Experience with single-dose daclizumab in the prevention of acute rejection in heart transplantation.

Abstract:

INTRODUCTION:Daclizumab is a monoclonal antibody that binds to the interleukin-2 receptor. It has been used as induction therapy in heart transplantation with two to five repeated administrations over several weeks. The objective of our study was to estimate the efficacy and safety of induction therapy with only one dose of daclizumab in a consecutive series of patients undergoing heart transplantation. METHODS:Thirty-two consecutive heart transplants performed since July 2002, who received single-dose daclizumab as induction therapy, were compared with the 30 patients transplanted previously, who received OKT3. In both groups, maintenance immunosuppression included cyclosporine or tacrolimus, mycophenolate mofetil, and corticosteroids. Follow-up time was 1 year. RESULTS:There were no baseline differences between the two groups regarding age, gender, or etiology. In the group treated with daclizumab there were more diabetics (43% versus 10%, P = .01) and the ischemia time was longer (192 versus 156 minutes, P = .03). During the first posttransplant year, 76% of patients treated with OKT3 and 55% of those treated with daclizumab presented acute rejection > or =3A; 20% and 25%, respectively, presented infections; and 5 (17%) patients in the OKT3 group and 2 (6%) in the group treated with daclizumab died. None of these differences was statistically significant. CONCLUSIONS:Our experience suggests that induction therapy with a single-dose regimen of daclizumab seems to have an efficacy and safety profile similar to OKT3, and it is easier to administer and has a lower cost than other induction regimens.

journal_name

Transplant Proc

authors

Cuppoletti A,Perez-Villa F,Vallejos I,Roig E

doi

10.1016/j.transproceed.2005.10.086

subject

Has Abstract

pub_date

2005-11-01 00:00:00

pages

4036-8

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)01274-1

journal_volume

37

pub_type

杂志文章
  • In Vitro and In Vivo (Rabbit, Guinea Pig, Mouse) Properties of a Novel Resorbable Polymer and Allogenic Bone Composite for Guided Bone Regeneration and Orthopedic Implants.

    abstract:INTRODUCTION:Currently, there is no bone fixation material that could be fully replaced by the competent recipient bone. The creeping substitution of the bone graft by the recipient bone is the result of its unique potential related to the presence of bone morphogenetic proteins (BMPs). However, the size of the human b...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.02.121

    authors: Gut G,Ambroziak M,Bojar W,Szaraniec B,Chłopek J,Flis S,Koronkiewicz M,Jastrzębski Z

    更新日期:2018-09-01 00:00:00

  • A Noninvasive and Donor-independent Method Simultaneously Monitors Rejection and Infection in Patients With Organ Transplant.

    abstract:BACKGROUND:Rejection and infection are 2 major complications affecting the health and survival of patients receiving an allograft organ transplantation. We describe a diagnostic assay that simultaneously monitors for rejection and infection in recipients of kidney transplant by sequencing of cell-free DNA (cfDNA) in pl...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.04.051

    authors: Zhou Y,Yang G,Liu H,Chen Y,Li X,Ge J,Wang X,Niu H,Dong W,Jiang T,Shi H,Peng L,Liu L

    更新日期:2019-01-01 00:00:00

  • Clinical usefulness of 3-dimensional computerized tomographic renal angiography to detect transplant renal artery stenosis.

    abstract:OBJECTIVE:The aim of this study was to evaluate whether 3-dimensional computerized tomographic angiography (3D-CTA) is useful to detect transplant renal artery stenosis (TRAS). METHODS:Fourteen patients with clinically suspected TRAS underwent color Doppler ultrasonography (CDU) and 3D-CTA before renal angiography. We...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.12.007

    authors: Sun IO,Hong YA,Kim HG,Park HS,Choi SR,Chung BH,Chun HJ,Choi BS,Park CW,Kim YS,Yang CW

    更新日期:2012-04-01 00:00:00

  • 20-year experience with elderly donors in living renal transplantation.

