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Rapid generation of Epstein-Barr virus-specific T cells for cellular therapy.

Abstract：

:Lymphoproliferative disease after hematopoietic stem cell transplantation is a serious and life-threatening disease. CD8(+) T lymphocytes play a key role in the control of viral diseases and some tumors. Adoptive immunotherapy has been shown to be effective in controlling and preventing some virus-related diseases in transplant recipients. However, the ex vivo production of cells for adoptive transfer is labor-intensive and expensive. To simplify the culture procedures of Epstein-Barr virus (EBV)-specific cytotoxic T lymphocytes, we explored a novel method, a rapid expansion protocol, that only used recombinant human interleukin to initiate the growth of clinical-grade EBV-specific T cells. After restimulation with EBV peptides principally from latent antigens and immediate/early antigens, the CD8(+) cells obtained could produce cytokines that had cytotoxic activity against target cells. This method provides a new possibility for the treatment of life-threatening EBV-associated malignancies.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Hao QF,Yang YX,Wang Y,Chen LM,Sheng GY,Luan Z

doi

10.1016/j.transproceed.2013.04.015

subject

Has Abstract

pub_date

2014-01-01 00:00:00

pages

21-5

issue

1

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(13)01141-X

journal_volume

46

pub_type

杂志文章

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