当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Differentiated expression patterns of growth factors in routine formalin-fixed endomyocardial biopsies in the early postoperative phase after heart transplantation.

Differentiated expression patterns of growth factors in routine formalin-fixed endomyocardial biopsies in the early postoperative phase after heart transplantation.

Abstract：

BACKGROUND:Platelet-derived growth factor (PDGF) and fibroblast growth factor (FGF) seem to play a key role in immunological reactions shortly after heart transplantation (HTx). The aim of this study was to analyze the time course of the expression of PDGF A and B, PDGF-receptor alpha (PDGF-Ralpha) and beta, aFGF, and bFGF on formalin-fixed routine endomyocardial biopsies. PATIENTS AND METHODS:Right ventricular endomyocardial biopsies were obtained from 36 heart transplant recipients up to 2 weeks after HTx. According to the clinical course in the first postoperative year, 3 groups were formed: (1) clinically uneventful course (n = 12); (2) cardiac/systemic infections (n = 12); (3) acute rejection (n = 12). The growth factor expression was examined immunohistochemically. RESULTS:In the early phase after HTx, PDGF A, PDGF B, PDGF-Ralpha, and PDGF-Rbeta were predominantly expressed in endothelial cells. The main expression of PDGF-Ralpha and bFGF was found in cardiomyocytes, endothelial cells, and smooth muscle cells. During the first 2 postoperative weeks, PDGF A, PDGF B, and PDGF-Rbeta showed a similar time course of expression: A significantly elevated expression in the first week was followed by a decrease in the second week. In the rejection group, PDGF A was significantly elevated after the first week. CONCLUSIONS:The increased expression of PDGF in the first postoperative week can be interpreted as an unspecific reaction to peritransplant injury. The prolonged expression of PDGF A, PDGF B, and PDGF-Rbeta showed that there were ongoing immunological reactions in the transplant during week 2. The persistence of elevated PDGF A expression might be of prognostic value in terms of a risk factor for either infection or rejection.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Koch A,Schmidt CI,Dengler TJ,Remppis A,Sack FU,Schirmacher P,Hagl S,Karck M,Schnabel PA

doi

10.1016/j.transproceed.2006.12.018

subject

Has Abstract

pub_date

2007-03-01 00:00:00

pages

554-7

issue

2

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(06)01565-X

journal_volume

39

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Early renal transplantation after donor renal angiography affects initial graft function.

    abstract：BACKGROUND:Renal angiography of a living donor is a common radiologic examination before transplantation. However, the contrast agent used during this procedure can cause contrast nephropathy. There are insufficient data regarding whether this radiocontrast exposure detoriates renal function and survival after transpla...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.122

    authors： Tutal E,Canver B,Can S,Colak T,Sezer S,Haberal M

    更新日期：2012-06-01 00:00:00

  • Expression and Significance of RANTES and MCP-1 in Renal Tissue With Chronic Renal Allograft Dysfunction.

    abstract：BACKGROUND:To investigate the expression of RANTES (regulated upon activation, normal T-cell-expressed and -secreted) and monocyte chemoattractant protein-1 (MCP-1) in renal allografts with chronic renal allograft dysfunction (CRAD), and explore its relationship with interstitial fibrosis and tubular atrophy (IF/TA). ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.05.007

    authors： Yan Q,Jiang H,Wang B,Sui W,Zhou H,Zou G

    更新日期：2016-07-01 00:00:00

  • Bile CXC motif chemokine 10 levels correlate with anti-donor cytotoxic T cell responses after liver transplantation.

    abstract：BACKGROUND:CXC motif chemokine 10 (CXCL10), known as interferon-γ-induced protein 10, is an inflammatory cytokine secreted by various cells in response to interferon-γ. CXCR3, the receptor of CXCL10, is predominantly expressed on activated T, B, natural killer, and dendritic cells, as well as macrophages. CXCR3 promote...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.092

    authors： Morimoto H,Ide K,Tanaka Y,Ishiyama K,Ohira M,Tahara H,Teraoka Y,Yamashita M,Abe T,Hashimoto S,Hirata F,Tanimine N,Saeki Y,Shimizu S,Sakai H,Yano T,Tashiro H,Ohdan H