    abstract:PURPOSE:This study evaluates the impact of living renal donors (LD) aged 60 years and older on graft performance and patient survival in an old-for-young constellation. PATIENTS AND METHODS:We analyzed 144 consecutive LDs between January 1983 and December 2002 (19 patients 60+/125 controls). RESULTS:Mean donor age in...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2003.10.034

    authors: Giessing M,Slowinski T,Deger S,Tuerk I,Schönberger S,Budde K,Loening SA

    更新日期:2003-12-01 00:00:00

  • Transplantation in Congenital Heart Disease: A Challenge.

    abstract:BACKGROUND:Heart failure is the leading cause of death in grown-up congenital heart disease patients (GUCH). Although heart transplantation (OHT) remains the gold standard in end-stage heart failure, the ratio of GUCH patients undergoing this procedure remains low. OBJECTIVE:Describe the cohort of GUCH patients underg...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.12.027

    authors: Palomo-López N,Escalona-Rodríguez S,Martín-Villén L,Herruzo-Avilés Á,Hinojosa-Pérez R,Escoresca-Ortega A,Porras-López M,Corcia-Palomo Y,Adsuar-Gómez A

    更新日期:2020-03-01 00:00:00

  • Factors affecting survival and tumor recurrence in patients transplanted for hepatocellular carcinoma and coexistent hepatitis C virus.

    abstract::A better understanding of tumor factors influencing patient and graft survival and recurrence of hepatocellular carcinoma (HCC) associated with hepatitis C virus (HCV) cirrhosis may be useful to maximize the benefits of liver transplantation (OLT). Sixty-three adults underwent OLT for end-stage liver disease secondary...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.09.022

    authors: Briceño J,Ruiz J,Ciria R,Naranjo A,Sánchez-Hidalgo J,Luque A,Rufián S,de la Mata M,López-Cillero P

    更新日期:2008-11-01 00:00:00

  • Results of Transplantation of Kidneys Procured From Donors After Brain Death Aged 60 Years and Older.

    abstract:OBJECTIVE:To analyze results of transplantation of kidneys procured from donors after brain death aged 60 years and older (hereafter denoted by "≥60") compared to kidneys procured from donors after brain death aged 40-59 years (hereafter denoted by "40-59") in medium-term follow-up period, and to assess factors that af...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.02.102

    authors: Franczyk S,Skrabaka D,Jędrusik E,Ziaja J,Kolonko A,Świder R,Sekta S,Czerwiński J,Owczarek AJ,Durlik M,Więcek A,Cierpka L,Król R

    更新日期:2018-01-01 00:00:00

  • Clinical significance of prophylactic antibiotics in renal transplantation.

    abstract:INTRODUCTION:The use of new selective immunosuppressants as well as the emergence of new antimicrobial resistances raise the use of prophylactic antibiotics as a matter of controversy. The purpose of this study was to retrospectively analyze the clinical significance of prophylactic antibiotics in kidney transplantatio...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.10.059

    authors: Choi SU,Lee JH,Oh CK,Shin GT,Kim H,Kim SJ,Kim SI

    更新日期:2013-05-01 00:00:00

  • Steroid-free immunosuppression after liver transplantation does not increase the risk of graft fibrosis.

    abstract:BACKGROUND:Steroid-free immunosuppression after liver transplantation (OLT) is effective and safe in the short and mid terms. However, research has shown a higher risk for late fibrosis among pediatric liver transplant recipients who have steroids withdrawn. Our aim was to test this hypothesis in the adult population. ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.03.118

    authors: Manzia TM,Toti L,Angelico R,Di Cocco P,Orlando G,Tisone G

    更新日期:2010-05-01 00:00:00

  • Analysis of urinary gene expression of epithelial-mesenchymal transition markers in kidney transplant recipients.

    abstract:INTRODUCTION:Renal graft dysfunction due to acute rejection, acute tubular necrosis, or anticalcineurin toxicity with development of interstitial fibrosis or tubular atrophy are the primary causes of graft failure. Determination of kidney function using the serum creatinine concentration demonstrates low sensitivity as...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.07.051

    authors: Gomez-Alamillo C,Benito-Hernandez A,Ramos-Barron MA,Agüeros C,Rodrigo E,Ruiz JC,Sanchez M,San Cosme L,Arias M

