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Ischemic preconditioning improves rat kidney graft function after severe ischemia/reperfusion injury.

Abstract：

UNLABELLED:Ischemic preconditioning (IP) has been shown to ameliorate renal ischemia reperfusion injury. Using a rat kidney transplantation model we determined if IP improves graft function after prolonged cold storage. MATERIALS AND METHODS:Syngeneic rat kidneys were divided into two groups. Prior to 42 hours of cold storage in UW and transplantation, one group (n = 10) received IP (15 minutes of warm ischemia/10 minutes of reperfusion), whereas another group (n = 10) received no treatment. Early graft function and 1-week recipient survival were assessed. RESULTS:Recipient survival was not significantly different between groups [70% (IP) vs 40% (non-IP); P = .28]. IP treatment led to a quicker recovery of renal function. On PODs 3 and 6, serum creatinine levels in the IP group were significantly lower compared with the untreated group. In conclusion, one cycle of IP (15/10) accelerates recovery of renal graft function after severe ischemia reperfusion injury. This simple treatment modality may improve outcomes of renal transplants with prolonged cold storage.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Fuller TF,Freise CE,Feng S,Niemann CU

doi

10.1016/j.transproceed.2004.12.274

subject

Has Abstract

pub_date

2005-01-01 00:00:00

pages

377-8

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)01732-4

journal_volume

37

pub_type

杂志文章

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