    更新日期：2014-04-01 00:00:00

  • Renal function and tubular phosphate handling in long-term cyclosporine- and tacrolimus-based immunosuppression in kidney transplantation.

    abstract：:The aim of the study was to assess impaired tubular phosphate reabsorption and renal function among patients on cyclosporine- or tacrolimus-based immunosuppression for 2 years after kidney transplantation. Among 60 cadaveric kidney allograft recipients observed for 48 months, 40 received cyclosporine, azathioprine, an...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.12.083

    authors： Falkiewicz K,Kamińska D,Nahaczewska W,Boratyńska M,Owczarek H,Klinger M,Woźniak M,Patrzałek D,Szyber P

    更新日期：2006-01-01 00:00:00

  • Real-time Intraoperative Fluorescent Lymphography: A New Technique for Lymphatic Sparing Surgery.

    abstract：BACKGROUND:Many surgical procedures can produce persistent lymphorrhea, lymphoceles, and lymphedema after lymph node and lymph vessel damage. Appropriate visualization of the lymphatic system is challenging. Indocyanine green (ICG) is a well-known nontoxic dye for lymphatic flow evaluation. ICG fluorescence-guided lymp...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.08.017

    authors： Ietto G,Amico F,Soldini G,Chiappa C,Franchin M,Iovino D,Romanzi A,Saredi G,Cassinotti E,Boni L,Tozzi M,Carcano G

    更新日期：2016-11-01 00:00:00

  • Minimizing Hepatic Artery Thrombosis and Establishing Safety of Grafts With Dual Arteries in Living Donor Liver Transplantation.

    abstract：BACKGROUND:Hepatic artery thrombosis (HAT) is a dreaded complication following living donor liver transplantation (LDLT) and can lead to graft failure and biliary complications. We evaluated the results of our arterial anastomotic technique and outcomes in grafts with dual arterial supply. PATIENTS AND METHODS:Between...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.065

    authors： Mehta NN,Mangla V,Varma V,Lalwani S,Mehrotra S,Chawla D,Nundy S

    更新日期：2018-06-01 00:00:00

  • Hand-assisted Laparoscopic Left Donor Nephrectomy Without a Hand-assisted Device: Is it Possible?

    abstract：BACKGROUND:Live donor nephrectomy is an important donor source. Donor nephrectomy can be performed by laparoscopy or hand-assisted laparoscopy. Different types of hand port devices can be used for assistance. In the literature there are few studies about hand-assisted laparoscopy without a hand port. In this study, we ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.07.016

    authors： Karabay O,Tasci H,Hasbahceci M,Kadioglu H

    更新日期：2019-12-01 00:00:00

  • How reconstructive transplantation is different from organ transplantation--and how it is not.

    abstract：:An evolution of understanding and knowledge gained over more than 100 years in the field of solid organ transplantation (SOT) led to the first successful clinical cases of composite tissue allotransplantation. In many ways reconstructive transplantation (RT) is similar to SOT; however, certain characteristics make thi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2011.08.044

    authors： Hautz T,Brandacher G,Engelhardt TO,Pierer G,Lee WP,Pratschke J,Schneeberger S

    更新日期：2011-11-01 00:00:00

  • Outcome after steroid withdrawal in heart transplantation.

    abstract：BACKGROUND:There is a lack of consensus and insufficient data to assess the impact of late steroid withdrawal after heart transplantation (HTx). The aim of the study was to investigate the security and feasibility of corticosteroid withdrawal at 1 year after transplantation. METHODS AND RESULTS:Steroid withdrawal was ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.028

    authors： Castel MA,Vallejos I,Ramos P,Arias A,Bravo C,Ferrero M,Rivero D,Sionis A,Pérez-Villa F,Roig E