    更新日期:2010-10-01 00:00:00

  • Male sexual function in patients receiving different types of renal replacement therapy.

    abstract:BACKGROUND:Patients with end-stage renal disease (ESRD) experience erectile dysfunction (ED). Although it is a benign disorder, ED is related to physical and psychosocial health, and it has a significant impact on the quality of life (QOL). The objective of the present study was to investigate the effects of different ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.09.025

    authors: Yavuz D,Acar FN,Yavuz R,Canoz MB,Altunoglu A,Sezer S,Durukan E

    更新日期:2013-01-01 00:00:00

  • Retrospective evaluation of donor pain and pain management after laprascopic nephrectomy.

    abstract:PURPOSE:The purpose of this study was to evaluate donor pain and pain management beginning immediately postoperatively until hospital discharge. METHODS:All kidney donors were included from 2008 and 2009. Demographic data, operative data, pain scores in the postanesthesia care unit, and visual analog pain scale (VAS) ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.06.038

    authors: Gorevski E,Wead S,Tevar A,Succop P,Volek P,Martin-Boone J

    更新日期:2011-09-01 00:00:00

  • Rehabilitation of ischemically damaged human kidneys by normothermic extracorporal hemoperfusion in situ with oxygenation and leukocyte depletion.

    abstract::The potential use of donors after cardiac death is an important issue. The crucial point in uncontrolled donors after cardiac death is the warm ischemic time. Definition of the limit of warm ischemic time was 1 of our tasks; an other was to develop a preservation protocol. Five uncontrolled donors kidneys with warm is...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.01.071

    authors: Reznik O,Bagnenko S,Skvortsov A,Ananyev A,Senchik K,Loginov I,Moysyuk Y

    更新日期:2010-06-01 00:00:00

  • Brain death caused by electric shock and organ donation in children.

    abstract:INTRODUCTION:There are still few publications about brain death caused by electric shock and the use of organs for donation in this situation. We sought to present our experience, with brain dead pediatric donors caused by electric shock. MATERIAL AND METHODS:Notification registers of potential donors were analyzed fr...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.01.033

    authors: Todeschini DP,Maito ED,Maldotti A,Moreira AL,Capaverde FB,Figueiredo FM,Oliveira DM,Costa MG,Hoelfmann N,Londero GG,Leães PE,Garcia VD

    更新日期:2007-03-01 00:00:00

  • Endothelial nitric oxide synthase protects transplanted mouse livers against storage/reperfusion injury: Role of vasodilatory and innate immunity pathways.

    abstract::Endothelial nitric oxide synthase (eNOS) plays a role in microcirculatory and immunomodulatory responses after warm ischemia/reperfusion. We hypothesized that eNOS is essential to maintain microcirculation, attenuate macrophage infiltration and decrease graft injury after liver transplantation. Liver transplantation w...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.10.171

    authors: Theruvath TP,Zhong Z,Currin RT,Ramshesh VK,Lemasters JJ

    更新日期:2006-12-01 00:00:00

  • Transplantation of cryopreserved pancreatic islets into the portal vein.

    abstract::Pancreatic islet cells of rats obtained by the collagenase digestion method were preserved from 7 to 10 days at -80 degrees C in a deep freezer or at -196 degrees C in liquid nitrogen with Dulbecco modified Eagle's medium, supplemented with 10% or 20% DMSO (dimethyl sulfoxide); thawing was performed in a 37 degree C w...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:

    authors: Nakagawara G,Kojima Y,Mizukami T,Ono S,Miyazaki I

    更新日期:1981-06-01 00:00:00

  • Total parenteral nutrition: challenges and practice in the cirrhotic patient.

    abstract::Patients with cirrhosis develop metabolic derangements of protein, carbohydrate, and lipid metabolism. Malnutrition is commonplace and is associated with morbidity and mortality. Specific nutrient deficiencies may occur and enteral or parenteral nutritional support may improve outcome in appropriately selected patient...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.transproceed.2006.05.030

    authors: Buchman AL

    更新日期:2006-07-01 00:00:00

  • Internal jugular versus subclavian vein catheterization for central venous catheterization in orthotopic liver transplantation.

