当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Effectiveness of rituximab and intravenous immunoglobulin therapy in renal transplant recipients with chronic active antibody-mediated rejection.

Effectiveness of rituximab and intravenous immunoglobulin therapy in renal transplant recipients with chronic active antibody-mediated rejection.

Abstract：

BACKGROUND:Chronic active antibody-mediated rejection (CAMR) is an important cause of chronic kidney allograft dysfunction, but there has been no effective treatment protocol established for it. METHODS:Six renal transplant recipients who showed progressive deterioration in graft function and CAMR as diagnosed by biopsy were enrolled. We administered a single dose of rituximab (375 mg/m(2)), followed by intravenous immunoglobulin (IVIg, 0.4 g/kg) for 4 days. The efficacy of this protocol was assessed on the basis of the improvement in allograft function, the amount of proteinuria, and the change in donor-specific antibodies (DSAs). We categorized the patients into 2 groups, responders and nonresponders, according to their response to the treatment. RESULTS:All of the patients showed progressive deterioration of graft function before the diagnosis of CAMR. Luminex solid-phase assays showed that 3 patients had DSAs. After the treatment, allograft function improved or stabilized in 3 patients in the responder group, but still showed a deteriorating pattern in the nonresponder group. In the responder group, the amount of proteinuria also decreased after the treatment, but it increased in the nonresponder group. On diagnosis of CAMR, the nonresponders showed a longer posttransplantation period, a higher degree of transplant glomerulopathy, more severely deteriorated allograft function, and higher proteinuria compared with the responders. CONCLUSIONS:The combination of rituximab and IVIg was effective in early-stage CAMR, but the effect was limited in the advanced stage.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hong YA,Kim HG,Choi SR,Sun IO,Park HS,Chung BH,Choi BS,Park CW,Kim YS,Yang CW

doi

10.1016/j.transproceed.2011.12.006

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

182-4

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(11)01668-X

journal_volume

44

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Simultaneous Determination of Everolimus, Sirolimus, Tacrolimus, and Cyclosporine-A by Mass Spectrometry.

    abstract：:Measurement of immunosuppressive drug concentrations cyclosporine A (CyA), tacrolimus (TAC), sirolimus (SIR), and everolimus (EVE) in blood is an important application of therapeutic drug monitoring. These immunosuppressive agents are used in combined regimens and nowadays the liquid chromatography and tandem mass spe...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.01.077

    authors： Dinéia Perez J,Sanches Aragão D,Aparecida Ronchi F,Febba AC,Rosso CF,Tedesco-Silva Junior H,Medina de Abreu Pestana JO,Casarini DE

    更新日期：2020-06-01 00:00:00

  • Mode of delivery in women after liver transplantation.

    abstract：AIM:A high rate of cesarean sections has been reported among high-risk pregnancies in liver transplant recipients. The aim of this study was to analyze the course of deliveries and the indications for cesarean sections in women after liver transplantation. MATERIALS AND METHODS:From 2001 to 2006, we noted 21 deliverie...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.09.011

    authors： Jabiry-Zieniewicz Z,Bobrowska K,Pietrzak B,Kaminski P,Wielgos M,Durlik M,Zieniewicz K

    更新日期：2007-11-01 00:00:00

  • Utility of Oxford Classification in Post-Transplant Immunoglobulin A Nephropathy.

    abstract：BACKGROUND:With increasing graft survival, post-transplant immunoglobulin A nephropathy (IgAN) has emerged as an important cause of chronic graft dysfunction in renal allograft recipients. We studied the clinico-pathological features of post-transplant IgAN regardless of the primary disease. The aim was to study the us...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.10.002

    authors： Agrawal V,Singh A,Kaul A,Verma R,Jain M,Pandey R

    更新日期：2017-12-01 00:00:00

  • Difficulties in organ procurement and transplantation in the aboriginal minority people in Taiwan.