    更新日期：2009-07-01 00:00:00

  • Excellent long-term results in de novo renal transplant recipients treated with proliferation signal inhibitors and reduced calcineurin inhibitors exposure.

    abstract：BACKGROUND:A new class of immunosuppressants, proliferation signal inhibitors (PSI)--sirolimus and everolimus--has the potential to prevent chronic allograft nephropathy (CAN). This retrospective analysis reports a 6-year practice using PSI at a single center, comparing a regimen based on reduced-dose calcineurin inhib...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.05.047

    authors： Carmellini M,Collini A,Ruggieri G,Garosi G,Bernini M

    更新日期：2008-07-01 00:00:00

  • Hemolytic anemia is not a frequent complication of ABO unmatched renal allografts from living related donors.

    abstract：:In summary, we could not document an increased incidence of HA nor a detrimental effect of CyA use in our recipients of ABO-unmatched LRD kidneys. Thus, it would appear that the incidence of HA in this situation is low enough that no special pretreatment of the kidney transplant or recipient is warranted. Since the lo...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Baldwin WM 3rd,Bollinger RR,Sanfilippo F

    更新日期：1987-12-01 00:00:00

  • Gastrointestinal complications of hepatic transplantation.

    abstract：:In this series of 150 orthotopic hepatic transplants, clinically significant gastrointestinal hemorrhage occurred in 34 patients (23%). Five patients (15%) survived this complication. Enteric perforations occurred in 20 patients following 198 biliary-enteric procedures. Only one patient survived. Enteric perforations ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Koep LJ,Starzl TE,Weil R 3rd

    更新日期：1979-03-01 00:00:00

  • Anesthesia for ventricular assist device placement in pediatric patients: experience from a single center.

    abstract：BACKGROUND:The use of a ventricular assist device (VAD) as a bridge to heart transplantation in the pediatric population has evolved over the past decades This article presents our institution's clinical experience in the anesthetic management of pediatric patients with end-stage heart failure who underwent implantatio...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.02.068

    authors： Kocabas S,Askar FZ,Yagdi T,Engin C,Ozbaran M

    更新日期：2013-04-01 00:00:00

  • Impact of Skin Cancer Awareness on Prophylactic Behavior Among Renal Transplant Recipients.

    abstract：BACKGROUND:Renal transplant recipients (RTRs) have a risk for skin cancer. The most important risk factor, and the only one that depends on patient behavior, is the exposure to ultraviolet light. The aim of this study was to assess the level of skin cancer awareness and its impact on preventative behavior among RTRs. ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.11.040

    authors： Imko-Walczuk B,Graczyk M,Korban M,Kiełbowicz M,Dębska-Ślizień A,Rutkowski B

    更新日期：2016-06-01 00:00:00

  • Massive degeneration and atrophy of the native heart after heterotopic transplantation: a case report.

    abstract：:Extreme myocardial degeneration leading to advanced stages of cardiomyopathy with extensive atrophy is rarely observed before patients die. However, heterotopic transplantation is a special situation wherein this phenomenon can be observed. The greater part of the failed heart shows recuperation after receiving circul...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.02.012

    authors： Fiorelli AI,Coelho GH,Lima JL,Lourenço DD,Gutierres P,Bacal F,Bocchi E,Dias RR,Stolf NA

    更新日期：2009-04-01 00:00:00

  • Optimal Donor Selection During Verification Process: Which Factors Are Worth Knowing?

    abstract：BACKGROUND:The selection of optimal donor is crucial for successful hematopoietic stem cell transplantation (HSCT). Thereby, it is appropriate to know, in addition to basic human leukocyte antigen (HLA) gene matches, other immunogenic or nonimmunogenic parameters predicting the outcome of transplant. OBJECTIVE:A unifi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.08.043

    authors： Houdová L,Fetter M,Jindra P,Georgiev D

    更新日期：2018-12-01 00:00:00

  • Endothelial dysfunction in peritoneal dialysis patients with and without failed renal transplants.

