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Effect of early conversion to everolimus together with prophylaxis with valganciclovir in the prevention of cytomegalovirus infection in heart transplant recipients.

Abstract：

INTRODUCTION:Viral infections, especially cytomegalovirus (CMV), are a leading cause of early death and morbidity after heart transplantation. Several strategies have been used to minimize the risk, including universal prophylaxis with ganciclovir or valganciclovir and preemptive therapy. Lately, everolimus (EVE) efficacy studies have shown a protective effect against CMV infection. METHODS:We studied retrospectively a series of 223 heart transplant patients, dividing them into 5 groups according to CMV prevention strategy: 16 patients were at low risk for infection (negative recipient [R-]/negative donor [D-]) and received no treatment; 26 patients received prophylactic therapy with ganciclovir, 8 patients prophylaxis with valganciclovir, 145 patients received preemptive therapy and 28 patients prophylaxis with valganciclovir and early conversion to EVE. RESULTS:There were no cases of CMV infection in the low-risk group. There was 1 case of CMV infection in the group that received valganciclovir and conversion to EVE. Among the patients who received prophylaxis with ganciclovir or valganciclovir or preemptive therapy, CMV infection was detected in 68 patients (37%). CONCLUSIONS:Early conversion to EVE in addition to valganciclovir prophylaxis was superior to other strategies in our series for the prevention of CMV infection.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Díaz Molina B,Velasco Alonso E,Lambert Rodríguez JL,Rodríguez Bernardo MJ,Rozado Castaño J,Padrón Encalada R,Martín Fernández M,Pun Chinchai F,Colunga Blanco S,García Campos A

doi

10.1016/j.transproceed.2014.11.026

subject

Has Abstract

pub_date

2015-01-01 00:00:00

pages

130-1

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(14)01278-0

journal_volume

47

pub_type

杂志文章

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