    abstract：BACKGROUND:Aboriginal people (AP) are a minority group in Taiwan. Little information on their perspectives on organ transplantation (OT) is available. Their rights for organ donation (OD) and as OT recipients (OTR) are constrained as a vulnerable population in society. This research sought to explore various Highland A...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.03.022

    authors： Shih FJ,Chang YC,Chen CF,Lin FJ,Huang YS,Yan YH,Shih FJ,Chen CR

    更新日期：2012-05-01 00:00:00

  • Postexposure prophylaxis of H1N1 with oseltamivir in a newly transplanted kidney recipient receiving intense immunosuppressive therapy.

    abstract：:Solid organ transplant recipients undergoing immunosuppressive therapy are considered to be at high risk for serious infectious complications. Recently in the United States, a pandemic of H1N1 flu infection has been reported with serious complications. We describe H1N1 infection in a living kidney donor and the 42-yea...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.09.052

    authors： Marfo K,Chapochnick-Friedmann J,Akalin E,Lu A

    更新日期：2009-12-01 00:00:00

  • Living donor transplant: wider selection criteria.

    abstract：:The availability of cadaveric donor organs is insufficient for actual needs. The organ demand increases by 20% per year. Living donor transplant (LDT) may be a valid therapeutical alternative provided one uses proper criteria. LDT provides many advantages, like improved patient and organ survival, short waiting time, ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.02.003

    authors： Splendiani G,Cipriani S,Valeri M,Torlone N,Vega A,Tullio T,Condò S,Dominijanni S,Casciani CU

    更新日期：2004-04-01 00:00:00

  • Effects of hemorrhagic shock in early and late partial posthepatectomy rats.

    abstract：INTRODUCTION:The purpose of the study was to determine the compensatory function of the remnant liver as a blood reservoir after 70% hepatectomy in rats to counteract hemorrhagic shock and reperfusion. METHODS AND MATERIALS:One hour of hemorrhagic shock followed by 1 hour of resuscitation induced in normal rats (group...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.066

    authors： Huang CJ,Chen CL,Goto S,Lai CY,Kao YS,Wang CH,Eng HL,Concejero AM,Wang CC,Cheng YF,Cheng KW,Nakano T,Jawan B

    更新日期：2010-04-01 00:00:00

  • Change of hepatitis B virus DNA and covalently closed circular DNA status in liver graft after liver transplantation.

    abstract：:Recurrence of hepatitis B virus (HBV) occurs despite prophylaxis, and covalently closed circular DNA (cccDNA) is thought to play a role owing to its resistance to prophylactic agents used. The aim of this study was to evaluate the changes of HBV DNA and cccDNA within the liver graft during liver transplantation (LT). ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.081

    authors： Kwon CH,Suh KS,Shin JO,Kim SJ,Joh JW

    更新日期：2014-04-01 00:00:00

  • Metabolic profile and cardiovascular risk in a population of renal transplant recipients.

    abstract：INTRODUCTION:Cardiovascular disease is more common in renal transplant recipients (RTRs) than in the general population, and is the major cause of both graft loss and patient death in RTRs. OBJECTIVES:This study aimed to characterize the cardiovascular risk factors, calculate the 7-year risk for major adverse cardiac ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.03.031

    authors： Gonçalves M,Vieira P,Resende L,Durães J,Rosa N,Teixeira JA,Silva G

    更新日期：2015-05-01 00:00:00

  • Investigation of the biomechanical integrity of decellularized rat abdominal aorta.

    abstract：OBJECTIVES:The loss or damage of an organ or tissue is one of the most common and devastating problems in healthcare today. Tissue engineering applies the principles of engineering and biology toward the development of functional biological replacements that are able to maintain, improve, or restore the function of pat...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.11.061

    authors： Katsimpoulas M,Morticelli L,Michalopoulos E,Gontika I,Stavropoulos-Giokas C,Kostakis A,Haverich A,Korossis S

    更新日期：2015-05-01 00:00:00

  • Functional evaluation of chondrocyte sheeting immunodelusive immunoisolated bioartificial pancreas.

