Effects of Granulocyte and Monocyte Adsorptive Apheresis in Renal Transplantation Recipients With Concomitant Cytomegalovirus Infection.


BACKGROUND:Granulocyte and monocyte adsorptive apheresis (GMAA) is widely used as a treatment for active ulcerative colitis (UC) in Japan. Much attention has been paid to the possibility of GMAA for the treatment and control of cytomegalovirus (CMV) reactivation in patients with refractory UC and concomitant CMV infection. In this study, the effects of the combination of GMAA and antiviral therapy were examined in renal transplant recipients with concomitant CMV infection. METHODS:Combination therapy of GMAA and antiviral drugs was performed 9 times in 7 renal transplant recipients with concomitant CMV infection. Four of the cases were positive for CMV-IgG, and 3 were negative. The clinical presentation of CMV infection was viremia in 6 cases and disease (CMV retinitis) in 1 case. CMV infection was diagnosed by using an antigenemia assay (C7-HRP). GMAA session was performed once, and the duration of the session was 120 min. Immediately after the GMAA session, ganciclovir was administered at 5 mg/kg/body weight. CMV infection was monitored based on C7-HRP and CMV-DNA in the peripheral blood samples. RESULTS:All cases became negative for C7-HRP and CMV-DNA within 21 days (median, 14 days; range, 3-21 days) and 17 days (median, 6 days; range, 3-17 days), respectively, after starting the combination therapy. No side effects of GMAA were observed. CONCLUSIONS:This case series found that GMAA in combination with antiviral drugs may shorten the duration of treatment against CMV infection in renal transplant recipients. Further studies in a larger number of patients are required to confirm these results.


Transplant Proc


Naganuma T,Takemoto Y,Iwai T,Kuwabara N,Uchida J,Nakatani T,Kitamura K,Masuda A,Ohmori K,Matsuura M,Nakase H




Has Abstract


2016-04-01 00:00:00














  • Pancreas transplants from donors aged 45 years or older.

    abstract:AIMS:Since donor age of 45 years or more is considered a relative contraindication for pancreas transplantation (PTx), we herein report our experience with these donors. METHODS:Pancreases from donors aged 45 years or older were used in 16 of 147 PTx procedures (11%). The final decision to accept a graft for PTx was b...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Boggi U,Del Chiaro M,Signori S,Vistoli F,Amorese G,Croce C,Morelli L,Vanadia Bartolo T,Pietrabissa A,Barsotti M,Rizzo G,Mosca F

    更新日期:2005-03-01 00:00:00

  • Computed Tomography as Primary Screening for Appraisal of Pulmonary Small Nodules in Liver Transplant Candidates.

    abstract:BACKGROUND:Chest computed tomography (CT) as a primary screening method in candidates for living donor liver transplantation (LDLT) is not yet a standardized procedure. The aim of this study is to present our methods and result of evaluation of pulmonary small nodules (PSN) after CT as a primary screening tool. PATIEN...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Wu YJ,Lin CC,Chang YM,Wang SH,Lin YH,Lu HI,Concejero AM,Chen CL,Lin TL

    更新日期:2016-05-01 00:00:00

  • The family interview in the process of donating organs and tissues for transplantation: perceptions of potential donors' relatives.

    abstract:BACKGROUND:The family interview is a complex phase of the organ donation process because it involves aspects of the interviewer, the interviewee, the interview location, and ethical and legal issues. However, there are few publications on this phase of the donation process. This study aimed to reveal the meaning assign...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: dos Santos MJ,Massarollo MC,de Moraes EL

    更新日期:2014-07-01 00:00:00

  • Histocompatibility testing for highly sensitized transplant candidates.

    abstract::HLA antibodies can develop for many different reasons and are often present in the serum of patients awaiting renal transplantation. These antibodies can limit the patient's ability to find a compatible donor and are a risk factor for poor graft outcome. Detection of HLA antibodies is important for identifying compati...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Saidman SL

    更新日期:2007-04-01 00:00:00

  • Risk factors and prognosis of patients with primary graft failure after heart transplantation: an Asian center experience.

    abstract:BACKGROUND:Although primary graft failure (PGF) after heart transplantation is a feared complication, most reports have come from Western countries. We analyzed the incidence in our hospital and tried to determine the predictive risk factors for PGF that require mechanical circulatory support or high dosage of inotropi...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chen JW,Chen YS,Chi NH,Huang SC,Yu HY,Chou NK,Wang CH,Wang SS

    更新日期:2014-04-01 00:00:00

  • The effect of HBsAg-positivity of kidney donors on long-term patient and graft outcome.

