Short- and long-term hemodynamic effects of captopril in patients with pulmonary hypertension and selected connective tissue disease.


:To assess the pulmonary and systemic hemodynamic effects of oral captopril in patients with connective tissue disease and pulmonary hypertension, we performed right heart catheterization in eight patients with diffuse systemic sclerosis, the CREST syndrome, or mixed connective tissue diseases prior to and immediately following administration of captopril (dose range 12.5 to 50.0 mg, short-term study). Four of these patients underwent repeat right heart catheterization after three to six months of oral captopril therapy (long-term study). In the short-term study, oral captopril produced a significant decrease in mean pulmonary vascular resistance from 6.2 +/- 3.6 to 4.6 +/- 3.8 units (p < 0.01). This was accompanied by a significant decrease in mean pulmonary artery pressure, mean blood pressure, mean systemic vascular resistance and a significant increase in cardiac output. Similar changes in pulmonary hemodynamics were noted in the long-term study. Thus, oral captopril is capable of producing an acute and sustained reduction in pulmonary vascular resistance in patients with pulmonary hypertension associated with the aforementioned connective tissue diseases.






Alpert MA,Pressly TA,Mukerji V,Lambert CR,Mukerji B




Has Abstract


1992-11-01 00:00:00
















  • Respiratory failure due to pulmonary lymphangitis carcinomatosis.

    abstract::A man with primary lung cancer developed respiratory failure due to lymphangitis carcinomatosis that was diagnosed by transbronchial lung biopsy specimen. After combination chemotherapy with high-dose etoposide and cisplatin (CDDP), he was able to cease oxygen therapy and showed improvement of his lymphangitis carcino...


    pub_type: 杂志文章


    authors: Fujita J,Yamagishi Y,Kubo A,Takigawa K,Yamaji Y,Takahara J

    更新日期:1993-03-01 00:00:00

  • Transition from exercise to rest. Ventilatory and arterial blood gas responses.

    abstract::The mechanisms leading to rapid changes in arterial blood gas values soon after exercise ends have not been well established. To further study these phenomena, we exercised seven normal male volunteers to exhaustion on a cycle ergometer with a 25-W/min ramped protocol measuring arterial blood gas values, and breath-by...


    pub_type: 杂志文章


    authors: O'Neill AV,Johnson DC

    更新日期:1991-05-01 00:00:00

  • Environmental tobacco smoke exposure during travel among adults with asthma.

    abstract:OBJECTIVES:In California, state law now prohibits smoking in most public places. We examined the prevalence and short-term health impact of environmental tobacco smoke (ETS) exposure during travel among adults with asthma. DESIGN, SETTING, AND PARTICIPANTS:A cohort of 374 nonsmoking adults with asthma recruited from a...


    pub_type: 杂志文章


    authors: Eisner MD,Blanc PD

    更新日期:2002-09-01 00:00:00

  • Noninvasive evaluation of instantaneous total mechanical activity of the respiratory muscles during pressure support ventilation.

    abstract:OBJECTIVE:The measurement of esophageal pressure (Pes) is the conventional method for the evaluation of the forces applied to the respiratory system by the respiratory muscles. As an alternative to Pes measurement, we propose the calculation of the instantaneous net pressure applied by the respiratory muscles [Pmusc(t)...


    pub_type: 临床试验,杂志文章,随机对照试验


    authors: Iotti GA,Braschi A,Brunner JX,Palo A,Olivei MC

    更新日期:1995-07-01 00:00:00

  • Antithrombotic therapy in atrial fibrillation: the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy.

    abstract::This chapter about antithrombotic therapy in atrial fibrillation (AF) is part of the Seventh ACCP Conference on Antithrombotic and Thrombolytic Therapy: Evidence Based Guidelines. Grade 1 recommendations are strong and indicate that the benefits do, or do not, outweigh risks, burden, and costs. Grade 2 suggests that i...


    pub_type: 指南,杂志文章,实务指引,评审


    authors: Singer DE,Albers GW,Dalen JE,Go AS,Halperin JL,Manning WJ

    更新日期:2004-09-01 00:00:00

  • Propofol-induced pancreatitis: recurrence of pancreatitis after rechallenge.

    abstract::We report a case of pancreatitis, which occurred while the patient was on a propofol drip and then recurred after resolution following an inadvertent rechallenge with propofol. The initial episode was associated with hypertriglyceridemia, whereas the latter was not. The association between propofol and pancreatitis is...


