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Effects of isoflurane and propofol on hepatic and renal functions and coagulation profile after right hepatectomy in living donors.

Abstract：

:We compared postoperative hepatic and renal functions and coagulation profiles in living donors undergoing right hepatectomy under isoflurane (n = 40) versus propofol (n = 40) anesthesia. After induction, anesthesia was maintained with isoflurane/air-O2 (group I) or propofol/air-O2 (group P) in addition to remifentanil and atracurium infusion in both groups. Aspartate aminotransferase, alanine aminotransferase, international normalized ratio (INR), activated partial thromboplastin time (aPTT), albumin, total bilirubin, blood urea nitrogen, creatinine, estimated glomerular filtration rate (GFR), platelet count, and hemoglobin levels were measured in the preoperative period, after end of the operation, and on the first, third, fifth and seventh postoperative days (PODs). INR was significantly increased on POD 3 and aPTT on POD 5 in group I compared with group P (P < .05). Albumin level was significantly lower in Group I on POD 1 and 3 (P < .05). GFR was significantly lower on POD 1 in the group I compared with group P (P < .05). The postoperative coagulation, GFR, and albumin values were superior following administration of propofol than isoflurane in donors who underwent living hepatectomy; however, both approaches were clinically safe, with no significant clinical difference.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Ozgul U,Ucar M,Erdogan MA,Aydogan MS,Toprak HI,Colak C,Durmus M,Ersoy MO

doi

10.1016/j.transproceed.2013.02.056

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

966-70

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)00245-5

journal_volume

45

pub_type

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