Endogenous cortisol exerts antiemetic effect similar to that of exogenous corticosteroids.

abstract：BACKGROUND:Dichloroacetate (DCA), through the inhibition of aerobic glycolysis (the 'Warburg effect') and promotion of pyruvate oxidation, induces growth reduction in many tumours and is now undergoing several clinical trials. If aerobic glycolysis is active in multiple myeloma (MM) cells, it can be potentially targete...

journal_title：British journal of cancer

authors： Sanchez WY,McGee SL,Connor T,Mottram B,Wilkinson A,Whitehead JP,Vuckovic S,Catley L

更新日期：2013-04-30 00:00:00

abstract：BACKGROUND:Pheochromocytoma (PCC) and paraganglioma (PGL) are uncommon neoplasms with high morbidity in advanced stages. Effective systemic treatments are limited. METHODS:A multisite phase 2 trial evaluated sunitinib in patients with progressive PCC/PGL. Patients received 50 mg orally for 4-6 weeks. RESULTS:Between ...

journal_title：British journal of cancer

authors： O'Kane GM,Ezzat S,Joshua AM,Bourdeau I,Leibowitz-Amit R,Olney HJ,Krzyzanowska M,Reuther D,Chin S,Wang L,Brooks K,Hansen AR,Asa SL,Knox JJ

更新日期：2019-06-01 00:00:00

abstract：:The prognostic value of flow cytometric parameters and tumour growth rate of melanoma metastases under the mouse renal capsule was investigated for tumours from 117 consecutive patients referred to the Helsinki University Central Hospital Melanoma Team. DNA flow cytometry (FCM) was interpretable for the tumours of 114...

journal_title：British journal of cancer

authors： Muhonen T,Pyrhönen S,Laasonen A,Wasenius VM,Asko-Seljavaara S,Franssila K,Kangas L

更新日期：1992-09-01 00:00:00

abstract：BACKGROUND:Colorectal cancer (CRC) is the third most common cancer worldwide. Accurately identifying stage II CRC patients at risk for recurrence is an unmet clinical need. KCNQ1 was previously identified as a tumour suppressor gene and loss of expression was associated with poor survival in patients with CRC liver met...

journal_title：British journal of cancer

authors： den Uil SH,Coupé VM,Linnekamp JF,van den Broek E,Goos JA,Delis-van Diemen PM,Belt EJ,van Grieken NC,Scott PM,Vermeulen L,Medema JP,Bril H,Stockmann HB,Cormier RT,Meijer GA,Fijneman RJ

更新日期：2016-12-06 00:00:00

abstract：:Choriocarcinoma can be imaged by external scintigraphy after intravenous administration of radiolabelled antibody directed against human chorionic gonadotrophin (HCG). The purpose of this study was to investigate whether antibody imaging was sufficiently sensitive and specific to improve the selection of patients for ...

journal_title：British journal of cancer

authors： Begent RH,Bagshawe KD,Green AJ,Searle F

更新日期：1987-06-01 00:00:00

abstract：:The incidence of gastro-oesophageal junction (GEJ) adenocarcinoma is increasing in Western countries and prognosis is poor since metastasis is most often present at diagnosis. We examined samples from 87 resected type II GEJ adenocarcinomas, 30 of these with endoscopic diagnostic biopsy material, to evaluate transform...

journal_title：British journal of cancer

authors： D'Errico A,Barozzi C,Fiorentino M,Carella R,Di Simone M,Ferruzzi L,Mattioli S,Grigioni WF

更新日期：2000-02-01 00:00:00

abstract：:To estimate the prevalence of TP53 mutations in familial breast cancer, constant denaturant gel electrophoresis (CDGE) was used to screen exons 5-8 of the TP53 gene for germline mutations. Genomic DNA from 128 breast cancer patients belonging to 109 families with familial cancer were screened. No germline mutations we...

