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Impact of patient characteristics and comorbidity profile on activation of patients on the kidney transplantation waiting list.

Abstract：

BACKGROUND:The aim of this study was to examine which demographic and comorbidity factors affected the activation of patients with end-stage renal disease on the national kidney transplantation waiting list. METHODS:This was a prospective cohort study across 13 transplantation centers in the United Kingdom from October 1, 2006 to September 30, 2007. Data were collected for all new adult patients (n = 1530) referred to the renal transplantation assessment clinic. The proportion of patients who were activated to the waiting list after a minimum one year follow-up was estimated. Factors influencing activation of patients on the waiting list were examined. RESULTS:A total of 872 (58.9%) patients were activated to the transplantation waiting list. The likelihood of activation to the transplantation waiting list was lower in patients older than 65 years (P = .021), nonwhite ethnicity (P < .0001), smokers (P < .0001), and those in whom diabetes was the cause of renal failure (P = .004). Multivariate analysis showed that there was an adverse impact of comorbidity such as ischemic heart disease (P = .003), diabetes (P = .006), and peripheral vascular disease (P = .007) on the likelihood of activation to the waiting list. CONCLUSION:Patient characteristics and comorbidity are associated with the probability of activation of patients to the waiting list.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Akolekar D,Forsythe JL,Oniscu GC

doi

10.1016/j.transproceed.2013.03.033

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

2115-22

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00503-4

journal_volume

45

pub_type

杂志文章,多中心研究

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