Radiation-enhanced differentiation of erythroid progenitor cells and its relation to reproductive cell death.

abstract：PURPOSE:A minority of patients exhibits severe late normal tissue toxicity after radiotherapy (RT), possibly related to their inherent individual radiation sensitivity. This study aimed to evaluate four different candidate in vitro cellular radiosensitivity assays for prediction of late normal tissue reactions, in a re...

journal_title：International journal of radiation biology

authors： Vandevoorde C,Depuydt J,Veldeman L,De Neve W,Sebastià N,Wieme G,Baert A,De Langhe S,Philippé J,Thierens H,Vral A

更新日期：2016-12-01 00:00:00

abstract：PURPOSE:To study the formation and subsequent reactions of the 5-methyl-2'-deoxycytidine cation radical (5-Me-2'-dC•(+)) in nucleosides and DNA-oligomers and compare to one-electron oxidized thymidine. MATERIALS AND METHODS:Employing electron spin resonance (ESR), cation radical formation and its reactions were invest...

journal_title：International journal of radiation biology

authors： Adhikary A,Kumar A,Palmer BJ,Todd AD,Heizer AN,Sevilla MD

更新日期：2014-06-01 00:00:00

abstract：PURPOSE:Immune cells accumulate in and around cancers and cooperate with each other using specific cytokines to attack the cancer cells. The heavy-ion beams for cancer therapy may stimulate immune cells and affect on the immune system. However, it is still poorly understood how the immune cells are stimulated by ion-be...

journal_title：International journal of radiation biology

authors： Mutou-Yoshihara Y,Funayama T,Yokota Y,Kobayashi Y

更新日期：2012-03-01 00:00:00

abstract：PURPOSE:Up to 90% of hereditary breast cancer cases are linked to germ-line mutations in one of the two copies of the BRCA1 or BRCA2 genes. Brca1 and Brca2 proteins are both involved in the cellular defence against DNA damage, although the precise function of the proteins is still not known. Some studies on a small num...

journal_title：International journal of radiation biology

authors： Nieuwenhuis B,Van Assen-Bolt AJ,Van Waarde-Verhagen MA,Sijmons RH,Van der Hout AH,Bauch T,Streffer C,Kampinga HH

更新日期：2002-04-01 00:00:00

abstract：:Intact Chinese hamster ovary cells were exposed to the restriction endonucleases (REs) AluI or BamHI. In metaphase spreads from these cells, 300 breakpoints per RE were localized in G-banded chromosome type aberrations (dicentrics, translocations, rings, terminal and interstitial deletions). The majority of breakpoint...

journal_title：International journal of radiation biology

authors： Folle GA,Obe G

更新日期：1995-10-01 00:00:00

abstract：:The chemical instability of DNA under physiological conditions requires that cells have highly developed processes for repairing stochastic single-strand damage. It is proposed here that provided ionizing-radiation-induced single-strand damage does not occur at a rate sufficient to perturb the dynamic steady state bet...

journal_title：International journal of radiation biology

authors： Baverstock KF

更新日期：1991-10-01 00:00:00

abstract：PURPOSE:To clarify the experimental conditions that might influence the release of cytokines in the culture medium and give some basic input for building a model for cytokine (e.g., Interleukin-6, IL-6) regulation in the case of 'sham irradiation' and after ionising radiation exposure. MATERIALS AND METHODS:The influe...

journal_title：International journal of radiation biology

authors： Facoetti A,Mariotti L,Ballarini F,Bertolotti A,Nano R,Pasi F,Ranza E,Ottolenghi A

更新日期：2009-08-01 00:00:00

abstract：:The effect of a siderophore analogue 3,4,3-LIHOPO has been investigated in rat after intramuscular injection of 238Pu, 239Pu and 241Am simulating puncture wounds. Various treatment regimens were used to remove the radioactivity from its injection site and to reduce its retention in body tissues. The local deposits cou...

journal_title：International journal of radiation biology

authors： Volf V,Burgada R,Raymond KN,Durbin PW

更新日期：1996-07-01 00:00:00

abstract：PURPOSE:Primary fibroblasts are not suitable for in vitro macrocolony assay due to their inability to form distinct colonies. Here we present a modification of agarose overlay that yielded extensive improvement in their colony formation and assessment of radiosensitivity. MATERIALS AND METHODS:Macrocolony formation wa...

journal_title：International journal of radiation biology

authors： Chandna S,Dagur RS,Mathur A,Natarajan AT,Harms-Ringdahl M,Haghdoost S

更新日期：2014-05-01 00:00:00

abstract：:Eelpout (Zoarces viviparus), a marine fish, were exposed to gamma-radiation at a dose-rate of 2.0 mGy h-1. They were injected with the antigen trinitrophenyl-keyhole limpet haemocyanin (TNP-KLH) and their specific humoral immune response to the TNP hapten measured. There were no differences in the primary antibody res...

