当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > A Single-center Experience on the Value of Pancreas Graft Biopsies and HLA Antibody Monitoring After Simultaneous Pancreas-Kidney Transplantation.

A Single-center Experience on the Value of Pancreas Graft Biopsies and HLA Antibody Monitoring After Simultaneous Pancreas-Kidney Transplantation.

Abstract：

BACKGROUND:In simultaneous pancreas-kidney transplantation (SPKT), monitoring of the pancreas allograft is more complex than the kidney allograft due to difficulties in obtaining pancreas histology and weak clinical evidence supporting the role of donor-specific antibodies (DSA). METHODS:We performed a single-center retrospective analysis of all 17 SPKT recipients who underwent a total of 22 pancreas allograft indication biopsies from October 2009 to September 2012. Fifteen patients had at least 2 DSA measurements: pretransplantation and at the time of biopsy. RESULTS:All 7 patients (100%) with post-transplantation DSA-positivity (de novo: n = 6; persistent: n = 1) at biopsy had at least 1 rejection episode either of the pancreas (n = 4) or the kidney (n = 3), with 3 antibody-mediated rejections (AMR). In contrast, only 4 of 8 patients (50%) without post-transplantation DSA had evidence of rejection, with 1 AMR. Findings during pancreas allograft biopsy procedures led to a change of immunosuppressive therapy in 11 of 15 (73%) patients. Patient survival, graft survival, and function were not adversely affected by the presence of post-transplantation DSA. One major and 2 minor procedure-related complications occurred during the pancreas biopsies. CONCLUSIONS:In this small retrospective analysis, pancreas allograft histology provided the most therapeutically relevant information, rather than the kidney histology or DSA monitoring.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Becker LE,Hallscheidt P,Schaefer SM,Klein K,Grenacher L,Waldherr R,Macher-Goeppinger S,Schemmer P,Mehrabi A,Suesal C,Zeier M,Morath C

doi

10.1016/j.transproceed.2015.09.013

subject

Has Abstract

pub_date

2015-10-01 00:00:00

pages

2504-12

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(15)00865-9

journal_volume

47

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Relationship Between Satisfaction With Social Support and Self-Efficacy and the Occurrence of Depressive Symptoms and Stress in Heart Transplant Recipients.

    abstract：:Heart transplantation is a recognized and effective therapeutic method for treating end-stage circulatory failure. Physical factors and psychosocial issues among heart transplant recipients have been addressed in an increasing number of studies. According to the transactional model of stress, social support is one of ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.156

    authors： Milaniak I,Wilczek-Rużyczka E,Wierzbicki K,Piątek J,Kapelak B,Przybyłowski P

    更新日期：2018-09-01 00:00:00

  • Risk factors for death following liver retransplantation.

    abstract：AIM:Our goal was to retrospectively analyze graft loss and mortality risk factors using multi-centre data on liver retransplantation. MATERIAL AND METHODS:Between 1991-1995, 640 patients underwent 718 liver transplants in Barcelona. Mean age of the 74 patients receiving a second transplant was 47.6 years (range 19-65)...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00585-2

    authors： Bilbao I,Figueras J,Grande L,Clèries M,Jaurrieta E,Visa J,Margarit C

    更新日期：2003-08-01 00:00:00

  • Heterogeneity of human pancreata in perspective of the isolation of the islets of langerhans.

    abstract：:The success of human islet isolation is hampered by the varied and unpredictable outcomes of the islet isolation procedure. Pancreata which meet well-defined criteria are no guarantee for success. Interindividual variations may contribute to the differences in isolation outcomes. The present study examined several str...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.12.022

    authors： Töns HA,Terpstra OT,Bouwman E

    更新日期：2008-03-01 00:00:00

  • Critical progressive small-graft injury caused by intrasinusoidal pressure elevation following living donor liver transplantation.

    abstract：:In adult-to-adult living liver transplantation, small-for-size graft syndrome sometimes occurs. The relationship between the hemodynamic changes and histologic findings has not been studied in patients with failure of small-for-size grafts. We analyzed the relationship between the postoperative hemodynamic changes and...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.09.036

    authors： Sugimoto H,Kaneko T,Hirota M,Nagasaka T,Kobayashi T,Inoue S,Takeda S,Kiuchi T,Nakao A

