当前位置： SCI文献检索 > TRANSPLANTATION PROCEEDINGS期刊下所有文献 > Functional evaluation of chondrocyte sheeting immunodelusive immunoisolated bioartificial pancreas.

Functional evaluation of chondrocyte sheeting immunodelusive immunoisolated bioartificial pancreas.

Abstract：

:In islet transplantation, encapsulation of immunoisolated islets may provide a way to protect the graft from immune attacks with no immunosuppression. To develop an immunodelusive immunoisolated bioartificial pancreas (BAP), chondrocyte sheets were prepared by cell sheet engineering. We made an immunoisolated BAP encapsulated with rodent-derived chondrocyte sheets and then evaluated its function. Sprague-Dawley rats were used as the source of auricular cartilage and chondrocytes were maintained and expanded by passages. Lewis rats were prepared for islet isolation. A 3-dimensional chondrocyte sheeting immunodelusive immunoisolated BAP (CSI-BAP) was created by multi-layering and unifying the chondrocyte sheets. Subsequently, islets were embedded between each multi-layer sheet. To evaluate the function of the CSI-BAP, a glucose challenge test was performed and secretion of insulin in the culture medium was measured by an enzyme-linked immunosorbent assay. When observed by phase-contrast microscopy, the CSI-BAP maintained close connections between chondrocyte sheets. Islets in the CSI-BAP maintained viability at day 10 and showed good insulin secretion, as revealed by a prompt reaction to increased concentrations of glucose at days 5 and 10. In long-term culture, the CSI-BAP maintained its ability to secrete insulin for 8 weeks. This BAP technology could be an important tool for successful islet transplantation without immunosuppressive drugs.

journal_name

Transplant Proc

journal_title

Transplantation proceedings

authors

Kim JY,Lee JI,Jeong JH,Park YJ,Kim SJ,Fang YH,Cho Y,Huh KH,Joo DJ,Kim MS,Kim YS

doi

10.1016/j.transproceed.2010.02.043

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

903-6

issue

3

eissn

0041-1345

issn

1873-2623

pii

S0041-1345(10)00258-7

journal_volume

42

pub_type

杂志文章

相关文献

TRANSPLANTATION PROCEEDINGS文献大全
  • Simple evaluation of engraftment by secretory unit of islet transplant objects for living donor and cadaveric donor fresh or cultured islet transplantation.

    abstract：BACKGROUND:Evaluation of engraftment is important to assess the success of islet transplantation. Recently we developed secretory unit of islet transplant objects (SUITO) index for simple evaluation of engraftment. Assuming that normal subjects aged <40 years have 100% pancreatic beta-cell function, SUITO index was cal...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.09.045

    authors： Matsumoto S,Yamada Y,Okitsu T,Iwanaga Y,Noguchi H,Nagata H,Yonekawa Y,Nakai Y,Ueda M,Ishii A,Yabunaka E,Tanaka K

    更新日期：2005-10-01 00:00:00

  • Prophylactic adenine arabinoside following marrow transplantation.

    abstract：:Interstitial pneumonia is a major cause of morbidity and mortality following allogeneic marrow transplantation for hematologic malignancy. In this prospective randomized study, 22 of 40 patients received prophylactic adenine arabinoside (Ara-A) at a dose of 5 mg/kg/day administered intravenously on an intermittent sch...

    journal_title：Transplantation proceedings

    pub_type： 临床试验,杂志文章,随机对照试验

    doi：

    authors： Kraemer KG,Neiman PE,Reeves WC,Thomas ED

    更新日期：1978-03-01 00:00:00

  • Altered expression of hepatocyte growth factor in cardiac allografts of nonhuman primates.

    abstract：:Hepatocyte growth factor (HGF) plays a critical role in transplant rejection. Herein we addressed whether HGF expression could be used for accurate and early diagnosis of acute and chronic rejection in cardiac transplantation. We used a heterotopic cardiac transplantation model using nonhuman primates (Macaca fuscata,...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.10.075

    authors： Suzuki J,Kawauchi M,Ogawa M,Isobe M

    更新日期：2006-12-01 00:00:00

  • Individualization of immunosuppressive therapy. III. Sirolimus associated with a reduced incidence of malignancy.

