Clinical efficacy of doxycycline for pleurodesis.

Abstract:

:To determine the efficacy of doxycycline as a pleural sclerosing agent, we examined the outcomes in 31 patients (aged 31 to 87 years) receiving doxycycline (500 to 1,000 mg) through a chest tube for malignant pleural effusions or persistent bronchopleural fistulae. Of the 27 patients with malignant pleural effusions, 21 patients had a complete short-term response (no fluid reaccumulation during the initial hospitalization); 5 of the 6 short-term nonresponders had partial control of effusions, with improvement in respiratory symptoms. Of the 23 patients who survived longer than 1 month, 15 patients did not have reaccumulation of fluid during follow-up. All four patients with persistent bronchopleural fistulae had resolution of their air leaks; one patient had recurrence with a partial pneumothorax. Pleural pain controllable with narcotic therapy was the only important complication. Thus, doxycycline is a suitable substitute for tetracycline as a pleural sclerosing agent.

journal_name

Chest

journal_title

Chest

authors

Heffner JE,Standerfer RJ,Torstveit J,Unruh L

doi

10.1378/chest.105.6.1743

subject

Has Abstract

pub_date

1994-06-01 00:00:00

pages

1743-7

issue

6

eissn

0012-3692

issn

1931-3543

pii

S0012-3692(15)44085-1

journal_volume

105

pub_type

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