Abstract：
:As culture filtrates of Mycobacterium tuberculosis have been shown by numerous workers to be antigenically heterogeneous, a series of experiments has been started to identify some of the different antigens likely to be useful in laboratory tests for measuring the antibodies in human blood. The work involves the fractionation of concentrated culture filtrates by various chemical procedures, the chemical analysis of the fractions, and their subsequent testing and cross-testing with various serological procedures.A number of fractions made from filtrates of heated and unheated cultures have been tested for activity in the Middlebrook-Dubos haemagglutination test. As might be expected, the fractions were found to vary in potency, some showing at least a thousand times more erythrocyte-sensitizing activity than others. Cross-inhibition tests made with the most active preparations indicated the existence of at least two different substances responsible for sensitizing erythrocytes to agglutination, one being demonstrable only in certain unheated fractions.Antibodies detected with the tannic acid haemagglutination test have a different serological specificity from those detected by the Middlebrook-Dubos test. Different heated fractions gave strong cross-reactions with each other in the tannic acid haemagglutination procedure, and little difference could be seen between them; in contrast, four active fractions from unheated filtrates were distinct from each other, showing very little cross-reaction.Results obtained with another haemagglutination procedure, consisting of agglutination of normal erythrocytes by antiserum-antigen mixtures, showed that this method detected another antigen, not measured in the tannic acid or Middlebrook-Dubos techniques under the conditions of the tests.The present experiments have shown that the culture filtrates and fractions thereof contain a series of distinct antigens or at least characteristic combinations of antigens that differ in serological specificity and in their ability to react in the different tests. Further experiments are necessary to determine whether the serological differences are of any special significance in relation to tuberculous disease or bacterial type specificity.
journal_name
Bull World Health Organjournal_title
Bulletin of the World Health Organizationauthors
subject
Has Abstractpub_date
1955-01-01 00:00:00pages
285-99issue
1-2eissn
0042-9686issn
1564-0604journal_volume
12pub_type
杂志文章abstract：:In serological tests for syphilis, leprosy sera often give biologically false positive reactions. These may be due to the presence of non-specific elements-for example, the ubiquitous lipid antibodies-in the leprosy sera; or they may be the result of errors in technique or unfavourable working conditions in the labora...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1960-01-01 00:00:00
abstract：:Enzyme immunoassays represent in many cases the preferred procedure for the detection of antigens or corresponding antibodies. However, many of the current procedures are performed suboptimally. This article reviews the available designs, auxiliary recognition systems, production and purification of antibodies, conjug...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：
更新日期：1985-01-01 00:00:00
abstract：:Despite major obstacles, activities to control sexually transmitted diseases (STDs) were initiated in Haiti in 1992 in collaboration with local nongovernmental organizations. The approaches included review of available local data, assessment of STD case management practices and constraints, and development of specific...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1998-01-01 00:00:00
abstract：:Vaccines constitute the single most important cost factor in the Expanded Programme on Immunization (EPI) in Mozambique and in view of future new disease-control initiatives, the proportional expenditure on vaccines will only increase. Airfreight may contribute up to at least 25% of the total cost of delivered vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1997-01-01 00:00:00
abstract：:As stocks of the first International Standard for Chorionic Gonadotrophin were running low, the WHO Expert Committee on Biological Standardization authorized the National Institute for Medical Research, London, in 1960 to proceed with arrangements to replace it. This paper describes the nature and handling of the prop...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：:This article reviews the development of the WHO project on the histological classification of tumours, which has included the establishment of several collaborating centres and has involved more than 300 pathologists in over 50 countries. The project has resulted in the publication, over the last 14 years, of 25 volum...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1981-01-01 00:00:00
abstract：:The respective vectors of the two forms of bilharziasis in Egypt do not have the same ecological distribution. Bulinus truncatus is most abundant in large canals, and decreases in density as the water approaches and flows into drains. Biomphalaria alexandrina is most abundant in drains, and decreases in density upstre...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1966-01-01 00:00:00
abstract：:Between April and July 1966 a comparative trial of two live attenuated measles vaccines (Schwarz and Beckenham 31), given intramuscularly or intradermally, was conducted in Hong Kong. Some 910 non-immune children completed the trial. The Beckenham 31 vaccine caused significantly more complications than Schwarz vaccine...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1967-01-01 00:00:00
abstract：:The author reviews the growing body of evidence that urban populations of Culex pipiens fatigans have increased extensively during recent years in both Africa and Asia. Two main factors seem to be responsible-the spread of urbanization, providing favourable habitats for this essentially urban mosquito; and the increas...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:Uruguay is hosting the WHO Global Conference on Noncommunicable Diseases (NCDs) this month, from 18-20 October. Tabaré Vázquez, the President of Uruguay, tells the Bulletin of the World Health Organization about his country's efforts to prevent and fight NCDs and why countries should step up the global response. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.17.031017
更新日期：2017-10-01 00:00:00
abstract：:The nature of psychiatric disorders in tropical regions is affected much more by the effect on the patient of certain environmental and cultural factors than by any specific features of tropical diseases. In places where the standards of health care and health education are not yet fully developed, abnormalities of ph...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1979-01-01 00:00:00
abstract：:A test procedure involving simply-constructed, portable test-equipment has been developed for detecting resistance to DDT residual applications by adult mosquitos. The procedure involves timed exposures of adult female mosquitos to DDT residues in chambers made of paper and screen wire, and the determination of the su...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1953-01-01 00:00:00