    abstract：OBJECTIVE:We examined the occurrence of neoplasms among 1008 renal transplant recipients treated with a sirolimus-cyclosporine (CsA) +/- prednisone (Pred) regimen. METHODS:A comprehensive database of demographic, laboratory, clinical, and histopathologic features of these patients all followed in our transplant center...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2006.01.019

    authors： Yakupoglu YK,Buell JF,Woodle S,Kahan BD

    更新日期：2006-03-01 00:00:00

  • Serum level of soluble fibrinogen-like protein 2 in renal allograft recipients with acute rejection: a preliminary study.

    abstract：BACKGROUND:Soluble fibrinogen-like protein 2 (sfgl2), which is mainly secreted by T cells, is a novel effector of regulatory T cells with immunosuppressive functions. The aim of this study was to investigate serum levels of sfgl2 among renal allograft recipients. METHODS:From November 2010 to August 2011 we retrospect...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.05.082

    authors： Zhao Z,Yang C,Tang Q,Zhao T,Jia Y,Ma Z,Rong R,Xu M,Zhu T

    更新日期：2012-12-01 00:00:00

  • UW solution improves duration and quality of clinical liver preservation.

    abstract：:Prolonged liver preservation (up to 17 hours) with UW solution had no adverse effect on perioperative blood loss or results of postoperative serum biochemistry studies. After use of this solution, biliary and vascular complications as well as evidence of histologic damage were less. The advantages of the extended pres...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Cooper J,Rettke SR,Ludwig J,Ayalon A,Sterioff S,Wiesner RH,Krom RA

    更新日期：1990-04-01 00:00:00

  • Nitric oxide levels in the intestines of mice submitted to ischemia and reperfusion: L-arginine effects.

    abstract：OBJECTIVE:Usually an experimental necrotizing enterocolitis experimental model, we Investigated nitric oxide levels in intestinal tissues of newborn mice with or without l-arginine therapy during sessions of ischemia and reoxygenation. METHODS:Twenty-six newborn mice from the Wistar EPM-1 lineage, weighing from 4.5 to...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2008.02.044

    authors： Cintra AE,Martins JL,Patrício FR,Higa EM,Montero EF

    更新日期：2008-04-01 00:00:00

  • Postexposure prophylaxis of H1N1 with oseltamivir in a newly transplanted kidney recipient receiving intense immunosuppressive therapy.

    abstract：:Solid organ transplant recipients undergoing immunosuppressive therapy are considered to be at high risk for serious infectious complications. Recently in the United States, a pandemic of H1N1 flu infection has been reported with serious complications. We describe H1N1 infection in a living kidney donor and the 42-yea...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.09.052

    authors： Marfo K,Chapochnick-Friedmann J,Akalin E,Lu A

    更新日期：2009-12-01 00:00:00

  • Impact of hand-assisted laparoscopic living donor nephrectomy on donor's quality of life, emotional, and social state.

    abstract：BACKGROUND:Laparoscopic donor nephrectomy has become the preferred method for live kidney donation in many centers. Herein we have reported on donor-related quality of life (QoL) and social state after laparoscopic hand-assisted nephrectomy (HALDN) for living kidney donation. PATIENTS AND METHODS:Between December, 200...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.01.078

    authors： Hoda MR,Hamza A,Wagner S,Greco F,Fornara P

    更新日期：2010-06-01 00:00:00

  • Role of resistive index measurement in diagnosis of acute rejection episodes following successful kidney transplantation.

    abstract：OBJECTIVE:This study was performed to evaluate the role of resistive index (RI) in the diagnosis of rejection episodes following successful kidney transplantation. MATERIALS AND METHODS:One hundred and one unrelated living first kidney allograft adult recipients (75 males and 26 females) of overall mean age of 39 year...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2009.07.050

    authors： Mehrsai A,Salem S,Ahmadi H,Baradaran N,Taherimahmoudi M,Nikoobakht MR,Rezaeidanesh M,Mansoori D,Pourmand G

