Abstract：
:The author reviews the use of mixed diphtheria-pertussis-tetanus antigens in the light of the information which has become available in recent years. When diphtheria toxoid and tetanus toxoid, adsorbed or unadsorbed, are added to either plain or adsorbed pertussis vaccine, a satisfactory level of diphtheria antitoxin can be obtained in children over 6 months of age and of tetanus antitoxin in children of any age. As to the duration of immunity, it appears that provided three doses of mixed antigens are given for the primary immunization of children 6 months old a substantial proportion will have effective antitoxin titres three years later, but that with two doses only the antitoxin levels fall more rapidly.Reviewing the evidence, the author considers that mixed antigens will be useful in future immunization campaigns, although he makes it clear that extensive investigations, particularly on the immunizing effect of the pertussis component, must be undertaken before their value can be finally assessed.The reactions to and complications after inoculation with mixed antigens are then discussed, particularly in relation to convulsions, encephalopathy, and poliomyelitis. Finally, the author considers provisional recommendations for the use of mixed antigens, pointing out that the main question in all countries is whether the advantages of giving all three antigens simultaneously to children under 6 month of age, necessary because of the pertussis mortality in the first months of life, outweigh the disadvantages.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
COCKBURN WCsubject
Has Abstractpub_date
1955-01-01 00:00:00pages
409-22issue
3eissn
0042-9686issn
1564-0604journal_volume
13pub_type
杂志文章abstract：:The occurrence of three deaths and substantial morbidity among members of a "package tour" who stayed at the same hotel in Benidorm, Spain, during the summer of 1973 provided an opportunity to study the experiences of persons undertaking this type of holiday and some of the factors that might affect their health. Of 2...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:DDE and the o,p' and p,p' isomers of DDT were assayed in 94 human biopsy fat samples from hospitals in Delhi by gas chromatography. DDT was present in all except 2 samples at concentrations from 0.17 to 176.5 mg per kg of body fat. The average total DDT content was 21.8+/-2.9 mg/kg, of which 45.9% was DDE. The average...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:More than 1300 compounds have so far been included in the WHO Programme for Evaluating and Testing New Insecticides, which is designed to disclose compounds that may satisfactorily replace those to which insect vectors of disease have become resistant. The authors describe the successful passage of o-isopropoxyphenyl ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1969-01-01 00:00:00
abstract：Objective:To raise awareness about the importance of public pharmaceutical standards, identify if and, if so, where current pharmacopeias are falling short in the development of new and complete monographs and foster collaboration among the various pharmacopeias, to prioritize, develop and make available standards for ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.17.205807
更新日期：2018-06-01 00:00:00
abstract：:Vaccines constitute the single most important cost factor in the Expanded Programme on Immunization (EPI) in Mozambique and in view of future new disease-control initiatives, the proportional expenditure on vaccines will only increase. Airfreight may contribute up to at least 25% of the total cost of delivered vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:The findings in a highly selected group of patients, such as those attending clinics or sanatoria, cannot be used as the basis for assessing the true prevalence of strains of Mycobacterium tuberculosis with acquired or primary resistance or of sensitive strains in a community. The present report describes the prevalen...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:A national cross-sectional survey of the heights and weights of Kuwaiti preschool-age children of 0-5 years was conducted on a stratified multistage sample of 2554 subjects from high and low socioeconomic levels. The collected data were used to compare the nutritional status of these children with their American count...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVE:To estimate the proportion of participants in clinical trials who understand different components of informed consent. METHODS:Relevant studies were identified by a systematic review of PubMed, Scopus and Google Scholar and by manually reviewing reference lists for publications up to October 2013. A meta-ana...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.14.141390
更新日期：2015-03-01 00:00:00
abstract：:Many countries in Latin America and the Caribbean (LAC) are currently reforming their national health sectors and also implementing a comprehensive approach to reproductive health care. Three regional workshops to explore how health sector reform could improve reproductive health services have revealed the inherently ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2000-01-01 00:00:00
abstract：OBJECTIVE:To determine the impact of user fees on the utilization of health services in a community-based cost-sharing scheme in Kabarole District, western Uganda. METHODS:Of the 38 government health units that had introduced user-fee financing schemes, 11 were included in the study. Outpatient utilization was assesse...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2001-01-01 00:00:00
abstract：OBJECTIVE:To evaluate the implementation of a programme to provide primary care physicians for remote and deprived populations in Brazil. METHODS:The Mais Médicos (More Doctors) programme was launched in July 2013 with public calls to recruit physicians for priority areas. Other strategies were to increase primary car...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.16.178236
更新日期：2017-02-01 00:00:00
abstract：:Stigma, discrimination and lack of legal recognition remain major barriers for transgender people to access the health services they need. Vijay Shankar Balakrishnan reports. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.16.021116
更新日期：2016-11-01 00:00:00
abstract：:Current transportation policies in mega-cities worldwide lead to major threats to health through traffic injuries, air pollution, noise, reduction in physical activities, and adverse impact on urban quality of life. In addition, a large section of the population in cities in low-income countries has to live in informa...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：2003-01-01 00:00:00
