this report, we describe a patient who, following intravenous dipyridamole thallium imagin...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.92.6.1102

    authors: Lewen MK,Labovitz AJ,Kern MJ,Chaitman BR

    更新日期:1987-12-01 00:00:00

  • Preflight medical screenings of patients. Analysis of health and flight characteristics.

    abstract::We evaluated the demographic, medical, and flight characteristics of 1,115 passengers who were routinely referred for preflight medical screening by a major domestic air carrier. The largest category consisted of 892 patients who requested in-flight oxygen therapy for cardiopulmonary conditions, of which COPD and card...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.104.3.788

    authors: Gong H Jr,Mark JA,Cowan MN

    更新日期:1993-09-01 00:00:00

  • Lung cancer and pleural effusion. Clinical significance and study of pleural metastatic locations.

    abstract::We reviewed results of 78 diagnostic thoracoscopic examinations of patients with lung cancer and homolateral pleural effusion. The study stresses the main locations of pleural metastasis in cases of lung cancer and correlates these data with the pleural spread from extrathoracic primary neoplasms. Also pointed out is ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.87.5.649

    authors: Cantó A,Ferrer G,Romagosa V,Moya J,Bernat R

    更新日期:1985-05-01 00:00:00

  • Short- and long-term hemodynamic effects of captopril in patients with pulmonary hypertension and selected connective tissue disease.

    abstract::To assess the pulmonary and systemic hemodynamic effects of oral captopril in patients with connective tissue disease and pulmonary hypertension, we performed right heart catheterization in eight patients with diffuse systemic sclerosis, the CREST syndrome, or mixed connective tissue diseases prior to and immediately ...

    journal_title:Chest

    pub_type: 杂志文章

    doi:10.1378/chest.102.5.1407

    authors: Alpert MA,Pressly TA,Mukerji V,Lambert CR,Mukerji B

    更新日期:1992-11-01 00:00:00