    abstract::The number of patients on the kidney waiting list is increasing, creating a shortage of donor organs. To solve this problem, there is an interest in transplanting organs formerly considered marginal or undesirable. We performed seven (four living related, three cadaveric) kidney transplants from hepatitis B surface an...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Berber I,Aydin C,Yigit B,Turkmen F,Titiz IM,Altaca G

    更新日期:2005-12-01 00:00:00

  • Preexisting Cerebral Aspergillosis Successfully Treated After Liver Transplantation: A Case Report.

    abstract:BACKGROUND:Invasive aspergillosis (IA) is a rare condition that generally affects immunosuppressed patients. The mortality of IA is known to be >90% in liver transplantation (LT) recipients; the lung is the most commonly affected organ, followed by the brain. There have been reports in the literature of cerebral asperg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Lee JS,Kim SH,Kwon JH,Yoon YC

    更新日期:2017-12-01 00:00:00

  • Infrared Thermal Imaging as a Method of Improving Skin Graft Qualification Procedure and Skin Graft Survivability.

    abstract:BACKGROUND:Appropriate wound classification (evaluation of skin damage depth) is a key element in the first days after the burn injury. In this study, we used a thermovision system to evaluate the degree of burn wound shortly after injury and the regenerative process of engraftment of autologous split-thickness skin gr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Klama-Baryła A,Kitala D,Łabuś W,Kraut M,Szapski M,Smętek W

    更新日期:2020-09-01 00:00:00

  • Cephalic duodenopancreatectomy in the treatment of a bleeding duodenal ulcer in a pancreas recipient: a case report.

    abstract::Pancreas transplantation is currently the only known therapy to restore glycemic metabolism in type 1 diabetic patients. Its most prevalent indication is in association with kidney transplantation (simultaneous pancreas and kidney transplantation SPK) for patients with type 1 diabetes mellitus (DM1) and nephropathy, w...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Pires IS,Morais de Siqueira R,Kroth LV,Hartmann M,Falavigna M,Traessel MA,Queiroz de Carvalho JE,d'Avila D,Saitovitch D,Neto SG

    更新日期:2010-03-01 00:00:00

  • Donor MHC class I peptides in conjunction with self-epitopes induce donor-specific tolerance in a dose-dependent manner but unable to abrogate chronic rejection.

    abstract::Understanding specific tolerance mechanisms is a primary goal of transplantation science. We have previously shown that hosts treated with MHC class I protein have donor sequences in the alpha1-helix of the alpha1 domain on a background of self-epitopes, resulting in the development of donor-specific tolerance. Howeve...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Semiletova NV,Shen XD,Feldman DM,Busuttil RW,Kupiec-Weglinski JW,Ghobrial RM

    更新日期:2005-05-01 00:00:00

  • Decrease in serum tacrolimus level and rise in serum creatinine under late addition of cinacalcet in a renal transplant recipient with hyperparathyroidism: a case report.

    abstract::Cinacalcet is a calcimimetic drug that has been approved for treatment of secondary and tertiary hyperparathyroidism in patients with renal failure requiring renal replacement therapy. A few cases of successful treatment in renal transplant patients immunosuppressed with cyclosporine have been reported. Herein we have...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Maass E,Mueller GA,Heller T,Koziolek MJ

    更新日期:2007-12-01 00:00:00

  • De novo colorectal cancer: five-year survival is markedly lower in transplant recipients compared with the general population.

    abstract:INTRODUCTION:The biological behavior of most solid tumors in transplant recipients has not been adequately compared to the general population. The purpose of the present study was to compare outcomes in de novo colorectal cancer (CRC) following solid organ transplantation to those observed in the general population (SE...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Buell JF,Papaconstantinou HT,Skalow B,Hanaway MJ,Alloway RR,Woodle ES

    更新日期:2005-03-01 00:00:00

  • Cholangiocarcinoma, 10-Year Survival After Liver Transplantation: A Case Report.

    abstract::Cholangiocarcinoma is the second most common neoplasm in the liver, with a very poor, short-term prognosis. Today, surgery associated with or without an adjuvant is the only curative treatment. Liver transplantation (LT) is the best treatment for hepatocellular carcinoma tumor. In recent years, treatment of hilar chol...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Herrero Torres MA,Dominguez Bastante M,Molina Raya A,Palomo Lopez I,Santoyo Villalba J,Villegas Herrera MT,Becerra Massare A,Brea Gomez E,Zambudio Carroll N,Villar Del Moral JM

    更新日期:2020-03-01 00:00:00

  • Pulmonary tuberculosis in an HIV- and hepatitis C virus-coinfected kidney-pancreas transplant recipient: a case report.