abstract：:The WHO Alliance for Global Elimination of Trachoma by 2020 has increased the need to identify ocular chlamydial infections by clinical examination in areas of both high and low prevalence. The relationship between clinically active trachoma (as defined by clinical examination) and chlamydial infection is known for ar...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1999-01-01 00:00:00
abstract：:In 1961 the WHO Expert Committee on Biological Standardization asked the National Institute for Medical Research, London, to collect and study material to replace the first International Standard for Serum Gonadotrophin, stocks of which were running low. This paper describes the material that was contributed, its dist...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:Until about 10 years ago heparin was prepared from ox lungs and was regarded as a homogeneous polymer (of a sulfated mucopolysaccharide) with a relatively constant biological activity of about 100 IU/mg. The mucus and mucosa of the intestine of hog, sheep and ox have now become the main industrial source of bulk start...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1970-01-01 00:00:00
abstract：:The Haemosporidia, which comprise the malaria parasites, have probably evolved from Coccidia of the intestinal epithelium of the vertebrate host by adaptation first to some tissues of the internal organs and then to life in the circulating cells of the blood.The present opinion is that, among the malaria parasites of ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1965-01-01 00:00:00
abstract：OBJECTIVE:To determine the direct medical costs of type 1 diabetes mellitus (T1DM) to the National Brazilian Health-Care System (NBHCS) and quantify the contribution of each individual component to the total cost. METHODS:A retrospective, cross-sectional, nationwide multicentre study was conducted between 2008 and 201...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,多中心研究
doi：10.2471/BLT.12.110387
更新日期：2013-06-01 00:00:00
abstract：:Although none of the currently available methods of contraception can be considered ideal for use by adolescents, many come reasonably close. The present article reviews the relative benefits and risks associated with each method. Oral contraceptives (OCs) appear to bear few specific risks for adolescents. Pills co...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1984-01-01 00:00:00
abstract：:The precautions to be taken and the procedures to be followed when giving intramuscular injections are well known, but they are not always satisfactorily observed under conditions such as those met with in mass treatment campaigns against the treponematoses, nor is the importance of employing uniform techniques always...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:Health financing is a complex health system function, which cannot be analysed accurately without tracking each step of the flow of funds separately. We analysed the revenue mix of the Hungarian health insurance fund from 1994 to 2015 and discuss the policy implications of our findings. We used the System of Health Ac...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.18.218982
更新日期：2019-05-01 00:00:00
abstract：:The reaction that occurs on direct radioelectrocomplexing (REC) between hepatitis B antibody (HB Ab) and (125)I-labelled HB Ag can be inhibited by unlabelled HB Ag. Inhibition of REC provides a rapid, sensitive method for the detection of HB Ag. ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:Mental health services are becoming more widely available than ever before to the Syrian population in spite of the crisis. Dale Gavlak reports. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.16.020116
更新日期：2016-01-01 00:00:00
abstract：PROBLEM:Streptococcus suis is a common cause of adult bacterial meningitis in Viet Nam, and possibly other parts of Asia, yet this disabling infection has been largely neglected. Prevention, diagnosis and treatment are relatively straightforward and affordable but, in early 2007, no national diagnostic, case management...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,实务指引
doi：10.2471/BLT.09.067959
更新日期：2010-06-01 00:00:00
abstract：OBJECTIVE:To determine whether integrating antiretroviral therapy (ART) into antenatal care (ANC) and maternal and child health (MCH) clinics could improve programmatic and patient outcomes. METHODS:The authors systematically searched PubMed, Embase, African Index Medicus and LiLACS for randomized controlled trials, p...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.12.107003
更新日期：2013-01-01 00:00:00
abstract：:The paucity of information on the ecology of wild animal reservoirs over most of the world is one of the factors that has led to hesitation and failure in controlling these diseases in many areas. Extensive application of ecological studies and methods would not only assist in zoonosis control but might well also lead...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1959-01-01 00:00:00
abstract：:The authors have attempted to prepare lysed BCG vaccines retaining the protective antigens of the BCG cell wall and yet eliciting in experimental animals limited sensitivity to the tuberculin substances, the advantage sought being to retain the usefulness of the tuberculin following vaccination as an indicator of supe...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：:There has been little change since 1955 in the laboratory techniques for seeking new antifilarial compounds, although one valuable addition to laboratory study has been the experimental infection of cats with Brugia malayi.The chief drug for the treatment and control of filariasis-whether caused by Wuchereria bancroft...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:This is a classification of tumours of fibrous tissue, fat, muscle, blood and lymph vessels, and mast cells, irrespective of the region of the body in which they arise. Tumours of fibrous tissue are divided into fibroma, fibrosarcoma (including "canine haemangiopericytoma"), other sarcomas, equine sarcoid, and various...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：:Separation and concentration of parasitized erythrocytes from infected blood was achieved by centrifugation of a sample placed in a layer on top of a cushion of a Ficoll solution with a critical density. Pure suspensions of parasitized erythrocytes were obtained from Plasmodium berghei infected rodent blood, whereas r...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1977-01-01 00:00:00