    更新日期：2009-09-01 00:00:00

  • Use of cyclosporine in hematopoietic cell transplantation.

    abstract：:Early attempts to perform successful allogeneic hematopoietic stem cell transplants were plagued by graft rejection and graft-versus-host disease, leading many investigators to lose hope that bone marrow transplantation could ever become a useful therapeutic approach in clinical medicine. Although many subsequent disc...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章,评审

    doi：10.1016/j.transproceed.2004.01.043

    authors： Hogan WJ,Storb R

    更新日期：2004-03-01 00:00:00

  • Epidemiology of HIV-Associated Tuberculosis in Urumqi, China.

    abstract：:The aim of this work was to understand the epidemiologic characteristics of TB and human immunodeficiency virus (HIV) dual infection cases, thus providing the basis for effective prevention and control measures. On the basis of HIV/TB screening of new and old TB and HIV/acquired immunodeficiency syndrome (AIDS) patien...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2015.09.017

    authors： Li WG,Zhao L,Zhao H

    更新日期：2015-10-01 00:00:00

  • Living donor kidney transplantation: chance for the recipient--financial risk for the donor?

    abstract：BACKGROUND:With living donation, in addition to the medical risk, the financial risk for the donor is essential, especially in case of complications that potentially can led to disability and loss of work. We report the experiences of those who have donated a kidney in our transplant center. METHODS:We contacted 80 do...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(03)00675-4

    authors： Wolters HH,Heidenreich S,Senninger N

    更新日期：2003-09-01 00:00:00

  • FK778 controls acute rejection after rat liver allotransplantation showing positive interaction with FK506.

    abstract：:This study including prevention and rescue experiments was performed to examine the efficacy of FK778 and its interactions with FK506. In the prevention experiment, Brown-Norway rats transplanted with a 7 Lewis livers received day-course of FK778 or a combination of FK778 and FK506 treatment. For the rescue experiment...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2005.02.016

    authors： Yamamoto S,Okuda T,Yamasaki K,Tanaka H,Takemura S,Minamiyama Y,Ikeda K,Hirohashi K,Suehiro S

    更新日期：2005-01-01 00:00:00

  • Biopharmaceutical aspects of FK-506.

    abstract：:FK is a potent immunosuppressive agent. FK can be analyzed in biologic fluids by EIA. The oral absorption of FK is rapid but variable in dogs. After intramuscular administration, FK is slowly and continuously absorbed. FK is primarily eliminated by metabolism. Less than 1% of the administered dose is excreted in the b...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Venkataramanan R,Warty VS,Zemaitis MA,Sanghvi AT,Burckart GJ,Seltman H,Todo S,Makowka L,Starzl TE

    更新日期：1987-10-01 00:00:00

  • Increasing Use of the Expanded Criteria for Living Kidney Donation and Good Outcomes of Living Kidney Donors in Korea.

    abstract：BACKGROUND:Donor shortage for kidney transplantation may increase the number of expanded-criteria living donors (ECLDs). We investigated recent trends for ECLD use and the long-term outcomes of living kidney donors. METHODS:We retrospectively analyzed medical records of 1,144 living kidney donors who donated at the Se...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.02.091

    authors： Lim HJ,Jambaldorj E,Lee Y,Kang SS,Koo TY,Ahn C,Yang J

    更新日期：2016-09-01 00:00:00

  • Comparison of erythrocyte membrane fatty acid contents in renal transplant recipients and dialysis patients.

    abstract：BACKGROUND:Alterations of erythrocyte membrane fatty acid (FA) composition play important roles in cellular function because they change the membrane microenvironment, including transmembrane receptors. The erythrocyte membrane oleic acid content is higher among patients with acute coronary syndrome and also in dialysi...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.04.041

    authors： Oh JS,Kim SM,Sin YH,Kim JK,Park Y,Bae HR,Son YK,Nam HK,Kang HJ,An WS

    更新日期：2012-12-01 00:00:00

  • Rat renal allograft tolerance is associated with local TGF-beta and absence of IL-2r expression within chimeric immunocytic foci.