    abstract::Tuberculosis (TB) is a serious infection in immunocompromised patients, such as solid organ transplant recipients and HIV-infected patients. The diagnosis and treatment in this population present several challenges because of the aspecific clinical manifestations, the difficulty in diagnosis, and the choice of the mos...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Dalla Gasperina D,Tozzi M,Astuti N,Balsamo ML,Donati D,Rossi A,Dionigi R,Grossi PA

    更新日期:2011-05-01 00:00:00

  • Smoking following renal transplantation in Hungary and its possible deleterious effect on renal graft function.

    abstract::Smoking is a known risk factor for kidney damage and also influences graft function following renal transplantation. Because smoking habits following kidney transplantation are not systematically evaluated, we analyzed them in a single center in Hungary. The survey was conducted among 402 randomly selected kidney graf...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Gombos P,Langer RM,Korbely R,Varga M,Kaposi A,Dinya E,Müller V

    更新日期:2010-07-01 00:00:00

  • Randomized, Open-Label, Phase IV, Korean Study of Kidney Transplant Patients Converting From Cyclosporine to Prolonged-Release Tacrolimus Plus Standard- or Reduced-Dose Corticosteroids.

    abstract:BACKGROUND:This 24-week, multicenter, randomized, exploratory, comparative, open-label, phase-IV study assessed the safety and efficacy of prolonged-release tacrolimus (PR-T) with reduced-dose versus standard-dose corticosteroids in stable kidney transplant recipients in Korea after converting from cyclosporine-based t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究,随机对照试验


    authors: Baek CH,Kim CD,Lee DR,Kim YH,Yang J,Kim BS,Lee JS,Han SY,Kim SW,Lee S,Lee KW,Kong JM,Shin BC,Lee SH,Chae DW,Kwon YJ,Jiang H,Lee H,Park SK

    更新日期:2019-04-01 00:00:00

  • Cyclosporine versus tacrolimus in kidney transplantation: are there differences in nephrotoxicity?

    abstract::Cyclosporine and tacrolimus, two calcineurin inhibitors, show different side effects and toxicities. The data concerning their nephrotoxicity are few and conflicting. A retrospective study was performed in 2 groups of renal transplant recipients treated with cyclosporine or tacrolimus to evaluate graft function and si...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Martins L,Ventura A,Branco A,Carvalho MJ,Henriques AC,Dias L,Sarmento AM,Amil M

    更新日期:2004-05-01 00:00:00

  • New-onset Diabetes Mellitus After Kidney Transplantation-A Paired Kidney Analysis.

    abstract:BACKGROUND:New-onset diabetes mellitus (NODAT) is a severe complication after kidney transplantation. It is associated with increased risk of graft failure, cardiovascular disease, mortality and infections. METHODS:We retrospectively (partially using the registry database) analyzed risk factors and clinical consequenc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bzoma B,Konopa J,Chamienia A,Łukiański M,Kobiela J,Śledziński Z,Dębska-Ślizień A

    更新日期:2018-01-01 00:00:00

  • Successful solid organ transplantation from septicemic cadaveric donors: case report.

    abstract::Systemic donor infections especially with gram-negative organisms are regarded as an absolute contraindication to cadaveric organ donation for transplantation. This is largely due to fear of transmitting the pathogenic organisms to the immunosuppressed recipient. However, due to the current shortage of organs availabl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sözen H,Fidan K,Mahli A,Singin E,Buyan N,Sindel S,Söylemezoğlu O,Arinsoy T,Dalgic A

    更新日期:2008-01-01 00:00:00

  • Massive ascites due to right heart failure after cardiac transplantation and its treatment: a case report.

    abstract::Ascites is a common clinical condition during right heart failure. In this short report we have presented a patient with massive ascites due to right heart failure after cardiac transplantation who was previously operated for Ebstein's anomaly and pulmonary stenosis as well as mitral and tricuspid valve repairs. Right...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Sezgin A,Uguz E,Akay T,Aşlamaci S

    更新日期:2008-01-01 00:00:00

  • Factors Affecting eGFR Slope of Renal Transplant Patients During the First 2 Years.

    abstract:PURPOSE:In healthy individuals, glomerular filtration rate decreases by 1 mL/min/y after a peak level of 125.0 mL/min has been reached in adulthood. Any reduction greater than this is a progressive slope (slope more negative than -1 mL/min/y, stable [-1 to +1]), or an improvable slope if it shows more of an increase, t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Atay FF,Taskapan H,Berktas B,Yildirim O,Dogan M,Piskin T

    更新日期:2019-09-01 00:00:00

  • Contamination of the Preservation Solution in Solid Organ Transplantation.