    abstract：:In islet transplantation, encapsulation of immunoisolated islets may provide a way to protect the graft from immune attacks with no immunosuppression. To develop an immunodelusive immunoisolated bioartificial pancreas (BAP), chondrocyte sheets were prepared by cell sheet engineering. We made an immunoisolated BAP enca...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.043

    authors： Kim JY,Lee JI,Jeong JH,Park YJ,Kim SJ,Fang YH,Cho Y,Huh KH,Joo DJ,Kim MS,Kim YS

    更新日期：2010-04-01 00:00:00

  • Ethical and legal issues in donation after cardiac death in Italy.

    abstract：:In Italy death of a human being must be declared either after brain death or after 20 minutes of cardiac arrest, certified by continuous electrocardiography (EKG) recording. It is my personal opinion that in such circumstances after cardiac death (DCD) will allow at best only the retrieval of few marginal kidneys and ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.03.057

    authors： Bruzzone P

    更新日期：2010-05-01 00:00:00

  • Approach of the Clinicians Practicing in Intensive Care Units to Brain Death Diagnosis and Training Expectations in Turkey: A Web-Based Survey.

    abstract：BACKGROUND:For health professionals, recognizing and diagnosing brain death is vital for the development of organ transplantation. However, cadaveric organ donation rates remain insufficient, and this problem has become one of the most serious obstacles in the treatment of end-organ failure. OBJECTIVES:This study exam...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.05.023

    authors： Ferhatoglu SY,Ferhatoglu MF,Gurkan A

    更新日期：2020-12-01 00:00:00

  • Short- and Long-Term Outcomes of Live Donor Renal Allografts From Older and Younger Donors.

    abstract：BACKGROUND:The rising demand for living renal donors has led to the recruitment of older donors. Findings vary, but these grafts appear to survive as long as grafts from standard criteria deceased and expanded criteria deceased donors. We investigated the effects of donor age ≥65 years and the presence or absence of do...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.08.046

    authors： Matsuyama T,Ushigome H,Osaka M,Masuda K,Harada S,Nakamura T,Nobori S,Iida T,Yoshimura N

    更新日期：2018-12-01 00:00:00

  • Comparison of 3 Explant-Based Prognostic Models as Predictors of Hepatocellular Carcinoma Recurrence After Liver Transplantation: Analysis of Our Experience.

    abstract：:Tumor load is often underdiagnosed on radiological examination previous to liver transplantation (LT) for hepatocarcinoma (CHC). Thus, post-liver transplant explant analysis is required following transplantation to assess the risk of the recurrence of CHC. The objectives were to compare the characteristics of CHC on p...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.03.132

    authors： Mirón Fernández I,León Díaz FJ,Sánchez Segura J,Sánchez Pérez B,Pérez Daga JA,Fernández Aguilar JL,Montiel Casado MC,Santoyo Santoyo J

    更新日期：2019-01-01 00:00:00

  • Ischemic preconditioning improves rat kidney allograft function after ischemia/reperfusion injury: the role of tumor necrosis factor-alpha.

    abstract：OBJECTIVE:The aim of this study was to investigate the early protection of ischemic preconditioning (IPC) and its mechanisms in transplanted rat kidneys. MATERIALS AND METHODS:Thirty-six male Sprague-Dawley (SD) rat donors and recipients were randomly divided into the following groups: sham-operated group (A; n = 6); ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.06.113

    authors： Jia RP,Xie JJ,Luo FY,Zhu JG

    更新日期：2008-12-01 00:00:00

  • Importance of organ preservation solution composition in reducing myocardial edema during machine perfusion for heart transplantation.

    abstract：OBJECTIVE:Machine perfusion preservation has been used experimentally to extend the storage interval of donor hearts. We previously demonstrated that machine perfusion with glucose-supplemented Celsior preservation solution led to superior reperfusion function but resulted in increased myocardial edema compared with co...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.02.073

    authors： Cobert ML,Peltz M,West LM,Jessen ME

    更新日期：2010-06-01 00:00:00

  • Role of regulated upon activation normal T-cell expressed and secreted in a model of retransplantation acute rejection mediated by alloreactive memory CD4+ T cells.