    更新日期：2004-11-01 00:00:00

  • Metabolic profile and cardiovascular risk in a population of renal transplant recipients.

    abstract：INTRODUCTION:Cardiovascular disease is more common in renal transplant recipients (RTRs) than in the general population, and is the major cause of both graft loss and patient death in RTRs. OBJECTIVES:This study aimed to characterize the cardiovascular risk factors, calculate the 7-year risk for major adverse cardiac ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.03.031

    authors： Gonçalves M,Vieira P,Resende L,Durães J,Rosa N,Teixeira JA,Silva G

    更新日期：2015-05-01 00:00:00

  • Effects of polyethylene glycol and hydroxyethyl starch in University of Wisconsin preservation solution on human red blood cell aggregation and viscosity.

    abstract：:University of Wisconsin (UW) preservation solution is considered an effective flush and cold storage liquid. However, recent studies have provided evidence of the hyperaggregating effect on human red blood cells (RBC) of hydroxyethyl starch (HES), one of the components of the UW solution. In contrast, preservation sol...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.02.068

    authors： Mosbah IB,Franco-Gou R,Abdennebi HB,Hernandez R,Escolar G,Saidane D,Rosello-Catafau J,Peralta C

    更新日期：2006-06-01 00:00:00

  • Experience with Alemtuzumab (Campath-1H) as induction agent in renal transplantation followed by steroid-free immunosuppression.

    abstract：BACKGROUND:The purpose of this study was to describe the initial experience with alemtuzumab as induction followed by steroid-free immunosuppression in kidney transplantation. METHODS:One hundred patients who received renal transplants from living and deceased donors were followed for a median period of 12 months (ran...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.02.026

    authors： Baez Y,Giron F,Niño-Murcia A,Rodríguez J,Salcedo S

    更新日期：2008-04-01 00:00:00

  • Reasons for Noninclusion on the Kidney Transplant Waiting List: Analysis in a Set of Hemodialysis Centers.

    abstract：INTRODUCTION:End-stage renal disease patients' access to the renal transplant (RT) waiting list (WL) depends on general criteria and their specific application in the different treatment units. METHODS:Study in nonhospital hemodialysis centers (n = 9), dependent on an adult RT center. Cases included 228 patients consi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.09.066

    authors： Toapanta-Gaibor NG,Suñer-Poblet M,Cintra-Cabrera M,Pérez-Valdivia MÁ,Suárez-Benjumea A,Gonzalez-Roncero FM,Bernal-Blanco G,Rocha-Castilla JL,Gentil-Govantes MÁ

    更新日期：2018-03-01 00:00:00

  • Analysis of the Eurotransplant Kidney Allocation Algorithm: How Should We Balance Utility and Equity?

    abstract：BACKGROUND:Since 2014, expected graft and recipient survival are matched by the U.S. kidney allocation system to improve organ utility. This mechanism is based on the kidney donor profile index (KDPI) and the estimated posttransplant survival score (EPTS). Here we analyzed 1. the transferability of these scores into th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.08.040

    authors： Schulte K,Klasen V,Vollmer C,Borzikowsky C,Kunzendorf U,Feldkamp T

    更新日期：2018-12-01 00:00:00

  • Endovascular Treatment for Very Early Hepatic Artery Stenosis Following Living-Donor Liver Transplantation: Report of Two Cases.

    abstract：BACKGROUND:Some literature has reported on endovascular treatment for very early hepatic artery stenosis (HAS; within 2 weeks after liver transplantation, and has deemed endovascular treatment to be a contraindication because out of serious complications associated with the procedure. We report on 2 cases of very early...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.074

    authors： Goto Y,Shirahama N,Sasaki S,Kawahara R,Sakai H,Ishikawa H,Hisaka T,Ogata T,Yasunaga M,Akagi Y,Tanaka H,Okuda K

