Heterogeneity of human pancreata in perspective of the isolation of the islets of langerhans.


:The success of human islet isolation is hampered by the varied and unpredictable outcomes of the islet isolation procedure. Pancreata which meet well-defined criteria are no guarantee for success. Interindividual variations may contribute to the differences in isolation outcomes. The present study examined several structural elements in the anatomy of the human pancreas for possible relevance for islet isolation. Sixty pancreata were used for histochemical and immunochemical analyses. We assessed the total percentage of endocrine tissue and the size distribution of the islets. Sirius Red staining quantified total collagen content; the degree of islet encapsulation with collagen was correlated with total collagen. We analyzed the percentage of pancreatic edema and amount of intraparenchymal fat. The percentage of endocrine tissue varied 5-fold with wide variations in islet size distribution. A strong variation was observed for total collagen; its content increased slightly with age. The number of islets totally encapsulated with collagen varied strongly with no relation to age or to total collagen. Pancreatic edema and intraparenchymal fat also showed great differences. These differences justifies continued study to evaluate the correlation of these variables with isolation outcomes.


Transplant Proc


Töns HA,Terpstra OT,Bouwman E




Has Abstract


2008-03-01 00:00:00














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    pub_type: 杂志文章


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    journal_title:Transplantation proceedings

    pub_type: 临床试验,杂志文章


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    journal_title:Transplantation proceedings

    pub_type: 杂志文章,多中心研究


    authors: Close N,Alejandro R,Hering B,Appel M,CITR Investigators.

    更新日期:2007-01-01 00:00:00

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    pub_type: 杂志文章


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    更新日期:2009-09-01 00:00:00

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    journal_title:Transplantation proceedings

    pub_type: 杂志文章


    authors: Bonavida B,Roman JM,Hutchinson IV

    更新日期:1980-03-01 00:00:00