当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Basiliximab (Simulect) reduces acute rejection among sensitized kidney allograft recipients.

Basiliximab (Simulect) reduces acute rejection among sensitized kidney allograft recipients.

Abstract：

AIMS:Our goal was to evaluate the efficacy and safety of basiliximab (Simulect) as immunosuppressive induction therapy for the prevention of acute allograft rejection among sensitized kidney recipients. METHODS:Fifty-six adult recipients receiving cadaveric kidney transplant with panel reactive antibody class I ranging from 30% to 50% and or class II 30% to 80% were randomized at about a 2:1 ratio to the Simulect group (36 patients) or matching control group (20 patients). All patients received baseline triple immunosuppressive therapy with cyclosporine (Neoral), mycophenolate mofetil, and steroids. Simulect was given in two doses of 20 mg each on day 0 (2 hours before operation) and day 4 after transplantation. RESULTS:There was no hyperacute rejection in either group and delayed graft function occurred in three control patients. The incidence of acute rejection during the first 3 months was 11.1% in the Simulect group compared with 50% in the placebo group (77.8% reduction, P < .01). No apparent adverse and toxic events were recorded in the Simulect group. The mean daily dose of steroids was significantly higher in the control group 2 to 4 weeks posttransplantation. No clinically meaningful differences in the mean dose of cyclosporine were observed between the two groups; in addition, there were no statistically significant differences in the rate of patient or graft survival. CONCLUSIONS:On the basis of appropriate selection of the donor and recipient, Simulect is effective and safety for the sensitized recipients as immunosuppressive induction therapy.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Tan J,Yang S,Wu W

doi

10.1016/j.transproceed.2005.01.071

subject

Has Abstract

pub_date

2005-03-01 00:00:00

pages

903-5

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(05)00100-4

journal_volume

37

pub_type

临床试验,杂志文章,随机对照试验

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Neutrophilic reversible airways dysfunction after liver transplantation: a case report.

    abstract：:In the present case report we have described a 46-year-old female patient who underwent a liver transplantation in 1998 for polycystic disease and developed a syndrome of increasing dyspnea, with sputum production and a progressive decline in pulmonary function [forced expiratory volume in one second (FEV(1)) (decreas...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.02.021

    authors： Verleden GM,Vos R,De Vleeschauwer S,Verleden S,Dupont L,Nevens F,Verbeken E,Vanaudenaerde BM

    更新日期：2011-06-01 00:00:00

  • Altered expression of hepatocyte growth factor in cardiac allografts of nonhuman primates.

    abstract：:Hepatocyte growth factor (HGF) plays a critical role in transplant rejection. Herein we addressed whether HGF expression could be used for accurate and early diagnosis of acute and chronic rejection in cardiac transplantation. We used a heterotopic cardiac transplantation model using nonhuman primates (Macaca fuscata,...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.075

    authors： Suzuki J,Kawauchi M,Ogawa M,Isobe M

    更新日期：2006-12-01 00:00:00

  • Rehabilitation of ischemically damaged human kidneys by normothermic extracorporal hemoperfusion in situ with oxygenation and leukocyte depletion.

    abstract：:The potential use of donors after cardiac death is an important issue. The crucial point in uncontrolled donors after cardiac death is the warm ischemic time. Definition of the limit of warm ischemic time was 1 of our tasks; an other was to develop a preservation protocol. Five uncontrolled donors kidneys with warm is...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.01.071

    authors： Reznik O,Bagnenko S,Skvortsov A,Ananyev A,Senchik K,Loginov I,Moysyuk Y

    更新日期：2010-06-01 00:00:00

  • The new method of time-lag ligation for portosystemic shunt using coronary artery bypass graft occluder for adult living donor liver transplantation.

    abstract：:We performed a living donor liver transplantation (LDLT) for a 57-year-old man who had end-stage liver failure with portal hypertension and an inferior mesenteric vein-left testicular vein (IMV-LTV) shunt. At operation, we did not clamp the shunt but encircled it with a coronary artery bypass graft (CABG) occluder (Su...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.08.055

    authors： Kokai H,Sato Y,Yamamoto S,Oya H,Nakatsuka H,Kobayashi T,Watanabe T,Takizawa K,Hatakeyama K