    abstract：BACKGROUND:It is unknown what role Regulated Upon Activation Normal T-Cell Exposed and Secreted may play in retransplantation or T-cell memory-transfer models. The experiment observed the influence of the chemokine RANTES in a mouse model of acute cardiac allograft rejection induced by adoptive transfer of alloreactive...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.11.005

    authors： Zhou X,Shan Z,Liang H,Lin Z,Qiu S,Kuang F,Zhuang J,Qi Z

    更新日期：2013-03-01 00:00:00

  • Multidrug-resistant gram-positive infections in patients with ventricular assist devices: the role of daptomycin.

    abstract：OBJECTIVES:The rate of infection in patients who require ventricular assist devices (VADs) is estimated at more than 35%. Infections with multidrug-resistant (MDR) organisms in VAD recipients present a high mortality rate. Daptomycin (Cubicin, Novartis, Nuremberg, Germany), a new cyclic lipopeptide antibiotic, is usefu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.126

    authors： Beiras-Fernandez A,Kur F,Kiefer S,Sodian R,Schmoeckel M,Weis M,Reichart B,Weis F

    更新日期：2009-07-01 00:00:00

  • The acoustic radiation force impulse elastography evaluation of liver fibrosis in posttransplantation dysfunction of living donor liver transplantation.

    abstract：BACKGROUND:The acoustic radiation force impulse elastography (ARFI) is a new technology of elastography integrated into B-mode ultrasonography. It has been a reliable method to evaluate liver fibrosis of chronic liver disease in recent years, but less applied in the posttransplantation liver. The aim of the study was t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.12.012

    authors： Liao CC,Chen TY,Tsang LC,Ou SY,Yu CY,Hsu HW,Cheng YF,Chiu KW,Eng HL,Chen CL,Huang TL

    更新日期：2014-04-01 00:00:00

  • Role of N-acetylcysteine on renal function in patients after orthotopic heart transplantation undergoing coronary angiography.

    abstract：INTRODUCTION:The aim of this study was to assess nephroprotective influence of intravenous N-acetylcysteine (NAC) on renal function after radiocontrast use in calcineurin inhibitor-treated patients after orthotopic heart transplantation (OHT). MATERIALS AND METHODS:We analyzed the results of 112 consecutive coronary a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,随机对照试验

    doi：10.1016/j.transproceed.2007.08.057

    authors： Barańska-Kosakowska A,Zakliczyński M,Przybylski R,Zembala M

    更新日期：2007-11-01 00:00:00

  • Outcome of Living Donor Transplant Kidneys With Multiple Arteries.

    abstract：BACKGROUND:Living donor transplantation (LDT) using kidneys with multiple arteries (MA) has previously been reported to be associated with increased complications and poorer outcomes in recipients. The objective of this study was to investigate outcomes of LDT with MA at the National University Hospital of Singapore, a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.12.104

    authors： Lim YM,Han X,Raman L,Ng TK,Goh TH,Vathsala A,Tiong HY

    更新日期：2016-04-01 00:00:00

  • Endothelial dysfunction in peritoneal dialysis patients with and without failed renal transplants.

    abstract：BACKGROUND:Endothelial dysfunction (ED) is a common, early abnormality that predisposes patients to develop atherosclerosis and cardiovascular events; inflammation is associated with atherosclerosis and malnutrition. Patients with failed transplants are usually complicated by inflammation; however, ED in this group of ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.200

    authors： Gorgulu N,Yelken B,Caliskan Y,Elitok A,Cimen O,Yazici H,Oflaz H,Turkmen A,Bozfakioglu S,Sever MS

    更新日期：2009-11-01 00:00:00

  • Liver transplantation in management of alveolar echinococcosis: two case reports.

    abstract：:Hepatic alveolar echinococcosis is an infectious disease caused by the larval stage of Echinococcus multilocularis, which grows primarily in the liver of an infected person and develops as a tumorlike lesion. In advanced cases, the organisms infiltrate every organ neighboring the liver and spread hematogenously to dis...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.07.022

    authors： Moray G,Shahbazov R,Sevmis S,Karakayali H,Torgay A,Arslan G,Savas N,Yilmaz U,Haberal M