abstract：:E-health encompasses a diverse set of informatics tools that have been designed to improve public health and health care. Little information is available on the impacts of e-health programmes, particularly in low- and middle-income countries. We therefore conducted a scoping review of the published and non-published l...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,评审
doi：10.2471/BLT.11.099069
更新日期：2012-05-01 00:00:00
abstract：:Rabbits have commonly been used for testing the blood-level duration limit of penicillin, but have proved not to be entirely suitable. Experiments reported in this paper on the use of sheep suggest that these animals can be successfully used for the testing of procaine benzylpenicillin with aluminium monostearate (PAM...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1961-01-01 00:00:00
abstract：:This paper gives a comprehensive account of the first six years of operation of an onchocerciasis control pilot project in an area of over 3000 km(2) in the Abuja Emirate, Northern Nigeria. Control was attempted by the use of DDT against the larvae of the vector, Simulium damnosum. For the first two years technical DD...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:There have been 4 waves of imported malaria in the USA. They occurred during the colonization of the country and during the Second World War, the UN Police Action in Korea, and the Viet-Nam conflict. The first 3 episodes are briefly described and the data on imported malaria from Viet-Nam are discussed in detail.Endem...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1974-01-01 00:00:00
abstract：OBJECTIVE:To examine if economic development in China correlates with physical growth among Chinese children and adolescents. METHODS:The height, body weight and physical activity level of children and adolescents aged 18 years and under, as well as dietary data, were obtained from seven large surveys conducted in Chi...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.13.126243
更新日期：2014-08-01 00:00:00
abstract：:At the request of the Ministry of Health of the USSR, a controlled field trial of a polyvaccine containing typhoid, paratyphoid and dysentery antigens and a purified tetanus toxoid was undertaken in 1958. The main object of this trial, which was carried out over a 10-month period simultaneously in four localities, was...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1962-01-01 00:00:00
abstract：:Chikungunya (CHIK) virus, harvested from infected BHK-21 cell cultures and highly purified by a method combining zinc acetate precipitation, Sephadex-Sepharose column chromatography, and sucrose density gradient centrifugation, was subjected to ultraviolet (UV) irradiation and treatment with formalin. Inactivation of ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-05-01 00:00:00
abstract：:This paper describes the research conducted by a WHO collaborative study group for the development of a questionnaire method for the assessment of quality in child-care settings. The results of an inter-rater reliability study undertaken in Greece and Nigeria suggest that the Child Care Facility Schedule (CCFS), compo...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1991-01-01 00:00:00
abstract：:This Memorandum summarizes current knowledge on the epidemiology of cholera and diarrhoea due to enterotoxigenic Escherichia coli (ETEC) and outlines the results of recent research to develop an effective oral vaccine against cholera. The meeting reviewed current research on the protective antigens of ETEC and made a ...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1990-01-01 00:00:00
abstract：:Stigma, discrimination and lack of legal recognition remain major barriers for transgender people to access the health services they need. Vijay Shankar Balakrishnan reports. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.16.021116
更新日期：2016-11-01 00:00:00
abstract：:DDE and the o,p' and p,p' isomers of DDT were assayed in 94 human biopsy fat samples from hospitals in Delhi by gas chromatography. DDT was present in all except 2 samples at concentrations from 0.17 to 176.5 mg per kg of body fat. The average total DDT content was 21.8+/-2.9 mg/kg, of which 45.9% was DDE. The average...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
abstract：OBJECTIVE:To estimate the proportion of participants in clinical trials who understand different components of informed consent. METHODS:Relevant studies were identified by a systematic review of PubMed, Scopus and Google Scholar and by manually reviewing reference lists for publications up to October 2013. A meta-ana...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章,meta分析,评审
doi：10.2471/BLT.14.141390
更新日期：2015-03-01 00:00:00
abstract：:The United Republic of Tanzania is the first mainland sub-Saharan country to launch a national methadone programme as part of its battle to fight the twin epidemics of heroin addiction and HIV infection. Fumbuka Ng'wanakilala reports. ...
journal_title：Bulletin of the World Health Organization
pub_type： 新闻
doi：10.2471/BLT.13.030213
更新日期：2013-02-01 00:00:00
abstract：:A survey of the sandfly population of Iran was conducted in the interests of providing further knowledge of the biology of these vectors of leishmaniasis, sandfly fever and kalaazar. The search for specimens was carried out in the Tabriz, Sarab, Caspian Sea, Teheran and Kazerun areas, both inside buildings and in natu...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1961-01-01 00:00:00
abstract：:Some of the acute diarrhoeas of man are specific infectious diseases. Another and major proportion have no demonstrated infectious agent. No characteristic clinical pattern regularly distinguishes one specific disease entity from another, nor specific from non-specific infections, nor epidemic from endemic disease. Si...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1964-01-01 00:00:00
abstract：:A comprehensive field investigation in several parts of India has revealed that the presence of coliforms in drinking water is associated with hydrogen sulfide-producing organisms. This paper describes a simple, rapid, and inexpensive field test for the screening of drinking water for faecal pollution, based on the de...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1982-01-01 00:00:00
abstract：:The One Health concept covers the interrelationship between human, animal and environmental health and requires multistakeholder collaboration across many cultural, disciplinary, institutional and sectoral boundaries. Yet, the implementation of the One Health approach appears hampered by shortcomings in the global fra...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：10.2471/BLT.17.202705
更新日期：2018-03-01 00:00:00
abstract：:Part 1 of this Memorandum appeared in Vol. 49, pages 81-91. Part 2 covers neoplasia of the bovine urinary bladder; tumours of unknown cause (including melanomas, osteosarcomas, mammary tumours, lymphosarcomas, mastocytomas, transmissible venereal tumours, and histiocytomas); and the applications of animal models in st...
journal_title：Bulletin of the World Health Organization
pub_type： 杂志文章
doi：
更新日期：1973-01-01 00:00:00