    更新日期：2009-12-01 00:00:00

  • Increased Stiffness of the Remnant Right Lobe Liver After Left Lobectomy or Lateral Segmentectomy in Donors of Living-Donor Liver Transplantation.

    abstract：BACKGROUND:Liver stiffness is associated with the degree of fibrosis along with other factors. Abrupt change of liver perfusion after hepatectomy is one such factor. In this study, we performed ultrasound elastography to explore the stiffness of the right lobe liver before and after hepatectomy in donors who underwent ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.03.046

    authors： Wang HK,Lai YC,Lin YH,Chiou HJ,Chou YH

    更新日期：2017-06-01 00:00:00

  • Comparison of paired exchange kidney transplantations with living related kidney transplantations.

    abstract：OBJECTIVE:Paired-exchange kidney transplantation (PETx) gains an importance because it is difficult to find suitable organs. The aim of this study was to compare biochemical and clinical parameters of PETx with those of living-related kidney transplantation (LRTx). METHOD:The 57 PETx included 18 female and 39 male rec...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.05.045

    authors： Tuncer M,Tekin S,Yücetin L,Şengül A,Demirbas A

    更新日期：2012-07-01 00:00:00

  • Body Mass Index and Unenhanced CT as a Predictor of Hepatic Steatosis in Potential Liver Donors.

    abstract：BACKGROUND:In living-donor liver transplantation, donor hepatic steatosis is crucial for both the donor and the recipient. Body mass index (BMI) and the unenhanced computed tomography liver attenuation index (CT LAI) are noninvasive methods to predict hepatic steatosis in living-donor liver candidates. AIM:To analyze ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.02.047

    authors： Adalı G,Bozkurt B,Ceyhan Ö,Server S,Doğusoy GB,Yüzer Y,Tokat Y

    更新日期：2019-09-01 00:00:00

  • Lower Urinary Tract Symptoms Due to Xanthoma of the Prostate After Kidney Transplantation: A Case Report.

    abstract：BACKGROUND:Prostatic xanthoma is a lesion of unknown cause that is often an incidental finding in patients undergoing needle biopsy or transurethral resection. To the best of our knowledge, we report on a unique case of a pure xanthoma without benign prostatic hyperplasia of the prostate in a patient with lower urinary...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2020.02.180

    authors： Billis A,Freitas LLL,Costa LBE,Barreto IS,Botega AAR,Pereira TA,D'Ancona CA

    更新日期：2020-11-01 00:00:00

  • Beneficial effects of fluvastatin on progressive renal allograft dysfunction.

    abstract：:To assess the time-dependent changes in renal function in relation to antioxidant and lipid-lowering effects of fluvastatin in hyperlipidemic renal transplant recipients, 20 patients were treated with fluvastatin 40 mg/d for 12 months, after failure of a dietary program. Plasma malondialdehyde (MDA) levels and lipid p...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章

    doi：10.1016/s0041-1345(03)00376-2

    authors： Konstadinidou I,Boletis JN,Perrea D,Triantafyllou A,Filiopoulos V,Stamataki E,Kostakis A,Stathakis ChP

    更新日期：2003-06-01 00:00:00

  • Nutritional outcomes following pediatric intestinal transplantation.

    abstract：BACKGROUND:This study sought to describe the long-term nutritional outcomes of children after intestinal transplant (SBT). METHODS:Between 1991 and March 2005, 30 children received 33 SBT at a single center. Eligibility criteria included patient and graft survival >6 months. Weight, height, albumin, prealbumin, zinc (...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.05.051

    authors： Venick RS,Farmer DG,Saikali D,Gordon S,Colangelo J,Reyen L,McDiarmid SV,Vargas JH,Ament ME,Busuttil RW

    更新日期：2006-07-01 00:00:00

  • The proteasome inhibitor bortezomib inhibits intimal hyperplasia of autologous vein grafting in rat model.