journal_title：British journal of cancer

authors： Zelada-Hedman M,Børresen-Dale AL,Claro A,Chen J,Skoog L,Lindblom A

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:Little is known about the effect of participating in a colorectal cancer (CRC) screening programme on quality of life (QOL), neither for participants with a negative nor for those with a positive test result. These findings, however, are important to evaluate the impact of CRC screening. METHODS:Participant...

journal_title：British journal of cancer

authors： Kapidzic A,Korfage IJ,van Dam L,van Roon AH,Reijerink JC,Zauber AG,van Ballegooijen M,Kuipers EJ,van Leerdam ME

更新日期：2012-10-09 00:00:00

abstract：BACKGROUND:It has been reported that although young patients present with more advanced disease, when adjusted for stage, cancer-specific survival is not different after surgery for colorectal cancer. However, few studies have examined non-cancer survival in young patients and 10-year survival has rarely been reported....

journal_title：British journal of cancer

authors： McMillan DC,McArdle CS

更新日期：2009-08-18 00:00:00

abstract：BACKGROUND:Selecting patients with 'sufficient life expectancy' for Phase I oncology trials remains challenging. The Royal Marsden Hospital Score (RMS) previously identified high-risk patients as those with ≥ 2 of the following: albumin <35 g l(-1); LDH > upper limit of normal; >2 metastatic sites. This study developed...

journal_title：British journal of cancer

authors： Ploquin A,Olmos D,Lacombe D,A'Hern R,Duhamel A,Twelves C,Marsoni S,Morales-Barrera R,Soria JC,Verweij J,Voest EE,Schöffski P,Schellens JH,Kramar A,Kristeleit RS,Arkenau HT,Kaye SB,Penel N

更新日期：2012-09-25 00:00:00

abstract：:The 62 kDa protein product of the c-myc oncogene (p62 c-myc) is thought to be involved in the control of normal cellular proliferation and differentiation. We have measured oncoprotein levels using a flow cytometric assay in 141 operable breast cancers and have correlated levels with prognostic variables, patient surv...

journal_title：British journal of cancer

authors： Locker AP,Dowle CS,Ellis IO,Elston CW,Blamey RW,Sikora K,Evan G,Robins RA

更新日期：1989-11-01 00:00:00

abstract：:Comparative genomic hybridization (CGH) was used to detect copy number changes of DNA sequences in the Ewing family of tumours (ET). We analysed 20 samples from 17 patients. Fifteen tumours (75%) showed copy number changes. Gains of DNA sequences were much more frequent than losses, the majority of the gains affecting...

journal_title：British journal of cancer

authors： Armengol G,Tarkkanen M,Virolainen M,Forus A,Valle J,Böhling T,Asko-Seljavaara S,Blomqvist C,Elomaa I,Karaharju E,Kivioja AH,Siimes MA,Tukiainen E,Caballín MR,Myklebost O,Knuutila S

更新日期：1997-01-01 00:00:00

abstract：BACKGROUND:The role of different subtypes of tumour infiltrating lymphocytes (TILs) in breast ductal carcinoma in situ (DCIS) is still poorly defined. This study aimed to assess the prognostic significance of B and T lymphocytes and immune checkpoint proteins expression in DCIS. METHODS:A well characterised DCIS cohor...

journal_title：British journal of cancer

authors： Toss MS,Abidi A,Lesche D,Joseph C,Mahale S,Saunders H,Kader T,Miligy IM,Green AR,Gorringe KL,Rakha EA

更新日期：2020-05-01 00:00:00

abstract：:This phase I study investigated the maximum tolerated dose and pharmacokinetics of a 3-weekly administration of BMS-188797, a paclitaxel derivate, at three dose levels (DLs) (80, 110 and 150 mg m(-2) DL), combined with cisplatin (standard dose 75 mg m(-2)). In 16 patients with advanced malignancies treated, one patien...