    abstract::The aim of this study was to compare incidence rates of mechanical and infectious complications associated with central venous catheterization via the internal jugular vein (IJV) versus the subclavian vein (SV) among 45 consecutive patients undergoing orthotopic liver transplantation (OLT) between January 2000 and Jun...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.transproceed.2005.07.021

    authors: Torgay A,Pirat A,Candan S,Zeyneloglu P,Arslan G,Haberal M

    更新日期:2005-09-01 00:00:00

  • Evaluation of Recurrence Predictors and Survival Probability After Liver Transplantation for Hepatocellular Carcinoma: Analysis From a Single Center.

    abstract:BACKGROUND:Liver transplantation is the criterion standard treatment for hepatocellular carcinoma, but tumor recurrence remains a problem leading to a worse prognosis. We aimed to evaluate factors associated with recurrence of hepatocellular carcinoma and survival after this procedure. METHODS:We retrospectively revie...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.02.063

    authors: Boteon YL,Carvalheiro da Silva AP,Boin IF,de Ataide EC

    更新日期:2016-07-01 00:00:00

  • Liver transplant results for hepatocellular carcinoma applying strict preoperative selection criteria.

    abstract:INTRODUCTION:Liver transplantation is currently the best therapeutic option for small hepatocellular carcinoma (HC) in selected cirrhotic patients. The main aim of this study was to analyze the results of a recent series of liver transplant cirrhotic patients with small HC applying strict preoperative selection criteri...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.02.059

    authors: Santoyo J,Suarez MA,Fernández-Aguilar JL,Jiménez M,Perez Daga JA,Sánchez-Perez B,Gonzalez Poveda I,Gonzalez-Sanchez A,Ramírez C,de la Fuente A

    更新日期:2005-04-01 00:00:00

  • Anti-Gal titers in healthy adults and inflammatory bowel disease patients.

    abstract:INTRODUCTION:ALPHA-GAL is a glycoconjugate present on cell membranes of mammals and bacteria but not humans who display anti-Gal antibodies (AB) in high titers provoked by the commensal gut flora. In the present study, we sought to determine the longitudinal course of alpha-Gal specific AB titers of all isotypes over 8...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2011.09.074

    authors: Mangold A,Lebherz D,Papay P,Liepert J,Hlavin G,Lichtenberger C,Adami A,Zimmermann M,Klaus D,Reinisch W,Ankersmit HJ

    更新日期:2011-12-01 00:00:00

  • Transitional Study of Patient-Controlled Analgesia Morphine With Ketorolac to Patient-Controlled Analgesia Morphine With Parecoxib Among Donors in Adult Living Donor Liver Transplantation: A Single-Center Experience.

    abstract:BACKGROUND:In this study, as our center transitions from using patient-controlled analgesia (PCA) morphine with intravenous (IV) ketorolac to PCA morphine with IV parecoxib, the two regimens are compared in terms of quality of pain control. METHODS:Post-operative pain management sheets were collected retrospectively a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.11.021

    authors: Lim KI,Liu CK,Chen CL,Wang CH,Huang CJ,Cheng KW,Wu SC,Shih TH,Yang SC,Lee YE,Jawan B,Juang SE

    更新日期:2016-05-01 00:00:00

  • Techniques to Ameliorate the Impact of Second Warm Ischemic Time on Kidney Transplantation Outcomes.

    abstract::Anastomosing the renal artery and vein in transplant recipients without a cooling mechanism exposes the kidney to temperatures exceeding the metabolic threshold (15°C to 18°C), at which the protective effects of renal hypothermia are lost. This anastomotic time, or second warm ischemic time, can be deleterious to graf...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.transproceed.2018.09.003

    authors: Hameed AM,Yuen L,Pang T,Rogers N,Hawthorne WJ,Pleass HC

    更新日期:2018-12-01 00:00:00

  • DNA released from rejecting organs is an indicator of the degree of graft cellular damage.