    abstract：OBJECTIVE:Increasing evidence indicates that inflammation plays an important role in intimal hyperplasia (IH) induced by autologous vein grafts. The proteasome inhibitor bortezomib shows anti-inflammatory effects, so we used an autologous vein transplantation model to test whether bortezomib inhibits neointimal formati...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.01.063

    authors： He XP,Li XX,Bi YW,Yue WM,Sun WY,Pang XY,Gu XH

    更新日期：2008-06-01 00:00:00

  • Successful Treatment of Urinary Tract Infection in Kidney Transplant Recipients Caused by Multiresistant Klebsiella pneumoniae Producing New Delhi Metallo-Beta-Lactamase (NDM-1) With Strains Genotyping.

    abstract：BACKGROUND:Klebsiella pneumoniae New Delhi metallo-beta-lactamase-1 (NDM-1) strains have recently become a new threat in kidney transplant recipients due to the strains' resistance to almost all antibiotics, including carbapenems. METHODS:We present a case series of 3 patients with urinary tract infections (UTIs) caus...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.01.060

    authors： Wilkowski P,Ciszek M,Dobrzaniecka K,Sańko-Resmer J,Łabuś A,Grygiel K,Grochowiecki T,Młynarczyk G,Pączek L

    更新日期：2016-06-01 00:00:00

  • Perioperative kinetics of heat shock protein 60 in serum during orthotopic liver transplantation.

    abstract：INTRODUCTION:Heat shock proteins (HSP) play essential roles in the synthesis, transport, and folding of proteins. During ischemia/reperfusion (I/R) injury to orthotopic liver transplants (OLT), disassembly of oligomeric complexes and unfolding of proteins are likely to occur, producing a major burden on HSP to prevent ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.05.033

    authors： Faybik P,Wachauer D,Hetz H,Bachleitner T,Steltzer H,Schett G,Krenn CG

    更新日期：2004-06-01 00:00:00

  • Vascular cell adhesion molecule-1-targeted detection of endothelial activation in human microvasculature.

    abstract：:The hallmark of endothelial activation, an early and critical step in many alloimmune and inflammatory responses, is the transcriptional induction and expression of endothelial adhesion molecules (eg, vascular cell adhesion molecule-1 [VCAM-1]). We assessed the feasibility of VCAM-1-targeted in vivo detection of endot...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.05.060

    authors： Sadeghi MM,Schechner JS,Krassilnikova S,Gharaei AA,Zhang J,Kirkiles-Smith N,Sinusas AJ,Zaret BL,Bender JR

    更新日期：2004-06-01 00:00:00

  • The role of dendritic cells in the gastrointestinal field effect.

    abstract：INTRODUCTION:Intestinal manipulation leads to local bowel wall inflammation that subsequently spreads over the entire gastrointestinal tract. Previously, this gastrointestinal field effect had been demonstrated by us in a rodent model. We herein postulated an immunologic mechanism mediated by activated leukocytes. The ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.06.087

    authors： Koscielny A,Boerner T,Wehner S,Kurts C,Kalff JC

    更新日期：2006-07-01 00:00:00

  • A comparison of open surgery and endovascular intervention for hepatic artery complications after pediatric liver transplantation.

    abstract：:There are currently 2 major therapeutic options for the treatment of hepatic artery complications: endovascular intervention and open surgery. We herein report a retrospective analysis of 14 pediatric patients with hepatic artery complications after pediatric living donor liver transplantation (LDLT) at our institutio...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.08.012

    authors： Wakiya T,Sanada Y,Mizuta K,Urahashi T,Ihara Y,Yamada N,Okada N,Egami S,Nakata M,Hakamada K,Yasuda Y

    更新日期：2013-01-01 00:00:00

  • Hand-assisted Laparoscopic Left Donor Nephrectomy Without a Hand-assisted Device: Is it Possible?