    更新日期：2009-09-01 00:00:00

  • Mycophenolic acid upregulates B7-DC expression on dendritic cells, which is associated with impaired allostimulatory capacity of dendritic cells.

    abstract：:In addition to its effects on lymphocytes, mycophenolic acid (MPA) may inhibit the allostimulatory capacity of dendritic cells (DC) via unknown mechanisms. B7-H1 and B7-DC surface markers on DC negatively regulate T-cell responses via the receptor PD-1. In this study, we sought to investigate whether B7-H1 and B7-DC a...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.02.093

    authors： Geng L,Jiang G,Xie H,Fang Y,Dong S,Chen Y,Shen M,Zheng S

    更新日期：2006-06-01 00:00:00

  • Severe colchicine intoxication in a renal transplant recipient on cyclosporine.

    abstract：:Using colchicine to treat an acute gout crisis in an organ transplant recipient (TR) on cyclosporine (CsA) may result in life-threatening intoxication. We report the case of a 59-year-old kidney transplant recipient on CsA who was treated with colchicine for acute gout crisis. Seven days later, he developed rhabdomyol...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.09.028

    authors： Garrouste C,Philipponnet C,Kaysi S,Enache I,Tiple A,Heng AE

    更新日期：2012-11-01 00:00:00

  • Liver transplantation in Wilson's disease: are its indications established?

    abstract：UNLABELLED:The indications of progressive neurological deterioration despite no hepatic insufficiency, for liver transplant (OLT) in patients with Wilson's disease (WD) who do not improve with medical treatment is widely debated. The aim of this paper was to present our OLT experience in WD. PATIENTS AND METHODS:Fourt...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.06.039

    authors： Marin C,Robles R,Parrilla G,Ramírez P,Bueno FS,Parrilla P

    更新日期：2007-09-01 00:00:00

  • Transplant of Tissue-Engineered Artificial Autologous Human Skin in Andalusia: An Example of Coordination and Institutional Collaboration.

    abstract：:A new model of tissue-engineered artificial autologous human skin developed in Andalusia is currently being transplanted into patients suffering from large burns within the Andalusian Public Healthcare System. This product is considered an advanced therapy medicinal product (ATMP) in Europe, and its clinical use impli...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.08.014

    authors： Egea-Guerrero JJ,Carmona G,Correa E,Mata R,Arias-Santiago S,Alaminos M,Gacto P,Cuende N

    更新日期：2019-11-01 00:00:00

  • In Vitro and In Vivo (Rabbit, Guinea Pig, Mouse) Properties of a Novel Resorbable Polymer and Allogenic Bone Composite for Guided Bone Regeneration and Orthopedic Implants.

    abstract：INTRODUCTION:Currently, there is no bone fixation material that could be fully replaced by the competent recipient bone. The creeping substitution of the bone graft by the recipient bone is the result of its unique potential related to the presence of bone morphogenetic proteins (BMPs). However, the size of the human b...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.121

    authors： Gut G,Ambroziak M,Bojar W,Szaraniec B,Chłopek J,Flis S,Koronkiewicz M,Jastrzębski Z

    更新日期：2018-09-01 00:00:00

  • Effect of methylene blue on the hemodynamic instability resulting from liver ischemia and reperfusion in rabbits.

    abstract：:The experimental investigation was performed to study the effects of methylene blue (MB) on hemodynamic, biochemical, and tissue changes among rabbits undergoing liver ischemia and reperfusion (IR). Twenty-four rabbits were randomized into 5 groups: 1, SHAM, control; 2, MB infusion bolus (3 mg/kg); 3, IR, hepatic isch...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.108

    authors： Rosique RG,Rosique MJ,Rosique IA,Tirapelli LF,Castro e Silva O Jr,dos Santos JS,Evora PR

    更新日期：2011-12-01 00:00:00