Abstract：
PROBLEM:Streptococcus suis is a common cause of adult bacterial meningitis in Viet Nam, and possibly other parts of Asia, yet this disabling infection has been largely neglected. Prevention, diagnosis and treatment are relatively straightforward and affordable but, in early 2007, no national diagnostic, case management or prevention guidelines existed in Viet Nam. APPROACH:Enhanced detection of S. suis infections was established in 2007 as part of a collaborative research programme between the National Hospital for Tropical Diseases, a key national hospital with very close links to the Ministry of Health, and a research group affiliated with Oxford University based in Viet Nam. The results were reported directly to policy-makers at the Ministry of Health. LOCAL SETTING:Viet Nam is a low-income country with a health-care system that has seen considerable improvements and increased autonomy. However, parts of the system remain fairly centralized the Ministry of Health. RELEVANT CHANGES:Following the improved detection and reporting of S. suis cases, the Ministry of Health issued guidance to all hospitals in Viet Nam on the clinical and laboratory diagnosis, treatment and prevention of S. suis. A public health laboratory diagnostic service was established at the National Institute of Hygiene and Epidemiology and training courses were conducted for clinicians and microbiologists. Ministry of Health guidance on surveillance and control of communicable diseases was updated to include a section on S. suis. LESSONS LEARNT:Research collaborations can efficiently inform and influence national responses if they are well positioned to reach policy-makers.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
Horby P,Wertheim H,Ha NH,Trung NV,Trinh DT,Taylor W,Ha NM,Lien TT,Farrar J,Van Kinh Ndoi
10.2471/BLT.09.067959subject
Has Abstractpub_date
2010-06-01 00:00:00pages
458-61issue
6eissn
0042-9686issn
1564-0604journal_volume
88pub_type
杂志文章,实务指引abstract：:Although trench fever appears to be endemic in many areas of the world, recognition of the disease has been handicapped by the difficulties of making a clinical diagnosis and the unavailability of a simple laboratory procedure to establish the etiology. The author describes a method for the in vitro cultivation of Ric...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:Since the first attempt at vaccination more than 200 years ago, debate has been ongoing about the relative benefits and risks. However, debate was overshadowed by the threat of crippling illness and death. Over the years, vaccination programs succeeded in its goals: eradication of smallpox, near eradication of polio,...
journal_title：Bulletin of the World Health Organization
pub_type： 评论,杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:A trial of the CHAT, type 1, attenuated poliovirus strain of Koprowski was begun in August 1958 in Léopoldville, a city of 350 000 people, and possessing modern medical facilities, including an institute of public health.Paralytic poliomyelitis is endemic in the city; since 1951 there has been an average annual incide...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:As culture filtrates of Mycobacterium tuberculosis have been shown by numerous workers to be antigenically heterogeneous, a series of experiments has been started to identify some of the different antigens likely to be useful in laboratory tests for measuring the antibodies in human blood. The work involves the fracti...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:Concentration of infected erythrocytes was achieved in cell suspensions derived from long-term culture of Plasmodium falciparum growing asynchronously in human erythrocytes. This new procedure involves the slow centrifugation (at 33 g) of erythrocyte suspensions through 5% Ficoll solutions. Mature asexual erythrocytic...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:Many global health institutions, including the World Health Organization, consider primary health care as the path towards achieving universal health coverage (UHC). However, there remain concerns about the feasibility and effectiveness of this approach in low-resource countries. Ethiopia has been implementing the pri...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.19.248328
更新日期：2020-12-01 00:00:00
abstract：:This account of the conduct of the Similium Control Scheme at Abuja, Northern Nigeria, over the period 1956-66 shows that, by larvicide treatment of some 160 km of rivers with DDT in the early wet season, the Simulium damnosum density has been reduced by about 90% of its precontrol level each year over an area of more...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:In an attempt to prepare highly specific antiserum to variola virus, a chimpanzee was inoculated with a virulent human strain of this virus. Three uninoculated chimpanzees were housed in the same room; two of these developed clinical disease with seroconversion, while the third developed no evidence of infection and n...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:An autogenous species belonging to the Aedes (Stegomyia) scutellaris subgroup was found on the island of Tafahi, Kingdom of Tonga. A subcolony was established at Johns Hopkins University, Baltimore, Md., USA, where cross-breeding experiments were conducted with the Samoan strain of A. polynesiensis. The cross between ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：:The authors have compared the value of multiple doses of duck-embryo and HEP Flury vaccine with that of pooled 5% sheep-brain vaccine in experimental rabies infection in guinea-pigs. They found that the duck-embryo vaccine given in a dosage corresponding to 14 ml of 10% vaccine (the dosage recommended for human treatm...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:This study is devoted to a general discussion of the role of bacteriophagy in cholera. The author examines early and late observations, indicating that a new epoch in the history of the subject began in 1927, when large-scale investigations on cholera bacteriophagy were started in India. The main results are set out u...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1955-01-01 00:00:00
abstract：:Chloroquine-resistant Plasmodium falciparum has been spreading rapidly after its emergence in 1988 in Yekepa. The in vivo and in vitro susceptibilities to quinine and quinidine, compared to chloroquine, were studied by investigating the number of treatment days required for radical cure and estimating the quinine conc...
