Impact of patient characteristics and comorbidity profile on activation of patients on the kidney transplantation waiting list.

Abstract:

BACKGROUND:The aim of this study was to examine which demographic and comorbidity factors affected the activation of patients with end-stage renal disease on the national kidney transplantation waiting list. METHODS:This was a prospective cohort study across 13 transplantation centers in the United Kingdom from October 1, 2006 to September 30, 2007. Data were collected for all new adult patients (n = 1530) referred to the renal transplantation assessment clinic. The proportion of patients who were activated to the waiting list after a minimum one year follow-up was estimated. Factors influencing activation of patients on the waiting list were examined. RESULTS:A total of 872 (58.9%) patients were activated to the transplantation waiting list. The likelihood of activation to the transplantation waiting list was lower in patients older than 65 years (P = .021), nonwhite ethnicity (P < .0001), smokers (P < .0001), and those in whom diabetes was the cause of renal failure (P = .004). Multivariate analysis showed that there was an adverse impact of comorbidity such as ischemic heart disease (P = .003), diabetes (P = .006), and peripheral vascular disease (P = .007) on the likelihood of activation to the waiting list. CONCLUSION:Patient characteristics and comorbidity are associated with the probability of activation of patients to the waiting list.

journal_name

Transplant Proc

authors

Akolekar D,Forsythe JL,Oniscu GC

doi

10.1016/j.transproceed.2013.03.033

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2115-22

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00503-4

journal_volume

45

pub_type

杂志文章,多中心研究
  • l-Arginine supplementation protects against hepatic ischemia-reperfusion lesions in rabbits.

    abstract::We evaluated the effects of a substrate in the biosynthesis of nitric oxide (NO)-l-arginine (LARG)-on hepatic lesions caused by ischemia/reperfusion (I/R) injury in rabbit livers. Rabbits were pretreated with LARG (150 mg/kg IV) or saline solution 0.9% (SS) before the hepatic I/R procedure. The effects of LARG on hepa...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.02.050

    authors: Taha MO,Simões MJ,Haddad MA,Capelato RC,Budny N,Matsumoto AH,Soares PC,Santos WM,Armeato GD,Araki CM,Gomes JS,Magalhães KG,Tersariol IL,Monteiro HP,Oliveira-Júnior IS,Jurkiewicz A,Caricati-Neto A

    更新日期:2009-04-01 00:00:00

  • Randomized clinical assay for hepatic grafts preservation with University of Wisconsin or histidine-tryptophan-ketoglutarate solutions in liver transplantation.

    abstract::University of Wisconsin (UW) solution has been the standard for preservation of liver transplantation grafts since 1989. However, some studies demonstrated that histidine-tryptophan-ketoglutarate (HTK) solution is also effective. The purpose of this study was to compare the efficacy of both solutions in liver transpla...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.transproceed.2006.06.071

    authors: Meine MH,Zanotelli ML,Neumann J,Kiss G,de Jesus Grezzana T,Leipnitz I,Schlindwein ES,Fleck A Jr,Gleisner AL,de Mello Brandão A,Marroni CA,Cantisani GP

    更新日期:2006-07-01 00:00:00

  • Hemophagocytic Syndrome as Uncommon Cause of Severe Pancytopenia After Liver Transplantation.

    abstract:BACKGROUND:A rare but life-threatening cause of pancytopenia after liver transplantation is hemophagocytic syndrome. We present a 48-year-old woman who underwent liver transplantation and developed a hemophagocytic syndrome secondary to Epstein-Barr virus with a fatal course, despite initial treatment with immunosuppre...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2020.02.060

    authors: Valenzuela EF,García AC,García-Pajares F,Tejada JT,Muñoz RN,Martín CM,Delgado LS,Martín CA,Álvarez CA,Fernández-Fontecha E,Sánchez-Antolín G

    更新日期:2020-06-01 00:00:00

  • Vitality of pancreatic islets labeled for magnetic resonance imaging with iron particles.

