Successful pancreas-renal transplantation without induction therapy.

Abstract:

:Most pancreas transplant centers initially use immunosuppression with antilymphocyte induction because the pancreas appears to be a highly immunogeneic organ. Although the addition of an antilymphocyte agent provides enhanced immunosuppression in the early posttransplant period, it is associated with added costs and adverse reactions. In this study we evaluated the safety and efficacy of tacrolimus (Tac), mycophenolate mofetil (MMF), and steroid immunosuppression without induction after simultaneous kidney-pancreas transplantation (SKPT). Six patients (30%) displayed rejection episodes with a mean follow-up of 12 months (range = 4 to 18 months). No graft was lost due to rejection. The results of this series suggest that SKPT can be safely performed without induction therapy.

journal_name

Transplant Proc

authors

Nicoluzzi J

doi

10.1016/j.transproceed.2005.11.027

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

4438-9

issue

10

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)01322-9

journal_volume

37

pub_type

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