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Persistent thrombocytopenia in liver transplant patients.

Abstract：

INTRODUCTION:The occurrence of thrombocytopenia in the perioperative period after a liver transplant is not uncommon. However, there are few studies on persistent thrombocytopenia during the longer follow up period of patients after liver transplantation. We examined the prevalence of and contributing factors to persistent thrombocytopenia beyond 1 year post-liver transplantation. METHODS:We analyzed adult patients followed for at least 1 year posttransplant with full blood counts and abdominal scans, as well as clinical notes. RESULTS:The 35 patients of mean age at transplant of 50 years and showed a mean follow-up of about 4 years showed a prevalence of persistent thrombocytopenia at 12 months of 54% and at 3 years of 25%. Factors that were associated with persistent thrombocytopenia were pretransplant variceal bleeding, splenomegaly, and thrombocytopenia at 3 and 6 months posttransplant. After multivariate analysis only the latter represented independent factors for persistent thrombocytopenia at 1 and 3 years posttransplant, respectively. CONCLUSION:Persistent thrombocytopenia improved over time posttransplant; no bleeding problem was observed among the affected cases.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Sutedja DS,Wai CT,Teoh KF,Lee HL,DaCosta M,Kaur M,Lee YM,Lee KH,Mak K,Quak SH,Isaac J,Lim SG,Prabhakaran K

doi

10.1016/j.transproceed.2004.07.001

subject

Has Abstract

pub_date

2004-10-01 00:00:00

pages

2331-3

issue

8

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(04)00783-3

journal_volume

36

pub_type

杂志文章

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