    更新日期：2018-06-01 00:00:00

  • Antigen sampling on the Peyer's patches in a murine small bowel transplantation model.

    abstract：AIM:This study investigated changes in the mucosal barrier of transplanted intestines with particular emphasis on antigen sampling by Peyer's patches (PPs). METHODS:Heterotopic small bowel transplantation (SBTx) was performed as described previously. C57BL/6 mice were used as donors and BALB/c (allogeneic) or C57BL/6 ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.08.057

    authors： Ping X,Li Y,Li J

    更新日期：2010-11-01 00:00:00

  • Laparoscopic approach for down-staging in hepatocellular carcinoma patients who are candidates for liver transplantation.

    abstract：INTRODUCTION:The aim of this study was to assess the impact of laparoscopic thermoablation (LTA) and laparoscopic resection (LR) as neoadjuvant therapy before orthotopic liver transplantation (OLT) for hepatocellular carcinoma (HCC). METHODS:From June 2005 to November 2010, 50 consecutive patients affected by HCC with...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.07.014

    authors： Casaccia M,Andorno E,Santori G,Fontana I,Varotti G,Ferrari C,Ertreo M,Valente U

    更新日期：2013-09-01 00:00:00

  • Acute effects of a single dose of phosphodiesterase type 5 inhibitor (sildenafil) on systemic arterial blood pressure during exercise and 24-hour ambulatory blood pressure monitoring in heart transplant recipients.

    abstract：BACKGROUND:Arterial systemic hypertension (SH) can be associated with a decrease in endothelium-dependent nitric oxide (NO). Sildenafil increases cyclic guanosine monophosphate (cGMP), a mediator of NO. However, little is known about the effects of PDE5 inhibition on 24-hour ambulatory pressure (ABP) and exercise blood...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2007.04.029

    authors： Guimaraes GV,d'Avila VM,Pires P,Bacal F,Stolf N,Bocchi E

    更新日期：2007-12-01 00:00:00

  • T-cell response to staphylococcal enterotoxin B is reduced among heart failure patients on ventricular device support.

    abstract：:Infections are the major complication among patients on left ventricular device (LVAD) support. One mechanism that may explain the elevated incidence of infection is a deficiency in cellular immunity after LVAD placement. To test this hypothesis, we evaluated the in vitro T-cell-proliferative and cytokine response fol...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.153

    authors： Kimball P,Flattery M,Kasirajan V

    更新日期：2006-12-01 00:00:00

  • Placental/umbilical cord blood: experience of st. Eugenio Hospital collection center.

    abstract：BACKGROUND:Umbilical cord blood (UCB) contains stem cells and may be an alternative source to bone marrow and peripheral blood stem cells for allogeneic transplantation for the treatment of hematologic malignancies and genetic disorders. Many UCB banks have been established worldwide to quickly provide high quality mat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.06.065

    authors： Tamburini A,Malerba C,Picardi A,Amadori S,Calugi A

    更新日期：2005-07-01 00:00:00

  • Effectiveness of rituximab and intravenous immunoglobulin therapy in renal transplant recipients with chronic active antibody-mediated rejection.

    abstract：BACKGROUND:Chronic active antibody-mediated rejection (CAMR) is an important cause of chronic kidney allograft dysfunction, but there has been no effective treatment protocol established for it. METHODS:Six renal transplant recipients who showed progressive deterioration in graft function and CAMR as diagnosed by biop...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.12.006

    authors： Hong YA,Kim HG,Choi SR,Sun IO,Park HS,Chung BH,Choi BS,Park CW,Kim YS,Yang CW

    更新日期：2012-01-01 00:00:00

  • Mortality while awaiting liver retransplantation: predictability of MELD scores.

    abstract：INTRODUCTION:Model for End-stage Liver Disease (MELD) scores at the time of listing on the transplant waiting list have been shown to accurately predict 3-month mortality in adults. There is no data assessing the accuracy of the MELD scores in predicting mortality of patients awaiting liver retransplantation. We sought...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.03.004

    authors： Watt KD,Menke T,Lyden E,McCashland TM

    更新日期：2005-06-01 00:00:00

  • Are large nonfunctional kidneys risk factors for posttransplantation urinary tract infection in patients with end-stage renal disease due to autosomal dominant polycystic kidney disease?

