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Expression and Significance of RANTES and MCP-1 in Renal Tissue With Chronic Renal Allograft Dysfunction.

Abstract：

BACKGROUND:To investigate the expression of RANTES (regulated upon activation, normal T-cell-expressed and -secreted) and monocyte chemoattractant protein-1 (MCP-1) in renal allografts with chronic renal allograft dysfunction (CRAD), and explore its relationship with interstitial fibrosis and tubular atrophy (IF/TA). METHODS:An immunohistochemical assay and computer-assisted, genuine colored image analysis system were used to detect the expression of RANTES and MCP-1 in renal allografts with CRAD. The relationship among the expression level of MCP-1, RANTES, and the grade of inflammatory cell infiltration, interstitial fibrosis, and tubular atrophy in renal allografts were analyzed. Ten specimens of healthy renal tissue were used as controls. RESULTS:Compared to the normal tissues, the expressions of RANTES and MCP-1 were significantly higher in the renal tissues with CRAD (P < .001), and the expressions tended to increase along with the pathological grade of IF/TA. The expression of RANTES and MCP-1 were positively correlated with the pathological grades of IF/TA (r = 0.940 and 0.954 respectively, P < .001 for both). CONCLUSION:In renal allograft tissue with CRAD, the up-regulated expressions of RANTES and MCP-1 may be related to the progression of chronic renal allograft dysfunction and allograft fibrosis.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Yan Q,Jiang H,Wang B,Sui W,Zhou H,Zou G

doi

10.1016/j.transproceed.2016.05.007

subject

Has Abstract

pub_date

2016-07-01 00:00:00

pages

2034-9

issue

6

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(16)30160-9

journal_volume

48

pub_type

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