    abstract:INTRODUCTION:Preservation solutions (PS), in which grafts for patients undergoing liver transplantation are stored, represent a medium suitable for microorganism growth and a potential source for transmission of pathogenic germs to the transplant recipients. The aim of the present study was to review the relevant liter...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审


    authors: Sotiropoulos GC,Kostakis ID,Prodromidou A,Garoufalia Z,Stamopoulos P,Machairas N

    更新日期:2019-03-01 00:00:00

  • The new method of time-lag ligation for portosystemic shunt using coronary artery bypass graft occluder for adult living donor liver transplantation.

    abstract::We performed a living donor liver transplantation (LDLT) for a 57-year-old man who had end-stage liver failure with portal hypertension and an inferior mesenteric vein-left testicular vein (IMV-LTV) shunt. At operation, we did not clamp the shunt but encircled it with a coronary artery bypass graft (CABG) occluder (Su...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kokai H,Sato Y,Yamamoto S,Oya H,Nakatsuka H,Kobayashi T,Watanabe T,Takizawa K,Hatakeyama K

    更新日期:2009-12-01 00:00:00

  • Antiviral therapy for hepatitis B after kidney transplantation.

    abstract::The clinical outcome of HBsAg-positive renal transplant recipients has been adversely affected by potentially fatal acute hepatitic exacerbations and chronic liver disease, in addition to the increased risk of hepatocellular carcinoma. The difficulty in predicting the evolution and severity of liver disease after kidn...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Chan TM

    更新日期:2004-09-01 00:00:00

  • C2 monitoring of cyclosporine in stable renal transplant patients results in lower costs and improved renal function.

    abstract:INTRODUCTION:C2 (2-hour post-absorption levels) monitoring of cyclosporine (CsA) seems to reduce the rate of acute rejection episodes (ARE) without increasing nephrotoxicity during the first months after transplant. There are a few reports on the impact of adopting this strategy in patients with stable renal transplant...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章


    authors: Domínguez J,Fuenzalida D,Norambuena R,Pais E,Cortes Monroy G,Llanos R

    更新日期:2005-04-01 00:00:00

  • Health-related quality of life after pediatric liver transplant: single-center experience in Chile.

    abstract:INTRODUCTION:Orthotopic liver transplantation is the treatment of choice for most terminal liver diseases in children. Currently, the improved survival of these patients is well documented, but their quality of life post-transplant is not described. In Chile, Hospital Luis Calvo Mackenna (HLCM) has performed pediatric ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Alba A,Uribe M,Hunter B,Monzón P,Ferrada C,Heine C,Auad H

    更新日期:2013-01-01 00:00:00

  • Pregnancy after renal transplantation: ten-year single-center experience.

    abstract::There has been an increase in the number of pregnancies among renal transplant recipients. Our experience included 61 pregnancies in 53 patients from January 1997 to April 2007, with 6 patients having multiple pregnancies. Patients were studied for clinical, obstetrical, and perinatal outcomes. The mean patient age wa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Ghafari A,Sanadgol H

    更新日期:2008-01-01 00:00:00

  • The importance of clinical parameters when differentiating cholestatic hepatitis C virus from allograft rejection.

    abstract:BACKGROUND:The exact cause and appropriate treatment for cholestasis following liver transplantation in recipients with hepatitis C virus recurrence (RHCV) are difficult to determine. Our objective was to determine the diagnostic accuracy of clinical and histological parameters in liver transplant recipients with RHCV ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Neff GW,Shire N,Ruiz P,O'Brien C,Garcia M,Dela Garza J,Rudich SR,Reddy KR

    更新日期:2005-12-01 00:00:00

  • Pancreas Transplantation: Small-Center Experience in Type 1 Diabetes Mellitus in a High-Incidence Region.

    abstract:BACKGROUND:Pancreas transplantation (PT) is the best option of care for patients with type I diabetes mellitus (T1DM). METHODS:From July 2005 to September 2014, we performed 27 PT from deceased donors (24 simultaneous pancreas-kidney transplantations [SPKT] and 3 pancreas transplantations alone) in a region with a hig...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Tondolo V,Manunza R,Pellegrino RA,Zamboni F

    更新日期:2015-09-01 00:00:00

  • Association between hepatitis B and hepatocellular carcinoma recurrence in patients undergoing liver transplantation.

    abstract:BACKGROUND/AIMS:Hepatitis B virus (HBV) and hepatocellular carcinoma (HCC) recurrences affect both patient and graft survivals post-orthotopic liver transplantation (OLT) in HBV patients with HCC. We analyzed the relationship between HBV and HCC recurrence in a large cohort of HBV-OLT patients with versus without HCC. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Kiyici M,Yilmaz M,Akyildiz M,Arikan C,Aydin U,Sigirli D,Nart D,Yilmaz F,Ozacar T,Karasu Z,Kilic M

    更新日期:2008-06-01 00:00:00