journal_title：British journal of cancer

authors： du Bois A,Jung B,Loehr A,Schaller-Kranz T,Cohen M,Frickhofen N

更新日期：2006-01-16 00:00:00

abstract：BACKGROUND:Head and neck squamous cell carcinoma (HNSCC) patients frequently develop treatment resistance to cetuximab, a monoclonal antibody against EGFR, as well as radiotherapy. Here we addressed extracellular signal-regulated kinase 1/2 (ERK1/2) regulation by cetuximab or fractionated irradiation (IR) and conducted...

journal_title：British journal of cancer

authors： Rong C,Muller MF,Xiang F,Jensen A,Weichert W,Major G,Plinkert PK,Hess J,Affolter A

更新日期：2020-07-01 00:00:00

abstract：:Expression of vascular endothelial growth factor (VEGF), an important angiogenic factor in colon cancer, is tightly regulated by factors in the microenvironment. However, specific factors indigenous to the organ microenvironment of colon cancer growth that regulate VEGF expression in human colon cancer are not well de...

journal_title：British journal of cancer

authors： Akagi Y,Liu W,Xie K,Zebrowski B,Shaheen RM,Ellis LM

更新日期：1999-07-01 00:00:00

abstract：:Transformation of primary hamster embryo cells was investigated using 3-methylcholanthrene (MCA), a combination of MCA and 12-O-tetradecanoylphorbol-13-acetate (TPA), and initiation with MCA or dibenz(a,h)anthracene (DBA) followed by promotion with TPA. Evidence for transformation was (a) abnormal cellular morphology,...

journal_title：British journal of cancer

authors： Poiley JA,Raineri R,Pienta RJ

更新日期：1979-01-01 00:00:00

abstract：BACKGROUND:Our previous study demonstrated that extracellular adenosine 5'-triphosphate (ATP) stimulated prostate cancer cell invasion via P2Y receptors. However, the purinergic receptor subtype(s) involved in this process remains unclear. Here we aimed to determine whether P2Y2, one subtype of P2Y receptors, was invol...

journal_title：British journal of cancer

authors： Li WH,Qiu Y,Zhang HQ,Liu Y,You JF,Tian XX,Fang WG

更新日期：2013-09-17 00:00:00

abstract：:For the presentation of peptide antigens to cytotoxic CD8+ T lymphocytes of the immune system, the expression of human leukocyte antigen (HLA) class I molecules on the cell surface is necessary. There is increasing evidence that surface HLA class I antigen expression is altered in a variety of human tumours by either ...

journal_title：British journal of cancer

authors： Vora AR,Rodgers S,Parker AJ,Start R,Rees RC,Murray AK

更新日期：1997-01-01 00:00:00

abstract：:Little is known about the factors that enable the mobilisation of human mesenchymal stem cells (MSC) from the bone marrow into the blood stream and their recruitment to and retention in the tumour. We found specific migration of MSC towards growth factors present in pancreatic tumours, such as PDGF, EGF, VEGF and spec...

journal_title：British journal of cancer

authors： Beckermann BM,Kallifatidis G,Groth A,Frommhold D,Apel A,Mattern J,Salnikov AV,Moldenhauer G,Wagner W,Diehlmann A,Saffrich R,Schubert M,Ho AD,Giese N,Büchler MW,Friess H,Büchler P,Herr I

更新日期：2008-08-19 00:00:00

abstract：:Following relapse on endocrine therapy for advanced, hormone receptor-positive breast cancer, it is common for patients to experience responses to alternative endocrine agents. Fulvestrant ('Faslodex') is a new type of endocrine treatment--an oestrogen receptor (ER) antagonist with no agonist effects. Fulvestrant down...

journal_title：British journal of cancer

authors： Johnston S

更新日期：2004-03-01 00:00:00

abstract：:The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtypes, growth rates and sensitivities to conventional cytostatic agents....

journal_title：British journal of cancer

authors： Boven E,Schipper H,Erkelens CA,Hatty SA,Pinedo HM

更新日期：1993-07-01 00:00:00

abstract：:Metallothioneins (MT) are ubiquitous, intracellular small proteins with high affinity for heavy metal ions. In the last decades, it was shown that MT overexpression in a variety of cancers is associated with resistance to anticancer drugs and is combined with a poor prognosis. In this prospective study, we examined th...