journal_title：Bulletin of the World Health Organization
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：1991-01-01 00:00:00
abstract：:When mice are immunized with radiation-attenuated sporozoites they are solidly protected against sporozoite challenge by an immune response that has been shown to require CD8+ lymphocytes in several strains of mice. The target of this CD8+ T-cell-dependent immunity has not been established. Immune BALB/c mice were sho...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:A new immunodiffusion technique in agarose gel for the quantification of complement-fixing antibodies is described. The test involves the incorporation of antigen and complement in a primary agarose gel. Heat-inactivated serum samples are allowed to diffuse radially from wells overnight at 4 degrees C. A secondary gel...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Highly sensitive case definitions were first introduced by national poliomyelitis eradication programmes to avoid missing true cases of the disease, though false-positive diagnostic errors could still occur owing to low specificity. Extensive data from all 1620 cases of acute, flaccid paralysis reported in Brazil duri...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1992-01-01 00:00:00
abstract：:Until very recently, rabies research had made few notable advances since the time of Pasteur, but during the past few years the use of modern virological techniques has led to rapid progress in research on the rabies virus. This article summarizes the present state of knowledge of pathogenesis, immunology, cultivation...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1968-01-01 00:00:00
abstract：:About 30 million people in Africa are estimated to be living with human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS), yet data about the natural history of infection on the continent are sparse. We reviewed the literature on the natural history of HIV-1 and HIV-2 infections among African adult...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：2004-06-01 00:00:00
abstract：:The systematic position of the so-called "species" of Leishmania is examined and an attempt made to determine their phylogenetic relationships. The morphology of the organisms as seen by light- and electron-microscopy is described; neither method provides useful criteria for the determination of species. The behaviour...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1971-01-01 00:00:00
abstract：:In 39 randomly selected villages and towns in Tumkur District, South India, approximately 2000 persons, tuberculosis cases and matched controls, were interviewed in order to determine how many had symptoms suggestive of tuberculosis. Approximately 70% of the bacteriologically confirmed cases and over half the radiolog...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:Much has been learnt of the epidemiology of yaws during eradication campaigns in populations in which the prevalence of active yaws was high, but not all has been published. The recognition of the importance of latent cases in the maintenance of yaws has contributed to the effectiveness of these campaigns. Yaws eradic...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:This paper describes the organization of an epidemiological survey, carried out by the Lipid Centre of the Institute of Experimental Medicine in Leningrad, particularly the ways in which subjects were recruited. The different methods of recruitment resulted in a total population response of 78.14%. A time index is int...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:Despite major obstacles, activities to control sexually transmitted diseases (STDs) were initiated in Haiti in 1992 in collaboration with local nongovernmental organizations. The approaches included review of available local data, assessment of STD case management practices and constraints, and development of specific...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：Objective:To assess cash transfer interventions for improving treatment outcomes of active pulmonary tuberculosis in low- and middle-income countries. Methods:We searched PubMed®, Embase®, Cochrane Library and ClinicalTrials.gov for studies published until 4 August 2017 that reported on cash transfer interventions dur...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.18.208959
更新日期：2018-07-01 00:00:00
abstract：:The authors present the results of a study carried out to determine the efficacy of chloroquine- and pyrimethamine-salt mixtures as a suppressive against sporozoite-induced vivax malaria (Chesson strain). The test subjects used in this study were volunteers of military age in the US Penitentiary at Atlanta, Ga. The su...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1958-01-01 00:00:00
abstract：:Marion Koopmans tells Fiona Fleck why the world needs a publicly-funded network of hubs in all regions with local experts able to respond to infectious disease threats as they emerge. ...
journal_title：Bulletin of the World Health Organization
pub_type： 传,历史文章,新闻
doi：10.2471/BLT.18.030218
更新日期：2018-02-01 00:00:00
abstract：:A simple grading system for trachoma, based on the presence or absence of five selected "key" signs, has been developed. The method was tested in the field and showed good observer agreement, the most critical point being the identification of severe cases of the disease. It is expected that the system will facilitate...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1987-01-01 00:00:00
abstract：:The gene for dieldrin resistance has been artificially male-linked so that females can be selectively killed with dieldrin. By intercrossing different sibling species of the Anopheles gambiae complex, batches consisting of sterile males only can be reared. This seems to have potential for use in genetic control operat...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1978-01-01 00:00:00
abstract：:Venereal diseases are known to occur most frequently in the age-groups of greatest sexual activity and more frequently among people in certain occupations (e.g., migrant labourers, military personnel and seafarers) than among the general population. The Brussels Agreement of 1924 and the great improvements in conditio...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1963-01-01 00:00:00
abstract：:The immunizing potency of liquid BCG vaccine prepared by the Tween 80 method was compared with that of control vaccine prepared by the usual grinding method. The former vaccine revealed higher immunizing properties than the latter although its inoculation dose was only one-fifth as great.With sodium glutamate as adjuv...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1957-01-01 00:00:00
abstract：:The magnitude and duration of dengue viraemia were studied in 153 patients with naturally acquired dengue infection in Jakarta, Indonesia. The duration of viraemia ranged from 2 to 12 days, but most patients had detectable circulating virus for 4-5 days. Accurate measurement of peak virus titres was not possible for m...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