    abstract：OBJECTIVES:The objective of this study was to evaluate the effect of bilateral nephrectomy on posttransplantation urinary tract infection (UTI) among patients with end-stage renal disease (ESRD) due to autosomal dominant polycystic kidney disease (ADPKD). METHODS:In a retrospective case-control design, 62 patients wit...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.02.058

    authors： Salehipour M,Jalaeian H,Salahi H,Bahador A,Davari HR,Nikeghbalian S,Sagheb MM,Raiss-Jalali GA,Roozbeh J,Behzadi S,Janghorban P,Sepas HN,Malek-Hosseini SA

    更新日期：2007-05-01 00:00:00

  • Islet preparation purity is overestimated, and less pure fractions have lower post-culture viability before clinical allotransplantation.

    abstract：BACKGROUND:Replacement of β-cells with the use of isolated islet allotransplantation (IT) is an emerging therapy for type 1 diabetics with hypoglycemia unawareness. The current standard protocol calls for a 36-72-hour culture period before IT. We examined 13 clinical islet preparations with ≥2 purity fractions to deter...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.06.011

    authors： Kitzmann JP,Karatzas T,Mueller KR,Avgoustiniatos ES,Gruessner AC,Balamurugan AN,Bellin MD,Hering BJ,Papas KK

    更新日期：2014-07-01 00:00:00

  • Gender-dependent histone deacetylases injury may contribute to differences in liver recovery rates of male and female mice.

    abstract：BACKGROUND:Hepatocytes undergo DNA synthesis shortly after liver damage triggered by partial hepatectomy (PH). This study revealed that the rate of liver damage recovery is gender-dependent. Furthermore, histone deacetylase (HDAC) epigenetic factors were discovered, at least in part, to govern the different liver recov...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.06.063

    authors： Wang Y,Ye F,Ke Q,Wu Q,Yang R,Bu H

    更新日期：2013-03-01 00:00:00

  • Safety of an immunosuppressant protocol based on sirolimus in liver transplant recipients with malignancies or high risk of tumor recurrence.

    abstract：BACKGROUND:The mammalian target of rapamycin inhibitors are immunosuppressive agents with antiproliferative effects and consequent potential application as anticancer agents. The safety and tolerance of calcineurin inhibitor (CNI)-free sirolimus-based immunosuppressant protocols in liver transplant recipients with mali...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.02.017

    authors： Castroagudín JF,Molina E,Tomé S,Otero E,Rodríguez M,Varo E

    更新日期：2009-04-01 00:00:00

  • Attenuation of canine warm ischemic small bowel injury by novel combination of nitric oxide donor, FK409, and cytokine suppressive anti-inflammatory agent FR167653.

    abstract：:Organ ischemia-reperfusion injury is caused by two consecutive steps, microcirculatory disturbance and neutrophil-endothelial cell interactions, which are caused by inflammatory cytokines. We examined the hypothesis that combination therapy with a donor (FK409) of nitric oxide, one of the potent mediators with diverse...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.08.067

    authors： Totsuka E,Murata A,Nishimura A,Umehara M,Nara M,Ono H,Nozaki T,Takiguchi M,Wajima N,Takahashi K,Seino K,Narumi S,Hakamada K,Sasaki M

    更新日期：2004-09-01 00:00:00

  • Level of Life Quality in Heart and Kidney Transplant Recipients: A Multicenter Study.

    abstract：OBJECTIVE:The main objective of the researchers was to determine the level of life quality among heart and kidney transplant recipients depending on the time and type of the transplant. METHODS:The study was conducted using standardized questionnaires: the 36-Item Short-Form Health Survey, Life Orientation Test-Revise...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,多中心研究

    doi：10.1016/j.transproceed.2020.03.038

    authors： Milaniak I,Rużyczka EW,Dębska G,Król B,Wierzbicki K,Tomaszek L,Przybyłowski P