    abstract::Warm and cold ischemia as well as rejection of the transplanted organ or tissue cause destructive changes in the graft parenchyma. Fragments of disintegrated cellular organelles are phagocytized and digested by recipient scavenger cells in lymph nodes, spleen, and liver. Some fragments engulfed by dendritic cells are ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.01.064

    authors: Interewicz B,Olszewski WL,Stanislawska J,Sikora M,Durlik M,Maksymowicz M

    更新日期:2005-01-01 00:00:00

  • Small bowel and colon transplantation in rats using porto-portal cuff anastomosis.

    abstract::Portal versus systemic venous drainage and colon grafting are major controversies in the techniques of intestinal transplantation. The rat is the best animal for research in this field. Nevertheless, this model requires complex microvascular anastomoses that are responsible for the high incidence of technical failures...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.05.062

    authors: Galvão FH,Santos RM,Neto AB,Machado MA,Bacchella T,Machado MC

    更新日期:2006-07-01 00:00:00

  • Modified liver-free multivisceral transplantation for a metastatic small bowel neuroendocrine tumor: a case report.

    abstract::Neuroendocrine tumors originating from the small bowel frequently metastasize to the lymph nodes and/or liver. Although surgical extirpation of the primary tumor and locoregional metastases epitomizes the management of patients with such tumors, this is not always possible with conventional surgical techniques. Nonres...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.01.007

    authors: Frilling A,Giele H,Vrakas G,Reddy S,Macedo R,Al-Nahhas A,Wasan H,Clift AK,Gondolesi GE,Vianna RM,Friend P,Vaidya A

    更新日期:2015-04-01 00:00:00

  • Association Safety of Liver Preservation Solutions at the State University of Campinas From 2010 to 2014.

    abstract::The probable reason for mixing solutions during the harvesting procedure is due to the presence of multiple transplant teams that have their own solution usage tradition. Despite numerous studies comparing the efficacy of different preservation solutions, there is no study addressing the associating solution and if th...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2017.01.058

    authors: Reigada CHP,de Ataide EC,Mattosinho TDAP,Costa LBE,Escanhoela CA,Boin IFSF

    更新日期:2017-05-01 00:00:00

  • Late Conversion to Belatacept After Kidney Transplantation: Outcome and Prognostic Factors.

    abstract:BACKGROUND:Conversion to belatacept at a later point after kidney transplantation (KT) as a rescue therapy has been shown to be beneficiary in an increasing number of patients, but prognostic factors for a favorable outcome have never been investigated. METHODS:The present study analyzed all KT patients after late con...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2017.05.013

    authors: Dürr M,Lachmann N,Zukunft B,Schmidt D,Budde K,Brakemeier S

    更新日期:2017-10-01 00:00:00

  • Combination therapy with anti-ICOS and cyclosporine enhances cardiac but not islet allograft survival.

    abstract::The blockade of costimulatory signals is a powerful strategy to prevent allograft rejection and facilitate transplantation tolerance. In recent years, a series of novel costimulatory molecules have been identified, including an inducible costimulatory molecule (ICOS). To date, little has been uncovered regarding the t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2003.08.029

    authors: Nanji SA,Hancock WW,Anderson CC,Zhu LF,Kneteman NM,Shapiro AM

    更新日期:2003-11-01 00:00:00

  • New strategies of cyclosporine monitoring in heart transplantation: initial results.

    abstract::The aim of this study was to evaluate cyclosporine (CyA) absorption profiles in heart transplantation to establish the most adequate monitoring strategy and determine the optimal therapeutic range for AUC(0-4) or C2 levels. A total of 22 full pharmacokinetic studies were performed at steady-state in 22 adult heart tra...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/s0041-1345(03)00657-2

    authors: Arizón del Prado JM,Aumente Rubio MD,Cárdenas Aranzana M,López Malo de Molina MD,Segura Saint-Gerons J,López Granados A,Rodríguez Esteban E,Ruiz Ortiz M,Romo Peñas E,Muñoz Carvajal I,González Rodríguez JR,Segura Saint-Gerons C,Va

    更新日期:2003-08-01 00:00:00