    abstract：BACKGROUND:Live donor nephrectomy is an important donor source. Donor nephrectomy can be performed by laparoscopy or hand-assisted laparoscopy. Different types of hand port devices can be used for assistance. In the literature there are few studies about hand-assisted laparoscopy without a hand port. In this study, we ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.07.016

    authors： Karabay O,Tasci H,Hasbahceci M,Kadioglu H

    更新日期：2019-12-01 00:00:00

  • Transfection of hairpin small interfering RNA expression vector targeting rat nuclear factor (NF) (κB) inhibits rat cell proliferation induced by NF-κB signal pathway activation.

    abstract：OBJECTIVE:The aim of this work was to construct one small interfering RNA (siRNA) eukaryotic expression vector targeting rat nuclear factor (NF)κB p65 and identify its inhibition effect on cell proliferation according to its down-regulation of NF-κB pathway. METHODS:The p65siRNA expression vector "pGenesil-1.2-p65siRN...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.09.168

    authors： He XP,Li XX,Wang ZH,Bi YW,Liu FY,Liu XY

    更新日期：2010-12-01 00:00:00

  • Elevation of Preoperative Ammonia Level Is Not Associated With the Incidence of Postoperative Delirium in Patients with Liver Transplantation: A Propensity Score Matching Analysis.

    abstract：INTRODUCTION:The preoperative elevation of ammonia may be associated with postoperative neurologic complications. The aim of this study was to evaluate the effect of preoperative ammonia level on the incidence of delirium in patients after liver transplantation (LT). MATERIALS AND METHODS:Patients (n = 260) who receiv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.11.012

    authors： Ri HS,Choi YJ,Park JY,Jin SJ,Lee YS,Son JM,Yoon SZ,Shin HW,Choi BH,Lee TB

    更新日期：2020-01-01 00:00:00

  • Insulin-like growth factor-I enhances choleretic action of FK506 in rats.

    abstract：:FK506 is an immunosuppressant for organ transplantation in the same clinical settings as cyclosporine (CsA). In the management of liver transplantation, FK506 has advantages over CsA, in terms of rejection and corticosteroid requirements. Recent clinical findings in liver transplant patients indicate that FK506, but n...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00358-0

    authors： Mabuchi M,Kawamura I,Takeshita S,Fushimi M,Takakura S,Hirosumi J,Mutoh S

    更新日期：2003-06-01 00:00:00

  • Effects of ischemic liver preconditioning on hepatic ischemia/reperfusion injury in the rat.

    abstract：:To minimize bleeding during major liver resections or liver transplantation, surgical measures have been adopted that induce ischemia-reperfusion injury (I/R) which may significantly contribute to morbidity and mortality of partial liver resections. Several methods have sought to minimize I/R hepatic lesions. The pres...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.01.011

    authors： Centurion SA,Centurion LM,Souza ME,Gomes MC,Sankarankutty AK,Mente ED,Castro e Silva O

    更新日期：2007-03-01 00:00:00

  • Modified quantitative subjective global assessment of nutrition in patients on the renal transplant waiting list.

    abstract：:Subjective global assessment (SGA) of nutritional status is a widely used and validated method for identifying and classifying malnutrition. It has been thought that this semiquantitative feature restricts the reliability and precision of the SGA. Recently, in an effort to assess nutritional status, a modified quantit...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.10.036

    authors： Demirağ A,Kalayci M,Kantarci G,Gökçe O

    更新日期：2009-01-01 00:00:00

  • Utility of Oxford Classification in Post-Transplant Immunoglobulin A Nephropathy.

    abstract：BACKGROUND:With increasing graft survival, post-transplant immunoglobulin A nephropathy (IgAN) has emerged as an important cause of chronic graft dysfunction in renal allograft recipients. We studied the clinico-pathological features of post-transplant IgAN regardless of the primary disease. The aim was to study the us...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2017.10.002

    authors： Agrawal V,Singh A,Kaul A,Verma R,Jain M,Pandey R

    更新日期：2017-12-01 00:00:00

  • Chronic rejection after combined liver and small bowel transplantation in a child with chronic intestinal pseudo-obstruction: a case report.