journal_title：International journal of radiation biology

authors： Greenwood LN,Knowles JF

更新日期：1995-01-01 00:00:00

abstract：:A comparison has been made of the in vitro light-activated drug cytotoxicities of two different porphyrin compounds, Photofrin II and TPPS4. An early passage human colon adenocarcinoma cell line, WiDr, has been exposed to either drug for 24 h, the excess drug washed from the cells and the cells irradiated with light u...

journal_title：International journal of radiation biology

authors： West CM,Moore JV

更新日期：1988-10-01 00:00:00

abstract：PURPOSE:To investigate whether extremely low frequency electromagnetic field (ELF-EMF) exposure could induce oxidative stress in workers performing tour-inspection near transformers and distribution power lines. MATERIALS AND METHODS:Occupational short-term 'spot' measurements were performed. In total, 310 inspection ...

journal_title：International journal of radiation biology

authors： Li L,Xiong DF,Liu JW,Li ZX,Zeng GC,Li HL

更新日期：2015-05-01 00:00:00

abstract：:Studies of protein phosphorylation in the second cell cycle of mouse embryos were assessed by [32P]-incorporation and one- and two-dimensional electrophoresis. Unirradiated and X-irradiated embryos were compared. X-irradiation in the G2 phase led to a block in this cell cycle phase. The phosphorylation of proteins wit...

journal_title：International journal of radiation biology

authors： Jung T,Streffer C

更新日期：1991-09-01 00:00:00

abstract：:In a series of studies to investigate activation energies and thermal enhancements of various chemotherapeutic agents the effect of 5-fluoruracil (5FU), an antimetabolite, on murine tumour cells was studied at elevated temperatures. Animal tumours were early generation isotransplants of a spontaneous fibrosarcoma, FSa...

journal_title：International journal of radiation biology

authors： Urano M,Kahn J,Reynolds R

更新日期：1991-01-01 00:00:00

abstract：PURPOSE:The recent rapid increase of hadron therapy applications requires the development of high performance, reliable in vivo models for preclinical research on the biological effects of high linear energy transfer (LET) particle radiation. AIM:The aim of this paper was to test the relative biological effectiveness ...

journal_title：International journal of radiation biology

authors： Szabó ER,Reisz Z,Polanek R,Tőkés T,Czifrus S,Pesznyák C,Biró B,Fenyvesi A,Király B,Molnár J,Brunner S,Daroczi B,Varga Z,Hideghéty K

更新日期：2018-11-01 00:00:00

abstract：:Experimental data for acute radiation-induced skin reactions are reviewed. These show that for dose fractionation schedules with gaps, repopulation is initiated after a lag period. After this lag period, the isoeffective dose for a given level of skin reaction first increases rapidly, but then slows. The timing of the...

journal_title：International journal of radiation biology

authors： Hopewell JW,Nyman J,Turesson I

更新日期：2003-07-01 00:00:00

abstract：PURPOSE:To evaluate the radiomodulatory influence of a leaf extract of Mentha piperita (Linn) on hepatic antioxidant status and lipid peroxidation in Swiss albino mice. MATERIALS AND METHODS:Animals were given either double distilled water or leaf extract of M. piperita orally (1 g/kg bwt/day) once a day for three con...

journal_title：International journal of radiation biology

authors： Samarth RM,Panwar M,Kumar M,Kumar A

更新日期：2006-05-01 00:00:00

abstract：PURPOSE:RENEB, 'Realising the European Network of Biodosimetry and Physical Retrospective Dosimetry,' is a network for research and emergency response mutual assistance in biodosimetry within the EU. Within this extremely active network, a number of new dosimetry methods have recently been proposed or developed. There ...

journal_title：International journal of radiation biology

authors： Ainsbury E,Badie C,Barnard S,Manning G,Moquet J,Abend M,Antunes AC,Barrios L,Bassinet C,Beinke C,Bortolin E,Bossin L,Bricknell C,Brzoska K,Buraczewska I,Castaño CH,Čemusová Z,Christiansson M,Cordero SM,Cosler G,Mo

更新日期：2017-01-01 00:00:00

abstract：:One of the major goals of cancer research is to identify and understand the causes of cellular proliferation. The role of cell death, or lack thereof, in carcinogenesis, tumour growth, metastatic spread and response to treatment has been largely overlooked even though the morphology of apoptosis (programmed cell death...

journal_title：International journal of radiation biology

authors： Blank KR,Rudoltz MS,Kao GD,Muschel RJ,McKenna WG

更新日期：1997-05-01 00:00:00

abstract：:Purpose: To evaluate the antioxidant and radio-protective effects of Nigella sativa oil (NSO) and thymoquinone (TQ) on radiation-induced oxidative stress in brain tissue.Materials and methods: Fifty-four Sprague-Dawley rats were divided into six groups to test the radio-protective effectiveness of Nigella sativa oil a...

