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Functional and histological comparison of rat liver preserved in University of Wisconsin solution compared with tissue preserved in a novel solution.

Abstract：

:An isolated perfused rat liver model was used to investigate biochemical and histologic changes during 2 hours of reperfusion after 24 hours of cold storage to compare Leeds solution (LS) with University of Wisconsin solution (UW). Compared with livers stored in UW, those perfused with LS showed significantly higher bile flow and lower enzyme production (P < .05 by 1-way analysis of variance). For example, after 120 minutes, alanine aminotransferase results were: LS 38.9 U/L vs UW 66.8 U/L and bile flows were LS 10.3 μg/15 min/g liver vs UW 9.2 μg/15 min/g liver. Histologically the reticulin breakdown was greater and its reformation slower in UW-preserved livers. Liver tissue was viable in both groups, as shown by the increased glycogen content after reperfusion in both groups, but seen at a higher rate among LS, perfused livers. In conclusion, LS compared favorably with UW to prevent ischemic damage and so could offer an alternative perfusion medium to UW.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Corps CL,Ahmed I,McKenzie S,Shires M,Potts DJ,Lodge JP

doi

10.1016/j.transproceed.2010.06.029

subject

Has Abstract

pub_date

2010-11-01 00:00:00

pages

3427-30

issue

9

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)01306-0

journal_volume

42

pub_type

杂志文章

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