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Worse renal transplant outcomes observed among Afro-Brazilian patients on prospective registry data of 2461 renal transplants at least 1 year follow-up.

Abstract：

:We present prospective registry data of 2461 (live donor = 1753 and deceased donor = 08) renal transplants performed between 1999 and 2003. All subjects were followed for more than 1 year after transplantation and most were treated with a calcineurin inhibitor and azathioprine. Afro-Brazilian, white, and mixed patients constituted 11% (272), 67.1% (1651), and 14.9% (367) of the population respectively. Mean dialysis time was 42.3 +/- 32.9 months and delayed graft function, occurred in more than 60%. Three-year patient survival rates were 96.3%, 92.8%, and 86.7% for living-related, living-unrelated, and deceased donors, respectively. Corresponding 3-year graft survival rates were 87.3%, 82.1%, and 71.3% and functional graft survival rates were 90.2%, 88.8%, and 81.5%. The poorer transplant outcome observed among Afro-Brazilian patients has been mainly attributed to differences in absorption of cyclosporine, tacrolimus, and mycophenolate mofetil.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Medina-Pestana JO,Sampaio EM,Vaz ML,Pinheiro-Machado PG,Tedesco-Silva H Jr

doi

10.1016/j.transproceed.2007.01.034

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

435-6

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(07)00074-7

journal_volume

39

pub_type

杂志文章

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