    更新日期：2020-09-01 00:00:00

  • Organ donation: Transplant Games, the "Island Effect," and other successful methods.

    abstract：:We have alluded to data showing that effective organisation has a well-documented effect on organ donation. We have also presented data demonstrating the positive effect of the Transplant Games on public opinion and through positive media influence, producing a very marked increase in organ donation. Attention has als...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(97)00776-8

    authors： Slapak M

    更新日期：1997-11-01 00:00:00

  • Endoscopic treatment of bile duct complications after orthotopic liver transplantation.

    abstract：AIM:To assess the indications and results of endoscopic retrograde cholangio-pancreatography (ERCP) in patients who have undergone ortotopic liver transplantation (OLT). METHODS:We reviewed data from 42 consecutive patients who underwent ERCP for biliary complications after OLT over an 8-year period, in particular rec...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.05.053

    authors： Polese L,Cillo U,Brolese A,Boccagni P,Neri D,Bassi D,Erroi F,Zanus G,D'Amico DF,Norberto L

    更新日期：2007-07-01 00:00:00

  • Analysis of Model for End-Stage Liver Disease (MELD) score in a liver transplantation waiting list.

    abstract：BACKGROUND:The Model for End-Stage Liver Disease (MELD) was introduced in 1999 to quantify the 3-month prognosis of cirrhotic patients after a transjugular intrahepatic portosystemic shunt (TIPS). Because of the imbalance between organ donors and patients on the waiting list, the MELD was adopted by the United States i...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.07.023

    authors： Ferraz-Neto BH,Hidalgo R,Thomé T,Melo VA Jr,Lobue A,Zurstrassen MP,Moraes JM Jr,Meira-Filho SP,Rezende MB,Fonseca LE,Pandullo FL,Soeiro FS,Afonso RC

    更新日期：2007-10-01 00:00:00

  • More Hippocampal Weight and Cells in Cardiac Allograft Transplanted Mice.

    abstract：:The hippocampus is a brain structure that plays a fundamental role in memory and learning. Many animal studies have demonstrated that the structure of the hippocampus has evolved through exercise and play. However, little is known on the relationship between the brain and immunological reaction. In this study, we inve...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.03.107

    authors： Yin E,Uchiyama M,Jin X,Kawai K,Takao M,Niimi M

    更新日期：2018-11-01 00:00:00

  • Imbalance of metallaproteinase/tissue inhibitors of metalloproteinase system in renal transplant recipients with chronic allograft injury.

    abstract：INTRODUCTION:Nowadays, renal allografts continue to be lost at the rate of 2% to 4% per year beyond the first year after transplantation due to chronic allograft injury. Excessive accumulation of extracellular matrix results from overproduction and/or defective degradation by proteolytic enzymes, among which metallopro...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.012

    authors： Mazanowska O,Kamińska D,Krajewska M,Zabińska M,Kopeć W,Boratyńska M,Chudoba P,Patrzalek D,Klinger M

    更新日期：2011-10-01 00:00:00

  • Thymoglobulin and rate of infectious complications after transplantation.

    abstract：UNLABELLED:Thymoglobulin is used as an induction agent in kidney transplantation, but the optimal dose is not well established. However, its use may be associated with increased infectious complications after transplantation. METHODS:This retrospective study of 61 high-risk renal recipients of transplants from decease...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.01.024

    authors： Clesca P,Dirlando M,Park SI,García R,Ferraz E,Pinheiro-Machado PG,Kushnaroff L,Tedesco-Silva H Jr,Medina-Pestana JO

    更新日期：2007-03-01 00:00:00

  • Selected activities in Scandiatransplant.

    abstract：:Scandiatransplant is the Nordic organ exchange organization. It has existed for 35 years and it is owned by all organ transplantation hospital departments in the five Nordic countries--Denmark, Finland, Iceland, Norway, and Sweden. The use of living organ donors for kidney transplantation has become a more common proc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.09.064

    authors： Grunnet N,Asmundsson P,Bentdal Ø,Friman S,Madsen M,Persson NH,Salmela K

    更新日期：2005-10-01 00:00:00