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Relationship of posttransplantation erythrocytosis to hypercalcemia in renal transplant recipients.

Abstract：

:Experimental studies have demonstrated that calcium is an essential molecule in modulation of erythropoiesis. The aim of this study was to investigate the role of serum calcium levels on the development of posttransplantation erythrocytosis (PTE) among renal transplant recipients. We enrolled 155 patients (36 females/119 males; mean age, 34.9 +/- 9.7 years) with normal graft function who underwent renal transplantation between 1999 and 2002. All of the demographic features and various laboratory parameters were retrospectively analyzed as possible factors associated with erythrocytosis. PTE appeared in 43 (27.7%) patients during the follow-up period. Sixty-three (40.6%) patients developed hypercalcemia (corrected serum calcium level > or =10.2 mg/dL). Serum calcium levels tended to increase in patients with PTE, but significantly decreased in patients without PTE (10.6 +/- 0.6 vs 9.8 +/- 0.5 mg/dL; P < .0001). Similarly, hypercalcemia was more common among patients with PTE compared with patients without PTE (74.4% vs 27.7%; P < .0001). Hypercalcemic patients had a significantly higher frequency of PTE than normocalcemic patients (50.7% vs 11.9%; P < .0001). There were no differences in other laboratory and demographic data between the patients with and without PTE (P > .05). These findings suggest that hypercalcemia may lead to increased PTE in renal transplant recipients.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Akcay A,Kanbay M,Huddam B,Usluogullari CA,Arat Z,Ozdemir FN,Haberal M

doi

10.1016/j.transproceed.2005.08.041

subject

Has Abstract

pub_date

2005-09-01 00:00:00

pages

3103-5

issue

7

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00870-5

journal_volume

37

pub_type

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