当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > 36-month follow-up of 75 renal allograft recipients treated with steroids, tacrolimus, and azathioprine or mycophenolate mofetil.

36-month follow-up of 75 renal allograft recipients treated with steroids, tacrolimus, and azathioprine or mycophenolate mofetil.

Abstract：

OBJECTIVES:The aim of this retrospective study was to assess the incidence of acute rejection episodes (AR), diabetes mellitus (DM), and serum creatinine (SCr) among renal transplant recipients treated with tacrolimus (Tac), steroids (S), and mycophenolate mofetil (MMF) or azathioprine (Aza). METHODS:Seventy-five renal allograft recipients enrolled in the COSTAMP study were followed for a period of 3 years. Patients were randomized to receive either Tac and MMF (n = 41) or Tac and Aza (n = 34) concomitantly with steroids. Follow-up assessments were performed at 3, 6, 12, 24, and 36 months. RESULTS:Patient survival at month 36 was 91.18% in the Tac/Aza/S group and 97.56% in the Tac/MMF/S group. Graft survival at month 36 was 82.35% and 85.37%, respectively. During the study period, 22 cases of biopsy-proven AR were diagnosed in 17 patients (22.6%). After 36 months the total number of AR was 11 in the Aza-treated group (32.4%) and 11 in the MMF-treated group (26.8%). DM was diagnosed de novo in 17 individuals (22.6%). During 36 months, 10 patients from Aza-treated group (29.4%) and seven from MMF-treated group developed DM (17.1%). Serum creatinine values were not significantly different in both arms of the study. Comparison of arterial blood pressure and total cholesterol revealed no significant changes in any of the studied groups. CONCLUSIONS:We conclude that combinations of steroids, tacrolimus, and azathioprine or MMF provide good results with regard to renal function.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Mucha K,Foroncewicz B,Paczek L,Pazik J,Lewandowska D,Krawczyk A,Pliszczynski J,Gradowska L,Durlik M,Walaszewski J,Nazarewski S,Szmidt J

doi

10.1016/s0041-1345(03)00815-7

subject

Has Abstract

pub_date

2003-09-01 00:00:00

pages

2176-8

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041134503008157

journal_volume

35

pub_type

临床试验,杂志文章,随机对照试验

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