    abstract：:Tolerance was induced in Lewis (LEW) rat renal allograft recipients of Brown Norway kidneys by multiple pretransplant donor-blood transfusions and prior limited cyclosporine A. Rat renal allograft tolerance was associated with the induction of systemic donor T cells (10%), an early phase of nonspecific suppressor-cell...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/s0041-1345(97)00284-4

    authors： Hewitt CW,Strande L,Santos M,Goodman M,Tarnoff M,Zaontz MR,DelRossi AJ,Doolin EJ

    更新日期：1997-06-01 00:00:00

  • Factors influencing the vaccinia-specific cytotoxic response of thymocytes from normal and chimeric mice.

    abstract：:Following adoptive transfer into irradiated recipients, thymocytes can be induced to respond strongly to vaccinia virus. High levels of cytotoxic T-lymphocyte (CTL) activity may be generated from thymus, but not from spleen, of 3-day-old mice. The capacity of thymocytes to differentiate into effector CTL tends to be l...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：

    authors： Doherty PC,Schwartz DH,Bennink JR,Korngold R

    更新日期：1981-12-01 00:00:00

  • Renal biopsy donor group: the influence of glomerulosclerosis on transplant outcomes.

    abstract：:The UNOS donor population was examined from 1999 to 2002, and approximately 25% of the over 23,000 donors were biopsied (Bx). There was a significant trend (P < .001) of older donors, cardiovascular accident, and hypertension in the Bx group versus the non-Bx group. The percent GS was directly correlated (P < .001) to...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2004.12.108

    authors： Cicciarelli J,Cho Y,Mateo R,El-Shahawy M,Iwaki Y,Selby R

    更新日期：2005-03-01 00:00:00

  • Reconstruction of the Outflow Tract in Cross-Auxiliary Double-Domino Donor Liver Transplantation.

    abstract：BACKGROUND:Auxiliary liver transplantation is accepted as an effective manner to expand the liver donor pool. A difficult surgical technical challenge of the procedure is hepatic vein reconstruction of the graft. METHODS:To resolve this problem, complex techniques are used to perform an innovative outflow tract recons...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2016.07.031

    authors： Qu W,Zhu ZJ,Wei L,Sun LY,Liu Y,Zeng ZG

    更新日期：2016-10-01 00:00:00

  • Decompressive craniectomy and brain death prevalence and mortality: 8-year retrospective review.

    abstract：:Decompressive craniectomy (DC) is a surgical practice that has been used since the late 19th century. The cerebral blood flow increase after the performance of a DC can delay and even prevent the development of cerebral circulatory arrest and brain death (BD). We aimed to determine the prevalence of BD, the use of DC,...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.07.107

    authors： Pereyra C,Benito Mori L,Schoon P,Violi D,Jacintho P,Segui G,Losio D,Lugaro M,Benavent G,Prieto M,Strati J,Diaz G

    更新日期：2012-09-01 00:00:00

  • Optimized technique in needle biopsy protocol shown to be of greater sensitivity and accuracy compared to wedge biopsy.

    abstract：BACKGROUND:Kidney biopsy is an important tool in determining allograft suitability for transplantation. Most deceased-donor renal biopsies performed today in the United States are wedge biopsies (WBs), with core needle biopsies being performed only by a minority of organ procurement organizations (OPOs). The lack of a ...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2010.04.058

    authors： Yushkov Y,Dikman S,Alvarez-Casas J,Giudice A,Hoffman A,Goldstein MJ

    更新日期：2010-09-01 00:00:00

  • Kidney dimensions at sonography are correlated with glomerular filtration rate in renal transplant recipients and in kidney donors.

    abstract：:The gold standard to assess renal function is the measurement of glomerular filtration rate (GFR). For practical reasons, renal function is often evaluated from serum creatinine (S Cr) or cystatin C (S Cys), and GFR is predicted from SCr. Ultrasound scanning of the kidneys is used only to evaluate renal morphology. Th...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.05.003

    authors： Paleologo G,Abdelkawy H,Barsotti M,Basha A,Bernabini G,Bianchi A,Caprio F,Emad A,Grassi G,Nerucci B,Tregnaghi C,Rizzo G,Donadio C

