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São Paulo lung transplantation waiting list: patient characteristics and predictors of death.

Abstract：

INTRODUCTION:Nowadays, lung transplantation (LTx) allocation in Brazil is based mainly on waiting time. There is a need to evaluate the equity of the current lung allocation system. OBJECTIVES:We sought to (1) determine the characteristics of registered patients on the waiting list and (2) identify predictors of death on the list. MATERIALS AND METHODS:We analyzed the medical records as well as clinical and laboratory data of 164 patients registered on the waiting list from 2001 to June 2008. Predictors of mortality were obtained using Cox proportional hazards analysis. RESULTS:Patients who were registered on the waiting list showed a mean age of 36.1 +/- 15.0 vs. 42.2 +/- 15.7 years, considering those who did versus did not, die on the list, respectively (P = .054). Emphysema was the most prevalent underlying disease among the patients who did not die on the list (28.8%); its prevalence was low among the patients who died on the list (6.5%; P = .009). The following variables correlated with the probability of death on the waiting list: emphysema or bronchiectasis diagnosis (hazard ratio [HR] = 0.15; P = .002); activated partial thromboplastin time > 30 seconds (HR = 3.28; P = .002); serum albumin > 3.5 g/dL (HR = 0.41; P = .033); and hemoglobin saturation > 85% (HR = 0.44; P = .031). CONCLUSIONS:Some variables seemed to predict death on the LTx waiting list; these characteristics should be used to improve the LTx allocation criteria in Brazil.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Costa da Silva F Jr,Afonso JE Jr,Pêgo-Fernandes PM,Caramori ML,Jatene FB

doi

10.1016/j.transproceed.2009.01.048

subject

Has Abstract

pub_date

2009-04-01 00:00:00

pages

927-31

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(09)00109-2

journal_volume

41

pub_type

杂志文章

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