journal_title：International journal of radiation biology

authors： Demir E,Taysi S,Ulusal H,Kaplan DS,Cinar K,Tarakcioglu M

更新日期：2020-02-01 00:00:00

abstract：PURPOSE:Ukrain, an alkaloid thiophosphoric acid derivative of Chelidonium majus L., has demonstrated a promising impact on chemotherapy in a variety of malignancies. The effects of the drug on cell survival, alteration of the cell cycle and induction of apoptosis were examined without and in combination with ionizing r...

journal_title：International journal of radiation biology

authors： Cordes N,Plasswilm L,Bamberg M,Rodemann HP

更新日期：2002-01-01 00:00:00

abstract：:Most estimates of the radiation dose lethal to 50 per cent of a human population are based on historical data taken from well-known experiences reflecting inadequately known physical and biological conditions, or from medical procedures where individual patients received advantages of modern clinical care. It has been...

journal_title：International journal of radiation biology

authors： Morris MD,Jones TD

更新日期：1989-03-01 00:00:00

abstract：:Samples of human rib were collected at autopsy and 20 were selected for marrow fat cell measurement, representing an age range of 16-96 years. The mean diameter of fat cells in red bone marrow of human rib was found to increase from around 48 microns at ages 16-29 years to around 65 microns at ages 82-96 years. There ...

journal_title：International journal of radiation biology

authors： Allen JE,Henshaw DL,Keitch PA,Fews AP,Eatough JP

更新日期：1995-12-01 00:00:00

abstract：PURPOSE:A key enzyme of polyamine catabolism, spermidine/spermine N(1)-acetyltransferase (SSAT), is responsive to antiproliferative agents. The role of SSAT in cellular responses to X-ray irradiation was examined. MATERIALS AND METHODS:Exponentially growing HeLa S3 cells were irradiated by X-rays, and mRNA levels for ...

journal_title：International journal of radiation biology

authors： Mita K,Fukuchi K,Hamana K,Ichimura S,Nenoi M

更新日期：2004-05-01 00:00:00

abstract：PURPOSE:To examine the heat sensitivity of DNA-dependent protein kinase (DNA-PK) activity in a variety of cultured mouse, hamster and human cell lines. MATERIALS AND METHODS:Eight cell lines, which have been routinely used in our laboratory, were examined. Cells were heated at 44.0 +/- 0.05 degrees C and DNA-PK activi...

journal_title：International journal of radiation biology

authors： Umeda N,Matsumoto Y,Yin HL,Tomita M,Enomoto A,Morita A,Mizukoshi T,Sakai K,Hosoi Y,Suzuki N

更新日期：2003-08-01 00:00:00

abstract：:The effect of gamma-radiation on aqueous solutions of saturated phospholipids, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC), 1,2-dipalmitoyl-sn-glycero-3-phosphoglycerol (DPPG), 1-palmitoyl-2-lyso-sn-glycero-3-phosphocholine (lysoPC), and bovine brain sphingomyelin (SM) has been investigated. It is shown that th...

journal_title：International journal of radiation biology

authors： Edimecheva IP,Kisel MA,Shadyro OI,Vlasov AP,Yurkova IL

更新日期：1997-05-01 00:00:00

abstract：PURPOSE:To present details of the recent version of the 'Local Effect Model' (LEM), that has been developed and implemented in treatment planning for the ion beam therapy pilot project performed at GSI Helmholtzzentrum für Schwerionenforschung in Darmstadt, Germany. MATERIALS AND METHODS:The new version of the model i...

journal_title：International journal of radiation biology

authors： Friedrich T,Scholz U,Elsässer T,Durante M,Scholz M

更新日期：2012-01-01 00:00:00

abstract：PURPOSE:To obtain compounds that will effectively reduce the fixation of uranium in its main target organs: bone and kidney. There is an urgent need for a chelating agent that is suitable and available for human use. MATERIALS AND METHODS:The efficacy of ethane-1-hydroxy-1,1-bisphosphonate (EHBP), already in use as a ...

journal_title：International journal of radiation biology

authors： Henge-Napoli MH,Ansoborlo E,Chazel V,Houpert P,Paquet F,Gourmelon P

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:Since the number of cancer patients treated by proton irradiation has increased in the last few years, it seems appropriate to study dose-dependent effects of proton irradiation on mammalian tissues in more detail. MATERIALS AND METHODS:Tissue samples of normal skin of mouse and swine, of a human tumour model ...

journal_title：International journal of radiation biology

authors： Synytsya A,Alexa P,Besserer J,De Boer J,Froschauer S,Gerlach R,Loewe M,Moosburger M,Obstová I,Quicken P,Sosna B,Volka K,Würkner M

更新日期：2004-08-01 00:00:00

abstract：:It follows from the present work that the vascularization of the normal tissue present in the treatment volume limits the temperatures achieved during heat treatment of invasive ductal breast carcinoma. The temperatures can often be increased by giving fractionated heat treatment because heat treatment may reduce the ...

journal_title：International journal of radiation biology

authors： Lyng H,Monge OR,Bøhler PJ,Rofstad EK

更新日期：1991-07-01 00:00:00