    pub_type: 杂志文章


    authors: Kumar AN,Schwartz DE,Lim KG

    更新日期:1999-04-01 00:00:00

  • Recombinant interferon alpha-2b in the management of malignant pleural effusions.

    abstract::Twenty-one patients with malignant pleural effusion (MPE) were prospectively entered into a nonrandomized, single-armed study to evaluate the efficacy and safety of recombinant interferon (IFN) alpha-2b (INTRON A; Schering-Plough; Kenilworth, NJ) as an intrapleural palliative agent. From March 1989 through February 19...


    pub_type: 临床试验,杂志文章


    authors: Wilkins HE 3rd,Connolly MM,Grays P,Marquez G,Nelson D

    更新日期:1997-06-01 00:00:00

  • Self-expanding stents in the treatment of tracheobronchial obstruction.

    abstract::The self-expandable stainless steel stents (Gianturco, William Cook, Bjaeverskov, Denmark) used extensively in biliary ducts and the vascular system have recently been modified for use in the tracheobronchial tree. Between March 1991 and September 1992, six patients with unresectable tracheobronchial and mediastinal d...


    pub_type: 杂志文章


    authors: Zannini P,Melloni G,Chiesa G,Carretta A

    更新日期:1994-07-01 00:00:00

  • Resection of pulmonary blebs and pleurodesis for spontaneous pneumothorax.

    abstract::Over a 20-year period, 83 patients underwent operative pleurodesis with resection of pulmonary blebs for spontaneous pneumothorax. Follow-up for all patients was between 5 and 25 years, with a mean of 9.1 years. There were five early (5.6 percent) and three late recurrences (3.6 percent). There were no deaths or need ...


    pub_type: 杂志文章


    authors: Donahue DM,Wright CD,Viale G,Mathisen DJ

    更新日期:1993-12-01 00:00:00

  • Fibrosing alveolitis, bronchiolitis obliterans, and sulfasalazine therapy.

    abstract::A patient with ulcerative colitis had extensive upper zone pulmonary disease while taking sulfasalazine. Pulmonary function tests showed progressive restrictive and obstructive disease. Lung biopsy showed bronchiolitis obliterans and chronic interstitial pneumonia or fibrosing alveolitis with a mild eosinophilic infil...


    pub_type: 杂志文章


    authors: Williams T,Eidus L,Thomas P

    更新日期:1982-06-01 00:00:00

  • Dynamics of left ventricular diastolic filling during exercise: a Doppler echocardiographic study of boys 10 to 14 years old.

    abstract:STUDY OBJECTIVE:Factors influencing diastolic filling of the left ventricle may serve as critical determinants of both maximal cardiac output and oxygen uptake. This study was conducted to assess diastolic filling dynamics of the left ventricle during progressive upright cycle exercise in children. METHODS:Twelve boys...


    pub_type: 杂志文章


    authors: Rowland T,Mannie E,Gawle L

    更新日期:2001-07-01 00:00:00

  • Pericarditis with effusion casued by Actinomyces israelii.

    abstract::Actinomyces israelii is a rare cause of pericarditis. Infection spreads to pericardium from an intrathoracic focus. Branching gram-positive filaments are seen on microscopic examination of clinical specimens. Cultures should be performed under anaerobic conditions. Both surgical drainage and antibiotics (penicillin) a...


    pub_type: 杂志文章


    authors: Schlossberg D,Franco-Jove D,Woodward C,Shulman J

    更新日期:1976-05-01 00:00:00

  • Single-nucleotide polymorphisms and lung disease: clinical implications.

    abstract::Human genetic variation has enormous implications for individual susceptibility to lung disease, as well as for differences in prognosis and response to therapeutic interventions. Single-nucleotide polymorphisms (SNPs) are the most common type of DNA sequence variation. An SNP is the substitution of a single base in t...


    pub_type: 杂志文章,评审


    authors: Tebbutt SJ,James A,Paré PD

    更新日期:2007-04-01 00:00:00

  • Cardiopulmonary exercise testing in children: an individualized protocol for workload increase.

    abstract:OBJECTIVES:To investigate the feasibility of individualized workload increments, as used in adults, for exercise testing in children; and to investigate whether this individualized protocol makes it possible to satisfy the usual criteria for maximal exercise (clinical exhaustion, predicted maximum heart rate [HRmax], o...


    pub_type: 杂志文章


    authors: Karila C,de Blic J,Waernessyckle S,Benoist MR,Scheinmann P

    更新日期:2001-07-01 00:00:00

  • Idiopathic bronchiolitis obliterans with organizing pneumonia. An acute and life-threatening syndrome.