journal_title：British journal of cancer

authors： Weinlich G,Eisendle K,Hassler E,Baltaci M,Fritsch PO,Zelger B

更新日期：2006-03-27 00:00:00

abstract：BACKGROUND:Evidence suggests that dysregulation of energy-sensing pathways closely associates with renal cell carcinoma (RCC) development. The metabolic regulation is largely controlled by 5'-AMP activated protein kinase (AMPK) which is activated through phosphorylation by LKB1. METHODS:The expression of LKB1 was dete...

journal_title：British journal of cancer

authors： Duivenvoorden WC,Beatty LK,Lhotak S,Hill B,Mak I,Paulin G,Gallino D,Popovic S,Austin RC,Pinthus JH

更新日期：2013-02-05 00:00:00

abstract：BACKGROUND:Melanoma is highly resistant to current modalities of therapy, with the extent of pigmentation playing an important role in therapeutic resistance. Nuclear factor-κB (NF-κB) is constitutively activated in melanoma and can serve as a molecular target for cancer therapy and steroid/secosteroid action. METHODS...

journal_title：British journal of cancer

authors： Janjetovic Z,Brozyna AA,Tuckey RC,Kim TK,Nguyen MN,Jozwicki W,Pfeffer SR,Pfeffer LM,Slominski AT

更新日期：2011-12-06 00:00:00

abstract：:Cellular adhesion molecules have been implicated in tumour progression and metastasis. This study examines for the first time the serum concentrations of circulating VCAM-1 and E-selectin in a consecutive series of 110 cancer patients seen in a general medical oncology clinic, and confirms and extends previous studies...

journal_title：British journal of cancer

authors： Banks RE,Gearing AJ,Hemingway IK,Norfolk DR,Perren TJ,Selby PJ

更新日期：1993-07-01 00:00:00

abstract：:Pleural effusion fluid obtained from eleven patients with metastatic spread to the pleura was screened for the ability to cause the dispersal--'scattering'--of MDCK colonies in vitro. Four of these samples proved to be positive using this assay. Of these two had titres high enough to warrant further purification on a ...

journal_title：British journal of cancer

authors： Kenworthy P,Dowrick P,Baillie-Johnson H,McCann B,Tsubouchi H,Arakaki N,Daikuhara Y,Warn RM

更新日期：1992-08-01 00:00:00

abstract：:The mature epidermal growth factor receptor (EGFR) neither associates with nor requires the molecular chaperone heat-shock protein 90 (Hsp90). Mutations in EGFR exons 18, 19, and 21 confer Hsp90 chaperone dependence. In non-small cell lung cancer (NSCLC), these mutations are associated with enhanced sensitivity to EGF...

journal_title：British journal of cancer

authors： Xu W,Soga S,Beebe K,Lee MJ,Kim YS,Trepel J,Neckers L

更新日期：2007-09-17 00:00:00

abstract：:Discrete masses are commonly detected during mammographic screening and most such lesions are benign. For lesions without pathognomonically benign imaging features that are still regarded likely to be non-malignant (Tabar grade 3) reliable biopsy results would be a clinically useful alternative to mammographic surveil...

journal_title：British journal of cancer

authors： Farshid G,Downey P,Gill P,Pieterse S

更新日期：2008-04-08 00:00:00

abstract：:There is increasing evidence that the presence of a systemic inflammatory response plays an important role in survival following curative resection for colorectal cancer. The present study evaluated the relationship between C-reactive protein concentrations and survival in a cohort of patients receiving adjuvant 5-flu...

journal_title：British journal of cancer

authors： Crozier JE,McKee RF,McArdle CS,Angerson WJ,Anderson JH,Horgan PG,McMillan DC

更新日期：2006-06-19 00:00:00