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The outcome of induction therapy with monoclonal antibodies in kidney transplantation among Iranian patients: a prospective study.

Abstract：

INTRODUCTION:The administration of interlukin-2 receptor antagonists for induction therapy has reduced the incidence of acute rejection episodes in kidney transplantation. Although some studies have investigated the efficacy of these monoclonal antibodies, there is little experience among Iranian kidney transplant recipients. MATERIALS AND METHODS:Forty-three patients randomly divided into 2 groups were prospectively followed for 3.4 years. Eighteen patients received 2 doses of basiliximab (group I) and another 25 patients received 5 doses of daclizumab (group II). The posttransplantation complications, last serum creatinine level, as well as graft and patient survival rates were compared to investigate the efficacy of these therapies. RESULTS:Among 43 patients, 11.6% experienced acute rejection episodes: 22.2% in group I and 4% in group II (P > .05). In this study, 4.6% of recipients underwent graft nephrectomy: 11.1% in group I and 4% in group II (P > .05). The mortality rate was 4.6%: 5.5% in group I and 4% in group II (P > .05). The mean serum creatinine level was 1.47 +/- 0.7 mg/dL. Although it was lower in group I, the difference was not significant. The 1-year graft and patient survival rates were 90.6% and 95.3%, respectively, with no significant differences between the groups. DISCUSSION:Although induction therapy with monoclonal antibodies may reduce the incidence of acute rejection episodes, graft and patient survival rates were unchanged compared with conventional therapies. Also, there were no significant differences between the results of induction therapy with basiliximab and daclizumab.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Naderi GH,Mehraban D,Ganji MR,Jafarpouriani M,Latif AH

doi

10.1016/j.transproceed.2009.06.180

subject

Has Abstract

pub_date

2009-09-01 00:00:00

pages

2768-71

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00912-9

journal_volume

41

pub_type

杂志文章,随机对照试验

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