    abstract::Idiopathic bronchiolitis obliterans with organizing pneumonia (BOOP) is a clinicopathologic syndrome characterized by an indolent course and favorable prognosis. This report describes five patients with a fulminating and life-threatening variant of this syndrome. Four patients presented with respiratory failure requir...


    pub_type: 杂志文章


    authors: Nizami IY,Kissner DG,Visscher DW,Dubaybo BA

    更新日期:1995-07-01 00:00:00

  • FVC to slow inspiratory vital capacity ratio: a potential marker for small airways obstruction.

    abstract:BACKGROUND:The ratio of FVC to slow inspiratory vital capacity (SVC) has been reported to reflect small airways obstruction, but its validity as such is still unclear. The aim of this study was to assess the applicability of the FVC/SVC ratio as a marker of small airways function in patients with bronchiolitis oblitera...


    pub_type: 杂志文章


    authors: Cohen J,Postma DS,Vink-Klooster K,van der Bij W,Verschuuren E,Ten Hacken NH,Koëter GH,Douma WR

    更新日期:2007-10-01 00:00:00

  • Prolonged reversible quadriparesis in mechanically ventilated patients who received long-term infusions of vecuronium.

    abstract::The use of neuromuscular blocking agents, particularly pancuronium, in patients receiving mechanical ventilation has been reported to cause prolonged paralysis and atrophy. We describe two mechanically ventilated patients with asthma who developed prolonged muscular weakness and atrophy after receiving the shorter-act...


    pub_type: 杂志文章


    authors: Margolis BD,Khachikian D,Friedman Y,Garrard C

    更新日期:1991-09-01 00:00:00

  • Complete obstruction of the left main coronary artery associated with congenital pulmonary valvular stenosis.

    abstract::The surgical treatment of the completely obstructed left main coronary artery is aortocoronary saphenous-vein bypass to the left coronary artery system. Without surgical intervention, this lesion has an exceedingly poor prognosis. This report describes a patient with atherosclerotic obstruction of the left main corona...


    pub_type: 杂志文章


    authors: Sutherland RD,Allison W,Guynes WA,Martinez HE

    更新日期:1976-02-01 00:00:00

  • Treadmill endurance during 2-year treatment with tiotropium in patients with COPD: a randomized trial.

    abstract:BACKGROUND:Disease progression in COPD is associated with a decline in exercise performance over time. We assessed whether tiotropium might mitigate this by determining its effect on treadmill endurance time (ET) over 2 years. METHODS:This was a randomized, double-blind, placebo-controlled trial of tiotropium, 18 μg d...


    pub_type: 杂志文章,随机对照试验


    authors: Cooper CB,Celli BR,Jardim JR,Wise RA,Legg D,Guo J,Kesten S

    更新日期:2013-08-01 00:00:00

  • Infarcted extralobar pulmonary sequestration.

    abstract::A 32-year-old man who presented with symptoms suggesting empyema was found at thoracotomy to have infarction of an extralobar pulmonary sequestration. He was completely relieved by excision of the sequestration after securing the systemic vascular pedicle which had undergone torsion. Recognition of the anomalous blood...


    pub_type: 杂志文章


    authors: Maull KI,McElvein RB

    更新日期:1975-07-01 00:00:00

  • Lipid mediator dysregulation in primary pulmonary hypertension.

    abstract::The characteristic arteriopathy of primary pulmonary hypertension (PPH) with attendant endothelial dysfunction provides an opportunity for enhanced cellular activation in the lung. Data from many laboratories support the concept of altered eicosanoid metabolism in PPH. Rigorously quantitative measurements of the excre...


    pub_type: 杂志文章,评审


    authors: Christman BW

    更新日期:1998-09-01 00:00:00

  • Pasteurella multocida pneumonia in a man with AIDS and nontraumatic feline exposure.

    abstract::A case of acute pneumonia due to Pasteurella multocida ssp multocida occurred in a young man with AIDS and chronic sinusitis. The pneumonia was diagnosed by bronchoscopy and responded to treatment with aztreonam. Epidemiologic investigation revealed the case was temporally related to nontraumatic exposure to cat secre...


    pub_type: 杂志文章


    authors: Drabick JJ,Gasser RA Jr,Saunders NB,Hadfield TL,Rogers LC,Berg BW,Drabick CJ

    更新日期:1993-01-01 00:00:00

  • Comparative Effectiveness and Safety of LABA-LAMA vs LABA-ICS Treatment of COPD in Real-World Clinical Practice.