    更新日期：2007-07-01 00:00:00

  • Transplant of Tissue-Engineered Artificial Autologous Human Skin in Andalusia: An Example of Coordination and Institutional Collaboration.

    abstract：:A new model of tissue-engineered artificial autologous human skin developed in Andalusia is currently being transplanted into patients suffering from large burns within the Andalusian Public Healthcare System. This product is considered an advanced therapy medicinal product (ATMP) in Europe, and its clinical use impli...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2019.08.014

    authors： Egea-Guerrero JJ,Carmona G,Correa E,Mata R,Arias-Santiago S,Alaminos M,Gacto P,Cuende N

    更新日期：2019-11-01 00:00:00

  • Alemtuzumab induction and antibody-mediated rejection in kidney transplantation.

    abstract：BACKGROUND:Induction therapy improves graft outcomes in kidney transplant recipients (KTRs). We aimed to compare the incidences of antibody-mediated rejection (AMR) and acute cellular rejection (ACR) as well as graft and patient outcomes in KTRs who underwent induction with alemtuzumab versus rabbit-antithymocyte globu...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2014.08.037

    authors： Noureldeen T,Albekioni Z,Machado L,Muddana N,Marcus RJ,Hussain SM,Sureshkumar KK

    更新日期：2014-12-01 00:00:00

  • A logistic regression model for predicting health-related quality of life in kidney transplant recipients.

    abstract：BACKGROUND:To develop a logistic regression model capable of predicting health-related quality of life (HRQOL) among kidney transplant recipients and determine its accuracy. METHODS:Three groups of patients were selected: 70 healthy controls, 136 kidney transplant patients as a derivation set, and another 110 kidney t...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2007.04.004

    authors： Khedmat H,Karami GR,Pourfarziani V,Assari S,Rezailashkajani M,Naghizadeh MM

    更新日期：2007-05-01 00:00:00

  • De novo malignancies after liver transplantation: incidence comparison with the Korean cancer registry.

    abstract：PURPOSE:De novo malignancy is not uncommon after liver transplantation (OLT). We have compared the incidence of novo malignancy following OLT with those among the general Korean population. METHODS:Between January 1998 and December 2008, 1952 adult OLT were performed, including 1714 living donor and 238 deceased donor...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.01.027

    authors： Park HW,Hwang S,Ahn CS,Kim KH,Moon DB,Ha TY,Song GW,Jung DH,Park GC,Namgoong JM,Yoon SY,Park CS,Park YH,Lee HJ,Lee SG

    更新日期：2012-04-01 00:00:00

  • The clinical implication of inhibiting platelet activation on chronic renal allograft dysfunction: a prospective cohort study.

    abstract：INTRODUCTION:Clinically chronic renal allograft dysfunction (CRAD) manifests as a progressive elevation of serum creatinine (Cr) with an associated deterioration in proteinuria and decrease in glomerular filtration rate (GFR) following the first year after transplantation. Currently, how to delay or reverse CRAD and im...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2011.05.047

    authors： Zhang Y,Zong HT,Yang CC,Zhang XD

    更新日期：2011-09-01 00:00:00

  • Incidence of hepatic artery variations in liver transplantation: does it really influence short- and long-term results?

    abstract：BACKGROUND:Some variations of hepatic artery, which show 30% incidence, must be taken into account to avoid damage to the liver transplant during harvesting, we analyzed the incidence of variations and their influence on postoperative results. PATIENTS AND METHODS:We performed a retrospective study of 325 liver transp...

    journal_title：Transplantation proceedings

    pub_type： 杂志文章

    doi：10.1016/j.transproceed.2012.09.064

    authors： Pérez-Saborido B,Pacheco-Sánchez D,Barrera Rebollo A,Pinto Fuentes P,Asensio Díaz E,Labarga Rodriguez F,Sarmentero Prieto JC,Martínez Díez R,Rodríguez Vielba P,Gonzálo Martín M,Rodríguez López M,de Anta Román A

    更新日期：2012-11-01 00:00:00