    abstract：BACKGROUND:Endothelial dysfunction (ED) is a common, early abnormality that predisposes patients to develop atherosclerosis and cardiovascular events; inflammation is associated with atherosclerosis and malnutrition. Patients with failed transplants are usually complicated by inflammation; however, ED in this group of ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.200

    authors： Gorgulu N,Yelken B,Caliskan Y,Elitok A,Cimen O,Yazici H,Oflaz H,Turkmen A,Bozfakioglu S,Sever MS

    更新日期：2009-11-01 00:00:00

  • Neuropsychological changes in a large sample of liver transplant candidates.

    abstract：:One-hundred forty-eight pre-liver transplant candidates completed a psychological interview and brief neuropsychological testing. Assessment measures included the Repeatable Battery of Neuropsychological Status, Shipley Institute of Living Scale, Trail Making Test Parts A and B (TMT-A and TMT-B), and the Folstein Mini...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.050

    authors： Meyer T,Eshelman A,Abouljoud M

    更新日期：2006-12-01 00:00:00

  • Estimating the Net Utility Gains Among Donors and Recipients of Adult Living Donor Kidney Transplant.

    abstract：OBJECTIVES:Living donor kidney transplant relieves the disease burden of patients with end-stage renal disease but may shorten donor life expectancy; however, their quality of life (QOL) is preserved. Nevertheless, the magnitude of the net gain of this procedure is unknown. We evaluated the QOL of both donors and recip...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.01.049

    authors： Hiragi S,Goto R,Tanaka Y,Matsuyama Y,Sawada A,SakaI K,Miyata H,Tamura H,Yanagita M,Kuroda T,Ogawa O,Kobayashi T

    更新日期：2019-04-01 00:00:00

  • Analysis of vascular complications after renal transplantation.

    abstract：PURPOSE:Despite medical and surgical advances, vascular complications remain common after renal transplant, occurring among 3%-15% of patients. These complications may compromise graft function. This study sought to evaluate the frequency and management of vascular complications after renal transplant. MATERIALS AND M...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.01.007

    authors： Aktas S,Boyvat F,Sevmis S,Moray G,Karakayali H,Haberal M

    更新日期：2011-03-01 00:00:00

  • Insights into subclinical rejection.

    abstract：:Several groups have performed graft biopsies at set times posttransplant ("protocol biopsies") and found unequivocal histologic criteria for acute rejection in a high proportion of patients with stable graft function. The significance of "subclinical" rejection remains controversial. Our group and others have shown th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2003.12.051

    authors： Rush D,Winnipeg Transplant Group.

    更新日期：2004-03-01 00:00:00

  • Cytomegalovirus infection renal transplant recipients: risk factors and outcome.

    abstract：OBJECTIVE:Cytomegalovirus (CMV) is the most common viral infection after allotransplantation; it can be a major cause of morbidity and mortality. Our aim was to analyze the main risk factors that lead to development of CMV infection and disease. PATIENTS AND METHODS:We retrospectively analyzed 207 patients who receive...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.06.057

    authors： Kanter J,Pallardó L,Gavela E,Escudero V,Beltrán S,Morales A,Avila A,Crespo JF

    更新日期：2009-07-01 00:00:00

  • New-Onset Diabetes After Transplantation: Comparison Between a Cyclosporine-Based and a Tacrolimus-Based Immunosuppressive Regimen.

    abstract：INTRODUCTION:New-onset diabetes after transplantation (NODAT) is a complication of renal transplantation (RT) with an adverse effect on graft survival. OBJECTIVES:The purpose of the present study was to compare modifiable or non-modifiable clinical and laboratory parameters as well as the course of patients and transp...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.08.037

    authors： Zolota A,Miserlis G,Solonaki F,Tranda A,Antoniadis N,Imvrios G,Fouzas I

    更新日期：2018-12-01 00:00:00

  • Comparison of paired exchange kidney transplantations with living related kidney transplantations.