    abstract::We previously described an in vivo method for pancreatic islet visualization using magnetic resonance imaging with the aid of superparamagnetic nanoparticles of iron oxide (Resovist) or by magnetic beads precoated with antibodies (Dynabeads). The aim of this study was to investigate the in vitro effect of islet labeli...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.09.052

    authors: Berkova Z,Kriz J,Girman P,Zacharovova K,Koblas T,Dovolilova E,Saudek F

    更新日期:2005-10-01 00:00:00

  • Intrarenal blood oxygenation and renal function measured by magnetic resonance imaging during long-term cyclosporine treatment.

    abstract::Treatment with cyclosporine (CsA) markedly affects the renin-angiotensin-aldosterone system in parallel with an increase in the net tubular reabsorption or a decrease in secretion. Since tubular reabsorption is closely linked to medullary oxygen consumption, the aim of the present study was to investigate the intraren...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.09.013

    authors: Kristensen DH,Pedersen M,Grøn MC,Flyvbjerg A,Madsen M,Frøkiaer J,Mortensen J

    更新日期:2005-10-01 00:00:00

  • Successful Re-resection for Locally Recurrent Retroperitoneal Liposarcoma at Four Years After Ex Vivo Tumor Resection and Autotransplantation of the Liver: A Case Report.

    abstract::Surgical resection should be considered for isolated locally recurrent retroperitoneal liposarcomas. We experienced a case of successful re-resection for locally recurrent retroperitoneal liposarcomas 4 years after ex vivo tumor resection and autotransplantation of the liver. A 75-year-old man was admitted to our hosp...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2016.01.026

    authors: Kobayashi T,Miura K,Ishikawa H,Soma D,Zhang Z,Yuza K,Hirose Y,Takizawa K,Nagahashi M,Sakata J,Kameyama H,Kosugi S,Wakai T

    更新日期:2016-05-01 00:00:00

  • Reliability of frozen section in the assessment of allograft steatosis in liver transplantation.

    abstract:BACKGROUND:Because liver allograft steatosis is an important risk factor of graft dysfunction after liver transplantation, it must be taken into consideration during graft acceptance. The aim of this study was to evaluate the reliability of frozen section in the assessment of liver steatosis before transplantation. ME...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2014.09.102

    authors: Hołówko W,Mazurkiewicz M,Grąt M,Koperski L,Lewandowski Z,Smoter P,Ziarkiewicz-Wróblewska B,Górnicka B,Zborowska H,Krawczyk M

    更新日期:2014-10-01 00:00:00

  • Split liver transplantation in Shiraz Transplant Center.

    abstract:BACKGROUND:Cadaveric organ splitting emerged from an improved understanding of the surgical anatomy of the liver as a possible mechanism to expand the organ pool. In this study, we have reported our first series of split liver transplantations (SLT). MATERIALS AND METHODS:From June 2006 to June 2008, we performed 17 p...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.07.052

    authors: Bahador A,Salahi H,Nikeghbalian S,Dehghani SM,Kakaei F,Sabet B,Kazemi K,Rajaei E,Gholami S,Malek-Hosseini SA

    更新日期:2009-09-01 00:00:00

  • Construction and characterization of a cDNA library from liver tissue of Chinese Banna minipig inbred line.

    abstract::A xenograft that performs efficient functions is an essential premise for successful xenotransplantation. Our early study indicated that Chinese Banna minipig inbred line (BMI) was an ideal xenograft donor. However, the activities of some proteins synthesized by the BMI liver are different from the human, which could ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2006.06.095

    authors: Tan W,Chen Y,Zhang L,Lu Y,Li S,Zeng R,Zeng Y,Li Y,Cheng J

    更新日期:2006-09-01 00:00:00

  • Public Awareness of Knowledge, Belief, and Attitude Regarding Organ Donation and Organ Transplantation: A National Survey From the United Arab Emirates.

    abstract:BACKGROUND:Organ donation in the United Arab Emirates (UAE) was restricted until recently to living donation. This survey was conducted to explore the public knowledge, belief, and attitude regarding donation during life and after death. METHODOLOGY:A 31-item survey was distributed among 900 participants (UAE resident...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2018.08.006

    authors: Janahi FK,Al Rais A,Al Rukhaimi M,Khamis AH,Hickey D

    更新日期:2018-12-01 00:00:00

  • Safety and efficacy of once-daily modified-release tacrolimus in liver transplant recipients: a multicenter postmarketing surveillance in Japan.