    abstract：:An 11-year-old boy with irreversible intestinal failure secondary to chronic intestinal pseudo-obstruction (CIPO) and intestinal failure-associated liver disease (IFALD) underwent a combined en bloc reduced liver and small bowel transplantation. He was discharged home after 9 weeks on full oral intake without requirin...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.01.066

    authors： Giovanelli M,Gupte GL,Sharif K,Mayer DA,Mirza DF

    更新日期：2008-06-01 00:00:00

  • Molecular actions of sirolimus: sirolimus and mTor.

    abstract：:Recent therapeutic strategies to combat organ allograft rejection have focused on T-cell signaling pathways and the molecules that comprise them. The macrolide antibiotic produced by the bacterium Streptomyces hygroscopicus, known as sirolimus or rapamycin, has shown great therapeutic potential in the transplant setti...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/s0041-1345(03)00230-6

    authors： Kirken RA,Wang YL

    更新日期：2003-05-01 00:00:00

  • Relationships Between Metabolic Syndrome, Microalbuminuria, and C-Reactive Protein in Turkish Kidney Transplant Recipients.

    abstract：AIM:The aims of this study were to report the prevalence of metabolic syndrome (MS) in a cohort of Turkish kidney transplant recipients and to define the relationships between MS, microalbuminuria and C-reactive protein (CRP), which are cardiovascular risk factors, in kidney transplant setting. METHODS:This cross sect...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.04.037

    authors： Sipahioglu MH,Unal A,Yazgac H,Tunca O,Arikan T,Kocyigit I,Tokgoz B,Oymak O

    更新日期：2015-06-01 00:00:00

  • C4d-positive acute humoral renal allograft rejection: rescue therapy by immunoadsorption in combination with tacrolimus and mycophenolate mofetil.

    abstract：OBJECTIVE:We investigated the efficacy of immunoadsorption (IA) in combination with tacrolimus (FK506) and mycophenolate mofetil (MMF) rescue therapy for C4d-positive acute humoral rejection (AHR) of renal transplants. METHODS:Six of 185 cadaveric renal allograft recipients developed AHR at a mean of 4.8 +/- 0.8 days ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.07.071

    authors： Liu M,Ji SM,Tang Zh,Ji DX,Chen HP,Liu ZH,Li LS

    更新日期：2004-09-01 00:00:00

  • Alpha-1 antitrypsin treatment of spontaneously diabetic nonobese diabetic mice receiving islet allografts.

    abstract：:Alpha-1 antitrypsin (AAT) is a serine protease inhibitor able to prevent diabetes onset in nonobese diabetic (NOD) mice and to prolong islet allograft survival in a nonautoimmune murine model. In this study, we explored the effect of chronic administration of human AAT (hAAT) on allogeneic (C57BL/6) islet graft surviv...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.02.010

    authors： Pileggi A,Molano RD,Song S,Zahr E,SanJose S,Villate S,Wasserfall C,Ricordi C,Atkinson MA,Inverardi L

    更新日期：2008-03-01 00:00:00

  • Mixed Hepatocellular Cholangiocarcinoma: A Review of Long-Term Outcomes Following Liver Transplantation.

    abstract：INTRODUCTION:Mixed hepatocellular cholangiocarcinoma (HCC-CC) represents a rare hepatic tumor, which demonstrates histological features of both hepatocellular carcinoma (HCC) and cholangiocarcinoma (CC). HCC-CC can be an unexpected finding in patients undergoing liver transplantation (LT) for HCC. The objective of our ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.01.073

    authors： Machairas N,Stamopoulos P,Kostakis ID,Garoufalia Z,Paspala A,Tsaparas P,Sotiropoulos GC

    更新日期：2019-03-01 00:00:00

  • Exercise performance comparison of bicaval and biatrial orthotopic heart transplant recipients.

    abstract：BACKGROUND:The standard biatrial technique for orthotopic heart transplantation uses a large atrial anastomosis to connect the donor and recipient atria. A modified technique involves bicaval and pulmonary venous anastomoses and is believed to preserve the anatomic configuration and physiological function of the atria....

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.08.085

    authors： Czer LS,Cohen MH,Gallagher SP,Czer LA,Soukiasian HJ,Rafiei M,Pixton JR,Awad M,Trento A

    更新日期：2011-12-01 00:00:00