    abstract:BACKGROUND:Long-acting β2-agonists (LABAs) and long-acting muscarinic antagonists (LAMAs) are recommended as initial maintenance treatments for COPD, with their combination (LABA-LAMA) advocated as the disease progresses. Randomized trials comparing the effectiveness of this combination with the alternative combination...


    pub_type: 杂志文章


    authors: Suissa S,Dell'Aniello S,Ernst P

    更新日期:2019-06-01 00:00:00

  • Value of Doppler index combining systolic and diastolic myocardial performance in predicting cardiopulmonary exercise capacity in patients with congestive heart failure: effects of dobutamine.

    abstract:STUDY OBJECTIVE:Doppler-derived myocardial performance index (MPI), a measure of combined systolic and diastolic myocardial performance, was assessed at rest and after low-dose dobutamine administration in patients with idiopathic or ischemic dilated cardiomyopathy. MPI also was correlated with other conventional echoc...


    pub_type: 杂志文章


    authors: Parthenakis FI,Kanakaraki MK,Kanoupakis EM,Skalidis EI,Diakakis GF,Filippou OK,Vardas PE

    更新日期:2002-06-01 00:00:00

  • Repetitive ventricular fibrillation preceded by both ST segment depression and elevation during acute myocardial ischemia.

    abstract::A patient had repetitive ventricular fibrillation preceded by alternating ST segment depression and elevation. The ECG changes were confined to the precordial leads only, reflecting subendocardial and transmural ischemia, respectively. It is speculated that the patient exhibited consecutive episodes of subtotal and to...


    pub_type: 杂志文章


    authors: Rechavia E,Sagie A,Kusniec J,Mager A,Sclarovsky S

    更新日期:1988-06-01 00:00:00

  • Pulmonary sequestration in the neonate.

    abstract::Pulmonary sequestration is a congenital anomaly resulting in nonfunctioning lung tissue in either the "extralobar" or "intralobar" position. Both forms derive their blood supply from the systemic circulation. Large pulmonary sequestrations can present in the newborn with potentially fatal respiratory distress. Surgica...


    pub_type: 杂志文章


    authors: Piccione W Jr,Burt ME

    更新日期:1990-01-01 00:00:00

  • Positive Kveim test in patients with coexisting sarcoidosis and human immunodeficiency virus infection.

    abstract::We present two cases of sarcoidosis complicated by HIV infection. Each case had a different level of sarcoidosis activity and coexisted with either an AIDS-related infection or a HIV-positive state. Manifestations of sarcoidosis were not apparent in the patient with the AIDS-defining opportunistic infection, but were ...


    pub_type: 杂志文章


    authors: Amin DN,Sperber K,Brown LK,Chusid ED,Teirstein AS

    更新日期:1992-05-01 00:00:00

  • Safety of inferior vena cava filter retrieval in anticoagulated patients.

    abstract:PURPOSES:To evaluate the safety of inferior vena cava (IVC) filter retrieval in therapeutically anticoagulated patients in comparison to prophylactically or not therapeutically anticoagulated patients with respect to retrieval-related hemorrhagic complications. MATERIALS AND METHODS:This was a retrospective study of 1...


    pub_type: 杂志文章


    authors: Hoppe H,Kaufman JA,Barton RE,Petersen BD,Lakin PC,Deloughery TG,Irani Z,Yavuz K,Keller FS

    更新日期:2007-07-01 00:00:00

  • Noninvasive positive-pressure ventilation: An experimental model to assess air and particle dispersion.

    abstract:BACKGROUND:Health-care workers are concerned about the risk of acquiring contagious diseases such as severe acute respiratory syndrome and avian influenza after recent outbreaks. We studied exhaled air and particle dispersion through an oronasal mask attached to a human-patient simulator (HPS) during noninvasive positi...


    pub_type: 杂志文章


    authors: Hui DS,Hall SD,Chan MT,Chow BK,Tsou JY,Joynt GM,Sullivan CE,Sung JJ

    更新日期:2006-09-01 00:00:00

  • Almitrine decreases the distensibility of the large pulmonary arteries in man.

    abstract::Almitrine improves blood gas values in patients with COPD, primarily through better ventilation-perfusion matching. The improvement comes largely from a vasomotor effect of the drug. The vasomotor mechanism is unknown. We suspected that decreased distensibility of the large pulmonary arteries was one probable effect o...


    pub_type: 杂志文章


    authors: Herve P,Musset D,Simonneau G,Wagner W Jr,Duroux P

    更新日期:1989-09-01 00:00:00