    abstract:INTRODUCTION:Modified-release formulation of tacrolimus (TAC-MR) has been developed with the intent of improving patient adherence and quality of life. A number of studies have indicated that the efficacy and safety of once-daily TAC-MR were comparable with those of the original formulation, twice-daily tacrolimus. How...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究

    doi:10.1016/j.transproceed.2013.11.071

    authors: Uemoto S,Abe R,Horike H,So M

    更新日期:2014-04-01 00:00:00

  • Evaluation of thyroid disease in kidney transplantation candidates: management and follow-up.

    abstract:INTRODUCTION:Diagnosis of thyroid disease is fundamental in the evaluation of patients awaiting kidney transplantation. We analyzed the incidence of thyroid disease in patients with end-stage renal disease (ESRD) and evaluated its evolution before and after kidney transplantation. PATIENTS AND METHODS:Between January ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.03.014

    authors: Veroux M,Giuffrida G,Gagliano M,Giaquinta A,Tallarita T,Sorbello M,Corona D,Zerbo D,Vizcarra D,Scriffignano V,Cannizzaro MA,Veroux P

    更新日期:2009-05-01 00:00:00

  • Fibromyalgia and its clinical relevance in renal transplant recipients.

    abstract:OBJECTIVE:Recent evidence suggests that fibromyalgia syndrome (FS) is associated with inflammation and endothelial dysfunction. Our aim was to determine the prevalence of FS in renal transplant recipients and to identify possible links between FS and clinical and laboratory parameters. METHODS:Ninety-nine kidney trans...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.01.026

    authors: Erkmen Uyar M,Sezer S,Bal Z,Guliyev O,Tutal E,Genctoy G,Kulah E,Ozdemir Acar N,Haberal M

    更新日期:2015-05-01 00:00:00

  • Use of cyclosporine in hematopoietic cell transplantation.

    abstract::Early attempts to perform successful allogeneic hematopoietic stem cell transplants were plagued by graft rejection and graft-versus-host disease, leading many investigators to lose hope that bone marrow transplantation could ever become a useful therapeutic approach in clinical medicine. Although many subsequent disc...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.transproceed.2004.01.043

    authors: Hogan WJ,Storb R

    更新日期:2004-03-01 00:00:00

  • Do we have to treat subclinical rejections in early protocol renal allograft biopsies?

    abstract::The aim of the present study was to evaluate whether treatment of subclinical, borderline rejections (SR/BR) or histological findings of chronic allograft nephropathy (CAN) in protocol biopsies in the first month posttransplantation after living related kidney transplantation has a beneficial effect on graft histology...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.08.023

    authors: Masin-Spasovska J,Spasovski G,Dzikova S,Petrusevska G,Lekovski Lj,Ivanovski N,Popov Z

    更新日期:2007-10-01 00:00:00

  • A logistic regression model for predicting health-related quality of life in kidney transplant recipients.

    abstract:BACKGROUND:To develop a logistic regression model capable of predicting health-related quality of life (HRQOL) among kidney transplant recipients and determine its accuracy. METHODS:Three groups of patients were selected: 70 healthy controls, 136 kidney transplant patients as a derivation set, and another 110 kidney t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.04.004

    authors: Khedmat H,Karami GR,Pourfarziani V,Assari S,Rezailashkajani M,Naghizadeh MM

    更新日期:2007-05-01 00:00:00

  • Intrahepatic cholangiocarcinoma arising in chronic viral hepatitis-associated cirrhosis: two transplant cases.

    abstract::Hepatitis C virus (HCV) or hepatitis B virus (HBV)-related cirrhosis is known to be a risk factor for hepatocellular carcinoma (HCC). Recently, these viruses have been reported to have an etiologic role in the development of intrahepatic cholangiocarcinoma (ICC). Herein we have reported two cases of HCV- and HBV-relat...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.06.071

    authors: Nart D,Ertan Y,Pala EE,Zeytunlu M,Kilic M,Yilmaz F

    更新日期:2008-12-01 00:00:00

  • Endoscopic management of urologic complications following renal transplantation: impact of ureteral anastomosis.