    abstract：OBJECTIVE:Paired-exchange kidney transplantation (PETx) gains an importance because it is difficult to find suitable organs. The aim of this study was to compare biochemical and clinical parameters of PETx with those of living-related kidney transplantation (LRTx). METHOD:The 57 PETx included 18 female and 39 male rec...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.05.045

    authors： Tuncer M,Tekin S,Yücetin L,Şengül A,Demirbas A

    更新日期：2012-07-01 00:00:00

  • Malignancy After Lung Transplantation: How to Manage Immunosuppression?

    abstract：:As newer immunosuppression has steadily induced tolerance and improved the survival time of graft, malignancy after lung transplantation has become an important cause of mortality. Cancer is the third most frequent cause of death among lung recipients who survive more than 1 year, and the oncogenic risk is believed to...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2019.09.012

    authors： Wang X,Dong M

    更新日期：2020-01-01 00:00:00

  • Partial Cystectomy of Paraganglioma of the Urinary Bladder Before Living Kidney Transplantation: Case Report.

    abstract：BACKGROUND:Paraganglioma (extra-adrenal pheochromocytoma) of the bladder is a very rare disease, accounting for 0.06% of all bladder tumors. Optimal management of bladder paraganglioma before kidney transplantation is unknown. We report a case of partial cystectomy for urinary bladder paraganglioma before living kidney...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.01.015

    authors： Kido K,Hatakeyama S,Hamano I,Yamamoto H,Imai A,Yoneyama T,Hashimoto Y,Koie T,Fujita T,Murakami R,Tomita H,Suzuki T,Narumi S,Ohyama C

    更新日期：2018-04-01 00:00:00

  • Survival after disseminated invasive aspergillosis in a multivisceral transplant recipient.

    abstract：:Disseminated invasive aspergillosis is a serious and potentially lethal infectious complication of immunosuppressed individuals, including transplant recipients. We report here a successfully treated case of disseminated Aspergillus fumigatus infection involving the lungs, brain, and endocardium in a multivisceral tra...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.015

    authors： Vianna R,Misra V,Fridell JA,Goldman M,Mangus RS,Tector J

    更新日期：2007-01-01 00:00:00

  • Carbapenem-resistant Acinetobacter baumannii Bacteremia in Liver Transplant Recipients.

    abstract：BACKGROUND:Acinetobacter baumannii has become an increasingly important nosocomial pathogen. Carbapenem is the preferred drug of choice for treatment of multidrug-resistant gram-negative bacilli, but carbapenem-resistant A baumannii (CRAB) has now emerged. The aim of this study was to determine the incidence, outcomes,...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.01.043

    authors： Kim YJ,Kim SI,Lee YD,Choi HJ,Choi JY,Yoon SK,You YK,Kim DG

    更新日期：2018-05-01 00:00:00

  • Changes in Renal Function After Heart Transplantation.

    abstract：:Renal function after heart transplantation (HTx) typically follows a biphasic pattern and an initial decay within 1 to 2 years. Trajectory of renal function after HTx is less reported, especially in Asia. The aims of this cohort study were to describe the changes in HTx recipients' serum creatinine and estimated glome...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2018.02.196

    authors： Tsao CI,Ting M,Chou NK,Chi NH,Chen YS,Huang SC,Tsan CY,Wang CH,Yu HY,Shun CT,Wang SS

    更新日期：2018-11-01 00:00:00

  • Thrombomodulin administration attenuates ischemia-reperfusion injury of the remnant liver after 70% hepatectomy in rats: simulated model of small-for-size graft in living donor liver transplantation.

    abstract：BACKGROUND:Hepatic ischemia-reperfusion injury (IRI) is a serious complication affecting liver function and postoperative course after liver transplantation. Thrombomodulin (TM) has been known to have anticoagulant and anti-inflammatory activities exerting a cytoprotective effect. We evaluated the cytoprotective effect...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2013.11.128

    authors： Tanemura A,Kuriyama N,Azumi Y,Ohsawa I,Kishiwada M,Mizuno S,Usui M,Sakurai H,Tabata M,Isaji S

    更新日期：2014-05-01 00:00:00