    abstract:OBJECTIVE:To evaluate the success of ureteral stent placement to treat or prepare for surgical treatment of urologic complications after renal transplantation, according to a type of ureteral anastomosis. PATIENT AND METHODS:From May 1989 to December 2006, we performed 703 kidney transplantations including 412 extrave...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2009.08.046

    authors: Tillou X,Raynal G,Demailly M,Hakami F,Saint F,Petit J

    更新日期:2009-10-01 00:00:00

  • A patient with hepatic artery thrombosis after living-donor liver transplantation survived the great East Japan earthquake 3 days after reoperation: a case report.

    abstract:BACKGROUND:On March 11, 2011, our hospital was severely damaged by the Great East Japan Earthquake. We report the rare case of a 5-month-old patient with hepatic artery thrombosis (HAT) after living donor liver transplantation (LDLT), who survived the earthquake that occurred 3 days after the reoperation; we were able ...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2012.11.023

    authors: Miyagi S,Kawagishi N,Satoh K,Sekiguchi S,Ohuchi N,Satomi S

    更新日期:2013-06-01 00:00:00

  • Ethical considerations in the early composite tissue allograft experience: a review of the Louisville Ethics Program.

    abstract::This paper reviews the formulation and evolution of the ethical component in one of the earliest clinical composite tissue allograft (CTA) programs, the hand transplantation program in Louisville, Kentucky, USA. The purpose was to derive lessons and define principles to give guidance for future programs and introducti...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,评审

    doi:10.1016/j.transproceed.2004.12.179

    authors: Tobin GR,Breidenbach WC,Klapheke MM,Bentley FR,Pidwell DJ,Simmons PD

    更新日期:2005-03-01 00:00:00

  • The outcome of induction therapy with monoclonal antibodies in kidney transplantation among Iranian patients: a prospective study.

    abstract:INTRODUCTION:The administration of interlukin-2 receptor antagonists for induction therapy has reduced the incidence of acute rejection episodes in kidney transplantation. Although some studies have investigated the efficacy of these monoclonal antibodies, there is little experience among Iranian kidney transplant reci...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,随机对照试验

    doi:10.1016/j.transproceed.2009.06.180

    authors: Naderi GH,Mehraban D,Ganji MR,Jafarpouriani M,Latif AH

    更新日期:2009-09-01 00:00:00

  • Histocompatibility testing for highly sensitized transplant candidates.

    abstract::HLA antibodies can develop for many different reasons and are often present in the serum of patients awaiting renal transplantation. These antibodies can limit the patient's ability to find a compatible donor and are a risk factor for poor graft outcome. Detection of HLA antibodies is important for identifying compati...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2007.01.053

    authors: Saidman SL

    更新日期:2007-04-01 00:00:00

  • Induction of porcine regulatory cells by mycophenolic Acid-treated dendritic cells.

    abstract::Tolerance induction in murine allogeneic transplantation is relatively easy, often by induction of regulatory T cells (Treg). Unfortunately, the implementation of these models in clinical situations has not yielded reliable protocols of tolerance induction in humans. Our project sought to create a preclinical model of...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2008.12.004

    authors: Pilon C,Meurens F,Dauba A,Salmon H,Velge-Roussel F,Lebranchu Y,Baron C

    更新日期:2009-03-01 00:00:00

  • The new body mass index system in predicting renal graft outcomes.

    abstract:BACKGROUND:Obesity has been related to poor renal graft function. The aim of this study was to compare the long-term graft outcomes of living-related kidney recipients regarding donor-to-recipient body mass index (BMI) parameters using the old Quetelet BMI formula and the new Trefethen BMI formula. METHODS:From Novemb...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2013.12.029

    authors: Wang HH,Lin KJ,Chu SH,Chiang YJ,Liu KL,Hsieh CY

    更新日期:2014-01-01 00:00:00

  • Functional and histological comparison of rat liver preserved in University of Wisconsin solution compared with tissue preserved in a novel solution.

    abstract::An isolated perfused rat liver model was used to investigate biochemical and histologic changes during 2 hours of reperfusion after 24 hours of cold storage to compare Leeds solution (LS) with University of Wisconsin solution (UW). Compared with livers stored in UW, those perfused with LS showed significantly higher b...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2010.06.029

    authors: Corps CL,Ahmed I,McKenzie S,Shires M,Potts DJ,Lodge JP

    更新日期:2010-11-01 00:00:00

  • Randomized, Open-Label, Phase IV, Korean Study of Kidney Transplant Patients Converting From Cyclosporine to Prolonged-Release Tacrolimus Plus Standard- or Reduced-Dose Corticosteroids.

    abstract:BACKGROUND:This 24-week, multicenter, randomized, exploratory, comparative, open-label, phase-IV study assessed the safety and efficacy of prolonged-release tacrolimus (PR-T) with reduced-dose versus standard-dose corticosteroids in stable kidney transplant recipients in Korea after converting from cyclosporine-based t...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究,随机对照试验

    doi:10.1016/j.transproceed.2019.01.057

    authors: Baek CH,Kim CD,Lee DR,Kim YH,Yang J,Kim BS,Lee JS,Han SY,Kim SW,Lee S,Lee KW,Kong JM,Shin BC,Lee SH,Chae DW,Kwon YJ,Jiang H,Lee H,Park SK

    更新日期:2019-04-01 00:00:00

  • Compensatory Hypertrophy After Living Donor Nephrectomy.

    abstract:BACKGROUND:Previous studies have shown that kidney volume enhances the estimation of glomerular filtration rate (eGFR) in kidney donors. This study aimed to describe the phenomenon of compensatory hypertrophy after donor nephrectomy as measured on computerized tomographic (CT) scans. METHODS:An institutional Domain Sp...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2015.12.082

    authors: Chen KW,Wu MW,Chen Z,Tai BC,Goh YS,Lata R,Vathsala A,Tiong HY

    更新日期:2016-04-01 00:00:00

  • Pulse Oximeter Usefulness for Blood Pressure Monitoring in Patients Implanted With Latest-Generation Continuous-Flow Device HeartMate 3.

    abstract:INTRODUCTION:The measurement of blood pressure (BP) and the management of hypertension in patients with continuous-flow ventricular assist devices (CF-VADs) can present unique challenges. Patients with CF-VADs often do not have a palpable pulse, and therefore traditional blood pressure measurement by auscultation or au...

    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章

    doi:10.1016/j.transproceed.2018.04.086

    authors: Montalto A,Palermo A,Gherli R,Cammardella A,Contento C,Piazza V,Musumeci F

    更新日期:2019-01-01 00:00:00

  • Rapamycin Modulate Treg/Th17 Balance via Regulating Metabolic Pathways: A Study in Mice.

    abstract::A regulatory T (Treg) cell/T helper 17 (Th17) cell imbalance is involved in many autoimmune diseases. Rapamycin (Rapa), a clinically used immunosuppressive drug, has been shown to inhibit Th17 cell differentiation but promote Treg cell generation. In this study, we aimed to study the mechanism of Rapa acting on Treg a...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2019.04.067

    authors: Zhang J,Jin H,Xu Y,Shan J

    更新日期:2019-01-01 00:00:00

  • Addition of cladribine to induction/consolidation regimen does not impair peripheral blood stem cell mobilization and bone marrow harvest for autotransplantation in acute myeloid leukemia patients.

    abstract:BACKGROUND:The previous study by the Polish Adult Leukemia Group has demonstrated that addition of cladribine to standard DNR+AraC induction potentiates the antileukemic activity. The goal of this study was to compare the efficacy of bone marrow or peripheral blood hematopoietic cell collection in patients who obtained...

    journal_title:Transplantation proceedings

    pub_type: 杂志文章

    doi:10.1016/j.transproceed.2005.10.100

    authors: Holowiecki J,Grosicki S,Sadus-Wojciechowska M,Kachel L,Hellmann A,Mital A,Skotnicki AB,Piatkowska-Jakubas B,Jedrzejczak WW,Paluszewska M,Wach M,Marianska B,Wrzesien-Kus A,Krawczyk-Kulis M,Wojnar J

    更新日期:2005-12-01 00:00:00